Research Topics
Genomes and Genes
| SEYYED HOSSEIN FATEMISummaryAffiliation: University of Minnesota Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Consensus paper: pathological role of the cerebellum in autismS Hossein Fatemi
University of Minnesota Medical School, 420 Delaware St SE, Minneapolis, MN 55455, USA
Cerebellum 11:777-807. 2012....- Comparative gene expression study of the chronic exposure to clozapine and haloperidol in rat frontal cortexS Hossein Fatemi
Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, 420 Delaware St SE, MMC 392, Minneapolis, MN 55455, United States
Schizophr Res 134:211-8. 2012..Our results show that clozapine and haloperidol cause changes in levels of many important genes that may be involved in etiology and treatment of schizophrenia... 
The viral theory of schizophrenia revisited: abnormal placental gene expression and structural changes with lack of evidence for H1N1 viral presence in placentae of infected mice or brains of exposed offspringS Hossein Fatemi
Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, 420 Delaware St SE, MMC 392, Minneapolis, MN 55455, USA
Neuropharmacology 62:1290-8. 2012....- Phosphodiesterase-4A expression is reduced in cerebella of patients with bipolar disorderS Hossein Fatemi
Department of Psychiatry, Division of Neuroscience Research, University of Minnesota, Minneapolis, Minnesota 55455, USA
Psychiatr Genet 18:282-8. 2008..We sought to examine whether PDE4A5 expression was altered in cerebella of patients with schizophrenia, bipolar disorder, and major depression... - Expression of GABA(B) receptors is altered in brains of subjects with autismS Hossein Fatemi
Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Cerebellum 8:64-9. 2009..Decreases in GABA(B) receptor subunits may help explain the presence of seizures that are often comorbid with autism, as well as cognitive difficulties prevalent in autism... - GABA(A) receptor downregulation in brains of subjects with autismS Hossein Fatemi
Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USA
J Autism Dev Disord 39:223-30. 2009..Our results demonstrate that GABA(A) receptors are reduced in three brain regions that have previously been implicated in the pathogenesis of autism, suggesting widespread GABAergic dysfunction in the brains of subjects with autism... - Expression of astrocytic markers aquaporin 4 and connexin 43 is altered in brains of subjects with autismS Hossein Fatemi
Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota 55455, USA
Synapse 62:501-7. 2008..Aquaporin 4 expression was decreased significantly in cerebellum. These data suggest that changes are apparent in markers for abnormal glial-neuronal communication (connexin 43 and aquaporin 4) in brains of subjects with autism... - The role of cerebellar genes in pathology of autism and schizophreniaS Hossein Fatemi
Department of Psychiatry, Division of Neuroscience Research, University of Minnesota, Medical School, MMC 392, 420 Delaware Street S E, Minneapolis, MN 55455, USA
Cerebellum 7:279-94. 2008.... - PDE4B polymorphisms and decreased PDE4B expression are associated with schizophreniaS Hossein Fatemi
Department of Psychiatry, University of Minnesota Medical School, MMC 392, Minneapolis, MN 55455, USA
Schizophr Res 101:36-49. 2008.... - Maternal infection leads to abnormal gene regulation and brain atrophy in mouse offspring: implications for genesis of neurodevelopmental disordersS Hossein Fatemi
Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, 420 Delaware St SE, MMC 392, Minneapolis, MN 55455, USA
Schizophr Res 99:56-70. 2008..We propose that maternal infection in mouse provides an heuristic animal model for studying the environmental contributions to genesis of schizophrenia and autism, two important examples of neurodevelopmental disorders... - Chronic psychotropic drug treatment causes differential expression of connexin 43 and GFAP in frontal cortex of ratsS Hossein Fatemi
Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, 420 Delaware St SE, MMC 392, Minneapolis, MN 55455, United States
Schizophr Res 104:127-34. 2008..GFAP protein expression was significantly decreased following chronic treatment with clozapine and valproic acid. These results suggest that astroglial markers GFAP and CX43 could be potential targets for therapeutic intervention... - The neurodevelopmental hypothesis of schizophrenia, revisitedS Hossein Fatemi
420 Delaware St SE, MMC 392, Minneapolis, MN 55455, USA
Schizophr Bull 35:528-48. 2009..We relate the neurodevelopmental model to a number of findings about schizophrenia. Finally, we also examine alternate explanations of the origin of schizophrenia including the neurodegenerative model... - Chronic psychotropic drug treatment causes differential expression of Reelin signaling system in frontal cortex of ratsS Hossein Fatemi
Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, 420 Delaware St SE, MMC 392, Minneapolis, MN 55455, USA
Schizophr Res 111:138-52. 2009..These changes may help explain the efficacy of these drugs and provide further support for the investigation of the Reelin and GABAergic signaling systems as therapeutic targets for the treatment of neuropsychiatric diseases... - Abnormal expression of myelination genes and alterations in white matter fractional anisotropy following prenatal viral influenza infection at E16 in miceS Hossein Fatemi
Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, 420 Delaware St SE, Minneapolis, MN 55455, USA
Schizophr Res 112:46-53. 2009..We propose that maternal infection in mouse impacts myelination genes... - Metabotropic glutamate receptor 5 upregulation in children with autism is associated with underexpression of both Fragile X mental retardation protein and GABAA receptor beta 3 in adults with autismS Hossein Fatemi
Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, Minneapolis, USA
Anat Rec (Hoboken) 294:1635-45. 2011..Taken together, our results provide further evidence that altered FMRP expression and increased mGluR5 protein production potentially lead to altered expression of GABA(A) receptors... - Dysregulation of fragile × mental retardation protein and metabotropic glutamate receptor 5 in superior frontal cortex of individuals with autism: a postmortem brain studyS Hossein Fatemi
Division of Neuroscience Research, Department of Psychiatry, University of Minnesota Medical School, 420 Delaware Street SE, MMC 392, Minneapolis, MN 55455, USA
Mol Autism 2:6. 2011..abstract:.. - Deficits in GABA(B) receptor system in schizophrenia and mood disorders: a postmortem studyS Hossein Fatemi
Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, 420 Delaware St SE, MMC 392, Minneapolis, MN 55455, USA
Schizophr Res 128:37-43. 2011..These results provide further evidence of GABAergic dysfunction in these three disorders as well as identify potential targets for therapeutic intervention... - Levels of phosphodiesterase 4A and 4B are altered by chronic treatment with psychotropic medications in rat frontal cortexS Hossein Fatemi
Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, MMC 392, Minneapolis, Minnesota 55455, USA
Synapse 64:550-5. 2010..Our results demonstrate altered expression of PDE4A and PDE4B in response to a variety of psychotropic medications suggesting potentially new therapeutic avenues for treatment of neuropsychiatric diseases... - mRNA and protein levels for GABAAalpha4, alpha5, beta1 and GABABR1 receptors are altered in brains from subjects with autismS Hossein Fatemi
Department of Psychiatry, Division of Neuroscience Research, University of Minnesota School of Medicine, 420 Delaware St SE MMC 392, Minneapolis, MN 55455, USA
J Autism Dev Disord 40:743-50. 2010..These results provide further evidence of impairment of GABAergic signaling in autism... - The role of lithium in modulation of brain genes: relevance for aetiology and treatment of bipolar disorderS Hossein Fatemi
Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, MMC 392, Minneapolis, MN 55455, USA
Biochem Soc Trans 37:1090-5. 2009.... - Prenatal viral infection of mice at E16 causes changes in gene expression in hippocampi of the offspringS Hossein Fatemi
Department of Psychiatry, Division of Neuroscience Research, University of Minnesota School of Medicine, Minneapolis 55455, USA
Eur Neuropsychopharmacol 19:648-53. 2009..MRI revealed a decrease in hippocampal volume at P35 (adolescence). Our results demonstrate altered gene expression and reduced hippocampal volume in the offspring following prenatal viral infection at E16... - Potential microbial origins of schizophrenia and their treatmentsS Hossein Fatemi
Department of Psychiatry, Division of Neuroscience Research and Departments of Pharmacology and Neuroscience, University of Minnesota Medical School, USA
Drugs Today (Barc) 45:305-18. 2009..Elucidation of the mechanisms for infectious roots of schizophrenia may open new avenues for effective treatment... - Viral regulation of aquaporin 4, connexin 43, microcephalin and nucleolinS Hossein Fatemi
Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, 420 Delaware Ave SE, MMC 392, Minneapolis, MN 55455, USA
Schizophr Res 98:163-77. 2008.... 
Human influenza viral infection in utero alters glial fibrillary acidic protein immunoreactivity in the developing brains of neonatal miceS H Fatemi
Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, Minneapolis, MN, USA
Mol Psychiatry 7:633-40. 2002..These results implicate a significant role of prenatal human influenza viral infection on subsequent gliosis, which persists throughout brain development in mice from birth to adolescence...- Reduced blood levels of reelin as a vulnerability factor in pathophysiology of autistic disorderS Hossein Fatemi
Department of Psychiatry, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
Cell Mol Neurobiol 22:139-52. 2002..5. These results suggest that Reelin 410 deficiency may be a vulnerability factor in the pathology of autism... - Purkinje cell size is reduced in cerebellum of patients with autismS Hossein Fatemi
Department of Psychiatry, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
Cell Mol Neurobiol 22:171-5. 2002..These data indicate the possibility of Purkinje cell atrophy in autism with significant neurohistological heterogeneity among individuals diagnosed with this disorder... - The role of fragile X mental retardation protein in major mental disordersS Hossein Fatemi
Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, 420 Delaware St SE, MMC 392, Minneapolis, MN 55455, USA
Neuropharmacology 60:1221-6. 2011..This article is part of a Special Issue entitled 'Trends in neuropharmacology: in memory of Erminio Costa'... - Glial fibrillary acidic protein is reduced in cerebellum of subjects with major depression, but not schizophreniaS Hossein Fatemi
Division of Neuroscience Research, Department of Psychiatry, University of Minnesota Medical School, MMC 392, Delaware Street 420, Minneapolis, MN 55455, USA
Schizophr Res 69:317-23. 2004.... - GABAergic dysfunction in schizophrenia and mood disorders as reflected by decreased levels of glutamic acid decarboxylase 65 and 67 kDa and Reelin proteins in cerebellumS Hossein Fatemi
Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, MMC 392, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Schizophr Res 72:109-22. 2005..We hypothesized that levels of GAD and Reelin would be altered in cerebellum of subjects with schizophrenia and mood disorders differentially vs. controls... - Reelin glycoprotein: structure, biology and roles in health and diseaseS H Fatemi
Division of Neuroscience Research, Department of Psychiatry, University of Minnesota Medical School, 420 Delaware Street, Minneapolis, MN 55455, USA
Mol Psychiatry 10:251-7. 2005.... - Reelin signaling is impaired in autismS Hossein Fatemi
Department of Psychiatry, Division of Neuroscience Research, University of Minnesota, Minneapolis, MN 55455, USA
Biol Psychiatry 57:777-87. 2005..Recent genetic linkage studies implicate Reelin glycoprotein in causation of autism. To further investigate these studies, brain levels of Reelin protein and mRNA and mRNAs for VLDLR, Dab-1, and GSK3 were investigated... - Prenatal viral infection in mouse causes differential expression of genes in brains of mouse progeny: a potential animal model for schizophrenia and autismS H Fatemi
University of Minnesota, Department of Psychiatry, Division of Neuroscience Research, Minneapolis, Minnesota 55455, USA
Synapse 57:91-9. 2005.... - Chronic olanzapine treatment causes differential expression of genes in frontal cortex of rats as revealed by DNA microarray techniqueS Hossein Fatemi
Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Neuropsychopharmacology 31:1888-99. 2006..Our results show for the first time that olanzapine causes changes in levels of several important genes that may be involved in the etiology and treatment of schizophrenia and other psychiatric disorders... - Altered levels of Reelin and its isoforms in schizophrenia and mood disordersS H Fatemi
Division of Neuroscience Research, Department of Psychiatry, University of Minnesota Medical School, Box 392, Mayo Building, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Neuroreport 12:3209-15. 2001..These findings suggest that blood Reelin levels and its isoforms may be used as potential peripheral markers to diagnose presence of several psychiatric disorders and may also serve as targets for future therapeutic interventions... - Reduction in Reelin immunoreactivity in hippocampus of subjects with schizophrenia, bipolar disorder and major depressionS H Fatemi
Department of Psychiatry, University of Minnesota Medical School, Minneapolis 55455, USA
Mol Psychiatry 5:654-63, 571. 2000.... - Dysregulation of Reelin and Bcl-2 proteins in autistic cerebellumS H Fatemi
Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, Minneapolis 55455, USA
J Autism Dev Disord 31:529-35. 2001..These results demonstrate for the first time that dysregulation of Reelin and Bcl-2 may be responsible for some of the brain structural and behavioral abnormalities observed in autism... - Defective corticogenesis and reduction in Reelin immunoreactivity in cortex and hippocampus of prenatally infected neonatal miceS H Fatemi
Department of Psychiatry, University of Minnesota Medical School, Minneapolis 55455, USA
Mol Psychiatry 4:145-54. 1999..These results implicate a potential role of prenatal viral infection in causation of neuronal migration abnormalities via reduction in Reelin production in neonatal brains... - Altered levels of the synaptosomal associated protein SNAP-25 in hippocampus of subjects with mood disorders and schizophreniaS H Fatemi
Department of Psychiatry, University of Minnesota Medical School, Box 392, Mayo Building, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Neuroreport 12:3257-62. 2001..The reported changes in SNAP-25 levels appear to be disease specific, separating synaptic pathology in unipolar depression from that observed in schizophrenia and bipolar disorders... - Reduction in anti-apoptotic protein Bcl-2 in autistic cerebellumS H Fatemi
Department of Psychiatry, University of Minnesota Medical School, Minneapolis 55455, USA
Neuroreport 12:929-33. 2001..These results indicate for the first time that autistic cerebellum may be vulnerable to pro-apoptotic stimuli and to neuronal atrophy as a consequence of decreased Bcl-2 levels... - Glial fibrillary acidic protein is elevated in superior frontal, parietal and cerebellar cortices of autistic subjectsJ A Laurence
Division of Neuroscience Research, University of Minnesota Medical School, Minneapolis, MN, USA
Cerebellum 4:206-10. 2005..This report confirms a recent report showing microglial and astroglial activation in autism. Increased GFAP levels in autistic brains signify gliosis, reactive injury, and perturbed neuronal migration processes... - Prenatal viral infection leads to pyramidal cell atrophy and macrocephaly in adulthood: implications for genesis of autism and schizophreniaS Hossein Fatemi
Department of Psychiatry, University of Minnesota Medical School, Minneapolis 55455, USA
Cell Mol Neurobiol 22:25-33. 2002..Moreover, abnormal corticogenesis is associated with development of abnormal behavior in the exposed adult mice... - Glutamic acid decarboxylase 65 and 67 kDa proteins are reduced in autistic parietal and cerebellar corticesS Hossein Fatemi
Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, 420 Delaware Street SE, Mayo Building, Box 392, Minneapolis, MN 55455, USA
Biol Psychiatry 52:805-10. 2002..Glutamic acid decarboxylase deficiency may be due to or associated with abnormalities in levels of glutamate/gamma amino butyric acid, or transporter/receptor density in autistic brain... - Maternal influenza infection causes marked behavioral and pharmacological changes in the offspringLimin Shi
Biology Division, California Institute of Technology, Pasadena, California 91125, USA
J Neurosci 23:297-302. 2003..Therefore, maternal viral infection has a profound effect on the behavior of adult offspring, probably via an effect of the maternal immune response on the fetus... - Levels of Bcl-2 and P53 are altered in superior frontal and cerebellar cortices of autistic subjectsMohsen Araghi-Niknam
Department of Neuroscience, Division of Neuroscience Research, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
Cell Mol Neurobiol 23:945-52. 2003..e. frontal, parietal, and cerebellar cortices of autistic subjects, alluding to deranged apoptotic mechanisms in autism... - Glial fibrillary acidic protein and glutamic acid decarboxylase 65 and 67 kDa proteins are increased in brains of neonatal BALB/c mice following viral infection in uteroS Hossein Fatemi
Schizophr Res 69:121-3. 2004 - Expression of phosphodiesterase 4 is altered in the brains of subjects with autismNatalie N Braun
Department of Psychiatry, Division of Neuroscience Research, University of Minnesota, Minneapolis, Minnesota, USA
Neuroreport 18:1841-4. 2007..Our results demonstrate altered expressions of the PDE4A and PDE4B proteins in the brains of subjects with autism and might provide new therapeutic avenues for the treatment of this debilitating disorder... - Reelin glycoprotein in autism and schizophreniaS Hossein Fatemi
Department of Psychiatry, University of Minnesota Medical School, Minneapolis 55455, USA
Int Rev Neurobiol 71:179-87. 2005 - Hippocampal CA1 pyramidal cell size is reduced in bipolar disorderLusha Liu
Department of Psychiatry, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Cell Mol Neurobiol 27:351-8. 2007..controls.5. These results indicate for the first time that pyramidal cell atrophy is present in hippocampus of subjects with bipolar disorder... - Varenicline efficacy and tolerability in a subject with schizophreniaS Hossein Fatemi
Schizophr Res 103:328-9. 2008
Research Grants
- Prenatal Virally Induced Brain Disorder in MouseSEYYED FATEMI; Fiscal Year: 2009..In addition, it is expected that the results will provide clues that will lead to fundamental advances in our knowledge of the pathogenesis of schizophrenia and, therefore, of how it can be prevented and treated. ..
- GABAergic and Reelin Deficits in SchizophreniaSEYYED HOSSEIN FATEMI; Fiscal Year: 2010..subjects with bipolar disorder, major depression, and matched controls. Such outcomes will be significant, because they are expected to identify biochemical mechanisms responsible for abnormal brain development. ..
- GABAergic Dysfunction in AutismSEYYED FATEMI; Fiscal Year: 2009..Such outcomes will be significant, because they are expected to identify biochemical mechanisms responsible for abnormal brain development in early childhood, as seen in autism. ..
- Varenicline and Smoking Cessation in SchizophreniaSEYYED HOSSEIN FATEMI; Fiscal Year: 2010..Such outcomes will be significant, because they will offer a new treatment for smoking cessation in this vulnerable population. ..
- GABAergic Dysfunction in AutismSEYYED HOSSEIN FATEMI; Fiscal Year: 2010..Such outcomes will be significant, because they are expected to identify biochemical mechanisms responsible for abnormal brain development in early childhood, as seen in autism. ..
- Varenicline and Smoking Cessation in SchizophreniaSEYYED FATEMI; Fiscal Year: 2009..Such outcomes will be significant, because they will offer a new treatment for smoking cessation in this vulnerable population. ..
- GABAergic Dysfunction in AutismSEYYED FATEMI; Fiscal Year: 2009..Such outcomes will be significant, because they are expected to identify biochemical mechanisms responsible for abnormal brain development in early childhood, as seen in autism. ..
- Prenatal Virally Induced Brain Disorder in MouseS Fatemi; Fiscal Year: 2007..In addition, it is expected that the results will provide clues that will lead to fundamental advances in our knowledge of the pathogenesis of schizophrenia and, therefore, of how it can be prevented and treated. ..