David P Faxon

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. ncbi Utilization and outcomes of unprotected left main coronary artery stenting and coronary artery bypass graft surgery
    Chuntao Wu
    University at Albany, State University of New York, Albany, New York, USA
    Ann Thorac Surg 86:1153-9. 2008
  2. ncbi Coronary interventions and their impact on post myocardial infarction survival
    David P Faxon
    Section of Cardiology, University of Chicago Hospitals, Chicago, IL 60637, USA
    Clin Cardiol 28:I38-44. 2005
  3. ncbi Bringing reality to drug-eluting stents
    David P Faxon
    Section of Cardiology, Department of Medicine, The University of Chicago, 5841 South Maryland Ave, MC 6080, Chicago, Ill 6063, USA
    Circulation 109:140-2. 2004
  4. ncbi Antiplatelet therapy in populations at high risk of atherothrombosis
    David P Faxon
    Section of Cardiology, Department of Medicine, University of Chicago, 5841 S Maryland Ave, Room B 608, MC 6080, Chicago, IL 60637, USA
    J Natl Med Assoc 98:711-21. 2006
  5. ncbi The effect of blockade of the CD11/CD18 integrin receptor on infarct size in patients with acute myocardial infarction treated with direct angioplasty: the results of the HALT-MI study
    David P Faxon
    Los Angeles County Medical Center and the University of Southern California School of Medicine, Los Angeles, California 60637, USA
    J Am Coll Cardiol 40:1199-204. 2002
  6. ncbi Early reperfusion strategies after acute ST-segment elevation myocardial infarction: the importance of timing
    David P Faxon
    Section of Cardiology, University of Chicago, IL 60637, USA
    Nat Clin Pract Cardiovasc Med 2:22-8. 2005
  7. ncbi Can beta-blocker use lower mortality and improve myocardial tissue recovery after acute myocardial infarction?
    David P Faxon
    Section of Cardiology at the University of Chicago, IL, USA
    Nat Clin Pract Cardiovasc Med 1:14-5. 2004
  8. ncbi The chain of scientific discovery: the critical role of the physician-scientist
    David P Faxon
    Section of Cardiology, The University of Chicago, Chicago, Ill 60637, USA
    Circulation 105:1857-60. 2002
  9. ncbi Facts and controversies of aspirin and clopidogrel therapy
    David P Faxon
    Department of Medicine, Brigham and Women s Hospital, Boston, MA 02120, USA
    Am Heart J 157:412-22. 2009
  10. ncbi Effects of heart failure and diabetes mellitus on long-term mortality after coronary revascularization (from the BARI Trial)
    Elizabeth M Holper
    Department of Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Am J Cardiol 100:196-202. 2007

Detail Information

Publications66

  1. ncbi Utilization and outcomes of unprotected left main coronary artery stenting and coronary artery bypass graft surgery
    Chuntao Wu
    University at Albany, State University of New York, Albany, New York, USA
    Ann Thorac Surg 86:1153-9. 2008
    ..Limited contemporary information is available on outcomes for patients with unprotected left main coronary artery (LMCA) disease who are revascularized...
  2. ncbi Coronary interventions and their impact on post myocardial infarction survival
    David P Faxon
    Section of Cardiology, University of Chicago Hospitals, Chicago, IL 60637, USA
    Clin Cardiol 28:I38-44. 2005
    ..Myocardial injury following reperfusion after ischemia can limit the benefits of PCI and fibrinolysis; however, strategies for minimizing reperfusion injury have not yet shown clinical efficacy...
  3. ncbi Bringing reality to drug-eluting stents
    David P Faxon
    Section of Cardiology, Department of Medicine, The University of Chicago, 5841 South Maryland Ave, MC 6080, Chicago, Ill 6063, USA
    Circulation 109:140-2. 2004
  4. ncbi Antiplatelet therapy in populations at high risk of atherothrombosis
    David P Faxon
    Section of Cardiology, Department of Medicine, University of Chicago, 5841 S Maryland Ave, Room B 608, MC 6080, Chicago, IL 60637, USA
    J Natl Med Assoc 98:711-21. 2006
    ....
  5. ncbi The effect of blockade of the CD11/CD18 integrin receptor on infarct size in patients with acute myocardial infarction treated with direct angioplasty: the results of the HALT-MI study
    David P Faxon
    Los Angeles County Medical Center and the University of Southern California School of Medicine, Los Angeles, California 60637, USA
    J Am Coll Cardiol 40:1199-204. 2002
    ..The purpose of this study was to determine whether Hu23F2G (LeukoArrest), an antibody to the CD11/CD18 integrin receptors, would reduce infarct size in patients undergoing primary angioplasty for an acute myocardial infarction...
  6. ncbi Early reperfusion strategies after acute ST-segment elevation myocardial infarction: the importance of timing
    David P Faxon
    Section of Cardiology, University of Chicago, IL 60637, USA
    Nat Clin Pract Cardiovasc Med 2:22-8. 2005
    ....
  7. ncbi Can beta-blocker use lower mortality and improve myocardial tissue recovery after acute myocardial infarction?
    David P Faxon
    Section of Cardiology at the University of Chicago, IL, USA
    Nat Clin Pract Cardiovasc Med 1:14-5. 2004
  8. ncbi The chain of scientific discovery: the critical role of the physician-scientist
    David P Faxon
    Section of Cardiology, The University of Chicago, Chicago, Ill 60637, USA
    Circulation 105:1857-60. 2002
  9. ncbi Facts and controversies of aspirin and clopidogrel therapy
    David P Faxon
    Department of Medicine, Brigham and Women s Hospital, Boston, MA 02120, USA
    Am Heart J 157:412-22. 2009
    ..Overall, despite the existing controversies, antiplatelet therapy with aspirin and/or clopidogrel remains a proven and essential therapeutic tool for safe and effective management of atherothrombotic risk in specific clinical settings...
  10. ncbi Effects of heart failure and diabetes mellitus on long-term mortality after coronary revascularization (from the BARI Trial)
    Elizabeth M Holper
    Department of Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Am J Cardiol 100:196-202. 2007
    ..In conclusion, patients with HF and a preserved EF have increased mortality over 10 years compared with those without HF. Only in patients with DM did HF with preserved EF confer additional risk...
  11. ncbi Use of antiplatelet agents and anticoagulants for cardiovascular disease: current standards and best practices
    David P Faxon
    Section of Cardiology, University of Chicago, Chicago, Illinois, USA
    Rev Cardiovasc Med 6:S3-14. 2005
    ..The efficacy of antiplatelet therapy is thus well established in treating atherothrombosis, but aggressive therapy is associated with an increased bleeding risk. Newer agents may provide improved efficacy with a lower risk of bleeding...
  12. ncbi Percutaneous coronary intervention in women
    Elizabeth M Holper
    Section of Cardiology, University of Chicago, USA
    J Am Med Womens Assoc 58:264-71. 2003
    ..This review will examine the sex differences in demographics and outcomes of women undergoing PCI...
  13. ncbi New data on early management of patients with ST-elevation myocardial infarction
    David P Faxon
    Division of Cardiology, Department of Medicine, Brigham and Women s Hospital, 1620 Tremont Street, OBC 3 12N, Boston, MA 02120, USA
    Curr Cardiol Rep 10:291-8. 2008
    ..National efforts to reduce delays and to improve access to timely therapy will significantly reduce mortality even further...
  14. ncbi Coronary intervention in patients with acute coronary syndrome: does every culprit lesion require revascularization?
    Sripal Bangalore
    Division of Cardiology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 0BC3 Room 012P, 1620 Tremont Street, Boston, MA 02120, USA
    Curr Cardiol Rep 12:330-7. 2010
    ..We present a review of the current body of evidence for safety and efficacy of multivessel revascularization in patients presenting with acute coronary syndromes...
  15. ncbi Plasma homocysteine levels and the left ventricular systolic function in coronary artery disease patients
    Syed W Bokhari
    University of Chicago Pritzker School of Medicine, Illinois 60637, USA
    Coron Artery Dis 16:153-61. 2005
    ..However, an association between hyperhomocysteinemia and the extent of coronary artery disease (CAD) remains controversial whereas its relationship with left ventricular systolic function has not been established...
  16. ncbi Multi-vessel coronary disease and percutaneous coronary intervention
    C Casey
    Section of Cardiology, Department of Medicine, University of Chicago, Chicago, Illinois, USA
    Heart 90:341-6. 2004
  17. ncbi The impact of ejection fraction on outcomes after percutaneous coronary intervention in patients with congestive heart failure: an analysis of the National Heart, Lung, and Blood Institute Percutaneous Transluminal Coronary Angioplasty Registry and Dynami
    Elizabeth M Holper
    University of Chicago, Chicago, IL 60637, USA
    Am Heart J 151:69-75. 2006
    ..We studied the outcomes of patients with CHF who underwent PCI in the National Heart, Lung, and Blood Institute-sponsored Percutaneous Transluminal Coronary Angioplasty (PTCA) and Dynamic registries...
  18. ncbi Facilitated percutaneous coronary intervention
    William B Borden
    Section of Cardiology, Department of Medicine, University of Chicago, Chicago, Illinois, USA
    J Am Coll Cardiol 48:1120-8. 2006
    ....
  19. ncbi Hormone therapy and the progression of coronary-artery atherosclerosis in postmenopausal women
    Howard N Hodis
    Atherosclerosis Research Unit, Keck School of Medicine, Los Angeles, CA 90033, USA
    N Engl J Med 349:535-45. 2003
    ..Whether 17beta-estradiol (the endogenous estrogen molecule) alone or administered sequentially with medroxyprogesterone acetate can slow the progression of atherosclerosis is unknown...
  20. ncbi Need for centers to care for patients with acute coronary syndromes
    Robert M Califf
    Division of Cardiology, Department of Medicine, Duke University Medical Center and Duke Clinical Research Institute, Durham, NC 27715, USA
    Circulation 107:1467-70. 2003
  21. ncbi Meta-analysis of multivessel coronary artery revascularization versus culprit-only revascularization in patients with ST-segment elevation myocardial infarction and multivessel disease
    Sripal Bangalore
    Department of Medicine, Division of Cardiology, New York University School of Medicine, New York, New York, USA
    Am J Cardiol 107:1300-10. 2011
    ..These findings support the need for a large-scale randomized trial to evaluate revascularization strategies in patients with STEMI and MVD...
  22. ncbi Prevention of intravenous contrast-induced nephropathy in hospital inpatients
    Rahul Kakkar
    Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA
    Crit Pathw Cardiol 7:1-4. 2008
    ..On the basis of the recently published clinical trial data and guidelines from the major radiologic societies, we developed an algorithmic approach to CIN prophylaxis in hospital inpatients...
  23. ncbi Coronary artery compression caused by a large pseudoaneurysm complicating an acute myocardial infarction
    Neeraj Jolly
    Department of Medicine, Section of Cardiology, The University of Chicago, 5841 S. Maryland Avenue, MC5076, Chicago, IL 60637, USA
    Echocardiography 21:85-6. 2004
  24. ncbi Update on radiation for restenosis
    Matthew H French
    Section of Cardiology, University of Chicago Pritzker School of Medicine, Chicago, IL, USA
    Rev Cardiovasc Med 3:1-6. 2002
    ..Intravascular radiation may soon be the standard of treatment for patients with in-stent restenosis and has the potential to reduce the recurrence rate to below 10%...
  25. ncbi Critical GI issues for the cardiologist: new insights and understanding. Introduction
    David P Faxon
    Section of Cardiology, University of Chicago, Chicago, Illinois, USA
    Rev Cardiovasc Med 6:S1-2. 2005
  26. ncbi Coronary artery disease in patients with Buerger's disease
    Thomas E Hong
    Section of Cardiology, University of Chicago Pritzker School of Medicine, Chicago, Illinois, USA
    Rev Cardiovasc Med 6:222-6. 2005
    ..Following the case presentation, we review the pathology, pathogenesis, and diagnostic criteria for Buerger's disease, and also include a review of the existing literature on coronary involvement in Buerger's disease...
  27. ncbi Current anticoagulation options in percutaneous intervention: designing patient-specific strategies
    Matthew H French
    Section of Cardiology, University of Chicago, Chicago, IL, USA
    Rev Cardiovasc Med 3:176-82. 2002
    ..However, the longer half-life and lack of monitoring of LMWH make its use more difficult. The direct thrombin inhibitors also have been shown to have advantages in the treatment of patients with heparin-induced thrombocytopenia...
  28. ncbi Optimizing antiplatelet therapy in acute coronary syndrome and percutaneous coronary intervention
    David P Faxon
    Division of Cardiology, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02120, USA
    Catheter Cardiovasc Interv 79:181-97. 2012
    ..Most importantly, early and effective antiplatelet therapy results in the best short- and long-term outcomes for patients with ACS or those undergoing PCI...
  29. ncbi Percutaneous coronary intervention for myocardial infarction with left ventricular dysfunction
    James D Flaherty
    Division of Cardiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Am J Cardiol 102:38G-41G. 2008
    ....
  30. ncbi The CHARISMA trial and the REACH registry outcomes
    David P Faxon
    J Natl Med Assoc 98:1713. 2006
  31. ncbi Recommendation to develop strategies to increase the number of ST-segment-elevation myocardial infarction patients with timely access to primary percutaneous coronary intervention
    Alice K Jacobs
    Circulation 113:2152-63. 2006
    ..Working within a framework of guiding principles, the group will recommend strategies to increase the number of STEMI patients with timely access to primary PCI...
  32. ncbi ACC/AHA 2002 guideline update for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction--summary article: a report of the American College of Cardiology/American Heart Association task force on practice guideli
    Eugene Braunwald
    J Am Coll Cardiol 40:1366-74. 2002
  33. ncbi Clinical progression of incidental, asymptomatic lesions discovered during culprit vessel coronary intervention
    Ruchira Glaser
    University of Pennsylvania, Philadelphia, PA 19104, USA
    Circulation 111:143-9. 2005
    ..CONCLUSIONS: Approximately 6% of PCI patients will have clinical plaque progression requiring nontarget lesion PCI by 1 year. Greater coronary artery disease burden confers a significantly higher risk for clinical plaque progression...
  34. ncbi Clinical studies on coronary revascularization in patients with type 2 diabetes
    Koon Hou Mak
    Department of Cardiology, National Heart Centre, Singapore, Singapore
    Eur Heart J 24:1087-103. 2003
    ..Current strategies to improve outcomes in patients with diabetes undergoing coronary revascularization procedures are discussed...
  35. ncbi ACC/AHA guideline update for perioperative cardiovascular evaluation for noncardiac surgery---executive summary a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1996 Guide
    Kim A Eagle
    Circulation 105:1257-67. 2002
  36. ncbi ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction--executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1999
    Elliott M Antman
    Circulation 110:588-636. 2004
  37. ncbi Systemic drug therapy for restenosis: "déjà vu all over again"
    David P Faxon
    Circulation 106:2296-8. 2002
  38. ncbi ACC/AHA guideline update for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction--2002: summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidel
    Eugene Braunwald
    Circulation 106:1893-900. 2002
  39. ncbi From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part II
    Morteza Naghavi
    The Center for Vulnerable Plaque Research, University of Texas Houston, The Texas Heart Institute, and President Bush Center for Cardiovascular Health, Memorial Hermann Hospital, Houston, USA
    Circulation 108:1772-8. 2003
    ..We encourage healthcare policy makers to promote translational research for screening and treatment of vulnerable patients...
  40. ncbi ACC/AHA 2002 guideline update for exercise testing: summary article. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1997 Exercise Testing Guidelines)
    Raymond J Gibbons
    J Am Coll Cardiol 40:1531-40. 2002
  41. ncbi Efficacy and safety of fondaparinux versus enoxaparin in patients with acute coronary syndromes undergoing percutaneous coronary intervention: results from the OASIS-5 trial
    Shamir R Mehta
    Department of Medicine, McMaster University and Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada
    J Am Coll Cardiol 50:1742-51. 2007
    ..This study reports a prospectively planned analysis of patients with acute coronary syndrome who underwent early percutaneous coronary intervention (PCI) in the OASIS-5 (Fifth Organization to Assess Strategies in Ischemic Syndromes) trial...
  42. ncbi Strategies to improve early reperfusion in ST-elevation myocardial infarction
    David P Faxon
    Bringham and Women s Hospital and Boston Medical Center, Boston, Massachusetts, USA
    Rev Cardiovasc Med 8:127-34. 2007
    ..Although these strategies may help, there is growing enthusiasm for the development of primary PCI centers, with triage of patients to these centers through either an EMS bypass system or an interhospital transfer system...
  43. ncbi ACC/AHA 2002 guideline update for the management of patients with chronic stable angina--summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on the Management of Patients
    Raymond J Gibbons
    Circulation 107:149-58. 2003
  44. ncbi ACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline
    Andrew E Epstein
    Circulation 117:e350-408. 2008
  45. ncbi Randomized, blinded trial comparing fondaparinux with unfractionated heparin in patients undergoing contemporary percutaneous coronary intervention: Arixtra Study in Percutaneous Coronary Intervention: a Randomized Evaluation (ASPIRE) Pilot Trial
    Shamir R Mehta
    McMaster University and the Population Health Research Institute, Hamilton Health Sciences, General Division, 237 Barton St E, Hamilton, Ontario, Canada L6K 1B8
    Circulation 111:1390-7. 2005
    ..We performed a randomized trial to determine the safety and feasibility of fondaparinux in the percutaneous coronary intervention (PCI) setting...
  46. ncbi Assessing appropriateness of coronary angiography: another step in improving quality
    David P Faxon
    Ann Intern Med 149:276-8. 2008
  47. ncbi ACC/AHA/NASPE 2002 guideline update for implantation of cardiac pacemakers and antiarrhythmia devices: summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/NASPE Committee to
    Gabriel Gregoratos
    Circulation 106:2145-61. 2002
  48. ncbi 2008 Focused update incorporated into the ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to
    Robert O Bonow
    Circulation 118:e523-661. 2008
  49. ncbi ACC/AHA 2002 guideline update for exercise testing: summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1997 Exercise Testing Guidelines)
    Raymond J Gibbons
    Circulation 106:1883-92. 2002
  50. ncbi Improved outcomes for women undergoing contemporary percutaneous coronary intervention: a report from the National Heart, Lung, and Blood Institute Dynamic registry
    Alice K Jacobs
    Evans Memorial Department of Medicine, Boston University Medical Center, Boston, Massachusetts, USA
    J Am Coll Cardiol 39:1608-14. 2002
    ..The goal of this study was to determine whether women undergoing contemporary percutaneous coronary intervention (PCI) remain at increased risk in comparison with men and whether the outcomes in women have improved...
  51. ncbi ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1999 Guidelines for the Managem
    Elliott M Antman
    Circulation 110:e82-292. 2004
  52. ncbi ACC/AHA guidelines for the evaluation and management of chronic heart failure in the adult: executive summary
    Sharon A Hunt
    American College of Cardiology/American Heart Association Task Force on Practice Guidelines
    J Heart Lung Transplant 21:189-203. 2002
  53. ncbi ACC/AHA 2004 guideline update for coronary artery bypass graft surgery: summary article. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1999 Guidelines for Coronary Arte
    Kim A Eagle
    J Am Coll Cardiol 44:e213-310. 2004
  54. ncbi Atherosclerotic Vascular Disease Conference: Executive summary: Atherosclerotic Vascular Disease Conference proceeding for healthcare professionals from a special writing group of the American Heart Association
    David P Faxon
    Circulation 109:2595-604. 2004
  55. ncbi Beta-blocker therapy and primary angioplasty: what is the controversy?
    David P Faxon
    J Am Coll Cardiol 43:1788-90. 2004
  56. ncbi ACC/AHA/ESC guidelines for the management of patients with supraventricular arrhythmias--executive summary. a report of the American college of cardiology/American heart association task force on practice guidelines and the European society of cardiology
    Carina Blomstrom-Lundqvist
    J Am Coll Cardiol 42:1493-531. 2003
  57. ncbi ACC/AHA/ESC guidelines for the management of patients with supraventricular arrhythmias--executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology
    Carina Blomstrom-Lundqvist
    Circulation 108:1871-909. 2003
  58. ncbi Left main coronary revascularization at the crossroads
    Dean J Kereiakes
    Circulation 113:2480-4. 2006
  59. ncbi ACC/AHA/ASNC guidelines for the clinical use of cardiac radionuclide imaging--executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/ASNC Committee to Revise the 1995 Guideli
    Francis J Klocke
    J Am Coll Cardiol 42:1318-33. 2003
  60. ncbi ACC/AHA 2006 guideline update on perioperative cardiovascular evaluation for noncardiac surgery: focused update on perioperative beta-blocker therapy: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guideli
    Lee A Fleisher
    Circulation 113:2662-74. 2006
  61. ncbi A taxonomy for disease management: a scientific statement from the American Heart Association Disease Management Taxonomy Writing Group
    Harlan M Krumholz
    Yale University, USA
    Circulation 114:1432-45. 2006
    ....
  62. ncbi ACC/AHA/ASE 2003 guideline update for the clinical application of echocardiography--summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/ASE Committee to Update the 1997 Guid
    Melvin D Cheitlin
    J Am Coll Cardiol 42:954-70. 2003
  63. ncbi ACC/AHA/ASE 2003 guideline update for the clinical application of echocardiography: summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/ASE Committee to Update the 1997 Guid
    Melvin D Cheitlin
    Circulation 108:1146-62. 2003
  64. ncbi Development of systems of care for ST-elevation myocardial infarction patients: executive summary
    Alice K Jacobs
    Boston Medical Center, USA
    Circulation 116:217-30. 2007
  65. ncbi ACCF/AHA/SCAI 2007 update of the Clinical Competence Statement on Cardiac Interventional Procedures: a report of the American College of Cardiology Foundation/American Heart Association/American College of Physicians Task Force on Clinical Competence and
    Spencer B King
    Circulation 116:98-124. 2007
  66. ncbi ACCF/AHA/SCAI 2007 update of the clinical competence statement on cardiac interventional procedures: a report of the American College of Cardiology Foundation/American Heart Association/American College of Physicians Task Force on Clinical Competence and
    Spencer B King
    J Am Coll Cardiol 50:82-108. 2007