Fabeha Fazal

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Thrombin selectively engages LIM kinase 1 and slingshot-1L phosphatase to regulate NF-κB activation and endothelial cell inflammation
    Antony Leonard
    Dept of Pediatrics, Lung Biology and Disease Program, Univ of Rochester School of Medicine, 601 Elmwood Ave Box 850, Rochester, NY
    Am J Physiol Lung Cell Mol Physiol 305:L651-64. 2013
  2. pmc Critical role of non-muscle myosin light chain kinase in thrombin-induced endothelial cell inflammation and lung PMN infiltration
    Fabeha Fazal
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America
    PLoS ONE 8:e59965. 2013
  3. pmc Essential role of cofilin-1 in regulating thrombin-induced RelA/p65 nuclear translocation and intercellular adhesion molecule 1 (ICAM-1) expression in endothelial cells
    Fabeha Fazal
    Department of Pediatrics Neonatology, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 284:21047-56. 2009
  4. pmc Activation of Syk by protein kinase C-delta regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via tyrosine phosphorylation of RelA/p65
    Kaiser M Bijli
    Department of Pediatrics Neonatology, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Biol Chem 283:14674-84. 2008
  5. pmc Regulation of Rela/p65 and endothelial cell inflammation by proline-rich tyrosine kinase 2
    Kaiser M Bijli
    Department of Pediatrics, Lung Biology and Disease Program, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Am J Respir Cell Mol Biol 47:660-8. 2012
  6. pmc Protein kinase C-delta and phosphatidylinositol 3-kinase/Akt activate mammalian target of rapamycin to modulate NF-kappaB activation and intercellular adhesion molecule-1 (ICAM-1) expression in endothelial cells
    Mohd Minhajuddin
    Department of Pediatrics Neonatology, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 284:4052-61. 2009
  7. ncbi request reprint Inhibition of mammalian target of rapamycin potentiates thrombin-induced intercellular adhesion molecule-1 expression by accelerating and stabilizing NF-kappa B activation in endothelial cells
    Mohd Minhajuddin
    Department of Pediatrics, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Immunol 174:5823-9. 2005
  8. ncbi request reprint c-Src interacts with and phosphorylates RelA/p65 to promote thrombin-induced ICAM-1 expression in endothelial cells
    Kaiser M Bijli
    Department of Pediatrics, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 292:L396-404. 2007
  9. ncbi request reprint Evidence for actin cytoskeleton-dependent and -independent pathways for RelA/p65 nuclear translocation in endothelial cells
    Fabeha Fazal
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 282:3940-50. 2007
  10. ncbi request reprint RhoA/Rho-associated kinase pathway selectively regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via activation of I kappa B kinase beta and phosphorylation of RelA/p65
    Khandaker N Anwar
    Department of Pediatrics, University of Rochester School of Medicine, Rochester, NY 14642, USA
    J Immunol 173:6965-72. 2004

Collaborators

Detail Information

Publications13

  1. pmc Thrombin selectively engages LIM kinase 1 and slingshot-1L phosphatase to regulate NF-κB activation and endothelial cell inflammation
    Antony Leonard
    Dept of Pediatrics, Lung Biology and Disease Program, Univ of Rochester School of Medicine, 601 Elmwood Ave Box 850, Rochester, NY
    Am J Physiol Lung Cell Mol Physiol 305:L651-64. 2013
    ..Thus this study provides evidence for a novel role of LIMK1 and SSH-1L in selectively regulating EC inflammation associated with intravascular coagulation. ..
  2. pmc Critical role of non-muscle myosin light chain kinase in thrombin-induced endothelial cell inflammation and lung PMN infiltration
    Fabeha Fazal
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America
    PLoS ONE 8:e59965. 2013
    ..These results provide mechanistic insight into lung inflammatory response associated with intravascular coagulation and identify nmMLCK as a critical target for modulation of lung inflammation...
  3. pmc Essential role of cofilin-1 in regulating thrombin-induced RelA/p65 nuclear translocation and intercellular adhesion molecule 1 (ICAM-1) expression in endothelial cells
    Fabeha Fazal
    Department of Pediatrics Neonatology, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 284:21047-56. 2009
    ..Together, these data show that cofilin-1 occupies a central position in RhoA-actin pathway mediating nuclear translocation of RelA/p65 and expression of ICAM-1 in endothelial cells...
  4. pmc Activation of Syk by protein kinase C-delta regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via tyrosine phosphorylation of RelA/p65
    Kaiser M Bijli
    Department of Pediatrics Neonatology, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Biol Chem 283:14674-84. 2008
    ....
  5. pmc Regulation of Rela/p65 and endothelial cell inflammation by proline-rich tyrosine kinase 2
    Kaiser M Bijli
    Department of Pediatrics, Lung Biology and Disease Program, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Am J Respir Cell Mol Biol 47:660-8. 2012
    ..Thus, specific targeting of Pyk2 may be an effective anti-inflammatory strategy in vascular diseases associated with EC inflammation and intravascular coagulation...
  6. pmc Protein kinase C-delta and phosphatidylinositol 3-kinase/Akt activate mammalian target of rapamycin to modulate NF-kappaB activation and intercellular adhesion molecule-1 (ICAM-1) expression in endothelial cells
    Mohd Minhajuddin
    Department of Pediatrics Neonatology, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 284:4052-61. 2009
    ..Thus, these data reveal an important role of PKC-delta and PI3K/Akt pathways in activating mTOR as an endogenous modulator to ensure a tight regulation of NF-kappaB signaling of ICAM-1 expression in endothelial cells...
  7. ncbi request reprint Inhibition of mammalian target of rapamycin potentiates thrombin-induced intercellular adhesion molecule-1 expression by accelerating and stabilizing NF-kappa B activation in endothelial cells
    Mohd Minhajuddin
    Department of Pediatrics, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Immunol 174:5823-9. 2005
    ..These data define a novel role of mTOR in down-regulating thrombin-induced ICAM-1 expression in endothelial cells by controlling a delayed and transient activation of NF-kappaB...
  8. ncbi request reprint c-Src interacts with and phosphorylates RelA/p65 to promote thrombin-induced ICAM-1 expression in endothelial cells
    Kaiser M Bijli
    Department of Pediatrics, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 292:L396-404. 2007
    ..These data implicate an important role of c-Src in phosphorylating RelA/p65 to promote the transcriptional activity of NF-kappaB and thereby ICAM-1 expression in endothelial cells...
  9. ncbi request reprint Evidence for actin cytoskeleton-dependent and -independent pathways for RelA/p65 nuclear translocation in endothelial cells
    Fabeha Fazal
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 282:3940-50. 2007
    ....
  10. ncbi request reprint RhoA/Rho-associated kinase pathway selectively regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via activation of I kappa B kinase beta and phosphorylation of RelA/p65
    Khandaker N Anwar
    Department of Pediatrics, University of Rochester School of Medicine, Rochester, NY 14642, USA
    J Immunol 173:6965-72. 2004
    ....
  11. pmc Hug tightly and say goodbye: role of endothelial ICAM-1 in leukocyte transmigration
    Arshad Rahman
    Department of Pediatrics Neonatology, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Antioxid Redox Signal 11:823-39. 2009
    ..This review summarizes our current understanding of the "ICAM-1 paradigm" of TEM with an emphasis on the signaling events mediating ICAM-1 expression and activated by ICAM-1 engagement in endothelial cells...
  12. pmc Blocking NF-κB: an inflammatory issue
    Arshad Rahman
    Department of Pediatrics, Box 850, Lung Biology and Disease Program, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Proc Am Thorac Soc 8:497-503. 2011
    ....
  13. pmc GPR56 Regulates VEGF production and angiogenesis during melanoma progression
    Liquan Yang
    Departments of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York 14612, USA
    Cancer Res 71:5558-68. 2011
    ..We propose that components of the GPR56-mediated signaling pathway may serve as new targets for antiangiogenic treatment of melanoma...