N Fausto

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Distinct cellular responses differentiating alcohol- and hepatitis C virus-induced liver cirrhosis
    Sharon L Lederer
    Department of Microbiology, University of Washington, Seattle, WA, USA
    Virol J 3:98. 2006
  2. pmc Effect of ethanol on innate antiviral pathways and HCV replication in human liver cells
    Courtney R Plumlee
    Department of Laboratory Medicine, University of Washington, Seattle, USA
    Virol J 2:89. 2005
  3. pmc Impaired preneoplastic changes and liver tumor formation in tumor necrosis factor receptor type 1 knockout mice
    B Knight
    University of Western Australia, Department of Biochemistry, Nedlands WA 6907, Australia
    J Exp Med 192:1809-18. 2000
  4. ncbi request reprint The role of hepatocytes and oval cells in liver regeneration and repopulation
    Nelson Fausto
    Department of Pathology, University of Washington, Seattle, WA, USA
    Mech Dev 120:117-30. 2003
  5. ncbi request reprint Liver regeneration
    N Fausto
    Department of Pathology, University of Washington School of Medicine, Seattle 98195 7470, USA
    J Hepatol 32:19-31. 2000
  6. ncbi request reprint Lessons from genetically engineered animal models. V. Knocking out genes to study liver regeneration: present and future
    N Fausto
    Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98195 7470, USA
    Am J Physiol 277:G917-21. 1999
  7. ncbi request reprint Mouse liver tumorigenesis: models, mechanisms, and relevance to human disease
    N Fausto
    Department of Pathology, University of Washington School of Medicine, Seattle 98195 7470, USA
    Semin Liver Dis 19:243-52. 1999
  8. doi request reprint Mouse models of hepatocellular carcinoma
    Nelson Fausto
    Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    Semin Liver Dis 30:87-98. 2010
  9. ncbi request reprint Liver regeneration
    Nelson Fausto
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98195 7470, USA
    Hepatology 43:S45-53. 2006
  10. ncbi request reprint Liver regeneration and repair: hepatocytes, progenitor cells, and stem cells
    Nelson Fausto
    Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA
    Hepatology 39:1477-87. 2004

Research Grants

  1. PATHOGENESIS OF HEPATOCELLULAR CARCINOMA
    Nelson Fausto; Fiscal Year: 2009
  2. Environmetal Pathology/Toxicology Training Program
    Nelson Fausto; Fiscal Year: 2007
  3. GENE EXPRESSION IN REGENERATING AND NEOPLASTIC LIVERS
    Nelson Fausto; Fiscal Year: 2007
  4. PATHOGENESIS OF HEPATOCELLULAR CARCINOMA
    Nelson Fausto; Fiscal Year: 2007
  5. Pathogenesis of Hepatocellular Carcinomas
    Nelson Fausto; Fiscal Year: 2006
  6. PATHOGENESIS OF HEPATOCELLULAR CARCINOMA
    Nelson Fausto; Fiscal Year: 2001
  7. PATHOGENESIS OF HEPATOCELLULAR CARCINOMA
    Nelson Fausto; Fiscal Year: 2010

Detail Information

Publications72

  1. pmc Distinct cellular responses differentiating alcohol- and hepatitis C virus-induced liver cirrhosis
    Sharon L Lederer
    Department of Microbiology, University of Washington, Seattle, WA, USA
    Virol J 3:98. 2006
    ..Global transcriptional profiling using oligonucleotide microarrays was therefore performed on liver biopsies from patients with cirrhosis caused by either chronic alcohol consumption or chronic hepatitis C virus (HCV)...
  2. pmc Effect of ethanol on innate antiviral pathways and HCV replication in human liver cells
    Courtney R Plumlee
    Department of Laboratory Medicine, University of Washington, Seattle, USA
    Virol J 2:89. 2005
    ..To begin to address these issues, we characterized the interaction of acute ethanol on Jak-Stat and MAPK pathways in Huh7 cells, HCV replicon cells lines, and primary human hepatocytes...
  3. pmc Impaired preneoplastic changes and liver tumor formation in tumor necrosis factor receptor type 1 knockout mice
    B Knight
    University of Western Australia, Department of Biochemistry, Nedlands WA 6907, Australia
    J Exp Med 192:1809-18. 2000
    ..The TNF inflammatory pathway may be a target for therapeutic intervention during the early stages of liver carcinogenesis...
  4. ncbi request reprint The role of hepatocytes and oval cells in liver regeneration and repopulation
    Nelson Fausto
    Department of Pathology, University of Washington, Seattle, WA, USA
    Mech Dev 120:117-30. 2003
    ..Although bone marrow stem cells can generate oval cells and hepatocytes, transdifferentiation is very rare and inefficient...
  5. ncbi request reprint Liver regeneration
    N Fausto
    Department of Pathology, University of Washington School of Medicine, Seattle 98195 7470, USA
    J Hepatol 32:19-31. 2000
    ..Knowledge about the mechanisms of liver regeneration can now be applied to correct clinical problems caused by deficient liver growth...
  6. ncbi request reprint Lessons from genetically engineered animal models. V. Knocking out genes to study liver regeneration: present and future
    N Fausto
    Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98195 7470, USA
    Am J Physiol 277:G917-21. 1999
    ..Development of conditional, liver-specific knockout mice would be of great value for these studies...
  7. ncbi request reprint Mouse liver tumorigenesis: models, mechanisms, and relevance to human disease
    N Fausto
    Department of Pathology, University of Washington School of Medicine, Seattle 98195 7470, USA
    Semin Liver Dis 19:243-52. 1999
    ..This knowledge should be directly applicable to studies of human liver tumorigenesis...
  8. doi request reprint Mouse models of hepatocellular carcinoma
    Nelson Fausto
    Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    Semin Liver Dis 30:87-98. 2010
    ..The authors focus on models that best correlate with the human disease and offer important insights into the pathogenesis of HCC...
  9. ncbi request reprint Liver regeneration
    Nelson Fausto
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98195 7470, USA
    Hepatology 43:S45-53. 2006
    ..Most of the new knowledge about the molecular and cellular mechanisms of liver regeneration is both conceptually important and directly relevant to clinical problems...
  10. ncbi request reprint Liver regeneration and repair: hepatocytes, progenitor cells, and stem cells
    Nelson Fausto
    Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA
    Hepatology 39:1477-87. 2004
  11. ncbi request reprint Analysis of liver regeneration in mice lacking type 1 or type 2 tumor necrosis factor receptor: requirement for type 1 but not type 2 receptor
    Y Yamada
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98195 7705, USA
    Hepatology 28:959-70. 1998
    ..Inhibition of AP-1 and C/EBP binding and in the expression of c-jun and c-myc mRNA in the first 4 hours after PH, as well as the apparent lack of Fos in AP-1 complexes, had no effect on the timing or extent of DNA replication...
  12. pmc Expression of suppressors of cytokine signaling during liver regeneration
    J S Campbell
    University of Washington, Department of Pathology, Seattle, Washington 98195, USA
    J Clin Invest 107:1285-92. 2001
    ..Together, these results suggest that SOCS-3 may be a key component in downregulating STAT-3 signaling after PH and that SOCS-3 mRNA levels in the regenerating liver are regulated by IL-6...
  13. ncbi request reprint Bcl-2 delays and alters hepatic carcinogenesis induced by transforming growth factor alpha
    M E Vail
    Department of Pathology, University of Washington, Seattle 98195 7610, USA
    Cancer Res 61:594-601. 2001
    ..5 months of age was sufficient to inhibit TGF-alpha-induced tumorigenesis. These results indicate that Bcl-2 inhibits tumor progression in the liver, possibly by interfering with hepatocyte proliferation...
  14. ncbi request reprint Liver regeneration: prospects for therapy based on new technologies
    M A Kay
    Department of Medicine, University of Washington, Seattle 98195 7720, USA
    Mol Med Today 3:108-15. 1997
    ..This article reviews the basic principles of liver regeneration, experimental manipulations in animal models, and human clinical applications including cellular transplantation, gene therapy and artificial livers...
  15. pmc Prevention of hepatic apoptosis and embryonic lethality in RelA/TNFR-1 double knockout mice
    M E Rosenfeld
    Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    Am J Pathol 156:997-1007. 2000
    ..However, the absence of both TNFR-1 signaling and RelA activity in newborn mice makes these animals susceptible to endogenous hepatic infection...
  16. pmc Responses of nontransformed human hepatocytes to conditional expression of full-length hepatitis C virus open reading frame
    Weiliang Tang
    Department of Pathology, University of Washington School of Medicine, K078 Health Sciences Building, Box 357705, Seattle, WA 98195 7705, USA
    Am J Pathol 171:1831-46. 2007
    ..Expression of HCV ORF in host cells may contribute to HCV pathogenesis by producing oxidative stress and increasing the expression of genes related to the innate immune response and inflammation...
  17. pmc Hepatocyte-specific inhibition of NF-kappaB leads to apoptosis after TNF treatment, but not after partial hepatectomy
    Michelle L Chaisson
    Department of Pathology, University of Washington, Seattle 98195, USA
    J Clin Invest 110:193-202. 2002
    ..As NF-kappaB activation was not inhibited in liver NPCs, it is likely that these cells are responsible for mediating the proliferative and antiapoptotic effects of NF-kappaB during liver regeneration...
  18. pmc Regulation of liver regeneration and hepatocarcinogenesis by suppressor of cytokine signaling 3
    Kimberly J Riehle
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98195, USA
    J Exp Med 205:91-103. 2008
    ..By acting on cytokines and multiple proliferative pathways, SOCS3 modulates both physiological and neoplastic proliferative processes in the liver and may act as a tumor suppressor...
  19. ncbi request reprint Enhanced acetaminophen hepatotoxicity in transgenic mice overexpressing BCL-2
    M L Adams
    Department of Medicinal Chemistry, University of Washington, Seattle, 98195, USA
    Mol Pharmacol 60:907-15. 2001
    ..In conclusion, these data suggest for the first time that BAX may be an early determinant of APAP-mediated hepatotoxicity and that BCL-2 overexpression unexpectedly enhances APAP hepatotoxicity...
  20. pmc Relationships between deficits in tissue mass and transcriptional programs after partial hepatectomy in mice
    Jiangning Li
    Department of Pathology, School of Medicine, University of Washington, Seattle, WA 98195, USA
    Am J Pathol 175:947-57. 2009
    ..We suggest that the changes in gene expression during the first 4 to 6 hours after 2/3 PH may induce chromatin remodeling and facilitate the binding of new sets of transcription factors required for DNA replication...
  21. ncbi request reprint Heparin-binding epidermal growth factor-like growth factor links hepatocyte priming with cell cycle progression during liver regeneration
    Claudia Mitchell
    Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Biol Chem 280:2562-8. 2005
    ..Moreover, we show that hepatocyte DNA replication was delayed in HB-EGF knock-out mice. In summary, we show that HB-EGF is a key factor for hepatocyte progression through G(1)/S transition during liver regeneration...
  22. ncbi request reprint Differential regulation of rodent hepatocyte and oval cell proliferation by interferon gamma
    John T Brooling
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Hepatology 41:906-15. 2005
    ..The response of hepatocytes and oval cells to cytokine combinations may contribute to the differential proliferation of these cells in hepatic growth processes...
  23. ncbi request reprint Gene expression patterns that correlate with hepatitis C and early progression to fibrosis in liver transplant recipients
    Maria W Smith
    Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington 98195 8070, USA
    Gastroenterology 130:179-87. 2006
    ..Our goals were to identify molecular processes influencing the liver disease progression and to find potential gene markers of early fibrosis...
  24. pmc Gene expression profiling of the cellular transcriptional network regulated by alpha/beta interferon and its partial attenuation by the hepatitis C virus nonstructural 5A protein
    Gary K Geiss
    Department of Microbiology, School of Medicine, University of Washington, Seattle 98195, USA
    J Virol 77:6367-75. 2003
    ..These differences highlight the importance of comparing results from multiple model systems when investigating complex phenomena such as the cellular response to IFN and viral mechanisms of IFN resistance...
  25. ncbi request reprint Proinflammatory cytokine production in liver regeneration is Myd88-dependent, but independent of Cd14, Tlr2, and Tlr4
    Jean S Campbell
    Department of Pathology, University of Washington, 98195, USA
    J Immunol 176:2522-8. 2006
    ..In contrast, MyD88-dependent pathways appear to be responsible for TNF, IL-6, and their downstream signaling pathways...
  26. pmc Disruption of redox homeostasis in tumor necrosis factor-induced apoptosis in a murine hepatocyte cell line
    R H Pierce
    Department of Pathology, The University of Washington, Seattle 98195, USA
    Am J Pathol 157:221-36. 2000
    ..As injury was regulated to a larger extent by the glutathione content of the cells, we suggest that the combination of TNF+Act D causes apoptosis because Act D blocks the transcription of genes required for antioxidant defenses...
  27. pmc Isolation of multipotent progenitor cells from human fetal liver capable of differentiating into liver and mesenchymal lineages
    Y Y Dan
    Department of Pathology, University of Washington, Seattle, WA 98115, USA
    Proc Natl Acad Sci U S A 103:9912-7. 2006
    ..hFLMPCs survive and differentiate into functional hepatocytes in vivo when transplanted into animal models of liver disease. hFLMPCs are a valuable tool for the study of human liver development, liver injury, and hepatic repopulation...
  28. ncbi request reprint Reactive oxygen species derived from NADPH oxidase system is not essential for liver regeneration after partial hepatectomy
    Shinichi Ueno
    Department of Pathology, University of Washington School of Medicine, Seattle, Washington, USA
    J Surg Res 136:260-5. 2006
    ....
  29. ncbi request reprint Mechanisms of liver regeneration and their clinical implications
    Nelson Fausto
    Department of Pathology, University of Washington School of Medicine, 98195 7470 Seattle, WA, USA
    J Hepatobiliary Pancreat Surg 12:181-9. 2005
    ..In this review, we discuss a few selected aspects of liver regeneration that are of interest in both the laboratory and the clinic...
  30. ncbi request reprint Bcl-2 expression delays hepatocyte cell cycle progression during liver regeneration
    Mary E Vail
    Department of Pathology, University of Washington, Seattle, Washington, WA 98195 7705, USA
    Oncogene 21:1548-55. 2002
    ..These results show that Bcl-2 expression delays cell cycle progression in hepatocytes and suggests that it acts at a step involving cyclin E and p107...
  31. ncbi request reprint Acetaminophen-induced liver injury is attenuated in male glutamate-cysteine ligase transgenic mice
    Dianne Botta
    Department of Environmental and Occupational Health Sciences, Comparative Medicine, and Pathology, and UW NIEHS Center for Ecogenetics and Environmental Health, University of Washington, Seattle, Washington 68105, USA
    J Biol Chem 281:28865-75. 2006
    ..Because people are known to vary in their glutamate-cysteine ligase activity, this enzyme may also be an important determinant of sensitivity to acetaminophen-induced liver injury in humans...
  32. ncbi request reprint Cytosolic heat shock proteins and heme oxygenase-1 are preferentially induced in response to specific and localized intramitochondrial damage by tetrafluoroethylcysteine
    Han K Ho
    Department of Medicinal Chemistry, University of Washington, Box 357610, Seattle, WA 98195, USA
    Biochem Pharmacol 72:80-90. 2006
    ..The cytoprotective effects of such HSP responses suggest a plausible role in modulating the progression of TFEC-induced cellular injury...
  33. pmc Bcl-2 expression inhibits liver carcinogenesis and delays the development of proliferating foci
    Robert H Pierce
    Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    Am J Pathol 160:1555-60. 2002
    ..The data demonstrate that the expression of an anti-apoptotic gene during liver carcinogenesis causes a delay rather than an increase in tumorigenesis...
  34. ncbi request reprint Glutamate-cysteine ligase attenuates TNF-induced mitochondrial injury and apoptosis
    Dianne Botta
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195, USA
    Free Radic Biol Med 37:632-42. 2004
    ..Analysis of the effects of TNF on these parameters indicates that maintaining mitochondrial integrity mediates this protective effect in GCL-overexpressing cells...
  35. pmc Inactivation of p38 MAPK during liver regeneration
    Jean S Campbell
    Department of Pathology, University of Washington, School of Medicine, Seattle, WA 98195, USA
    Int J Biochem Cell Biol 43:180-8. 2011
    ..Our results suggest that p38 MAPK inactivation plays a permissible role in DNA replication during liver regeneration and is consistent with a role for p38 MAPK in the maintenance of hepatocyte cell cycle arrest in adult liver...
  36. ncbi request reprint The expression of transforming growth factor-alpha in cirrhosis, dysplastic nodules, and hepatocellular carcinoma: an immunohistochemical study of 70 cases
    Matthew M Yeh
    Department of Pathology, School of Medicine, University of Washington, Seattle, WA 98195 6100, USA
    Am J Surg Pathol 31:681-9. 2007
    ....
  37. ncbi request reprint Identification of a specific gene expression pattern associated with HCV-induced pathogenesis in HCV- and HCV/HIV-infected individuals
    Kathie Anne Walters
    Department of Microbiology, School of Medicine, University of Washington, Box 358070, Seattle, WA 98195 8070, USA
    Virology 350:453-64. 2006
    ..Importantly, the pattern of gene expression observed in EGE (+) patients has similarities to patients who developed fibrosis within 1 year of receiving a liver transplant...
  38. pmc Hepatitis C virus replication in transfected and serum-infected cultured human fetal hepatocytes
    Catherine A Lazaro
    Department of Pathology, University of Washington School of Medicine, K078 Health Sciences Building, Box 357705, Seattle, WA 98195 7705, USA
    Am J Pathol 170:478-89. 2007
    ..This culture system may be used to study the responses of nontransformed human hepatocytes to HCV infection, to analyze serum infectivity, and to clone novel HCVs from infected patients...
  39. pmc Suppressor of cytokine signaling expression with increasing severity of murine hepatic ischemia-reperfusion injury
    Lorrie A Langdale
    Department of Surgery, University of Washington, Veterans Administration, VA Puget Sound Health Care, Building 1, Room 314, 1660 South Columbian Way, Seattle, WA 98108, USA
    J Hepatol 49:198-206. 2008
    ..SOCS1 and SOCS3 ensure appropriate intensity and duration of cytokine signaling through negative feedback on JAK-STAT signaling. The contribution of SOCS1 and SOCS3-mediated regulation to the evolution of hepatic IR injury is unknown...
  40. pmc Distinct Nrf1/2-independent mechanisms mediate As 3+-induced glutamate-cysteine ligase subunit gene expression in murine hepatocytes
    James A Thompson
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Free Radic Biol Med 46:1614-25. 2009
    ....
  41. ncbi request reprint Transforming growth factor-beta differentially regulates oval cell and hepatocyte proliferation
    Lananh N Nguyen
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Hepatology 45:31-41. 2007
    ..These findings further suggest an underlying mechanism for the proliferation of oval cells in an environment inhibitory to hepatocytic proliferation...
  42. pmc Comparison of the cytotoxicity of the nitroaromatic drug flutamide to its cyano analogue in the hepatocyte cell line TAMH: evidence for complex I inhibition and mitochondrial dysfunction using toxicogenomic screening
    Kevin J Coe
    Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA
    Chem Res Toxicol 20:1277-90. 2007
    ..Thus, as compared to CYA, the nitroaromatic group of FLU enhances cytotoxicity to hepatocytes, likely through mechanisms involving mitochondrial dysfunction and ATP depletion that include complex I inhibition...
  43. pmc New concepts in liver regeneration
    Kimberly J Riehle
    Department of Surgery, University of Washington, Seattle, USA
    J Gastroenterol Hepatol 26:203-12. 2011
    ..This review traces the path that has been taken over the last few decades in the study of liver regeneration, highlights new concepts in the field, and discusses the challenges that still stand between us and clinical therapy...
  44. ncbi request reprint Interactions between MYC and transforming growth factor alpha alter the growth and tumorigenicity of liver progenitor cells
    Ronald S Y Cheung
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Carcinogenesis 28:2624-31. 2007
    ..We conclude that the tumorigenic growth effects of MYC in TGFalpha-expressing liver progenitor cells are not solely dependent on its apoptotic activity...
  45. ncbi request reprint Targeting stromal cells for the treatment of platelet-derived growth factor C-induced hepatocellular carcinogenesis
    Jean S Campbell
    Department of Pathology, University of Washington School of Medicine, Box 357705, Seattle, WA 98195, USA
    Differentiation 75:843-52. 2007
    ..Our findings suggest that imatinib may be efficacious in the treatment of hepatocarcinogenesis, particularly when neovascularization is present...
  46. pmc Caspase-3-Dependent Cleavage of the Glutamate-L-Cysteine Ligase Catalytic Subunit during Apoptotic Cell Death
    Christopher C Franklin
    Department of Pathology, University of Washington, Seattle, Washington 98195 7470, USA
    Am J Pathol 160:1887-94. 2002
    ..Our identification of GCLC as a target for caspase-3-dependent cleavage during apoptotic cell death suggests that this post-translational modification may represent a novel mechanism for regulating GSH biosynthesis during apoptosis...
  47. pmc Bone marrow-derived hepatocytes : rare but promising
    Claudia Mitchell
    University of Washington, Department of Pathology, Seattle, Washington 98195, USA
    Am J Pathol 161:349-50. 2002
  48. ncbi request reprint Identification of novel tumor markers in hepatitis C virus-associated hepatocellular carcinoma
    Maria W Smith
    Department of Microbiology, School of Medicine, and Washington National Primate Research Center, University of Washington, Seattle, Washington 98195, USA
    Cancer Res 63:859-64. 2003
    ..Thus, high throughput methods coupled with high-order statistical analyses may result in the development of new diagnostic tools for liver malignancies...
  49. ncbi request reprint TGFbeta1-induced suppression of glutathione antioxidant defenses in hepatocytes: caspase-dependent post-translational and caspase-independent transcriptional regulatory mechanisms
    Christopher C Franklin
    University of Washington, Department of Pathology, Box 357705, 1959 N E Pacific St, HSB K 088, Seattle, WA 98195 7705, USA
    FASEB J 17:1535-7. 2003
    ....
  50. ncbi request reprint Establishment, characterization, and long-term maintenance of cultures of human fetal hepatocytes
    Catherine A Lazaro
    Department of Pathology, University of Washington, Seattle, WA, USA
    Hepatology 38:1095-106. 2003
    ..In conclusion, HFH cultures, which might contain a population of hepatic stem cells, constitute an excellent tool for a variety of studies with human hepatocytes, including the mechanisms of viral infection...
  51. ncbi request reprint Hepatitis C virus and liver disease: global transcriptional profiling and identification of potential markers
    Maria W Smith
    Department of Microbiology, School of Medicine, University of Washington, Seattle, WA 98195, USA
    Hepatology 38:1458-67. 2003
    ..In conclusion, our microarray analysis identified several potential gene markers of HCV-associated liver disease and contributed to our rapidly expanding database of experiments describing HCV pathogenesis...
  52. ncbi request reprint BCL-xL overexpression effectively protects against tetrafluoroethylcysteine-induced intramitochondrial damage and cell death
    Han K Ho
    Department of Medicinal Chemistry, University of Washington, Box 357610, Seattle, WA 98195, USA
    Biochem Pharmacol 69:147-57. 2005
    ..Hence, TFEC-induced necrotic cell death in the TAMH cell line is mediated by BAX and antagonized by the anti-apoptotic BCL-2 family member, BCL-xL...
  53. pmc Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma
    Jean S Campbell
    Department of Pathology, University of Washington, Seattle, WA 98115, USA
    Proc Natl Acad Sci U S A 102:3389-94. 2005
    ..Moreover, PDGF-C transgenic mice represent a unique model for the study of hepatic fibrosis progressing to tumorigenesis...
  54. ncbi request reprint Nrf2 activation involves an oxidative-stress independent pathway in tetrafluoroethylcysteine-induced cytotoxicity
    Han K Ho
    Department of Medicinal Chemistry, Environmental and Occupational Health Sciences, and Pathology, University of Washington, Seattle, Washington 98195, USA
    Toxicol Sci 86:354-64. 2005
    ..Overall, the results implicate a role for Nrf2 in the cellular response to TFEC toxicity and suggest a previously unrecognized role for the ER in this model of mitochondrially initiated cytotoxicity...
  55. pmc NF-kappaB mediates alphavbeta3 integrin-induced endothelial cell survival
    M Scatena
    Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    J Cell Biol 141:1083-93. 1998
    ..In contrast, inhibition of MEK and PI3-kinase did not affect osteopontin-induced NF-kappaB activation. These studies identify NF-kappaB as an important signaling molecule in alphavbeta3 integrin-mediated endothelial cell survival...
  56. pmc Expression of Bcl-2 family during liver regeneration and identification of Bcl-x as a delayed early response gene
    S P Tzung
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Am J Pathol 150:1985-95. 1997
    ..In summary, the expression profiles of Bcl-2 family members during liver regeneration suggest a cell-cycle-dependent regulation as well as a physiological role for these apoptosis-modulating genes during growth and proliferation...
  57. ncbi request reprint A dataset of human liver proteins identified by protein profiling via isotope-coded affinity tag (ICAT) and tandem mass spectrometry
    Wei Yan
    The Institute for Systems Biology, 1441 North 34th Street, Seattle, WA 98103, USA
    Mol Cell Proteomics 3:1039-41. 2004
    ..An increase of the threshold to p > or = 0.9 (corresponding to an error rate of less than 1%) resulted in 2,159 unique protein identifications (1,146, 1,235, and 1,318 for the Huh7, HFH, and HH4 cells, respectively)...
  58. ncbi request reprint Mitochondrial aconitase modification, functional inhibition, and evidence for a supramolecular complex of the TCA cycle by the renal toxicant S-(1,1,2,2-tetrafluoroethyl)-L-cysteine
    Eric A James
    Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA
    Biochemistry 41:6789-97. 2002
    ....
  59. pmc Transferrin fails to provide protection against Fas-induced hepatic injury in mice with deletion of functional transferrin-receptor type 2
    Vladimir Lesnikov
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D1 100, P O Box 19024, Seattle, WA 98109 1024, USA
    Apoptosis 13:1005-12. 2008
    ..Both apoptotic Fas responses and cytoprotective effects of Tf were associated with significant shifts in plasma iron levels, which quantitatively differed between male and female mice...
  60. ncbi request reprint Protection of human and murine hepatocytes against Fas-induced death by transferrin and iron
    V A Lesnikov
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Apoptosis 11:79-87. 2006
    ..Survival of hepatocytes 'stressed' by Fas signals can be manipulated by Tf and iron and may be a target for prophylactic and therapeutic interventions...
  61. pmc Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor
    Y Yamada
    Department of Pathology, University of Washington, Seattle 98195, USA
    Proc Natl Acad Sci U S A 94:1441-6. 1997
    ..The results indicate that TNF, signaling through the TNFR-I, can initiate liver regeneration and acts by activating an interleukin 6-dependent pathway that involves the STAT3 transcription factor...
  62. ncbi request reprint Reciprocal and coordinate regulation of serum amyloid A versus apolipoprotein A-I and paraoxonase-1 by inflammation in murine hepatocytes
    Chang Yeop Han
    Department of Medicine, University of Washington, Seattle, WA 98195 6426, USA
    Arterioscler Thromb Vasc Biol 26:1806-13. 2006
    ..Because cytokines stimulate the hepatic expression of inflammatory markers, we investigated their role in regulating SAA, apoA-I, and PON-1 expression...
  63. ncbi request reprint Dimerizer-induced proliferation of genetically modified hepatocytes
    Zong Yi Li
    Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Mol Ther 5:420-6. 2002
    ..Drug-inducible in vivo expansion of genetically modified hepatocytes may have potential applications in hepatic gene transfer or in liver repopulation by transplanted hepatocytes or their progenitors. (c)2002 Elsevier Science (USA)...
  64. doi request reprint Defective DNA strand break repair causes chromosomal instability and accelerates liver carcinogenesis in mice
    Narci C Teoh
    Australian National University Medical School, Canberra, Australia
    Hepatology 47:2078-88. 2008
    ....
  65. ncbi request reprint Cell culture model for acetaminophen-induced hepatocyte death in vivo
    Robert H Pierce
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Biochem Pharmacol 64:413-24. 2002
    ..These results indicate that, although retaining some attributes of apoptosis, both APAP- and AMAP-mediated cell death have additional distinctive features consistent with longer term necrosis...
  66. ncbi request reprint Tweaking liver progenitor cells
    Nelson Fausto
    Nat Med 11:1053-4. 2005
  67. ncbi request reprint Hepatitis B virus pre-S2 mutant upregulates cyclin A expression and induces nodular proliferation of hepatocytes
    Hui Ching Wang
    Division of Clinical Research, National Health Research Institutes, Tainan, Taiwan
    Hepatology 41:761-70. 2005
    ..In conclusion, these in vitro and in vivo data support a role for Delta S2-LHBs in the hepatocyte hyperplasia and a likely role in the process of HBV-related tumorigenesis...
  68. ncbi request reprint Epidermal growth factor receptor transactivation mediates tumor necrosis factor-induced hepatocyte replication
    Gretchen M Argast
    Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, CO 80309, USA
    J Biol Chem 279:34530-6. 2004
    ..We suggest that TNF-induced transactivation of EGFR may provide an early signal for the entry of hepatocytes into the cell cycle and may integrate proliferative and survival pathways at the start of liver regeneration...
  69. ncbi request reprint Involvement of the innate immune system in liver regeneration and injury
    Nelson Fausto
    J Hepatol 45:347-9. 2006
  70. pmc Efficiency of hepatitis C virus infection in vitro
    Daniel Favre
    Am J Pathol 171:373; author reply 373. 2007
  71. pmc Different types of ground glass hepatocytes in chronic hepatitis B virus infection contain specific pre-S mutants that may induce endoplasmic reticulum stress
    Hui Ching Wang
    Graduate Institutes of Basic Medical Sciences, Molecular Medicine, and Immunology and Microbiology, National Cheng Kung University College of Medicine, Tainan, Taiwan
    Am J Pathol 163:2441-9. 2003
    ..This study therefore demonstrates that different GGHs may contain specific mutants and exhibit differential biological activities...
  72. pmc Decreased aquaporin expression leads to increased resistance to apoptosis in hepatocellular carcinoma
    Elizabeth M Jablonski
    Department of Biology, UNC at Charlotte, 9201 University City Blvd, Charlotte, NC, USA
    Cancer Lett 250:36-46. 2007
    ..In contrast, hepatocytes rapidly responded to osmotic challenge through AQP-dependent water movement and underwent cell death following apoptotic stimulation...

Research Grants17

  1. PATHOGENESIS OF HEPATOCELLULAR CARCINOMA
    Nelson Fausto; Fiscal Year: 2009
    ..The proposed experiments will increase our understanding of the mechanisms of hepatocellular carcinogenesis, and test therapeutic strategies that might be applied to human tumors. ..
  2. Environmetal Pathology/Toxicology Training Program
    Nelson Fausto; Fiscal Year: 2007
    ....
  3. GENE EXPRESSION IN REGENERATING AND NEOPLASTIC LIVERS
    Nelson Fausto; Fiscal Year: 2007
    ..5) Determine whether IFNy in combination with TNF can change liver regeneration after PH from a hepatocyte to a liver precursor cell (oval cell) response...
  4. PATHOGENESIS OF HEPATOCELLULAR CARCINOMA
    Nelson Fausto; Fiscal Year: 2007
    ..The proposed experiments will increase our understanding of the mechanisms of hepatocellular carcinogenesis, and test therapeutic strategies that might be applied to human tumors. ..
  5. Pathogenesis of Hepatocellular Carcinomas
    Nelson Fausto; Fiscal Year: 2006
    ..We expect that these studies will contribute to the understanding of the molecular pathogenesis of HCC development in mice and humans. ..
  6. PATHOGENESIS OF HEPATOCELLULAR CARCINOMA
    Nelson Fausto; Fiscal Year: 2001
    ..It is expected that the results from these experiments will lead to a better understanding of the pathogenesis of HCC and will have important implications for devising new therapeutic strategies for these tumors. ..
  7. PATHOGENESIS OF HEPATOCELLULAR CARCINOMA
    Nelson Fausto; Fiscal Year: 2010
    ..The proposed experiments will increase our understanding of the mechanisms of hepatocellular carcinogenesis, and test therapeutic strategies that might be applied to human tumors. ..