Research Topics
Genomes and Genes | N FaustoSummaryAffiliation: University of Washington Country: USA Publications
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Publications
Distinct cellular responses differentiating alcohol- and hepatitis C virus-induced liver cirrhosisSharon L Lederer
Department of Microbiology, University of Washington, Seattle, WA, USA
Virol J 3:98. 2006..Global transcriptional profiling using oligonucleotide microarrays was therefore performed on liver biopsies from patients with cirrhosis caused by either chronic alcohol consumption or chronic hepatitis C virus (HCV)...- Effect of ethanol on innate antiviral pathways and HCV replication in human liver cellsCourtney R Plumlee
Department of Laboratory Medicine, University of Washington, Seattle, USA
Virol J 2:89. 2005..To begin to address these issues, we characterized the interaction of acute ethanol on Jak-Stat and MAPK pathways in Huh7 cells, HCV replicon cells lines, and primary human hepatocytes... - Impaired preneoplastic changes and liver tumor formation in tumor necrosis factor receptor type 1 knockout miceB Knight
University of Western Australia, Department of Biochemistry, Nedlands WA 6907, Australia
J Exp Med 192:1809-18. 2000..The TNF inflammatory pathway may be a target for therapeutic intervention during the early stages of liver carcinogenesis... 
Liver regenerationN Fausto
Department of Pathology, University of Washington School of Medicine, Seattle 98195 7470, USA
J Hepatol 32:19-31. 2000..Knowledge about the mechanisms of liver regeneration can now be applied to correct clinical problems caused by deficient liver growth...- The role of hepatocytes and oval cells in liver regeneration and repopulationNelson Fausto
Department of Pathology, University of Washington, Seattle, WA, USA
Mech Dev 120:117-30. 2003..Although bone marrow stem cells can generate oval cells and hepatocytes, transdifferentiation is very rare and inefficient... - Liver regeneration and repair: hepatocytes, progenitor cells, and stem cellsNelson Fausto
Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA
Hepatology 39:1477-87. 2004 
Mouse models of hepatocellular carcinomaNelson Fausto
Department of Pathology, University of Washington, Seattle, Washington 98195, USA
Semin Liver Dis 30:87-98. 2010..The authors focus on models that best correlate with the human disease and offer important insights into the pathogenesis of HCC...- Lessons from genetically engineered animal models. V. Knocking out genes to study liver regeneration: present and futureN Fausto
Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98195 7470, USA
Am J Physiol 277:G917-21. 1999..Development of conditional, liver-specific knockout mice would be of great value for these studies... - Mouse liver tumorigenesis: models, mechanisms, and relevance to human diseaseN Fausto
Department of Pathology, University of Washington School of Medicine, Seattle 98195 7470, USA
Semin Liver Dis 19:243-52. 1999..This knowledge should be directly applicable to studies of human liver tumorigenesis... - Liver regenerationNelson Fausto
Department of Pathology, University of Washington School of Medicine, Seattle, WA 98195 7470, USA
Hepatology 43:S45-53. 2006..Most of the new knowledge about the molecular and cellular mechanisms of liver regeneration is both conceptually important and directly relevant to clinical problems... - Analysis of liver regeneration in mice lacking type 1 or type 2 tumor necrosis factor receptor: requirement for type 1 but not type 2 receptorY Yamada
Department of Pathology, University of Washington School of Medicine, Seattle, WA 98195 7705, USA
Hepatology 28:959-70. 1998..Inhibition of AP-1 and C/EBP binding and in the expression of c-jun and c-myc mRNA in the first 4 hours after PH, as well as the apparent lack of Fos in AP-1 complexes, had no effect on the timing or extent of DNA replication... - Bcl-2 delays and alters hepatic carcinogenesis induced by transforming growth factor alphaM E Vail
Department of Pathology, University of Washington, Seattle 98195 7610, USA
Cancer Res 61:594-601. 2001..5 months of age was sufficient to inhibit TGF-alpha-induced tumorigenesis. These results indicate that Bcl-2 inhibits tumor progression in the liver, possibly by interfering with hepatocyte proliferation... - Expression of suppressors of cytokine signaling during liver regenerationJ S Campbell
University of Washington, Department of Pathology, Seattle, Washington 98195, USA
J Clin Invest 107:1285-92. 2001..Together, these results suggest that SOCS-3 may be a key component in downregulating STAT-3 signaling after PH and that SOCS-3 mRNA levels in the regenerating liver are regulated by IL-6... - Prevention of hepatic apoptosis and embryonic lethality in RelA/TNFR-1 double knockout miceM E Rosenfeld
Department of Pathology, University of Washington, Seattle, Washington 98195, USA
Am J Pathol 156:997-1007. 2000..However, the absence of both TNFR-1 signaling and RelA activity in newborn mice makes these animals susceptible to endogenous hepatic infection... - Liver regeneration: prospects for therapy based on new technologiesM A Kay
Department of Medicine, University of Washington, Seattle 98195 7720, USA
Mol Med Today 3:108-15. 1997..This article reviews the basic principles of liver regeneration, experimental manipulations in animal models, and human clinical applications including cellular transplantation, gene therapy and artificial livers... - Responses of nontransformed human hepatocytes to conditional expression of full-length hepatitis C virus open reading frameWeiliang Tang
Department of Pathology, University of Washington School of Medicine, K078 Health Sciences Building, Box 357705, Seattle, WA 98195 7705, USA
Am J Pathol 171:1831-46. 2007..Expression of HCV ORF in host cells may contribute to HCV pathogenesis by producing oxidative stress and increasing the expression of genes related to the innate immune response and inflammation... - Regulation of liver regeneration and hepatocarcinogenesis by suppressor of cytokine signaling 3Kimberly J Riehle
Department of Pathology, University of Washington School of Medicine, Seattle, WA 98195, USA
J Exp Med 205:91-103. 2008..By acting on cytokines and multiple proliferative pathways, SOCS3 modulates both physiological and neoplastic proliferative processes in the liver and may act as a tumor suppressor... - Hepatocyte-specific inhibition of NF-kappaB leads to apoptosis after TNF treatment, but not after partial hepatectomyMichelle L Chaisson
Department of Pathology, University of Washington, Seattle 98195, USA
J Clin Invest 110:193-202. 2002..As NF-kappaB activation was not inhibited in liver NPCs, it is likely that these cells are responsible for mediating the proliferative and antiapoptotic effects of NF-kappaB during liver regeneration... - Enhanced acetaminophen hepatotoxicity in transgenic mice overexpressing BCL-2M L Adams
Department of Medicinal Chemistry, University of Washington, Seattle, 98195, USA
Mol Pharmacol 60:907-15. 2001..In conclusion, these data suggest for the first time that BAX may be an early determinant of APAP-mediated hepatotoxicity and that BCL-2 overexpression unexpectedly enhances APAP hepatotoxicity... - Relationships between deficits in tissue mass and transcriptional programs after partial hepatectomy in miceJiangning Li
Department of Pathology, School of Medicine, University of Washington, Seattle, WA 98195, USA
Am J Pathol 175:947-57. 2009..We suggest that the changes in gene expression during the first 4 to 6 hours after 2/3 PH may induce chromatin remodeling and facilitate the binding of new sets of transcription factors required for DNA replication... - Proinflammatory cytokine production in liver regeneration is Myd88-dependent, but independent of Cd14, Tlr2, and Tlr4Jean S Campbell
Department of Pathology, University of Washington, 98195, USA
J Immunol 176:2522-8. 2006..In contrast, MyD88-dependent pathways appear to be responsible for TNF, IL-6, and their downstream signaling pathways... - Gene expression patterns that correlate with hepatitis C and early progression to fibrosis in liver transplant recipientsMaria W Smith
Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington 98195-8070, USA
Gastroenterology 130:179-87. 2006..CONCLUSIONS: The identified gene expression patterns may prove useful for diagnostic and prognostic applications in HCV-infected patients, including predicting early progression to fibrosis... - Gene expression profiling of the cellular transcriptional network regulated by alpha/beta interferon and its partial attenuation by the hepatitis C virus nonstructural 5A proteinGary K Geiss
Department of Microbiology, School of Medicine, University of Washington, Seattle 98195, USA
J Virol 77:6367-75. 2003..These differences highlight the importance of comparing results from multiple model systems when investigating complex phenomena such as the cellular response to IFN and viral mechanisms of IFN resistance... - Heparin-binding epidermal growth factor-like growth factor links hepatocyte priming with cell cycle progression during liver regenerationClaudia Mitchell
Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98195, USA
J Biol Chem 280:2562-8. 2005..Moreover, we show that hepatocyte DNA replication was delayed in HB-EGF knock-out mice. In summary, we show that HB-EGF is a key factor for hepatocyte progression through G(1)/S transition during liver regeneration... - Differential regulation of rodent hepatocyte and oval cell proliferation by interferon gammaJohn T Brooling
Department of Pathology, University of Washington, Seattle, WA 98195, USA
Hepatology 41:906-15. 2005..The response of hepatocytes and oval cells to cytokine combinations may contribute to the differential proliferation of these cells in hepatic growth processes... - Isolation of multipotent progenitor cells from human fetal liver capable of differentiating into liver and mesenchymal lineagesY Y Dan
Department of Pathology, University of Washington, Seattle, WA 98115, USA
Proc Natl Acad Sci U S A 103:9912-7. 2006..hFLMPCs survive and differentiate into functional hepatocytes in vivo when transplanted into animal models of liver disease. hFLMPCs are a valuable tool for the study of human liver development, liver injury, and hepatic repopulation... - Reactive oxygen species derived from NADPH oxidase system is not essential for liver regeneration after partial hepatectomyShinichi Ueno
Department of Pathology, University of Washington School of Medicine, Seattle, Washington, USA
J Surg Res 136:260-5. 2006.... - Mechanisms of liver regeneration and their clinical implicationsNelson Fausto
Department of Pathology, University of Washington School of Medicine, 98195-7470 Seattle, WA, USA
J Hepatobiliary Pancreat Surg 12:181-9. 2005..In this review, we discuss a few selected aspects of liver regeneration that are of interest in both the laboratory and the clinic... - Bcl-2 expression delays hepatocyte cell cycle progression during liver regenerationMary E Vail
Department of Pathology, University of Washington, Seattle, Washington, WA 98195 7705, USA
Oncogene 21:1548-55. 2002..These results show that Bcl-2 expression delays cell cycle progression in hepatocytes and suggests that it acts at a step involving cyclin E and p107... - Bcl-2 expression inhibits liver carcinogenesis and delays the development of proliferating fociRobert H Pierce
Department of Pathology, University of Washington, Seattle, Washington 98195, USA
Am J Pathol 160:1555-60. 2002..The data demonstrate that the expression of an anti-apoptotic gene during liver carcinogenesis causes a delay rather than an increase in tumorigenesis... - Glutamate-cysteine ligase attenuates TNF-induced mitochondrial injury and apoptosisDianne Botta
Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195, USA
Free Radic Biol Med 37:632-42. 2004..Analysis of the effects of TNF on these parameters indicates that maintaining mitochondrial integrity mediates this protective effect in GCL-overexpressing cells... - Cytosolic heat shock proteins and heme oxygenase-1 are preferentially induced in response to specific and localized intramitochondrial damage by tetrafluoroethylcysteineHan K Ho
Department of Medicinal Chemistry, University of Washington, Box 357610, Seattle, WA 98195, USA
Biochem Pharmacol 72:80-90. 2006..The cytoprotective effects of such HSP responses suggest a plausible role in modulating the progression of TFEC-induced cellular injury... - Acetaminophen-induced liver injury is attenuated in male glutamate-cysteine ligase transgenic miceDianne Botta
Department of Environmental and Occupational Health Sciences, Comparative Medicine, and Pathology, and UW NIEHS Center for Ecogenetics and Environmental Health, University of Washington, Seattle, Washington 68105, USA
J Biol Chem 281:28865-75. 2006..Because people are known to vary in their glutamate-cysteine ligase activity, this enzyme may also be an important determinant of sensitivity to acetaminophen-induced liver injury in humans... - Identification of a specific gene expression pattern associated with HCV-induced pathogenesis in HCV- and HCV/HIV-infected individualsKathie Anne Walters
Department of Microbiology, School of Medicine, University of Washington, Box 358070, Seattle, WA 98195 8070, USA
Virology 350:453-64. 2006..Importantly, the pattern of gene expression observed in EGE (+) patients has similarities to patients who developed fibrosis within 1 year of receiving a liver transplant... - New concepts in liver regenerationKimberly J Riehle
Department of Surgery, University of Washington, Seattle, USA
J Gastroenterol Hepatol 26:203-12. 2011..This review traces the path that has been taken over the last few decades in the study of liver regeneration, highlights new concepts in the field, and discusses the challenges that still stand between us and clinical therapy... - Transforming growth factor-beta differentially regulates oval cell and hepatocyte proliferationLananh N Nguyen
Department of Pathology, University of Washington, Seattle, WA 98195, USA
Hepatology 45:31-41. 2007..These findings further suggest an underlying mechanism for the proliferation of oval cells in an environment inhibitory to hepatocytic proliferation... - Targeting stromal cells for the treatment of platelet-derived growth factor C-induced hepatocellular carcinogenesisJean S Campbell
Department of Pathology, University of Washington School of Medicine, Box 357705, Seattle, WA 98195, USA
Differentiation 75:843-52. 2007..Our findings suggest that imatinib may be efficacious in the treatment of hepatocarcinogenesis, particularly when neovascularization is present... - Suppressor of cytokine signaling expression with increasing severity of murine hepatic ischemia-reperfusion injuryLorrie A Langdale
Department of Surgery, University of Washington, Veterans Administration, VA Puget Sound Health Care, Building 1, Room 314, 1660 South Columbian Way, Seattle, WA 98108, USA
J Hepatol 49:198-206. 2008..SOCS1 and SOCS3 ensure appropriate intensity and duration of cytokine signaling through negative feedback on JAK-STAT signaling. The contribution of SOCS1 and SOCS3-mediated regulation to the evolution of hepatic IR injury is unknown... - Comparison of the cytotoxicity of the nitroaromatic drug flutamide to its cyano analogue in the hepatocyte cell line TAMH: evidence for complex I inhibition and mitochondrial dysfunction using toxicogenomic screeningKevin J Coe
Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA
Chem Res Toxicol 20:1277-90. 2007..Thus, as compared to CYA, the nitroaromatic group of FLU enhances cytotoxicity to hepatocytes, likely through mechanisms involving mitochondrial dysfunction and ATP depletion that include complex I inhibition... - Inactivation of p38 MAPK during liver regenerationJean S Campbell
Department of Pathology, University of Washington, School of Medicine, Seattle, WA 98195, USA
Int J Biochem Cell Biol 43:180-8. 2011..Our results suggest that p38 MAPK inactivation plays a permissible role in DNA replication during liver regeneration and is consistent with a role for p38 MAPK in the maintenance of hepatocyte cell cycle arrest in adult liver... - Interactions between MYC and transforming growth factor alpha alter the growth and tumorigenicity of liver progenitor cellsRonald S Y Cheung
Department of Pathology, University of Washington, Seattle, WA 98195, USA
Carcinogenesis 28:2624-31. 2007..We conclude that the tumorigenic growth effects of MYC in TGFalpha-expressing liver progenitor cells are not solely dependent on its apoptotic activity... - The expression of transforming growth factor-alpha in cirrhosis, dysplastic nodules, and hepatocellular carcinoma: an immunohistochemical study of 70 casesMatthew M Yeh
Department of Pathology, School of Medicine, University of Washington, Seattle, WA 98195 6100, USA
Am J Surg Pathol 31:681-9. 2007.... - Hepatitis C virus replication in transfected and serum-infected cultured human fetal hepatocytesCatherine A Lazaro
Department of Pathology, University of Washington School of Medicine, K078 Health Sciences Building, Box 357705, Seattle, WA 98195 7705, USA
Am J Pathol 170:478-89. 2007..This culture system may be used to study the responses of nontransformed human hepatocytes to HCV infection, to analyze serum infectivity, and to clone novel HCVs from infected patients... - Distinct Nrf1/2-independent mechanisms mediate As 3+-induced glutamate-cysteine ligase subunit gene expression in murine hepatocytesJames A Thompson
Department of Pathology, University of Washington, Seattle, WA 98195, USA
Free Radic Biol Med 46:1614-25. 2009.... - Hepatitis C virus and liver disease: global transcriptional profiling and identification of potential markersMaria W Smith
Department of Microbiology, School of Medicine, University of Washington, Seattle, WA 98195, USA
Hepatology 38:1458-67. 2003..In conclusion, our microarray analysis identified several potential gene markers of HCV-associated liver disease and contributed to our rapidly expanding database of experiments describing HCV pathogenesis... - BCL-xL overexpression effectively protects against tetrafluoroethylcysteine-induced intramitochondrial damage and cell deathHan K Ho
Department of Medicinal Chemistry, University of Washington, Box 357610, Seattle, WA 98195, USA
Biochem Pharmacol 69:147-57. 2005..Hence, TFEC-induced necrotic cell death in the TAMH cell line is mediated by BAX and antagonized by the anti-apoptotic BCL-2 family member, BCL-xL... - Establishment, characterization, and long-term maintenance of cultures of human fetal hepatocytesCatherine A Lazaro
Department of Pathology, University of Washington, Seattle, WA, USA
Hepatology 38:1095-106. 2003..In conclusion, HFH cultures, which might contain a population of hepatic stem cells, constitute an excellent tool for a variety of studies with human hepatocytes, including the mechanisms of viral infection... - TGFbeta1-induced suppression of glutathione antioxidant defenses in hepatocytes: caspase-dependent post-translational and caspase-independent transcriptional regulatory mechanismsChristopher C Franklin
University of Washington, Department of Pathology, Box 357705, 1959 N E Pacific St, HSB K 088, Seattle, WA 98195 7705, USA
FASEB J 17:1535-7. 2003.... - Identification of novel tumor markers in hepatitis C virus-associated hepatocellular carcinomaMaria W Smith
Department of Microbiology, School of Medicine, and Washington National Primate Research Center, University of Washington, Seattle, Washington 98195, USA
Cancer Res 63:859-64. 2003..Thus, high throughput methods coupled with high-order statistical analyses may result in the development of new diagnostic tools for liver malignancies... - Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinomaJean S Campbell
Department of Pathology, University of Washington, Seattle, WA 98115, USA
Proc Natl Acad Sci U S A 102:3389-94. 2005..Moreover, PDGF-C transgenic mice represent a unique model for the study of hepatic fibrosis progressing to tumorigenesis... - Nrf2 activation involves an oxidative-stress independent pathway in tetrafluoroethylcysteine-induced cytotoxicityHan K Ho
Department of Medicinal Chemistry, Environmental and Occupational Health Sciences, and Pathology, University of Washington, Seattle, Washington 98195, USA
Toxicol Sci 86:354-64. 2005..Overall, the results implicate a role for Nrf2 in the cellular response to TFEC toxicity and suggest a previously unrecognized role for the ER in this model of mitochondrially initiated cytotoxicity... - Bone marrow-derived hepatocytes : rare but promisingClaudia Mitchell
University of Washington, Department of Pathology, Seattle, Washington 98195, USA
Am J Pathol 161:349-50. 2002 - Caspase-3-Dependent Cleavage of the Glutamate-L-Cysteine Ligase Catalytic Subunit during Apoptotic Cell DeathChristopher C Franklin
Department of Pathology, University of Washington, Seattle, Washington 98195 7470, USA
Am J Pathol 160:1887-94. 2002..Our identification of GCLC as a target for caspase-3-dependent cleavage during apoptotic cell death suggests that this post-translational modification may represent a novel mechanism for regulating GSH biosynthesis during apoptosis... - NF-kappaB mediates alphavbeta3 integrin-induced endothelial cell survivalM Scatena
Department of Pathology, University of Washington, Seattle, Washington 98195, USA
J Cell Biol 141:1083-93. 1998..In contrast, inhibition of MEK and PI3-kinase did not affect osteopontin-induced NF-kappaB activation. These studies identify NF-kappaB as an important signaling molecule in alphavbeta3 integrin-mediated endothelial cell survival... - Expression of Bcl-2 family during liver regeneration and identification of Bcl-x as a delayed early response geneS P Tzung
Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
Am J Pathol 150:1985-95. 1997..In summary, the expression profiles of Bcl-2 family members during liver regeneration suggest a cell-cycle-dependent regulation as well as a physiological role for these apoptosis-modulating genes during growth and proliferation... - Mitochondrial aconitase modification, functional inhibition, and evidence for a supramolecular complex of the TCA cycle by the renal toxicant S-(1,1,2,2-tetrafluoroethyl)-L-cysteineEric A James
Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA
Biochemistry 41:6789-97. 2002.... - A dataset of human liver proteins identified by protein profiling via isotope-coded affinity tag (ICAT) and tandem mass spectrometryWei Yan
The Institute for Systems Biology, 1441 North 34th Street, Seattle, WA 98103, USA
Mol Cell Proteomics 3:1039-41. 2004..An increase of the threshold to p > or = 0.9 (corresponding to an error rate of less than 1%) resulted in 2,159 unique protein identifications (1,146, 1,235, and 1,318 for the Huh7, HFH, and HH4 cells, respectively)... - Transferrin fails to provide protection against Fas-induced hepatic injury in mice with deletion of functional transferrin-receptor type 2Vladimir Lesnikov
Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D1 100, P O Box 19024, Seattle, WA 98109 1024, USA
Apoptosis 13:1005-12. 2008..Both apoptotic Fas responses and cytoprotective effects of Tf were associated with significant shifts in plasma iron levels, which quantitatively differed between male and female mice... - Protection of human and murine hepatocytes against Fas-induced death by transferrin and ironV A Lesnikov
Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Apoptosis 11:79-87. 2006..Survival of hepatocytes 'stressed' by Fas signals can be manipulated by Tf and iron and may be a target for prophylactic and therapeutic interventions... - Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptorY Yamada
Department of Pathology, University of Washington, Seattle 98195, USA
Proc Natl Acad Sci U S A 94:1441-6. 1997..The results indicate that TNF, signaling through the TNFR-I, can initiate liver regeneration and acts by activating an interleukin 6-dependent pathway that involves the STAT3 transcription factor... - Reciprocal and coordinate regulation of serum amyloid A versus apolipoprotein A-I and paraoxonase-1 by inflammation in murine hepatocytesChang Yeop Han
Department of Medicine, University of Washington, Seattle, WA 98195-6426, USA
Arterioscler Thromb Vasc Biol 26:1806-13. 2006..Inflammation may convert HDL de novo into a more proatherogenic form by coordinate but inverse transcriptional regulation in the liver, rather than by physical displacement of apoA-I by SAA... - Dimerizer-induced proliferation of genetically modified hepatocytesZong-Yi Li
Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
Mol Ther 5:420-6. 2002..Drug-inducible in vivo expansion of genetically modified hepatocytes may have potential applications in hepatic gene transfer or in liver repopulation by transplanted hepatocytes or their progenitors. (c)2002 Elsevier Science (USA)... - Tweaking liver progenitor cellsNelson Fausto
Nat Med 11:1053-4. 2005 - Defective DNA strand break repair causes chromosomal instability and accelerates liver carcinogenesis in miceNarci C Teoh
Australian National University Medical School, Canberra, Australia
Hepatology 47:2078-88. 2008..CONCLUSION: These findings demonstrate that defects in the NHEJ DNA repair pathway may participate in the disruption of cell cycle checkpoints leading to chromosomal instability and accelerated development of HCC... - Epidermal growth factor receptor transactivation mediates tumor necrosis factor-induced hepatocyte replicationGretchen M Argast
Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, CO 80309, USA
J Biol Chem 279:34530-6. 2004..We suggest that TNF-induced transactivation of EGFR may provide an early signal for the entry of hepatocytes into the cell cycle and may integrate proliferative and survival pathways at the start of liver regeneration... - Cell culture model for acetaminophen-induced hepatocyte death in vivoRobert H Pierce
Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
Biochem Pharmacol 64:413-24. 2002..These results indicate that, although retaining some attributes of apoptosis, both APAP- and AMAP-mediated cell death have additional distinctive features consistent with longer term necrosis... - Involvement of the innate immune system in liver regeneration and injuryNelson Fausto
J Hepatol 45:347-9. 2006 - Hepatitis B virus pre-S2 mutant upregulates cyclin A expression and induces nodular proliferation of hepatocytesHui-Ching Wang
Division of Clinical Research, National Health Research Institutes, Tainan, Taiwan
Hepatology 41:761-70. 2005..In conclusion, these in vitro and in vivo data support a role for Delta S2-LHBs in the hepatocyte hyperplasia and a likely role in the process of HBV-related tumorigenesis... - Decreased aquaporin expression leads to increased resistance to apoptosis in hepatocellular carcinomaElizabeth M Jablonski
Department of Biology, UNC at Charlotte, 9201 University City Blvd, Charlotte, NC, USA
Cancer Lett 250:36-46. 2007..In contrast, hepatocytes rapidly responded to osmotic challenge through AQP-dependent water movement and underwent cell death following apoptotic stimulation... - Different types of ground glass hepatocytes in chronic hepatitis B virus infection contain specific pre-S mutants that may induce endoplasmic reticulum stressHui-Ching Wang
Graduate Institutes of Basic Medical Sciences, Molecular Medicine, and Immunology and Microbiology, National Cheng Kung University College of Medicine, Tainan, Taiwan
Am J Pathol 163:2441-9. 2003..This study therefore demonstrates that different GGHs may contain specific mutants and exhibit differential biological activities... - Efficiency of hepatitis C virus infection in vitroDaniel Favre
Am J Pathol 171:373; author reply 373. 2007
Research Grants
- PATHOGENESIS OF HEPATOCELLULAR CARCINOMANelson Fausto; Fiscal Year: 2009..The proposed experiments will increase our understanding of the mechanisms of hepatocellular carcinogenesis, and test therapeutic strategies that might be applied to human tumors. ..
- Environmetal Pathology/Toxicology Training ProgramNelson Fausto; Fiscal Year: 2007....
- GENE EXPRESSION IN REGENERATING AND NEOPLASTIC LIVERSNelson Fausto; Fiscal Year: 2007..5) Determine whether IFNy in combination with TNF can change liver regeneration after PH from a hepatocyte to a liver precursor cell (oval cell) response...
- PATHOGENESIS OF HEPATOCELLULAR CARCINOMANelson Fausto; Fiscal Year: 2007..The proposed experiments will increase our understanding of the mechanisms of hepatocellular carcinogenesis, and test therapeutic strategies that might be applied to human tumors. ..
- Pathogenesis of Hepatocellular CarcinomasNelson Fausto; Fiscal Year: 2006..We expect that these studies will contribute to the understanding of the molecular pathogenesis of HCC development in mice and humans. ..
- PATHOGENESIS OF HEPATOCELLULAR CARCINOMANelson Fausto; Fiscal Year: 2001..It is expected that the results from these experiments will lead to a better understanding of the pathogenesis of HCC and will have important implications for devising new therapeutic strategies for these tumors. ..
- PATHOGENESIS OF HEPATOCELLULAR CARCINOMANelson Fausto; Fiscal Year: 2010..The proposed experiments will increase our understanding of the mechanisms of hepatocellular carcinogenesis, and test therapeutic strategies that might be applied to human tumors. ..