SEYYED HOSSEIN FATEMI

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc Consensus paper: pathological role of the cerebellum in autism
    S Hossein Fatemi
    University of Minnesota Medical School, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Cerebellum 11:777-807. 2012
  2. ncbi Downregulation of GABAA Receptor Protein Subunits α6, β2, δ, ε, γ2, θ, and ρ2 in Superior Frontal Cortex of Subjects with Autism
    S Hossein Fatemi
    Division of Neuroscience Research, Department of Psychiatry, University of Minnesota Medical School, 420 Delaware St SE, MMC 392, Minneapolis, MN, 55455, USA
    J Autism Dev Disord 44:1833-45. 2014
  3. pmc Expression of GABAA α2-, β1- and ε-receptors are altered significantly in the lateral cerebellum of subjects with schizophrenia, major depression and bipolar disorder
    S H Fatemi
    1 Division of Neuroscience Research, Department of Psychiatry, University of Minnesota Medical School, Minneapolis, MN, USA 2 Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN, USA 3 Department of Neuroscience, University of Minnesota Medical School, Minneapolis, MN, USA
    Transl Psychiatry 3:e303. 2013
  4. pmc mRNA and protein expression for novel GABAA receptors θ and ρ2 are altered in schizophrenia and mood disorders; relevance to FMRP-mGluR5 signaling pathway
    S H Fatemi
    Division of Neuroscience Research, Department of Psychiatry, University of Minnesota Medical School, Minneapolis, MN, USA
    Transl Psychiatry 3:e271. 2013
  5. ncbi Comparative gene expression study of the chronic exposure to clozapine and haloperidol in rat frontal cortex
    S Hossein Fatemi
    Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, 420 Delaware St SE, MMC 392, Minneapolis, MN 55455, United States
    Schizophr Res 134:211-8. 2012
  6. pmc The viral theory of schizophrenia revisited: abnormal placental gene expression and structural changes with lack of evidence for H1N1 viral presence in placentae of infected mice or brains of exposed offspring
    S Hossein Fatemi
    Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, 420 Delaware St SE, MMC 392, Minneapolis, MN 55455, USA
    Neuropharmacology 62:1290-8. 2012
  7. pmc The neurodevelopmental hypothesis of schizophrenia, revisited
    S Hossein Fatemi
    420 Delaware St SE, MMC 392, Minneapolis, MN 55455, USA
    Schizophr Bull 35:528-48. 2009
  8. doi Phosphodiesterase-4A expression is reduced in cerebella of patients with bipolar disorder
    S Hossein Fatemi
    Department of Psychiatry, Division of Neuroscience Research, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Psychiatr Genet 18:282-8. 2008
  9. pmc Expression of GABA(B) receptors is altered in brains of subjects with autism
    S Hossein Fatemi
    Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Cerebellum 8:64-9. 2009
  10. pmc GABA(A) receptor downregulation in brains of subjects with autism
    S Hossein Fatemi
    Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USA
    J Autism Dev Disord 39:223-30. 2009

Research Grants

  1. Prenatal Virally Induced Brain Disorder in Mouse
    SEYYED FATEMI; Fiscal Year: 2009
  2. GABAergic and Reelin Deficits in Schizophrenia
    SEYYED HOSSEIN FATEMI; Fiscal Year: 2010
  3. Prenatal Virally Induced Brain Disorder in Mouse
    S Fatemi; Fiscal Year: 2005
  4. GABAergic Dysfunction in Autism
    SEYYED FATEMI; Fiscal Year: 2009
  5. Varenicline and Smoking Cessation in Schizophrenia
    SEYYED HOSSEIN FATEMI; Fiscal Year: 2010
  6. GABAergic Dysfunction in Autism
    SEYYED HOSSEIN FATEMI; Fiscal Year: 2010
  7. Varenicline and Smoking Cessation in Schizophrenia
    SEYYED FATEMI; Fiscal Year: 2009
  8. GABAergic Dysfunction in Autism
    SEYYED FATEMI; Fiscal Year: 2009
  9. GABAergic Dysfunction in Autism
    S Fatemi; Fiscal Year: 2007
  10. Prenatal Virally Induced Brain Disorder in Mouse
    S Fatemi; Fiscal Year: 2007

Detail Information

Publications53

  1. pmc Consensus paper: pathological role of the cerebellum in autism
    S Hossein Fatemi
    University of Minnesota Medical School, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Cerebellum 11:777-807. 2012
    ....
  2. ncbi Downregulation of GABAA Receptor Protein Subunits α6, β2, δ, ε, γ2, θ, and ρ2 in Superior Frontal Cortex of Subjects with Autism
    S Hossein Fatemi
    Division of Neuroscience Research, Department of Psychiatry, University of Minnesota Medical School, 420 Delaware St SE, MMC 392, Minneapolis, MN, 55455, USA
    J Autism Dev Disord 44:1833-45. 2014
    ..Our data demonstrate systematic changes in GABAA&B subunit expression in brains of subjects with autism, which may help explain the presence of cognitive abnormalities in subjects with autism. ..
  3. pmc Expression of GABAA α2-, β1- and ε-receptors are altered significantly in the lateral cerebellum of subjects with schizophrenia, major depression and bipolar disorder
    S H Fatemi
    1 Division of Neuroscience Research, Department of Psychiatry, University of Minnesota Medical School, Minneapolis, MN, USA 2 Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN, USA 3 Department of Neuroscience, University of Minnesota Medical School, Minneapolis, MN, USA
    Transl Psychiatry 3:e303. 2013
    ..New avenues for treatment, such as the use of neurosteroids to promote GABA modulation, could potentially ameliorate GABAergic dysfunction in these disorders...
  4. pmc mRNA and protein expression for novel GABAA receptors θ and ρ2 are altered in schizophrenia and mood disorders; relevance to FMRP-mGluR5 signaling pathway
    S H Fatemi
    Division of Neuroscience Research, Department of Psychiatry, University of Minnesota Medical School, Minneapolis, MN, USA
    Transl Psychiatry 3:e271. 2013
    ..There were no significant effects of confounds on any of the results...
  5. ncbi Comparative gene expression study of the chronic exposure to clozapine and haloperidol in rat frontal cortex
    S Hossein Fatemi
    Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, 420 Delaware St SE, MMC 392, Minneapolis, MN 55455, United States
    Schizophr Res 134:211-8. 2012
    ..Our results show that clozapine and haloperidol cause changes in levels of many important genes that may be involved in etiology and treatment of schizophrenia...
  6. pmc The viral theory of schizophrenia revisited: abnormal placental gene expression and structural changes with lack of evidence for H1N1 viral presence in placentae of infected mice or brains of exposed offspring
    S Hossein Fatemi
    Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, 420 Delaware St SE, MMC 392, Minneapolis, MN 55455, USA
    Neuropharmacology 62:1290-8. 2012
    ....
  7. pmc The neurodevelopmental hypothesis of schizophrenia, revisited
    S Hossein Fatemi
    420 Delaware St SE, MMC 392, Minneapolis, MN 55455, USA
    Schizophr Bull 35:528-48. 2009
    ..We relate the neurodevelopmental model to a number of findings about schizophrenia. Finally, we also examine alternate explanations of the origin of schizophrenia including the neurodegenerative model...
  8. doi Phosphodiesterase-4A expression is reduced in cerebella of patients with bipolar disorder
    S Hossein Fatemi
    Department of Psychiatry, Division of Neuroscience Research, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Psychiatr Genet 18:282-8. 2008
    ..We sought to examine whether PDE4A5 expression was altered in cerebella of patients with schizophrenia, bipolar disorder, and major depression...
  9. pmc Expression of GABA(B) receptors is altered in brains of subjects with autism
    S Hossein Fatemi
    Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Cerebellum 8:64-9. 2009
    ..Decreases in GABA(B) receptor subunits may help explain the presence of seizures that are often comorbid with autism, as well as cognitive difficulties prevalent in autism...
  10. pmc GABA(A) receptor downregulation in brains of subjects with autism
    S Hossein Fatemi
    Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USA
    J Autism Dev Disord 39:223-30. 2009
    ..Our results demonstrate that GABA(A) receptors are reduced in three brain regions that have previously been implicated in the pathogenesis of autism, suggesting widespread GABAergic dysfunction in the brains of subjects with autism...
  11. ncbi Chronic psychotropic drug treatment causes differential expression of connexin 43 and GFAP in frontal cortex of rats
    S Hossein Fatemi
    Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, 420 Delaware St SE, MMC 392, Minneapolis, MN 55455, United States
    Schizophr Res 104:127-34. 2008
    ..GFAP protein expression was significantly decreased following chronic treatment with clozapine and valproic acid. These results suggest that astroglial markers GFAP and CX43 could be potential targets for therapeutic intervention...
  12. pmc mRNA and protein levels for GABAAalpha4, alpha5, beta1 and GABABR1 receptors are altered in brains from subjects with autism
    S Hossein Fatemi
    Department of Psychiatry, Division of Neuroscience Research, University of Minnesota School of Medicine, 420 Delaware St SE MMC 392, Minneapolis, MN 55455, USA
    J Autism Dev Disord 40:743-50. 2010
    ..These results provide further evidence of impairment of GABAergic signaling in autism...
  13. pmc Expression of astrocytic markers aquaporin 4 and connexin 43 is altered in brains of subjects with autism
    S Hossein Fatemi
    Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Synapse 62:501-7. 2008
    ..Aquaporin 4 expression was decreased significantly in cerebellum. These data suggest that changes are apparent in markers for abnormal glial-neuronal communication (connexin 43 and aquaporin 4) in brains of subjects with autism...
  14. doi The role of cerebellar genes in pathology of autism and schizophrenia
    S Hossein Fatemi
    Department of Psychiatry, Division of Neuroscience Research, University of Minnesota, Medical School, MMC 392, 420 Delaware Street S E, Minneapolis, MN 55455, USA
    Cerebellum 7:279-94. 2008
    ....
  15. doi Chronic psychotropic drug treatment causes differential expression of Reelin signaling system in frontal cortex of rats
    S Hossein Fatemi
    Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, 420 Delaware St SE, MMC 392, Minneapolis, MN 55455, USA
    Schizophr Res 111:138-52. 2009
    ..These changes may help explain the efficacy of these drugs and provide further support for the investigation of the Reelin and GABAergic signaling systems as therapeutic targets for the treatment of neuropsychiatric diseases...
  16. pmc Abnormal expression of myelination genes and alterations in white matter fractional anisotropy following prenatal viral influenza infection at E16 in mice
    S Hossein Fatemi
    Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Schizophr Res 112:46-53. 2009
    ..We propose that maternal infection in mouse impacts myelination genes...
  17. pmc Potential microbial origins of schizophrenia and their treatments
    S Hossein Fatemi
    Department of Psychiatry, Division of Neuroscience Research and Departments of Pharmacology and Neuroscience, University of Minnesota Medical School, USA
    Drugs Today (Barc) 45:305-18. 2009
    ..Elucidation of the mechanisms for infectious roots of schizophrenia may open new avenues for effective treatment...
  18. pmc Prenatal viral infection of mice at E16 causes changes in gene expression in hippocampi of the offspring
    S Hossein Fatemi
    Department of Psychiatry, Division of Neuroscience Research, University of Minnesota School of Medicine, Minneapolis 55455, USA
    Eur Neuropsychopharmacol 19:648-53. 2009
    ..MRI revealed a decrease in hippocampal volume at P35 (adolescence). Our results demonstrate altered gene expression and reduced hippocampal volume in the offspring following prenatal viral infection at E16...
  19. doi The role of lithium in modulation of brain genes: relevance for aetiology and treatment of bipolar disorder
    S Hossein Fatemi
    Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, MMC 392, Minneapolis, MN 55455, USA
    Biochem Soc Trans 37:1090-5. 2009
    ....
  20. ncbi Levels of phosphodiesterase 4A and 4B are altered by chronic treatment with psychotropic medications in rat frontal cortex
    S Hossein Fatemi
    Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, MMC 392, Minneapolis, Minnesota 55455, USA
    Synapse 64:550-5. 2010
    ..Our results demonstrate altered expression of PDE4A and PDE4B in response to a variety of psychotropic medications suggesting potentially new therapeutic avenues for treatment of neuropsychiatric diseases...
  21. pmc The role of fragile X mental retardation protein in major mental disorders
    S Hossein Fatemi
    Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, 420 Delaware St SE, MMC 392, Minneapolis, MN 55455, USA
    Neuropharmacology 60:1221-6. 2011
    ..This article is part of a Special Issue entitled 'Trends in neuropharmacology: in memory of Erminio Costa'...
  22. pmc Deficits in GABA(B) receptor system in schizophrenia and mood disorders: a postmortem study
    S Hossein Fatemi
    Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, 420 Delaware St SE, MMC 392, Minneapolis, MN 55455, USA
    Schizophr Res 128:37-43. 2011
    ..These results provide further evidence of GABAergic dysfunction in these three disorders as well as identify potential targets for therapeutic intervention...
  23. pmc Dysregulation of fragile × mental retardation protein and metabotropic glutamate receptor 5 in superior frontal cortex of individuals with autism: a postmortem brain study
    S Hossein Fatemi
    Division of Neuroscience Research, Department of Psychiatry, University of Minnesota Medical School, 420 Delaware Street SE, MMC 392, Minneapolis, MN 55455, USA
    Mol Autism 2:6. 2011
    ..abstract:..
  24. ncbi PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia
    S Hossein Fatemi
    Department of Psychiatry, University of Minnesota Medical School, MMC 392, Minneapolis, MN 55455, USA
    Schizophr Res 101:36-49. 2008
    ....
  25. pmc Maternal infection leads to abnormal gene regulation and brain atrophy in mouse offspring: implications for genesis of neurodevelopmental disorders
    S Hossein Fatemi
    Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, 420 Delaware St SE, MMC 392, Minneapolis, MN 55455, USA
    Schizophr Res 99:56-70. 2008
    ..We propose that maternal infection in mouse provides an heuristic animal model for studying the environmental contributions to genesis of schizophrenia and autism, two important examples of neurodevelopmental disorders...
  26. ncbi Human influenza viral infection in utero alters glial fibrillary acidic protein immunoreactivity in the developing brains of neonatal mice
    S H Fatemi
    Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, Minneapolis, MN, USA
    Mol Psychiatry 7:633-40. 2002
    ..These results implicate a significant role of prenatal human influenza viral infection on subsequent gliosis, which persists throughout brain development in mice from birth to adolescence...
  27. ncbi Reduced blood levels of reelin as a vulnerability factor in pathophysiology of autistic disorder
    S Hossein Fatemi
    Department of Psychiatry, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Cell Mol Neurobiol 22:139-52. 2002
    ..5. These results suggest that Reelin 410 deficiency may be a vulnerability factor in the pathology of autism...
  28. ncbi Purkinje cell size is reduced in cerebellum of patients with autism
    S Hossein Fatemi
    Department of Psychiatry, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Cell Mol Neurobiol 22:171-5. 2002
    ..These data indicate the possibility of Purkinje cell atrophy in autism with significant neurohistological heterogeneity among individuals diagnosed with this disorder...
  29. pmc Metabotropic glutamate receptor 5 upregulation in children with autism is associated with underexpression of both Fragile X mental retardation protein and GABAA receptor beta 3 in adults with autism
    S Hossein Fatemi
    Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, Minneapolis, USA
    Anat Rec (Hoboken) 294:1635-45. 2011
    ..Taken together, our results provide further evidence that altered FMRP expression and increased mGluR5 protein production potentially lead to altered expression of GABA(A) receptors...
  30. ncbi Glial fibrillary acidic protein is reduced in cerebellum of subjects with major depression, but not schizophrenia
    S Hossein Fatemi
    Division of Neuroscience Research, Department of Psychiatry, University of Minnesota Medical School, MMC 392, Delaware Street 420, Minneapolis, MN 55455, USA
    Schizophr Res 69:317-23. 2004
    ....
  31. ncbi GABAergic dysfunction in schizophrenia and mood disorders as reflected by decreased levels of glutamic acid decarboxylase 65 and 67 kDa and Reelin proteins in cerebellum
    S Hossein Fatemi
    Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, MMC 392, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Schizophr Res 72:109-22. 2005
    ..We hypothesized that levels of GAD and Reelin would be altered in cerebellum of subjects with schizophrenia and mood disorders differentially vs. controls...
  32. ncbi Reelin glycoprotein: structure, biology and roles in health and disease
    S H Fatemi
    Division of Neuroscience Research, Department of Psychiatry, University of Minnesota Medical School, 420 Delaware Street, Minneapolis, MN 55455, USA
    Mol Psychiatry 10:251-7. 2005
    ....
  33. ncbi Reelin signaling is impaired in autism
    S Hossein Fatemi
    Department of Psychiatry, Division of Neuroscience Research, University of Minnesota, Minneapolis, MN 55455, USA
    Biol Psychiatry 57:777-87. 2005
    ..Recent genetic linkage studies implicate Reelin glycoprotein in causation of autism. To further investigate these studies, brain levels of Reelin protein and mRNA and mRNAs for VLDLR, Dab-1, and GSK3 were investigated...
  34. ncbi Prenatal viral infection in mouse causes differential expression of genes in brains of mouse progeny: a potential animal model for schizophrenia and autism
    S H Fatemi
    University of Minnesota, Department of Psychiatry, Division of Neuroscience Research, Minneapolis, Minnesota 55455, USA
    Synapse 57:91-9. 2005
    ....
  35. pmc Viral regulation of aquaporin 4, connexin 43, microcephalin and nucleolin
    S Hossein Fatemi
    Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, 420 Delaware Ave SE, MMC 392, Minneapolis, MN 55455, USA
    Schizophr Res 98:163-77. 2008
    ....
  36. ncbi Chronic olanzapine treatment causes differential expression of genes in frontal cortex of rats as revealed by DNA microarray technique
    S Hossein Fatemi
    Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Neuropsychopharmacology 31:1888-99. 2006
    ..Our results show for the first time that olanzapine causes changes in levels of several important genes that may be involved in the etiology and treatment of schizophrenia and other psychiatric disorders...
  37. ncbi Altered levels of Reelin and its isoforms in schizophrenia and mood disorders
    S H Fatemi
    Division of Neuroscience Research, Department of Psychiatry, University of Minnesota Medical School, Box 392, Mayo Building, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Neuroreport 12:3209-15. 2001
    ..These findings suggest that blood Reelin levels and its isoforms may be used as potential peripheral markers to diagnose presence of several psychiatric disorders and may also serve as targets for future therapeutic interventions...
  38. ncbi Reduction in Reelin immunoreactivity in hippocampus of subjects with schizophrenia, bipolar disorder and major depression
    S H Fatemi
    Department of Psychiatry, University of Minnesota Medical School, Minneapolis 55455, USA
    Mol Psychiatry 5:654-63, 571. 2000
    ....
  39. ncbi Dysregulation of Reelin and Bcl-2 proteins in autistic cerebellum
    S H Fatemi
    Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, Minneapolis 55455, USA
    J Autism Dev Disord 31:529-35. 2001
    ..These results demonstrate for the first time that dysregulation of Reelin and Bcl-2 may be responsible for some of the brain structural and behavioral abnormalities observed in autism...
  40. ncbi Defective corticogenesis and reduction in Reelin immunoreactivity in cortex and hippocampus of prenatally infected neonatal mice
    S H Fatemi
    Department of Psychiatry, University of Minnesota Medical School, Minneapolis 55455, USA
    Mol Psychiatry 4:145-54. 1999
    ..These results implicate a potential role of prenatal viral infection in causation of neuronal migration abnormalities via reduction in Reelin production in neonatal brains...
  41. ncbi Reduction in anti-apoptotic protein Bcl-2 in autistic cerebellum
    S H Fatemi
    Department of Psychiatry, University of Minnesota Medical School, Minneapolis 55455, USA
    Neuroreport 12:929-33. 2001
    ..These results indicate for the first time that autistic cerebellum may be vulnerable to pro-apoptotic stimuli and to neuronal atrophy as a consequence of decreased Bcl-2 levels...
  42. ncbi Altered levels of the synaptosomal associated protein SNAP-25 in hippocampus of subjects with mood disorders and schizophrenia
    S H Fatemi
    Department of Psychiatry, University of Minnesota Medical School, Box 392, Mayo Building, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Neuroreport 12:3257-62. 2001
    ..The reported changes in SNAP-25 levels appear to be disease specific, separating synaptic pathology in unipolar depression from that observed in schizophrenia and bipolar disorders...
  43. ncbi Glial fibrillary acidic protein is elevated in superior frontal, parietal and cerebellar cortices of autistic subjects
    J A Laurence
    Division of Neuroscience Research, University of Minnesota Medical School, Minneapolis, MN, USA
    Cerebellum 4:206-10. 2005
    ..This report confirms a recent report showing microglial and astroglial activation in autism. Increased GFAP levels in autistic brains signify gliosis, reactive injury, and perturbed neuronal migration processes...
  44. ncbi Prenatal viral infection leads to pyramidal cell atrophy and macrocephaly in adulthood: implications for genesis of autism and schizophrenia
    S Hossein Fatemi
    Department of Psychiatry, University of Minnesota Medical School, Minneapolis 55455, USA
    Cell Mol Neurobiol 22:25-33. 2002
    ..Moreover, abnormal corticogenesis is associated with development of abnormal behavior in the exposed adult mice...
  45. ncbi Glutamic acid decarboxylase 65 and 67 kDa proteins are reduced in autistic parietal and cerebellar cortices
    S Hossein Fatemi
    Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, 420 Delaware Street SE, Mayo Building, Box 392, Minneapolis, MN 55455, USA
    Biol Psychiatry 52:805-10. 2002
    ..To further investigate these studies, brain levels of rate limiting enzyme, glutamic acid decarboxylase, which is responsible for normal conversion of glutamate to gamma amino butyric acid in the brain, were investigated...
  46. ncbi Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring
    Limin Shi
    Biology Division, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 23:297-302. 2003
    ..Therefore, maternal viral infection has a profound effect on the behavior of adult offspring, probably via an effect of the maternal immune response on the fetus...
  47. ncbi Levels of Bcl-2 and P53 are altered in superior frontal and cerebellar cortices of autistic subjects
    Mohsen Araghi-Niknam
    Department of Neuroscience, Division of Neuroscience Research, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Cell Mol Neurobiol 23:945-52. 2003
    ..e. frontal, parietal, and cerebellar cortices of autistic subjects, alluding to deranged apoptotic mechanisms in autism...
  48. ncbi Glial fibrillary acidic protein and glutamic acid decarboxylase 65 and 67 kDa proteins are increased in brains of neonatal BALB/c mice following viral infection in utero
    S Hossein Fatemi
    Schizophr Res 69:121-3. 2004
  49. ncbi Reelin glycoprotein in autism and schizophrenia
    S Hossein Fatemi
    Department of Psychiatry, University of Minnesota Medical School, Minneapolis 55455, USA
    Int Rev Neurobiol 71:179-87. 2005
  50. ncbi Hippocampal CA1 pyramidal cell size is reduced in bipolar disorder
    Lusha Liu
    Department of Psychiatry, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Cell Mol Neurobiol 27:351-8. 2007
    ..controls.5. These results indicate for the first time that pyramidal cell atrophy is present in hippocampus of subjects with bipolar disorder...
  51. ncbi Expression of phosphodiesterase 4 is altered in the brains of subjects with autism
    Natalie N Braun
    Department of Psychiatry, Division of Neuroscience Research, University of Minnesota, Minneapolis, Minnesota, USA
    Neuroreport 18:1841-4. 2007
    ..Our results demonstrate altered expressions of the PDE4A and PDE4B proteins in the brains of subjects with autism and might provide new therapeutic avenues for the treatment of this debilitating disorder...
  52. doi Varenicline efficacy and tolerability in a subject with schizophrenia
    S Hossein Fatemi
    Schizophr Res 103:328-9. 2008

Research Grants13

  1. Prenatal Virally Induced Brain Disorder in Mouse
    SEYYED FATEMI; Fiscal Year: 2009
    ..In addition, it is expected that the results will provide clues that will lead to fundamental advances in our knowledge of the pathogenesis of schizophrenia and, therefore, of how it can be prevented and treated. ..
  2. GABAergic and Reelin Deficits in Schizophrenia
    SEYYED HOSSEIN FATEMI; Fiscal Year: 2010
    ..subjects with bipolar disorder, major depression, and matched controls. Such outcomes will be significant, because they are expected to identify biochemical mechanisms responsible for abnormal brain development. ..
  3. Prenatal Virally Induced Brain Disorder in Mouse
    S Fatemi; Fiscal Year: 2005
    ..In addition, it is expected that the results will provide clues that will lead to fundamental advances in our knowledge of the pathogenesis of schizophrenia and, therefore, of how it can be prevented and treated. ..
  4. GABAergic Dysfunction in Autism
    SEYYED FATEMI; Fiscal Year: 2009
    ..Such outcomes will be significant, because they are expected to identify biochemical mechanisms responsible for abnormal brain development in early childhood, as seen in autism. ..
  5. Varenicline and Smoking Cessation in Schizophrenia
    SEYYED HOSSEIN FATEMI; Fiscal Year: 2010
    ..Such outcomes will be significant, because they will offer a new treatment for smoking cessation in this vulnerable population. ..
  6. GABAergic Dysfunction in Autism
    SEYYED HOSSEIN FATEMI; Fiscal Year: 2010
    ..Such outcomes will be significant, because they are expected to identify biochemical mechanisms responsible for abnormal brain development in early childhood, as seen in autism. ..
  7. Varenicline and Smoking Cessation in Schizophrenia
    SEYYED FATEMI; Fiscal Year: 2009
    ..Such outcomes will be significant, because they will offer a new treatment for smoking cessation in this vulnerable population. ..
  8. GABAergic Dysfunction in Autism
    SEYYED FATEMI; Fiscal Year: 2009
    ..Such outcomes will be significant, because they are expected to identify biochemical mechanisms responsible for abnormal brain development in early childhood, as seen in autism. ..
  9. GABAergic Dysfunction in Autism
    S Fatemi; Fiscal Year: 2007
    ..Such outcomes will be significant, because they are expected to identify biochemical mechanisms responsible for abnormal brain development in early childhood, as seen in autism. ..
  10. Prenatal Virally Induced Brain Disorder in Mouse
    S Fatemi; Fiscal Year: 2007
    ..In addition, it is expected that the results will provide clues that will lead to fundamental advances in our knowledge of the pathogenesis of schizophrenia and, therefore, of how it can be prevented and treated. ..
  11. Prenatal Virally Induced Brain Disorder in Mouse
    S Fatemi; Fiscal Year: 2006
    ..In addition, it is expected that the results will provide clues that will lead to fundamental advances in our knowledge of the pathogenesis of schizophrenia and, therefore, of how it can be prevented and treated. ..