A Fasano

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc Modulation of intestinal tight junctions by Zonula occludens toxin permits enteral administration of insulin and other macromolecules in an animal model
    A Fasano
    Division of Pediatric Gastroenterology and Nutrition, University of Maryland, School of Medicine, Baltimore 21201, USA
    J Clin Invest 99:1158-64. 1997
  2. ncbi Novel approaches for oral delivery of macromolecules
    A Fasano
    Division of Pediatric Gastroenterology and Nutrition and Gastrointestinal Pathophysiology Section, Center for Vaccine Development, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA
    J Pharm Sci 87:1351-6. 1998
  3. ncbi Purification and preliminary characterization of the zonula occludens toxin receptor from human (CaCo2) and murine (IEC6) intestinal cell lines
    S Uzzau
    Division of Pediatric Gastroenterology, Center for Vaccine Development, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
    FEMS Microbiol Lett 194:1-5. 2001
  4. ncbi [Zonula occludens toxin: an innovative method of oral drugs delivery]
    M Di Pierro
    Division of Pediatric Gastroenterology and Nutrition and Gastrointestinal pathophisiology, Center for Vaccine Development, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
    Minerva Pediatr 53:15-22. 2001
  5. ncbi Bromelain prevents secretion caused by Vibrio cholerae and Escherichia coli enterotoxins in rabbit ileum in vitro
    T L Mynott
    Department of Medicine, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, USA
    Gastroenterology 113:175-84. 1997
  6. ncbi Zonula occludens toxin structure-function analysis. Identification of the fragment biologically active on tight junctions and of the zonulin receptor binding domain
    M Di Pierro
    Division of Pediatric Gastroenterology and Nutrition and Gastrointestinal Pathophysiology Section, Center for Vaccine Development, Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 276:19160-5. 2001
  7. ncbi Regulation of intercellular tight junctions by zonula occludens toxin and its eukaryotic analogue zonulin
    A Fasano
    Division of Pediatric Gastroenterology and Nutrition, Gastrointestinal Pathophysiology Section, Center for Vaccine Development, Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Ann N Y Acad Sci 915:214-22. 2000
  8. pmc Production of Vibrio cholerae accessory cholera enterotoxin (Ace) in the yeast Pichia pastoris
    M Trucksis
    Department of Medicine, University of Maryland School of Medicine, and Medical Science, Veterans Affairs Medical Center, Baltimore 21201, USA
    Infect Immun 65:4984-8. 1997
  9. ncbi Cellular microbiology: can we learn cell physiology from microorganisms?
    A Fasano
    Department of Pediatrics and Physiology, and Gastrointestinal Pathophysiology Section, Center for Vaccine Development, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA
    Am J Physiol 276:C765-76. 1999
  10. ncbi Different efficacy in vitro of hemoglobin based oxygen carriers and red cells
    E Bucci
    Department of Biochemistry and Molecular Biology, University of Maryland, School of Medicine Baltimore, MD 21201, USA
    Adv Exp Med Biol 510:89-92. 2003

Collaborators

Detail Information

Publications11

  1. pmc Modulation of intestinal tight junctions by Zonula occludens toxin permits enteral administration of insulin and other macromolecules in an animal model
    A Fasano
    Division of Pediatric Gastroenterology and Nutrition, University of Maryland, School of Medicine, Baltimore 21201, USA
    J Clin Invest 99:1158-64. 1997
    ..These studies offer an innovative strategy for the oral delivery of drugs and proteins normally not absorbed through the intestine...
  2. ncbi Novel approaches for oral delivery of macromolecules
    A Fasano
    Division of Pediatric Gastroenterology and Nutrition and Gastrointestinal Pathophysiology Section, Center for Vaccine Development, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA
    J Pharm Sci 87:1351-6. 1998
    ....
  3. ncbi Purification and preliminary characterization of the zonula occludens toxin receptor from human (CaCo2) and murine (IEC6) intestinal cell lines
    S Uzzau
    Division of Pediatric Gastroenterology, Center for Vaccine Development, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
    FEMS Microbiol Lett 194:1-5. 2001
    ..Our results suggest that Zot binding to its cellular membrane receptor requires a sequence that spans between amino acids 118 and 299...
  4. ncbi [Zonula occludens toxin: an innovative method of oral drugs delivery]
    M Di Pierro
    Division of Pediatric Gastroenterology and Nutrition and Gastrointestinal pathophisiology, Center for Vaccine Development, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
    Minerva Pediatr 53:15-22. 2001
    ....
  5. ncbi Bromelain prevents secretion caused by Vibrio cholerae and Escherichia coli enterotoxins in rabbit ileum in vitro
    T L Mynott
    Department of Medicine, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, USA
    Gastroenterology 113:175-84. 1997
    ..The aim of this study was to investigate the possible therapeutic effect of bromelain, a proteolytic extract obtained from pineapple stems on bacterial toxin and second-messenger agonist-induced intestinal secretion...
  6. ncbi Zonula occludens toxin structure-function analysis. Identification of the fragment biologically active on tight junctions and of the zonulin receptor binding domain
    M Di Pierro
    Division of Pediatric Gastroenterology and Nutrition and Gastrointestinal Pathophysiology Section, Center for Vaccine Development, Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 276:19160-5. 2001
    ..Amino acid comparison between the Zot active fragment and zonulin, combined with site-directed mutagenesis experiments, confirmed the presence of an octapeptide receptor-binding domain toward the amino terminus of the processed Zot...
  7. ncbi Regulation of intercellular tight junctions by zonula occludens toxin and its eukaryotic analogue zonulin
    A Fasano
    Division of Pediatric Gastroenterology and Nutrition, Gastrointestinal Pathophysiology Section, Center for Vaccine Development, Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Ann N Y Acad Sci 915:214-22. 2000
    ....
  8. pmc Production of Vibrio cholerae accessory cholera enterotoxin (Ace) in the yeast Pichia pastoris
    M Trucksis
    Department of Medicine, University of Maryland School of Medicine, and Medical Science, Veterans Affairs Medical Center, Baltimore 21201, USA
    Infect Immun 65:4984-8. 1997
    ..To our knowledge this is the first report of a biologically active bacterial toxin produced with the P. pastoris system. The purified protein may now be used in studies of the mechanism of action of Ace in physiologic systems...
  9. ncbi Cellular microbiology: can we learn cell physiology from microorganisms?
    A Fasano
    Department of Pediatrics and Physiology, and Gastrointestinal Pathophysiology Section, Center for Vaccine Development, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA
    Am J Physiol 276:C765-76. 1999
    ..The use of microbial pathogens to address questions in cell physiology is just now yielding promising applications and striking results...
  10. ncbi Different efficacy in vitro of hemoglobin based oxygen carriers and red cells
    E Bucci
    Department of Biochemistry and Molecular Biology, University of Maryland, School of Medicine Baltimore, MD 21201, USA
    Adv Exp Med Biol 510:89-92. 2003
  11. pmc Novel signaling interactions between proteinase-activated receptor 2 and Toll-like receptors in vitro and in vivo
    Q M Nhu
    Department of Microbiology and Immunology, University of Maryland, Baltimore UMB, School of Medicine, Baltimore, Maryland, USA
    Mucosal Immunol 3:29-39. 2010
    ..These data support and extend our recently described, novel model of PAR(2)-TLR4 "receptor cooperativity" and highlight the complexity of signaling integration between heterologous innate immune biosensors...