A Fasano

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc Toxins and the gut: role in human disease
    A Fasano
    Division of Pediatric Gastroenterology and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Gut 50:III9-14. 2002
  2. ncbi Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study
    Alessio Fasano
    Center for Celiac Research, University of Maryland School of Medicine, 22 S Greene St, N5W70, PO Box 140, Baltimore, MD 21201 1595, USA
    Arch Intern Med 163:286-92. 2003
  3. ncbi Intestinal epithelial tight junctions as targets for enteric bacteria-derived toxins
    Alessio Fasano
    Division of Pediatric Gastroenterology and Nutrition, School of Medicine, University of Maryland, Baltimore 21201, USA
    Adv Drug Deliv Rev 56:795-807. 2004
  4. ncbi Regulation of intercellular tight junctions by zonula occludens toxin and its eukaryotic analogue zonulin
    A Fasano
    Division of Pediatric Gastroenterology and Nutrition, Gastrointestinal Pathophysiology Section, Center for Vaccine Development, Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Ann N Y Acad Sci 915:214-22. 2000
  5. ncbi Current approaches to diagnosis and treatment of celiac disease: an evolving spectrum
    A Fasano
    Center for Celiac Research and Division of Pediatric Gastroenterology and Nutrition, University of Maryland, Hospital for Children, Baltimore, Maryland 21201, USA
    Gastroenterology 120:636-51. 2001
  6. ncbi Cellular microbiology: can we learn cell physiology from microorganisms?
    A Fasano
    Department of Pediatrics and Physiology, and Gastrointestinal Pathophysiology Section, Center for Vaccine Development, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA
    Am J Physiol 276:C765-76. 1999
  7. ncbi Purification and preliminary characterization of the zonula occludens toxin receptor from human (CaCo2) and murine (IEC6) intestinal cell lines
    S Uzzau
    Division of Pediatric Gastroenterology, Center for Vaccine Development, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
    FEMS Microbiol Lett 194:1-5. 2001
  8. ncbi Bromelain prevents secretion caused by Vibrio cholerae and Escherichia coli enterotoxins in rabbit ileum in vitro
    T L Mynott
    Department of Medicine, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, USA
    Gastroenterology 113:175-84. 1997
  9. pmc Modulation of intestinal tight junctions by Zonula occludens toxin permits enteral administration of insulin and other macromolecules in an animal model
    A Fasano
    Division of Pediatric Gastroenterology and Nutrition, University of Maryland, School of Medicine, Baltimore 21201, USA
    J Clin Invest 99:1158-64. 1997
  10. pmc Accessory cholera enterotoxin (Ace), the third toxin of a Vibrio cholerae virulence cassette
    M Trucksis
    Department of Medicine, University of Maryland School of Medicine, Baltimore
    Proc Natl Acad Sci U S A 90:5267-71. 1993

Collaborators

Detail Information

Publications72

  1. pmc Toxins and the gut: role in human disease
    A Fasano
    Division of Pediatric Gastroenterology and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Gut 50:III9-14. 2002
    ..This review focuses on the most recent outcomes of this multidisciplinary effort...
  2. ncbi Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study
    Alessio Fasano
    Center for Celiac Research, University of Maryland School of Medicine, 22 S Greene St, N5W70, PO Box 140, Baltimore, MD 21201 1595, USA
    Arch Intern Med 163:286-92. 2003
    ..The aim of this study was to determine the prevalence of CD in at-risk and not-at-risk groups in the United States...
  3. ncbi Intestinal epithelial tight junctions as targets for enteric bacteria-derived toxins
    Alessio Fasano
    Division of Pediatric Gastroenterology and Nutrition, School of Medicine, University of Maryland, Baltimore 21201, USA
    Adv Drug Deliv Rev 56:795-807. 2004
    ..Many pathogenic bacteria exploit this system to accomplish their pathogenic strategies by ultimately modulating intestinal permeability...
  4. ncbi Regulation of intercellular tight junctions by zonula occludens toxin and its eukaryotic analogue zonulin
    A Fasano
    Division of Pediatric Gastroenterology and Nutrition, Gastrointestinal Pathophysiology Section, Center for Vaccine Development, Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Ann N Y Acad Sci 915:214-22. 2000
    ....
  5. ncbi Current approaches to diagnosis and treatment of celiac disease: an evolving spectrum
    A Fasano
    Center for Celiac Research and Division of Pediatric Gastroenterology and Nutrition, University of Maryland, Hospital for Children, Baltimore, Maryland 21201, USA
    Gastroenterology 120:636-51. 2001
    ..The keystone treatment of CD patients is a lifelong elimination diet in which food products containing gluten are avoided...
  6. ncbi Cellular microbiology: can we learn cell physiology from microorganisms?
    A Fasano
    Department of Pediatrics and Physiology, and Gastrointestinal Pathophysiology Section, Center for Vaccine Development, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA
    Am J Physiol 276:C765-76. 1999
    ..The use of microbial pathogens to address questions in cell physiology is just now yielding promising applications and striking results...
  7. ncbi Purification and preliminary characterization of the zonula occludens toxin receptor from human (CaCo2) and murine (IEC6) intestinal cell lines
    S Uzzau
    Division of Pediatric Gastroenterology, Center for Vaccine Development, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
    FEMS Microbiol Lett 194:1-5. 2001
    ..Our results suggest that Zot binding to its cellular membrane receptor requires a sequence that spans between amino acids 118 and 299...
  8. ncbi Bromelain prevents secretion caused by Vibrio cholerae and Escherichia coli enterotoxins in rabbit ileum in vitro
    T L Mynott
    Department of Medicine, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, USA
    Gastroenterology 113:175-84. 1997
    ..The aim of this study was to investigate the possible therapeutic effect of bromelain, a proteolytic extract obtained from pineapple stems on bacterial toxin and second-messenger agonist-induced intestinal secretion...
  9. pmc Modulation of intestinal tight junctions by Zonula occludens toxin permits enteral administration of insulin and other macromolecules in an animal model
    A Fasano
    Division of Pediatric Gastroenterology and Nutrition, University of Maryland, School of Medicine, Baltimore 21201, USA
    J Clin Invest 99:1158-64. 1997
    ..These studies offer an innovative strategy for the oral delivery of drugs and proteins normally not absorbed through the intestine...
  10. pmc Accessory cholera enterotoxin (Ace), the third toxin of a Vibrio cholerae virulence cassette
    M Trucksis
    Department of Medicine, University of Maryland School of Medicine, Baltimore
    Proc Natl Acad Sci U S A 90:5267-71. 1993
    ..The gene encoding Ace is located immediately upstream of the genes encoding Zot and cholera toxin. The ctx, zot, and ace genes, which are located on a dynamic sector of the chromosome, comprise a V. cholerae "virulence cassette."..
  11. ncbi Human tissue transglutaminase ELISA and an old study: a revision of the blood donor screening study for coeliac disease in the USA
    E Neri
    Center for Celiac Research, University of Maryland at Baltimore, USA
    Scand J Gastroenterol 39:195-7. 2004
  12. pmc Vibrio cholerae produces a second enterotoxin, which affects intestinal tight junctions
    A Fasano
    Department of Medicine, University of Maryland School of Medicine, Baltimore 21201
    Proc Natl Acad Sci U S A 88:5242-6. 1991
    ..cholerae strains in volunteers and may represent another virulence factor of infectious diarrhea that must be eliminated to achieve a safe and effective live oral vaccine against cholera...
  13. pmc Shigella enterotoxin 1: an enterotoxin of Shigella flexneri 2a active in rabbit small intestine in vivo and in vitro
    A Fasano
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore 21201, USA
    J Clin Invest 95:2853-61. 1995
    ..ShET1, which is composed of two distinct subunits and is elaborated in vivo, where it elicits an immune response, may be important in the pathogenesis of diarrheal illness due to S. flexneri 2a...
  14. ncbi Zonula occludens toxin structure-function analysis. Identification of the fragment biologically active on tight junctions and of the zonulin receptor binding domain
    M Di Pierro
    Division of Pediatric Gastroenterology and Nutrition and Gastrointestinal Pathophysiology Section, Center for Vaccine Development, Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 276:19160-5. 2001
    ..Amino acid comparison between the Zot active fragment and zonulin, combined with site-directed mutagenesis experiments, confirmed the presence of an octapeptide receptor-binding domain toward the amino terminus of the processed Zot...
  15. pmc Production of Vibrio cholerae accessory cholera enterotoxin (Ace) in the yeast Pichia pastoris
    M Trucksis
    Department of Medicine, University of Maryland School of Medicine, and Medical Science, Veterans Affairs Medical Center, Baltimore 21201, USA
    Infect Immun 65:4984-8. 1997
    ..To our knowledge this is the first report of a biologically active bacterial toxin produced with the P. pastoris system. The purified protein may now be used in studies of the mechanism of action of Ace in physiologic systems...
  16. ncbi [Zonula occludens toxin: an innovative method of oral drugs delivery]
    M Di Pierro
    Division of Pediatric Gastroenterology and Nutrition and Gastrointestinal pathophisiology, Center for Vaccine Development, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
    Minerva Pediatr 53:15-22. 2001
    ....
  17. pmc Production of enterotoxin by Yersinia bercovieri, a recently identified Yersinia enterocolitica-like species
    A Sulakvelidze
    Division of Hospital Epidemiology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Infect Immun 67:968-71. 1999
    ..bercovieri strains did not hybridize with genetic probes for yst I, yst II, and other known enterotoxins...
  18. ncbi Novel approaches for oral delivery of macromolecules
    A Fasano
    Division of Pediatric Gastroenterology and Nutrition and Gastrointestinal Pathophysiology Section, Center for Vaccine Development, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA
    J Pharm Sci 87:1351-6. 1998
    ....
  19. doi Federation of International Societies of Pediatric Gastroenterology, Hepatology, and Nutrition consensus report on celiac disease
    A Fasano
    Mucosal Biology Research Center and Center for Celiac Research, University of Maryland School of Medicine, Baltimore, MD, USA
    J Pediatr Gastroenterol Nutr 47:214-9. 2008
  20. ncbi Different efficacy in vitro of hemoglobin based oxygen carriers and red cells
    E Bucci
    Department of Biochemistry and Molecular Biology, University of Maryland, School of Medicine Baltimore, MD 21201, USA
    Adv Exp Med Biol 510:89-92. 2003
  21. pmc European and North American populations should be screened for coeliac disease
    A Fasano
    Division of Pediatric GI and Nutrition, Center for Celiac Research, University of Maryland School of Medicine, Baltimore, USA
    Gut 52:168-9. 2003
  22. pmc Identification and cloning of a novel plasmid-encoded enterotoxin of enteroinvasive Escherichia coli and Shigella strains
    J P Nataro
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, USA
    Infect Immun 63:4721-8. 1995
    ..We believe that the sen gene product may constitute all or part of a novel enterotoxin in EIEC and Shigella spp...
  23. ncbi [Celiac disease; a world in exploration]
    F Fornaroli
    Center for Celiac Research, University of Maryland, Baltimore, MD, USA
    Minerva Pediatr 55:23-31. 2003
    ..g. the antigliadin antibody (AGA), the antiendomysial antibody (EMA) and the anti-tissue transglutaminase antibody (tTG). The keystone treatment of CD patients is a life-long gluten-free diet...
  24. ncbi The safety, tolerance, pharmacokinetic and pharmacodynamic effects of single doses of AT-1001 in coeliac disease subjects: a proof of concept study
    B M Paterson
    Alba Therapeutics Corporation, Baltimore, MD 21201, USA
    Aliment Pharmacol Ther 26:757-66. 2007
    ..AT-1001 is an inhibitor of paracellular permeability whose structure is derived from a protein secreted by Vibrio cholerae...
  25. ncbi The gluten connection: the association between schizophrenia and celiac disease
    A E Kalaydjian
    Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Acta Psychiatr Scand 113:82-90. 2006
    ..Given the immense cost to society, successful treatment options are imperative. Based on initial findings, gluten withdrawal may serve as a safe and economical alternative for the reduction of symptoms in a subset of patients...
  26. pmc Cloning of a gene (zot) encoding a new toxin produced by Vibrio cholerae
    B Baudry
    Department of Medicine, University of Maryland School of Medicine, Baltimore
    Infect Immun 60:428-34. 1992
    ..3-kb open reading frame which could potentially encode a 44.8-kDa polypeptide. The location of the zot gene encoding the new toxin is immediately upstream of the ctx operon encoding cholera toxin...
  27. pmc Novel signaling interactions between proteinase-activated receptor 2 and Toll-like receptors in vitro and in vivo
    Q M Nhu
    Department of Microbiology and Immunology, University of Maryland, Baltimore UMB, School of Medicine, Baltimore, Maryland, USA
    Mucosal Immunol 3:29-39. 2010
    ..These data support and extend our recently described, novel model of PAR(2)-TLR4 "receptor cooperativity" and highlight the complexity of signaling integration between heterologous innate immune biosensors...
  28. pmc Role of Vibrio cholerae neuraminidase in the function of cholera toxin
    J E Galen
    Department of Medicine, University of Maryland School of Medicine, Baltimore 21201
    Infect Immun 60:406-15. 1992
    ..It is concluded that NANase plays a subtle but significant role in the binding and uptake of CT by susceptible cells under defined conditions...
  29. ncbi Gliadin stimulation of murine macrophage inflammatory gene expression and intestinal permeability are MyD88-dependent: role of the innate immune response in Celiac disease
    Karen E Thomas
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, 21201, USA
    J Immunol 176:2512-21. 2006
    ....
  30. ncbi Clinical presentation of celiac disease in the pediatric population
    Alessio Fasano
    Mucosal Biology Research Center and Center for Celiac Research, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA
    Gastroenterology 128:S68-73. 2005
    ..There is growing interest in the social aspects of CD because the burden of illness related to this condition is doubtless higher than previously thought...
  31. ncbi Mechanisms of disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases
    Alessio Fasano
    Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Nat Clin Pract Gastroenterol Hepatol 2:416-22. 2005
    ..This review is timely given the increased interest in the role of a 'leaky gut' in the pathogenesis of gastrointestinal diseases and the advent of novel treatment strategies, such as the use of probiotics...
  32. ncbi VSL#3 probiotic preparation has the capacity to hydrolyze gliadin polypeptides responsible for Celiac Sprue
    Maria de Angelis
    Department of Plant Protection and Applied Microbiology, University of Bari, 70126 Bari, Italy
    Biochim Biophys Acta 1762:80-93. 2006
    ..Proteolytic activity by probiotic VSL#3 may have an importance during food processing to produce pre-digested and tolerated gliadins for increasing the palatability of gluten-free products...
  33. pmc Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3
    Karen M Lammers
    Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Gastroenterology 135:194-204.e3. 2008
    ..We aimed to establish the molecular basis of gliadin interaction with intestinal mucosa leading to intestinal barrier impairment...
  34. ncbi Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines
    Sandro Drago
    Mucosal Biology Research Center, Center for Celiac Research and Division of Pediatric Gastroenterology and Nutrition, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
    Scand J Gastroenterol 41:408-19. 2006
    ..We investigated whether gliadin has any immediate effect on zonulin release and signaling...
  35. pmc Physiological, pathological, and therapeutic implications of zonulin-mediated intestinal barrier modulation: living life on the edge of the wall
    Alessio Fasano
    University of Maryland School of Medicine, Mucosal Biology Research Center, Health Science Facility II, Baltimore, MD 21201, USA
    Am J Pathol 173:1243-52. 2008
    ..Understanding the role of zonulin-dependent intestinal barrier dysfunction in the pathogenesis of autoimmune diseases is an area of translational research that encompasses many fields...
  36. ncbi Zonulin upregulation is associated with increased gut permeability in subjects with type 1 diabetes and their relatives
    Anna Sapone
    Mucosal Biology Research Center, University of Maryland School of Medicine, 20 Penn Street, Room 345, Baltimore, MD 21201, USA
    Diabetes 55:1443-9. 2006
    ....
  37. ncbi Systemic autoimmune disorders in celiac disease
    Alessio Fasano
    Center for Celiac Research and Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Curr Opin Gastroenterol 22:674-9. 2006
    ..Celiac disease is an immune-mediated disorder clinically characterized by a multitude of symptoms and complications. The comorbidity between celiac disease and other autoimmune disorders has been clearly established...
  38. ncbi Effect of the six-mer synthetic peptide (AT1002) fragment of zonula occludens toxin on the intestinal absorption of cyclosporin A
    Keon Hyoung Song
    Pharmacokinetics Biopharmaceutics Laboratory, Department of Pharmaceutical Science, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    Int J Pharm 351:8-14. 2008
    ..This study suggests that AT1002-mediated tight junction modulation, combined with metabolic protection and stabilization, may be used to enhance the low oral bioavailability of certain drugs when administered concurrently...
  39. ncbi Screening for celiac disease in family members: is follow-up testing necessary?
    David Goldberg
    Department of Medicine, Columbia University College of Physicians and Surgeons, 161 Fort Washington Avenue, New York, NY 10032, USA
    Dig Dis Sci 52:1082-6. 2007
    ..We conclude that one-time testing for celiac disease among families with affected members is insufficient. Repeat testing should occur irrespective of the presence of symptoms...
  40. ncbi A prospective, double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac disease
    Carlo Catassi
    Center for Celiac Research, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Clin Nutr 85:160-6. 2007
    ..Treatment of celiac disease (CD) is based on the avoidance of gluten-containing food. However, it is not known whether trace amounts of gluten are harmful to treated patients...
  41. ncbi Permeability, zonulin production, and enteropathy in dermatitis herpetiformis
    Edgardo Smecuol
    Dr C Bonorino Udaondo Gastroenterology Hospital, Av Caseros 2061, 1264 Buenos Aires, Argentina
    Clin Gastroenterol Hepatol 3:335-41. 2005
    ..Our aim was to assess both intestinal permeability and serum zonulin levels in a group of patients with DH having variable grades of enteropathy...
  42. pmc Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic-prone rats
    Tammara Watts
    Mucosal Biology Research Center and Division of Pediatric Gastroenterology and Nutrition, and Division of Pediatric Research, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 102:2916-21. 2005
    ..Combined together, these findings suggest that the zonulin-induced loss in small intestinal barrier function is involved in the pathogenesis of T1D in the BB diabetic-prone animal model...
  43. ncbi Celiac disease--how to handle a clinical chameleon
    Alessio Fasano
    N Engl J Med 348:2568-70. 2003
  44. ncbi Host-dependent zonulin secretion causes the impairment of the small intestine barrier function after bacterial exposure
    Ramzi El Asmar
    Department of Pediatrics and Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Gastroenterology 123:1607-15. 2002
    ..On the basis of our recent discovery of zonulin, a modulator of small-intestinal tight junctions, we asked whether microorganisms might induce zonulin secretion and increased small-intestinal permeability...
  45. ncbi Structural and functional alterations of the gastrointestinal tract following radiation-induced injury in the rhesus monkey
    Roy M Vigneulle
    Department of Radiation Oncology, Greenebaum Cancer Center, Baltimore, Maryland 21201, USA
    Dig Dis Sci 47:1480-91. 2002
    ..Our integrated approach allowed a comprehensive study of the relationship between postirradiation tissue injury and changes in function over time in the gastrointestinal tract of the nonhuman primate...
  46. ncbi Relationship of HLA-DQ8 and severity of celiac disease: comparison of New York and Parisian cohorts
    Timothy C Johnson
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Clin Gastroenterol Hepatol 2:888-94. 2004
    ..We assessed whether differences in the frequency of HLA type may account for differences in severity of the disease by using cohorts of patients from New York and Paris...
  47. ncbi Coeliac disease in children
    Alessio Fasano
    School of Medicine, Mucosal Biology Research Center and Center for Celiac Research, University of Maryland, 22 S Pine St HSFII Building, Room 345, Baltimore, MD 21201, USA
    Best Pract Res Clin Gastroenterol 19:467-78. 2005
    ....
  48. ncbi Zonula occludens toxin increases the permeability of molecular weight markers and chemotherapeutic agents across the bovine brain microvessel endothelial cells
    Chetan S Karyekar
    Pharmacokinetics Biopharmaceutics Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 100 Penn Street, Baltimore, Maryland 21201, USA
    J Pharm Sci 92:414-23. 2003
    ..Modulation of paracellular transport with Zot may be used to increase the brain permeability of potent central nervous system-active drugs, including anticancer agents...
  49. ncbi Zonula occludens toxin (Zot) interferes with the induction of nasal tolerance to gliadin
    Mauro Rossi
    Istituto di Scienze dell Alimentazione, CNR, Via Roma 52, 83100, Avellino, Italy
    Immunol Lett 81:217-21. 2002
    ....
  50. ncbi Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition
    Ivor D Hill
    North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, Flourtown, PA 19031, USA
    J Pediatr Gastroenterol Nutr 40:1-19. 2005
    ..This document represents the official recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition on the diagnosis and treatment of celiac disease in children and adolescents...
  51. pmc Zonula occludens toxin acts as an adjuvant through different mucosal routes and induces protective immune responses
    Mariarosaria Marinaro
    Laboratory of Bacteriology and Medical Mycology, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Infect Immun 71:1897-902. 2003
    ..In conclusion, Zot is a novel and effective mucosal adjuvant that may be useful for the development of mucosal vaccines...
  52. ncbi Effect of the biologically active fragment of zonula occludens toxin, delta G, on the intestinal paracellular transport and oral absorption of mannitol
    Noha N Salama
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland at Baltimore, 100 Penn Street, Baltimore, MD 21201, USA
    Int J Pharm 251:113-21. 2003
    ....
  53. pmc Mechanisms of disease: protease functions in intestinal mucosal pathobiology
    Toni M Antalis
    Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Nat Clin Pract Gastroenterol Hepatol 4:393-402. 2007
    ....
  54. ncbi Infectious diarrhea in children: Working Group Report of the First World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition
    Geoffrey Davidson
    Commonwealth Association of Paediatric Gastroenterology and Nutrition, USA
    J Pediatr Gastroenterol Nutr 35:S143-50. 2002
  55. ncbi Enhanced nasal absorption of hydrophilic markers after dosing with AT1002, a tight junction modulator
    Keon Hyoung Song
    Department of Pharmaceutical Science, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    Eur J Pharm Biopharm 69:231-7. 2008
    ..AT1002 significantly increased the nasal absorption of molecular weight markers, PEG4000 and inulin. This study suggests that AT1002 may be used to enhance the systemic availability of macromolecules when administered concurrently...
  56. ncbi Ganglioside reactive antibodies in the neuropathy associated with celiac disease
    Armin Alaedini
    Department of Neurology and Neuroscience, Cornell University, 525 E 68th St, LC 807, New York, NY 10021, USA
    J Neuroimmunol 127:145-8. 2002
    ..The neuropathy of celiac disease may be autoimmune and associated with anti-ganglioside antibodies. The presence of IgG reactivity furthermore implicates a T cell-mediated response to ganglioside antigens...
  57. ncbi New developments in childhood celiac disease
    Carlo Catassi
    Center for Celiac Research, Division of Pediatric Gastroenterology and Nutrition, University of Maryland School of Medicine, 685 West Baltimore Street, HSF Building, Room 465, Baltimore, MD 21201, USA
    Curr Gastroenterol Rep 4:238-43. 2002
    ..The epidemiology, pathophysiology, diagnosis, and clinical spectrum of CD in children are highlighted...
  58. ncbi Latest developments in the pathogenesis and treatment of celiac disease
    David Branski
    Department of Pediatrics, Hadassah University Hospitals, Hadassah Medical Organization, 91120 Jerusalem, Israel
    J Pediatr 149:295-300. 2006
  59. pmc Zonula occludens toxin synthetic peptide derivative AT1002 enhances in vitro and in vivo intestinal absorption of low molecular weight heparin
    Nusrat A Motlekar
    Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, School of Pharmacy, Amarillo, TX 79106, USA
    J Drug Target 14:321-9. 2006
    ..These in vivo and in vitro results suggest that the co-administration of LMWH with AT1002 may be a useful delivery strategy to increase its permeability and hence oral absorption...
  60. ncbi Dual sugar gut-permeability testing on blood drop in animal models
    Fourogh Katouzian
    Department of Reproductive and Development Science and IRCCS, Instituto per I Infanzia Burlo Garofolo Clinica Pediatrica University of Trieste, Via dell Istria 65 1, IT 34100, Trieste, Italy
    Clin Chim Acta 352:191-7. 2005
    ..We measured the intestinal permeability induced by a fragment (DeltaG) of the zonula occludens toxin which opens the paracellular pathway...
  61. ncbi Seeing the light with celiac
    Carol E Semrad
    University of Chicago, Section of Gastroenterology, Chicago, Illinois, USA
    Clin Immunol 115:236-9. 2005
  62. ncbi Celiac disease as a cause of growth retardation in childhood
    Carlo Catassi
    Center for Celiac Research, Division of Pediatric Gastroenterology and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Curr Opin Pediatr 16:445-9. 2004
    ..Although the typical form of celiac disease, characterized by failure to thrive, is still the most frequent presentation in the pediatric age group, severe growth delay is less commonly seen in developed countries...
  63. ncbi Secreted autotransporter toxin produced by a diffusely adhering Escherichia coli strain causes intestinal damage in animal model assays
    Carla R Taddei
    Faculdade de Ciencias Farmaceuticas, Departamento de AnĂ¡lises, Clinicas e Toxicologicas, Universidade de Sao Paulo, Av Prof Lineu Prestes, 580 Bl 17, CEP 05508 900, Sao Paulo, Brazil
    FEMS Microbiol Lett 250:263-9. 2005
    ..Our results suggest that DAEC strains may be involved in diarrhea...
  64. ncbi Current concepts in the evaluation, diagnosis and management of acute infectious diarrhea
    Swati Gadewar
    Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, University of Maryland School of Medicine, 22 S Greene St N5W70, Baltimore, Maryland 21201 1595, USA
    Curr Opin Pharmacol 5:559-65. 2005
    ..For this reason, development of vaccines against the most important gastrointestinal infections remains a high priority...
  65. ncbi Enhancement of brain distribution of anticancer agents using DeltaG, the 12 kDa active fragment of ZOT
    Divya Menon
    Pharmacokinetics Biopharmaceutics Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20 Penn Street, HSF II 543, Baltimore, MD 21201 6808, USA
    Int J Pharm 306:122-31. 2005
    ..The objective of this study was to evaluate the ability of DeltaG, the 12 kDa active fragment of ZOT, to increase the brain distribution of MTX and paclitaxel, two commonly used anticancer agents with poor distribution into the brain...
  66. ncbi The impact of DeltaG on the oral bioavailability of low bioavailable therapeutic agents
    Noha N Salama
    Pharmacokinetics Biopharmaceutics Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland at Baltimore, 20 Penn Street, Baltimore, MD 21201, USA
    J Pharmacol Exp Ther 312:199-205. 2005
    ..This study suggests that DeltaG-mediated tight junction modulation, combined with metabolic protection, may be used to enhance the low oral bioavailability of certain drugs when administered concurrently...
  67. ncbi Celiac disease: is the atypical really typical? Summary of the recent National Institutes of Health Consensus Conference and latest advances
    Swati Gadewar
    Department of Pediatrics, Mucosal Biology Research Center, University of Maryland School of Medicine, Health Science Facility II Room 8345, 20 Penn Street, Baltimore, MD 21201, USA
    Curr Gastroenterol Rep 7:455-61. 2005
    ..There are several targets for new treatments. This article briefly summarizes the National Institutes of Health Consensus Statement and gives an overview of new findings in recent years and of future therapeutic options for CD...
  68. ncbi Intestinal infections and environmental enteropathy: Working Group report of the second World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition
    Eduardo Salazar-Lindo
    J Pediatr Gastroenterol Nutr 39:S662-9. 2004
  69. ncbi Tight junction modulation and its relationship to drug delivery
    Noha N Salama
    Pharmacokinetics Biopharmaceutics Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland at Baltimore, 100 Penn Street, Baltimore, Maryland 21201, USA
    Adv Drug Deliv Rev 58:15-28. 2006
    ..Above all, the transient opening of the TJs by Zot suggests that it could be used as a novel approach for the safe drug delivery of therapeutic agents...
  70. ncbi The effect of delta G on the transport and oral absorption of macromolecules
    Noha N Salama
    Pharmacokinetics Biopharmaceutics Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland at Baltimore, 20 Penn Street, Baltimore, Maryland 21201, USA
    J Pharm Sci 93:1310-9. 2004
    ..This study suggests that DeltaG may be used to enhance the oral bioavailability of macromolecules (e.g., proteins) after coadministration through modulation of paracellular transport...
  71. ncbi Celiac disease in the pediatric population
    Daniel Gelfond
    Division of Pediatric Gastroenterology and Nutrition, University of Maryland School of Medicine, Baltimore 21201, USA
    Pediatr Ann 35:275-9. 2006
  72. ncbi Detection of Celiac disease in primary care: a multicenter case-finding study in North America
    Carlo Catassi
    Mucosal Biology Research Center and Division of Pediatric Gastroenterology and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Gastroenterol 102:1454-60. 2007
    ..Celiac disease (CD) is one of the most common lifelong disorders in western countries. However, most cases remain currently undiagnosed in North America, mostly due to poor awareness of CD by primary care physicians...