Alessio Fasano

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. doi Federation of International Societies of Pediatric Gastroenterology, Hepatology, and Nutrition consensus report on celiac disease
    A Fasano
    Mucosal Biology Research Center and Center for Celiac Research, University of Maryland School of Medicine, Baltimore, MD, USA
    J Pediatr Gastroenterol Nutr 47:214-9. 2008
  2. ncbi Permeability, zonulin production, and enteropathy in dermatitis herpetiformis
    Edgardo Smecuol
    Dr C Bonorino Udaondo Gastroenterology Hospital, Av Caseros 2061, 1264 Buenos Aires, Argentina
    Clin Gastroenterol Hepatol 3:335-41. 2005
  3. pmc Novel therapeutic/integrative approaches for celiac disease and dermatitis herpetiformis
    Alessio Fasano
    Mucosal Biology Research and Center for Celiac Research, Health Science Facility II, University of Maryland School of Medicine, Room S345, 20 Penn Street, Baltimore, MD 21201, USA
    Clin Dev Immunol 2012:959061. 2012
  4. pmc Intestinal permeability and its regulation by zonulin: diagnostic and therapeutic implications
    Alessio Fasano
    Mucosal Biology Research Center and Center for Celiac Research, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Clin Gastroenterol Hepatol 10:1096-100. 2012
  5. pmc Zonulin, regulation of tight junctions, and autoimmune diseases
    Alessio Fasano
    Mucosal Biology Research Center and Center for Celiac Research, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Ann N Y Acad Sci 1258:25-33. 2012
  6. ncbi Systemic autoimmune disorders in celiac disease
    Alessio Fasano
    Center for Celiac Research and Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Curr Opin Gastroenterol 22:674-9. 2006
  7. ncbi Coeliac disease in children
    Alessio Fasano
    School of Medicine, Mucosal Biology Research Center and Center for Celiac Research, University of Maryland, 22 S Pine St HSFII Building, Room 345, Baltimore, MD 21201, USA
    Best Pract Res Clin Gastroenterol 19:467-78. 2005
  8. ncbi Mechanisms of disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases
    Alessio Fasano
    Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Nat Clin Pract Gastroenterol Hepatol 2:416-22. 2005
  9. pmc Physiological, pathological, and therapeutic implications of zonulin-mediated intestinal barrier modulation: living life on the edge of the wall
    Alessio Fasano
    University of Maryland School of Medicine, Mucosal Biology Research Center, Health Science Facility II, Baltimore, MD 21201, USA
    Am J Pathol 173:1243-52. 2008
  10. ncbi Clinical presentation of celiac disease in the pediatric population
    Alessio Fasano
    Mucosal Biology Research Center and Center for Celiac Research, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA
    Gastroenterology 128:S68-73. 2005

Research Grants

Detail Information

Publications79

  1. doi Federation of International Societies of Pediatric Gastroenterology, Hepatology, and Nutrition consensus report on celiac disease
    A Fasano
    Mucosal Biology Research Center and Center for Celiac Research, University of Maryland School of Medicine, Baltimore, MD, USA
    J Pediatr Gastroenterol Nutr 47:214-9. 2008
  2. ncbi Permeability, zonulin production, and enteropathy in dermatitis herpetiformis
    Edgardo Smecuol
    Dr C Bonorino Udaondo Gastroenterology Hospital, Av Caseros 2061, 1264 Buenos Aires, Argentina
    Clin Gastroenterol Hepatol 3:335-41. 2005
    ..Our aim was to assess both intestinal permeability and serum zonulin levels in a group of patients with DH having variable grades of enteropathy...
  3. pmc Novel therapeutic/integrative approaches for celiac disease and dermatitis herpetiformis
    Alessio Fasano
    Mucosal Biology Research and Center for Celiac Research, Health Science Facility II, University of Maryland School of Medicine, Room S345, 20 Penn Street, Baltimore, MD 21201, USA
    Clin Dev Immunol 2012:959061. 2012
    ..Last decade has seen new scientific developments in this disease and led to the formulation of new concepts of pathophysiology that offer possible targets for new treatments or interventions integrative to the gluten-free diet...
  4. pmc Intestinal permeability and its regulation by zonulin: diagnostic and therapeutic implications
    Alessio Fasano
    Mucosal Biology Research Center and Center for Celiac Research, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Clin Gastroenterol Hepatol 10:1096-100. 2012
    ..This information has translational implications, because the zonulin pathway is currently exploited to develop both diagnostic and therapeutic applications pertinent to a variety of immune-mediated diseases...
  5. pmc Zonulin, regulation of tight junctions, and autoimmune diseases
    Alessio Fasano
    Mucosal Biology Research Center and Center for Celiac Research, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Ann N Y Acad Sci 1258:25-33. 2012
    ....
  6. ncbi Systemic autoimmune disorders in celiac disease
    Alessio Fasano
    Center for Celiac Research and Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Curr Opin Gastroenterol 22:674-9. 2006
    ..Celiac disease is an immune-mediated disorder clinically characterized by a multitude of symptoms and complications. The comorbidity between celiac disease and other autoimmune disorders has been clearly established...
  7. ncbi Coeliac disease in children
    Alessio Fasano
    School of Medicine, Mucosal Biology Research Center and Center for Celiac Research, University of Maryland, 22 S Pine St HSFII Building, Room 345, Baltimore, MD 21201, USA
    Best Pract Res Clin Gastroenterol 19:467-78. 2005
    ....
  8. ncbi Mechanisms of disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases
    Alessio Fasano
    Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Nat Clin Pract Gastroenterol Hepatol 2:416-22. 2005
    ..This review is timely given the increased interest in the role of a 'leaky gut' in the pathogenesis of gastrointestinal diseases and the advent of novel treatment strategies, such as the use of probiotics...
  9. pmc Physiological, pathological, and therapeutic implications of zonulin-mediated intestinal barrier modulation: living life on the edge of the wall
    Alessio Fasano
    University of Maryland School of Medicine, Mucosal Biology Research Center, Health Science Facility II, Baltimore, MD 21201, USA
    Am J Pathol 173:1243-52. 2008
    ..Understanding the role of zonulin-dependent intestinal barrier dysfunction in the pathogenesis of autoimmune diseases is an area of translational research that encompasses many fields...
  10. ncbi Clinical presentation of celiac disease in the pediatric population
    Alessio Fasano
    Mucosal Biology Research Center and Center for Celiac Research, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA
    Gastroenterology 128:S68-73. 2005
    ..There is growing interest in the social aspects of CD because the burden of illness related to this condition is doubtless higher than previously thought...
  11. doi Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer
    Alessio Fasano
    Mucosal Biology Research Center and Center for Celiac Research, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Physiol Rev 91:151-75. 2011
    ..This review is timely given the increased interest in the role of a "leaky gut" in the pathogenesis of several pathological conditions targeting both the intestine and extraintestinal organs...
  12. doi Leaky gut and autoimmune diseases
    Alessio Fasano
    Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Clin Rev Allergy Immunol 42:71-8. 2012
    ..Both animal models and recent clinical evidence support this new paradigm and provide the rationale for innovative approaches to prevent and treat autoimmune diseases...
  13. ncbi Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines
    Sandro Drago
    Mucosal Biology Research Center, Center for Celiac Research and Division of Pediatric Gastroenterology and Nutrition, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
    Scand J Gastroenterol 41:408-19. 2006
    ..We investigated whether gliadin has any immediate effect on zonulin release and signaling...
  14. doi Natural history of celiac disease autoimmunity in a USA cohort followed since 1974
    Carlo Catassi
    Center for Celiac Research and Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore, MD, USA
    Ann Med 42:530-8. 2010
    ..The natural history and the possible changes of celiac disease (CD) prevalence over time are still unclear...
  15. pmc Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2
    Amit Tripathi
    Mucosal Biology Research Center, Center for Vascular and Inflammatory Diseases and Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 20201, USA
    Proc Natl Acad Sci U S A 106:16799-804. 2009
    ..Our results therefore characterize zonulin as a previously undescribed ligand that engages a key signalosome involved in the pathogenesis of human immune-mediated diseases that can be targeted for therapeutic interventions...
  16. ncbi Effect of the six-mer synthetic peptide (AT1002) fragment of zonula occludens toxin on the intestinal absorption of cyclosporin A
    Keon Hyoung Song
    Pharmacokinetics Biopharmaceutics Laboratory, Department of Pharmaceutical Science, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    Int J Pharm 351:8-14. 2008
    ..This study suggests that AT1002-mediated tight junction modulation, combined with metabolic protection and stabilization, may be used to enhance the low oral bioavailability of certain drugs when administered concurrently...
  17. pmc Neurologic and psychiatric manifestations of celiac disease and gluten sensitivity
    Jessica R Jackson
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Box 21247, Baltimore, MD 21228, USA
    Psychiatr Q 83:91-102. 2012
    ....
  18. pmc Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3
    Karen M Lammers
    Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Gastroenterology 135:194-204.e3. 2008
    ..We aimed to establish the molecular basis of gliadin interaction with intestinal mucosa leading to intestinal barrier impairment...
  19. pmc The active Zot domain (aa 288-293) increases ZO-1 and myosin 1C serine/threonine phosphorylation, alters interaction between ZO-1 and its binding partners, and induces tight junction disassembly through proteinase activated receptor 2 activation
    Simeon E Goldblum
    Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    FASEB J 25:144-58. 2011
    ..These modifications provoke selective disengagement of ZO-1 from its binding partners, occludin, claudin 1, and myosin 1C, coincident with opening of tjs...
  20. pmc Increased prevalence of transglutaminase 6 antibodies in sera from schizophrenia patients
    Nicola G Cascella
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Schizophr Bull 39:867-71. 2013
    ..The HC had a prevalence of 6%. Our results indicate a higher prevalence of tTG6 antibodies in SZ that may represent a biomarker useful to identify SZ patients who would benefit from a gluten-free diet...
  21. ncbi Gliadin stimulation of murine macrophage inflammatory gene expression and intestinal permeability are MyD88-dependent: role of the innate immune response in Celiac disease
    Karen E Thomas
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, 21201, USA
    J Immunol 176:2512-21. 2006
    ....
  22. pmc Proof of concept of microbiome-metabolome analysis and delayed gluten exposure on celiac disease autoimmunity in genetically at-risk infants
    Maria Sellitto
    Mucosal Biology Research Center and Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 7:e33387. 2012
    ..This study constitutes a definite proof-of-principle that these combined genomic and metabolomic approaches will be key to deciphering the role of the gut microbiota on CD onset...
  23. doi Celiac disease
    Carlo Catassi
    Mucosal Biology Research Center and Center for Celiac Research, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Curr Opin Gastroenterol 24:687-91. 2008
    ..This review will outline the most significant work that contributed to our current knowledge of the disease...
  24. ncbi Zonulin upregulation is associated with increased gut permeability in subjects with type 1 diabetes and their relatives
    Anna Sapone
    Mucosal Biology Research Center, University of Maryland School of Medicine, 20 Penn Street, Room 345, Baltimore, MD 21201, USA
    Diabetes 55:1443-9. 2006
    ....
  25. pmc Chromosomal and plasmid-encoded factors of Shigella flexneri induce secretogenic activity ex vivo
    Christina S Faherty
    Department of Medicine, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 7:e49980. 2012
    ..Moreover, the identification of all Shigella proteins responsible for enterotoxin activity is vital to our understanding of Shigella pathogenicity and to our success in developing safe and effective vaccine candidates...
  26. pmc Helicobacter pylori-induced disruption of monolayer permeability and proinflammatory cytokine secretion in polarized human gastric epithelial cells
    Maria Fiorentino
    University of Maryland, Mucosal Biology Research Center, Baltimore, Maryland, USA
    Infect Immun 81:876-83. 2013
    ..The NCI-N87 cell line provides an excellent model for the in vitro study of H. pylori pathogenesis and the epithelial cell host response to infection...
  27. pmc Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic-prone rats
    Tammara Watts
    Mucosal Biology Research Center and Division of Pediatric Gastroenterology and Nutrition, and Division of Pediatric Research, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 102:2916-21. 2005
    ..Combined together, these findings suggest that the zonulin-induced loss in small intestinal barrier function is involved in the pathogenesis of T1D in the BB diabetic-prone animal model...
  28. pmc Prevalence of celiac disease and gluten sensitivity in the United States clinical antipsychotic trials of intervention effectiveness study population
    Nicola G Cascella
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Meyer 144, Baltimore, MD 21287, USA
    Schizophr Bull 37:94-100. 2011
    ..Regression analyses failed to predict PANSS scores from AGA and tTG antibodies. Persons with schizophrenia have higher than expected titers of antibodies related to CD and gluten sensitivity...
  29. ncbi The effect of delta G on the transport and oral absorption of macromolecules
    Noha N Salama
    Pharmacokinetics Biopharmaceutics Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland at Baltimore, 20 Penn Street, Baltimore, Maryland 21201, USA
    J Pharm Sci 93:1310-9. 2004
    ..This study suggests that DeltaG may be used to enhance the oral bioavailability of macromolecules (e.g., proteins) after coadministration through modulation of paracellular transport...
  30. pmc Analysis of proteinase-activated receptor 2 and TLR4 signal transduction: a novel paradigm for receptor cooperativity
    Prasad Rallabhandi
    Department of Microbiology and Immunology, University of Maryland, Baltimore, Maryland 21201, USA
    J Biol Chem 283:24314-25. 2008
    ..Our data suggest a unique interaction between two distinct innate immune response receptors and support a novel paradigm of receptor cooperativity in inflammatory responses...
  31. pmc Spectrum of gluten-related disorders: consensus on new nomenclature and classification
    Anna Sapone
    Mucosal Biology Research Center and Center for Celiac Research, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    BMC Med 10:13. 2012
    ....
  32. pmc Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity
    Anna Sapone
    Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore, MD, USA
    BMC Med 9:23. 2011
    ....
  33. pmc Identification of a novel immunomodulatory gliadin peptide that causes interleukin-8 release in a chemokine receptor CXCR3-dependent manner only in patients with coeliac disease
    Karen M Lammers
    University of Maryland School of Medicine, Mucosal Biology Research Center, Baltimore, MD, USA
    Immunology 132:432-40. 2011
    ....
  34. doi Celiac disease diagnosis: simple rules are better than complicated algorithms
    Carlo Catassi
    Mucosal Biology Research and Center for Celiac Research, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
    Am J Med 123:691-3. 2010
    ....
  35. pmc Monocytes differentiated with IL-15 support Th17 and Th1 responses to wheat gliadin: implications for celiac disease
    Kristina M Harris
    Pathology Department, University of Maryland School of Medicine, Baltimore, MD, USA
    Clin Immunol 135:430-9. 2010
    ..Therefore, genetic and/or environmental factors that control IL-15 expression and responsiveness in the intestine likely participate in the pathogenesis of CD...
  36. ncbi A prospective, double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac disease
    Carlo Catassi
    Center for Celiac Research, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Clin Nutr 85:160-6. 2007
    ..Treatment of celiac disease (CD) is based on the avoidance of gluten-containing food. However, it is not known whether trace amounts of gluten are harmful to treated patients...
  37. pmc Membrane-anchored serine protease matriptase regulates epithelial barrier formation and permeability in the intestine
    Marguerite S Buzza
    Department of Physiology, Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 107:4200-5. 2010
    ..These results support a key role for matriptase in regulating intestinal epithelial barrier competence, and suggest an intriguing link between pericellular serine protease activity and tight junction assembly in polarized epithelia...
  38. ncbi Detection of Celiac disease in primary care: a multicenter case-finding study in North America
    Carlo Catassi
    Mucosal Biology Research Center and Division of Pediatric Gastroenterology and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Gastroenterol 102:1454-60. 2007
    ..Celiac disease (CD) is one of the most common lifelong disorders in western countries. However, most cases remain currently undiagnosed in North America, mostly due to poor awareness of CD by primary care physicians...
  39. pmc Trace gluten contamination may play a role in mucosal and clinical recovery in a subgroup of diet-adherent non-responsive celiac disease patients
    Justin R Hollon
    Division of Pediatric Gastroenterology and Nutrition, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Brady 320, Baltimore, MD, USA
    BMC Gastroenterol 13:40. 2013
    ..We aim to demonstrate that this diet reclassifies the majority of patients thought to have RCD type 1 (RCD1)...
  40. ncbi Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study
    Alessio Fasano
    Center for Celiac Research, University of Maryland School of Medicine, 22 S Greene St, N5W70, PO Box 140, Baltimore, MD 21201 1595, USA
    Arch Intern Med 163:286-92. 2003
    ..The aim of this study was to determine the prevalence of CD in at-risk and not-at-risk groups in the United States...
  41. doi Early feeding practices and their impact on development of celiac disease
    Alessio Fasano
    Mucosal Biology Research and Center for Celiac Research, School of Medicine, University of Maryland, Baltimore, MD, USA
    Nestle Nutr Workshop Ser Pediatr Program 68:201-9; discussion 210-3. 2011
    ....
  42. ncbi Zonula occludens toxin increases the permeability of molecular weight markers and chemotherapeutic agents across the bovine brain microvessel endothelial cells
    Chetan S Karyekar
    Pharmacokinetics Biopharmaceutics Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 100 Penn Street, Baltimore, Maryland 21201, USA
    J Pharm Sci 92:414-23. 2003
    ..Modulation of paracellular transport with Zot may be used to increase the brain permeability of potent central nervous system-active drugs, including anticancer agents...
  43. ncbi The impact of DeltaG on the oral bioavailability of low bioavailable therapeutic agents
    Noha N Salama
    Pharmacokinetics Biopharmaceutics Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland at Baltimore, 20 Penn Street, Baltimore, MD 21201, USA
    J Pharmacol Exp Ther 312:199-205. 2005
    ..This study suggests that DeltaG-mediated tight junction modulation, combined with metabolic protection, may be used to enhance the low oral bioavailability of certain drugs when administered concurrently...
  44. ncbi Tight junction modulation and its relationship to drug delivery
    Noha N Salama
    Pharmacokinetics Biopharmaceutics Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland at Baltimore, 100 Penn Street, Baltimore, Maryland 21201, USA
    Adv Drug Deliv Rev 58:15-28. 2006
    ..Above all, the transient opening of the TJs by Zot suggests that it could be used as a novel approach for the safe drug delivery of therapeutic agents...
  45. ncbi Host-dependent zonulin secretion causes the impairment of the small intestine barrier function after bacterial exposure
    Ramzi El Asmar
    Department of Pediatrics and Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Gastroenterology 123:1607-15. 2002
    ..On the basis of our recent discovery of zonulin, a modulator of small-intestinal tight junctions, we asked whether microorganisms might induce zonulin secretion and increased small-intestinal permeability...
  46. pmc Progress and pitfalls in Shigella vaccine research
    Eileen M Barry
    University of Maryland School of Medicine, Center for Vaccine Development, Baltimore, MD 21201, USA
    Nat Rev Gastroenterol Hepatol 10:245-55. 2013
    ..Herein, we review the latest progress in Shigella vaccine development within the framework of persistent obstacles...
  47. ncbi Enhanced nasal absorption of hydrophilic markers after dosing with AT1002, a tight junction modulator
    Keon Hyoung Song
    Department of Pharmaceutical Science, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    Eur J Pharm Biopharm 69:231-7. 2008
    ..AT1002 significantly increased the nasal absorption of molecular weight markers, PEG4000 and inulin. This study suggests that AT1002 may be used to enhance the systemic availability of macromolecules when administered concurrently...
  48. ncbi Enhancement of brain distribution of anticancer agents using DeltaG, the 12 kDa active fragment of ZOT
    Divya Menon
    Pharmacokinetics Biopharmaceutics Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20 Penn Street, HSF II 543, Baltimore, MD 21201 6808, USA
    Int J Pharm 306:122-31. 2005
    ..The objective of this study was to evaluate the ability of DeltaG, the 12 kDa active fragment of ZOT, to increase the brain distribution of MTX and paclitaxel, two commonly used anticancer agents with poor distribution into the brain...
  49. ncbi Cutting edge: IL-1 controls the IL-23 response induced by gliadin, the etiologic agent in celiac disease
    Kristina M Harris
    Pathology Department, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Immunol 181:4457-60. 2008
    ..These findings may provide therapeutic targets for this disease and other inflammatory conditions mediated by IL-23...
  50. pmc Mechanisms of disease: protease functions in intestinal mucosal pathobiology
    Toni M Antalis
    Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Nat Clin Pract Gastroenterol Hepatol 4:393-402. 2007
    ....
  51. ncbi Effect of the biologically active fragment of zonula occludens toxin, delta G, on the intestinal paracellular transport and oral absorption of mannitol
    Noha N Salama
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland at Baltimore, 100 Penn Street, Baltimore, MD 21201, USA
    Int J Pharm 251:113-21. 2003
    ....
  52. ncbi Intestinal epithelial tight junctions as targets for enteric bacteria-derived toxins
    Alessio Fasano
    Division of Pediatric Gastroenterology and Nutrition, School of Medicine, University of Maryland, Baltimore 21201, USA
    Adv Drug Deliv Rev 56:795-807. 2004
    ..Many pathogenic bacteria exploit this system to accomplish their pathogenic strategies by ultimately modulating intestinal permeability...
  53. ncbi Celiac disease as a cause of growth retardation in childhood
    Carlo Catassi
    Center for Celiac Research, Division of Pediatric Gastroenterology and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Curr Opin Pediatr 16:445-9. 2004
    ..Although the typical form of celiac disease, characterized by failure to thrive, is still the most frequent presentation in the pediatric age group, severe growth delay is less commonly seen in developed countries...
  54. ncbi Is this really celiac disease? Pitfalls in diagnosis
    Carlo Catassi
    University of Maryland School of Medicine, Mucosal Biology Research Center and Center for Celiac Research, Health Science Facility II, Baltimore, MD 21201, USA
    Curr Gastroenterol Rep 10:466-72. 2008
    ..Nevertheless, guidelines for the diagnosis of CD remain poorly appreciated and many health care professionals remain confused about its proper management. This review is intended to clarify "facts and fantasies" about CD diagnosis...
  55. ncbi Celiac disease: is the atypical really typical? Summary of the recent National Institutes of Health Consensus Conference and latest advances
    Swati Gadewar
    Department of Pediatrics, Mucosal Biology Research Center, University of Maryland School of Medicine, Health Science Facility II Room 8345, 20 Penn Street, Baltimore, MD 21201, USA
    Curr Gastroenterol Rep 7:455-61. 2005
    ..There are several targets for new treatments. This article briefly summarizes the National Institutes of Health Consensus Statement and gives an overview of new findings in recent years and of future therapeutic options for CD...
  56. doi Isolation, identification, and characterization of small bioactive peptides from Lactobacillus GG conditional media that exert both anti-Gram-negative and Gram-positive bactericidal activity
    Ruiliang Lu
    University of Maryland School of Medicine, Mucosal Biology Research Center, Health Science Facility II, 20 Penn St, Baltimore, MD 21201, USA
    J Pediatr Gastroenterol Nutr 49:23-30. 2009
    ..Therefore, the main objective of this work was to identify and characterize moieties elaborated by LGG that exert antibacterial activity...
  57. pmc Gut microbiota, tight junction protein expression, intestinal resistance, bacterial translocation and mortality following cholestasis depend on the genetic background of the host
    Samuel M Alaish
    Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA
    Gut Microbes 4:292-305. 2013
    ....
  58. doi Major signaling pathways in intestinal stem cells
    Tim Vanuytsel
    Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore, MD, USA
    Biochim Biophys Acta 1830:2410-26. 2013
    ..The discovery of markers to identify the intestinal stem cell population and the generation of powerful transgenic mouse models to study stem cell physiology have led to seminal discoveries in stem cell biology...
  59. ncbi New developments in childhood celiac disease
    Carlo Catassi
    Center for Celiac Research, Division of Pediatric Gastroenterology and Nutrition, University of Maryland School of Medicine, 685 West Baltimore Street, HSF Building, Room 465, Baltimore, MD 21201, USA
    Curr Gastroenterol Rep 4:238-43. 2002
    ..The epidemiology, pathophysiology, diagnosis, and clinical spectrum of CD in children are highlighted...
  60. ncbi Celiac disease in the pediatric population
    Daniel Gelfond
    Division of Pediatric Gastroenterology and Nutrition, University of Maryland School of Medicine, Baltimore 21201, USA
    Pediatr Ann 35:275-9. 2006
  61. pmc In vitro Intestinal Mucosal Epithelial Responses to Wild-Type Salmonella Typhi and Attenuated Typhoid Vaccines
    Maria Fiorentino
    Department of Pediatrics, Mucosal Biology Research Center, University of Maryland School of Medicine Baltimore, MD, USA
    Front Immunol 4:17. 2013
    ..We conclude that wild-type S. Typhi causes marked transient alterations of the intestinal mucosa that are more pronounced than those observed with Ty21a or new generation attenuated typhoid vaccine candidates...
  62. ncbi Structural and functional alterations of the gastrointestinal tract following radiation-induced injury in the rhesus monkey
    Roy M Vigneulle
    Department of Radiation Oncology, Greenebaum Cancer Center, Baltimore, Maryland 21201, USA
    Dig Dis Sci 47:1480-91. 2002
    ..Our integrated approach allowed a comprehensive study of the relationship between postirradiation tissue injury and changes in function over time in the gastrointestinal tract of the nonhuman primate...
  63. ncbi Current concepts in the evaluation, diagnosis and management of acute infectious diarrhea
    Swati Gadewar
    Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, University of Maryland School of Medicine, 22 S Greene St N5W70, Baltimore, Maryland 21201 1595, USA
    Curr Opin Pharmacol 5:559-65. 2005
    ..For this reason, development of vaccines against the most important gastrointestinal infections remains a high priority...
  64. doi Pediatric celiac disease
    Shamila Zawahir
    Mucosal Biology Research Center, Center for Celiac Research, Division of Pediatric Gastroenterology and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Curr Opin Pediatr 21:655-60. 2009
    ..Knowledge about the varied clinical manifestations and the proper approach to screening and diagnosing celiac disease will lead to appropriate early intervention in affected children..
  65. ncbi Zonula occludens toxin (Zot) interferes with the induction of nasal tolerance to gliadin
    Mauro Rossi
    Istituto di Scienze dell Alimentazione, CNR, Via Roma 52, 83100, Avellino, Italy
    Immunol Lett 81:217-21. 2002
    ....
  66. ncbi Screening for celiac disease in family members: is follow-up testing necessary?
    David Goldberg
    Department of Medicine, Columbia University College of Physicians and Surgeons, 161 Fort Washington Avenue, New York, NY 10032, USA
    Dig Dis Sci 52:1082-6. 2007
    ..We conclude that one-time testing for celiac disease among families with affected members is insufficient. Repeat testing should occur irrespective of the presence of symptoms...
  67. ncbi Infectious diarrhea in children: Working Group Report of the First World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition
    Geoffrey Davidson
    Commonwealth Association of Paediatric Gastroenterology and Nutrition, USA
    J Pediatr Gastroenterol Nutr 35:S143-50. 2002
  68. ncbi VSL#3 probiotic preparation has the capacity to hydrolyze gliadin polypeptides responsible for Celiac Sprue
    Maria de Angelis
    Department of Plant Protection and Applied Microbiology, University of Bari, 70126 Bari, Italy
    Biochim Biophys Acta 1762:80-93. 2006
    ..Proteolytic activity by probiotic VSL#3 may have an importance during food processing to produce pre-digested and tolerated gliadins for increasing the palatability of gluten-free products...
  69. ncbi Celiac disease--how to handle a clinical chameleon
    Alessio Fasano
    N Engl J Med 348:2568-70. 2003
  70. ncbi Intestinal infections and environmental enteropathy: Working Group report of the second World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition
    Eduardo Salazar-Lindo
    J Pediatr Gastroenterol Nutr 39:S662-9. 2004
  71. ncbi Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition
    Ivor D Hill
    North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, Flourtown, PA 19031, USA
    J Pediatr Gastroenterol Nutr 40:1-19. 2005
    ..This document represents the official recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition on the diagnosis and treatment of celiac disease in children and adolescents...
  72. ncbi Relationship of HLA-DQ8 and severity of celiac disease: comparison of New York and Parisian cohorts
    Timothy C Johnson
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Clin Gastroenterol Hepatol 2:888-94. 2004
    ..We assessed whether differences in the frequency of HLA type may account for differences in severity of the disease by using cohorts of patients from New York and Paris...
  73. pmc Zonula occludens toxin synthetic peptide derivative AT1002 enhances in vitro and in vivo intestinal absorption of low molecular weight heparin
    Nusrat A Motlekar
    Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, School of Pharmacy, Amarillo, TX 79106, USA
    J Drug Target 14:321-9. 2006
    ..These in vivo and in vitro results suggest that the co-administration of LMWH with AT1002 may be a useful delivery strategy to increase its permeability and hence oral absorption...
  74. ncbi Dual sugar gut-permeability testing on blood drop in animal models
    Fourogh Katouzian
    Department of Reproductive and Development Science and IRCCS, Instituto per I Infanzia Burlo Garofolo Clinica Pediatrica University of Trieste, Via dell Istria 65 1, IT 34100, Trieste, Italy
    Clin Chim Acta 352:191-7. 2005
    ..We measured the intestinal permeability induced by a fragment (DeltaG) of the zonula occludens toxin which opens the paracellular pathway...
  75. ncbi Ganglioside reactive antibodies in the neuropathy associated with celiac disease
    Armin Alaedini
    Department of Neurology and Neuroscience, Cornell University, 525 E 68th St, LC 807, New York, NY 10021, USA
    J Neuroimmunol 127:145-8. 2002
    ..The neuropathy of celiac disease may be autoimmune and associated with anti-ganglioside antibodies. The presence of IgG reactivity furthermore implicates a T cell-mediated response to ganglioside antigens...
  76. ncbi Secreted autotransporter toxin produced by a diffusely adhering Escherichia coli strain causes intestinal damage in animal model assays
    Carla R Taddei
    Faculdade de Ciencias Farmaceuticas, Departamento de AnĂ¡lises, Clinicas e Toxicologicas, Universidade de Sao Paulo, Av Prof Lineu Prestes, 580 Bl 17, CEP 05508 900, Sao Paulo, Brazil
    FEMS Microbiol Lett 250:263-9. 2005
    ..Our results suggest that DAEC strains may be involved in diarrhea...
  77. pmc Zonula occludens toxin acts as an adjuvant through different mucosal routes and induces protective immune responses
    Mariarosaria Marinaro
    Laboratory of Bacteriology and Medical Mycology, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Infect Immun 71:1897-902. 2003
    ..In conclusion, Zot is a novel and effective mucosal adjuvant that may be useful for the development of mucosal vaccines...
  78. ncbi Latest developments in the pathogenesis and treatment of celiac disease
    David Branski
    Department of Pediatrics, Hadassah University Hospitals, Hadassah Medical Organization, 91120 Jerusalem, Israel
    J Pediatr 149:295-300. 2006
  79. ncbi Seeing the light with celiac
    Carol E Semrad
    University of Chicago, Section of Gastroenterology, Chicago, Illinois, USA
    Clin Immunol 115:236-9. 2005

Research Grants20

  1. Zot, Zonulin, and Pathophysiology of Intestinal Tight Junctions
    Alessio Fasano; Fiscal Year: 2010
    ....
  2. REGULATION OF TIGHT JUNCTIONS AND ROLE IN DIARRHEA OF ZO
    Alessio Fasano; Fiscal Year: 2003
    ..abstract_text> ..
  3. Tight junctions and role in diarrhea of zot
    Alessio Fasano; Fiscal Year: 2006
    ....
  4. Tight junctions and role in diarrhea of zot
    Alessio Fasano; Fiscal Year: 2007
    ..abstract_text> ..