Michel Fausther

Summary

Affiliation: University of Arkansas for Medical Sciences
Location: Little Rock, Arkansas, USA
Summary:
Post-Doctoral Fellow.
Grants:
None.

Publications

  1. ncbi Coexpression of ecto-5'-nucleotidase/CD73 with specific NTPDases differentially regulates adenosine formation in the rat liver
    Michel Fausther
    Centre de Recherche en Rhumatologie et Immunologie, Quebec, QC, Canada
    Am J Physiol Gastrointest Liver Physiol 302:G447-59. 2012
  2. ncbi New insights on the pathogenesis of biliary cirrhosis provided by studies in FXR knockout mice
    Michel Fausther
    Division of Gastroenterology and Hepatology, University of Arkansas for the Medical Sciences, Little Rock, AR 72205, USA
    J Hepatol 55:939-40. 2011
  3. ncbi Extracellular nucleosides and nucleotides regulate liver functions via a complex system of membrane proteins
    Michel Fausther
    Centre de Recherche en Rhumatologie et Immunologie, CHU de Québec, QC, Canada
    C R Biol 334:100-17. 2011
  4. ncbi Identification of the ectonucleotidases expressed in mouse, rat, and human Langerhans islets: potential role of NTPDase3 in insulin secretion
    Elise G Lavoie
    Centre de Recherche en Rhumatologie et Immunologie, Centre Hospitalier Universitaire de Quebec, Quebec City, Quebec, Canada
    Am J Physiol Endocrinol Metab 299:E647-56. 2010
  5. ncbi High expression and activity of ecto-5'-nucleotidase/CD73 in the male murine reproductive tract
    Mireia Martín-Satué
    Centre de Recherche en Rhumatologie et Immunologie, Centre Hospitalier Universitaire de Quebec, Universite Laval, Quebec, Canada
    Histochem Cell Biol 133:659-68. 2010
  6. ncbi Cystic fibrosis remodels the regulation of purinergic signaling by NTPDase1 (CD39) and NTPDase3
    Michel Fausther
    Centre de Recherche en Rhumatologie et Immunologie, Universite Laval, Ste Foy, Quebec City, Canada
    Am J Physiol Lung Cell Mol Physiol 298:L804-18. 2010
  7. ncbi Endothelial P2Y2 receptor regulates LPS-induced neutrophil transendothelial migration in vitro
    Filip Kukulski
    Centre de Recherche en Rhumatologie et Immunologie, Centre Hospitalier Universitaire de Quebec, Universite Laval, Quebec, QC, Canada
    Mol Immunol 47:991-9. 2010
  8. ncbi Localization of plasma membrane bound NTPDases in the murine reproductive tract
    M Martín-Satué
    Centre de Recherche en Rhumatologie et Immunologie, Centre Hospitalier Universitaire de Quebec, Universite Laval, 2705 Blvd Laurier, Local T1 49, Quebec, QC, G1V 4G2, Canada
    Histochem Cell Biol 131:615-28. 2009
  9. ncbi Characterization of a monoclonal antibody as the first specific inhibitor of human NTP diphosphohydrolase-3 : partial characterization of the inhibitory epitope and potential applications
    Mercedes N Munkonda
    Centre de Recherche en Rhumatologie et Immunologie, Centre Hospitalier Universitaire de Quebec, Universite Laval, Canada
    FEBS J 276:479-96. 2009
  10. ncbi Cloning, purification, and identification of the liver canalicular ecto-ATPase as NTPDase8
    Michel Fausther
    Centre de Recherche en Rhumatologie et Immunologie, 2705 Boulevard Laurier, Local T1 49, G1V 4G2 Quebec, QC, Canada
    Am J Physiol Gastrointest Liver Physiol 292:G785-95. 2007

Collaborators

Detail Information

Publications13

  1. ncbi Coexpression of ecto-5'-nucleotidase/CD73 with specific NTPDases differentially regulates adenosine formation in the rat liver
    Michel Fausther
    Centre de Recherche en Rhumatologie et Immunologie, Quebec, QC, Canada
    Am J Physiol Gastrointest Liver Physiol 302:G447-59. 2012
    ..In conclusion, the specific cellular cocompartmentalization of CD73 with hepatic NTPDases is not redundant and may lead to the differential activation of P1 and P2 receptors, under normal and fibrotic conditions...
  2. ncbi New insights on the pathogenesis of biliary cirrhosis provided by studies in FXR knockout mice
    Michel Fausther
    Division of Gastroenterology and Hepatology, University of Arkansas for the Medical Sciences, Little Rock, AR 72205, USA
    J Hepatol 55:939-40. 2011
    ..Since there is no FXR expression in HSCs and MFBs in liver fibrosis, our data indicate that these cells may not represent direct therapeutic targets for FXR ligands...
  3. ncbi Extracellular nucleosides and nucleotides regulate liver functions via a complex system of membrane proteins
    Michel Fausther
    Centre de Recherche en Rhumatologie et Immunologie, CHU de Québec, QC, Canada
    C R Biol 334:100-17. 2011
    ..Here, we cover various aspects of the signalling pathways initiated by extracellular nucleosides and nucleotides in the liver, and discuss their overall impact on hepatic physiology...
  4. ncbi Identification of the ectonucleotidases expressed in mouse, rat, and human Langerhans islets: potential role of NTPDase3 in insulin secretion
    Elise G Lavoie
    Centre de Recherche en Rhumatologie et Immunologie, Centre Hospitalier Universitaire de Quebec, Quebec City, Quebec, Canada
    Am J Physiol Endocrinol Metab 299:E647-56. 2010
    ..Ecto-5'-nucleotidase is expressed in rat Langerhans islet cells but absent in human and mouse endocrine cells...
  5. ncbi High expression and activity of ecto-5'-nucleotidase/CD73 in the male murine reproductive tract
    Mireia Martín-Satué
    Centre de Recherche en Rhumatologie et Immunologie, Centre Hospitalier Universitaire de Quebec, Universite Laval, Quebec, Canada
    Histochem Cell Biol 133:659-68. 2010
    ..This study suggests close regulation of extracellular nucleoside and nucleotide levels in the genital tract by ecto-5'-nucleotidase that, in concurrence with NTPDases, may impact male fertility...
  6. ncbi Cystic fibrosis remodels the regulation of purinergic signaling by NTPDase1 (CD39) and NTPDase3
    Michel Fausther
    Centre de Recherche en Rhumatologie et Immunologie, Universite Laval, Ste Foy, Quebec City, Canada
    Am J Physiol Lung Cell Mol Physiol 298:L804-18. 2010
    ..This study provides evidence that an extensive remodeling of the enzymatic network regulating clearance occurs in the airways of CF patients...
  7. ncbi Endothelial P2Y2 receptor regulates LPS-induced neutrophil transendothelial migration in vitro
    Filip Kukulski
    Centre de Recherche en Rhumatologie et Immunologie, Centre Hospitalier Universitaire de Quebec, Universite Laval, Quebec, QC, Canada
    Mol Immunol 47:991-9. 2010
    ..In summary, endothelial P2Y(2) receptors control the early LPS-induced neutrophil TEM in vitro via Rho kinase activation...
  8. ncbi Localization of plasma membrane bound NTPDases in the murine reproductive tract
    M Martín-Satué
    Centre de Recherche en Rhumatologie et Immunologie, Centre Hospitalier Universitaire de Quebec, Universite Laval, 2705 Blvd Laurier, Local T1 49, Quebec, QC, G1V 4G2, Canada
    Histochem Cell Biol 131:615-28. 2009
    ..This descriptive study suggests close regulation of extracellular nucleotide levels in the genital tract by NTPDases that may impact specific biological functions...
  9. ncbi Characterization of a monoclonal antibody as the first specific inhibitor of human NTP diphosphohydrolase-3 : partial characterization of the inhibitory epitope and potential applications
    Mercedes N Munkonda
    Centre de Recherche en Rhumatologie et Immunologie, Centre Hospitalier Universitaire de Quebec, Universite Laval, Canada
    FEBS J 276:479-96. 2009
    ..Because insulin secretion is modulated by extracellular ATP and purinergic receptors, this finding suggests the potential application of these inhibitory antibodies for the study and control of insulin secretion...
  10. ncbi Cloning, purification, and identification of the liver canalicular ecto-ATPase as NTPDase8
    Michel Fausther
    Centre de Recherche en Rhumatologie et Immunologie, 2705 Boulevard Laurier, Local T1 49, G1V 4G2 Quebec, QC, Canada
    Am J Physiol Gastrointest Liver Physiol 292:G785-95. 2007
    ..The canalicular localization of this enzyme suggests its involvement in the regulation of bile secretion and/or nucleoside salvage...
  11. ncbi Expression of NTPDase1 and NTPDase2 in murine kidney: relevance to regulation of P2 receptor signaling
    Bellamkonda K Kishore
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah, USA
    Am J Physiol Renal Physiol 288:F1032-43. 2005
    ..NTPDases may modulate regulatory effects of ATP and degradation products within the vasculature and other sites and thereby potentially influence physiological as well as multiple pathological events in the kidney...
  12. ncbi Expression of ecto-ATPase NTPDase2 in human dental pulp
    X Liu
    Division of General Dentistry, University of Rochester Eastman Institute for Oral Health, 625 Elmwood Avenue, Rochester, NY 14620, USA
    J Dent Res 91:261-7. 2012
    ..These findings provide evidence for the existence of an apparatus for ATP release and degradation in human dental pulp, consistent with the involvement of ATP signaling in the process of dentin sensitivity and dental pain...