Research Topics
| A FasanoSummaryAffiliation: University of Maryland Country: USA Publications
Research Grants
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Publications
Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3Karen M Lammers
Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Gastroenterology 135:194-204.e3. 2008..We aimed to establish the molecular basis of gliadin interaction with intestinal mucosa leading to intestinal barrier impairment...- European and North American populations should be screened for coeliac diseaseA Fasano
Division of Pediatric GI and Nutrition, Center for Celiac Research, University of Maryland School of Medicine, Baltimore, USA
Gut 52:168-9. 2003 - Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic-prone ratsTammara Watts
Mucosal Biology Research Center and Division of Pediatric Gastroenterology and Nutrition, and Division of Pediatric Research, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Proc Natl Acad Sci U S A 102:2916-21. 2005..Combined together, these findings suggest that the zonulin-induced loss in small intestinal barrier function is involved in the pathogenesis of T1D in the BB diabetic-prone animal model... 
Permeability, zonulin production, and enteropathy in dermatitis herpetiformisEdgardo Smecuol
Dr. C. Bonorino Udaondo Gastroenterology Hospital, Av. Caseros 2061, 1264) Buenos Aires, Argentina
Clin Gastroenterol Hepatol 3:335-41. 2005..Increased permeability can be observed even in patients with no evidence of histologic damage in biopsy specimens. Patients with linear IgA dermatosis appear to be a distinct population with no evidence of gluten sensitivity...- Clinical presentation of celiac disease in the pediatric populationAlessio Fasano
Mucosal Biology Research Center and Center for Celiac Research, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA
Gastroenterology 128:S68-73. 2005..There is growing interest in the social aspects of CD because the burden of illness related to this condition is doubtless higher than previously thought... - Screening for celiac disease in family members: is follow-up testing necessary?David Goldberg
Department of Medicine, Columbia University College of Physicians and Surgeons, 161 Fort Washington Avenue, New York, NY 10032, USA
Dig Dis Sci 52:1082-6. 2007..We conclude that one-time testing for celiac disease among families with affected members is insufficient. Repeat testing should occur irrespective of the presence of symptoms... - Coeliac disease in childrenAlessio Fasano
School of Medicine, Mucosal Biology Research Center and Center for Celiac Research, University of Maryland, 22 S Pine St HSFII Building, Room 345, Baltimore, MD 21201, USA
Best Pract Res Clin Gastroenterol 19:467-78. 2005.... - Mechanisms of disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseasesAlessio Fasano
Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Nat Clin Pract Gastroenterol Hepatol 2:416-22. 2005..This review is timely given the increased interest in the role of a 'leaky gut' in the pathogenesis of gastrointestinal diseases and the advent of novel treatment strategies, such as the use of probiotics... - VSL#3 probiotic preparation has the capacity to hydrolyze gliadin polypeptides responsible for Celiac SprueMaria de Angelis
Department of Plant Protection and Applied Microbiology, University of Bari, 70126 Bari, Italy
Biochim Biophys Acta 1762:80-93. 2006..Proteolytic activity by probiotic VSL#3 may have an importance during food processing to produce pre-digested and tolerated gliadins for increasing the palatability of gluten-free products... - Gliadin stimulation of murine macrophage inflammatory gene expression and intestinal permeability are MyD88-dependent: role of the innate immune response in Celiac diseaseKaren E Thomas
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, 21201, USA
J Immunol 176:2512-21. 2006.... - Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell linesSandro Drago
Mucosal Biology Research Center, Center for Celiac Research and Division of Pediatric Gastroenterology and Nutrition, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
Scand J Gastroenterol 41:408-19. 2006..CONCLUSIONS: Based on our results, we concluded that gliadin activates zonulin signaling irrespective of the genetic expression of autoimmunity, leading to increased intestinal permeability to macromolecules... - Zonulin upregulation is associated with increased gut permeability in subjects with type 1 diabetes and their relativesAnna Sapone
Mucosal Biology Research Center, University of Maryland School of Medicine, 20 Penn Street, Room 345, Baltimore, MD 21201, USA
Diabetes 55:1443-9. 2006.... - Physiological, pathological, and therapeutic implications of zonulin-mediated intestinal barrier modulation: living life on the edge of the wallAlessio Fasano
University of Maryland School of Medicine, Mucosal Biology Research Center, Health Science Facility II, Baltimore, MD 21201, USA
Am J Pathol 173:1243-52. 2008..Understanding the role of zonulin-dependent intestinal barrier dysfunction in the pathogenesis of autoimmune diseases is an area of translational research that encompasses many fields... - Systemic autoimmune disorders in celiac diseaseAlessio Fasano
Center for Celiac Research and Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Curr Opin Gastroenterol 22:674-9. 2006..Celiac disease is an immune-mediated disorder clinically characterized by a multitude of symptoms and complications. The comorbidity between celiac disease and other autoimmune disorders has been clearly established... - A prospective, double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac diseaseCarlo Catassi
Center for Celiac Research, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Am J Clin Nutr 85:160-6. 2007..Treatment of celiac disease (CD) is based on the avoidance of gluten-containing food. However, it is not known whether trace amounts of gluten are harmful to treated patients... - Detection of Celiac disease in primary care: a multicenter case-finding study in North AmericaCarlo Catassi
Mucosal Biology Research Center and Division of Pediatric Gastroenterology and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Am J Gastroenterol 102:1454-60. 2007..Celiac disease (CD) is one of the most common lifelong disorders in western countries. However, most cases remain currently undiagnosed in North America, mostly due to poor awareness of CD by primary care physicians... - Effect of the six-mer synthetic peptide (AT1002) fragment of zonula occludens toxin on the intestinal absorption of cyclosporin AKeon Hyoung Song
Pharmacokinetics Biopharmaceutics Laboratory, Department of Pharmaceutical Science, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
Int J Pharm 351:8-14. 2008..This study suggests that AT1002-mediated tight junction modulation, combined with metabolic protection and stabilization, may be used to enhance the low oral bioavailability of certain drugs when administered concurrently... - Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and NutritionIvor D Hill
North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, Flourtown, PA 19031, USA
J Pediatr Gastroenterol Nutr 40:1-19. 2005..This document represents the official recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition on the diagnosis and treatment of celiac disease in children and adolescents... - Relationship of HLA-DQ8 and severity of celiac disease: comparison of New York and Parisian cohortsTimothy C Johnson
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Clin Gastroenterol Hepatol 2:888-94. 2004..We assessed whether differences in the frequency of HLA type may account for differences in severity of the disease by using cohorts of patients from New York and Paris... - Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter studyAlessio Fasano
Center for Celiac Research, University of Maryland School of Medicine, 22 S Greene St, N5W70, PO Box 140, Baltimore, MD 21201 1595, USA
Arch Intern Med 163:286-92. 2003..The aim of this study was to determine the prevalence of CD in at-risk and not-at-risk groups in the United States... - Host-dependent zonulin secretion causes the impairment of the small intestine barrier function after bacterial exposureRamzi El Asmar
Department of Pediatrics and Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Gastroenterology 123:1607-15. 2002..CONCLUSIONS: This zonulin-driven opening of the paracellular pathway may represent a defensive mechanism, which flushes out microorganisms and contributes to the host response against bacterial colonization of the small intestine... - Celiac disease--how to handle a clinical chameleonAlessio Fasano
N Engl J Med 348:2568-70. 2003 - Zonula occludens toxin increases the permeability of molecular weight markers and chemotherapeutic agents across the bovine brain microvessel endothelial cellsChetan S Karyekar
Pharmacokinetics Biopharmaceutics Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 100 Penn Street, Baltimore, Maryland 21201, USA
J Pharm Sci 92:414-23. 2003..Modulation of paracellular transport with Zot may be used to increase the brain permeability of potent central nervous system-active drugs, including anticancer agents... - Intestinal epithelial tight junctions as targets for enteric bacteria-derived toxinsAlessio Fasano
Division of Pediatric Gastroenterology and Nutrition, School of Medicine, University of Maryland, Baltimore 21201, USA
Adv Drug Deliv Rev 56:795-807. 2004..Many pathogenic bacteria exploit this system to accomplish their pathogenic strategies by ultimately modulating intestinal permeability... - Zonula occludens toxin (Zot) interferes with the induction of nasal tolerance to gliadinMauro Rossi
Istituto di Scienze dell Alimentazione, CNR, Via Roma 52, 83100, Avellino, Italy
Immunol Lett 81:217-21. 2002.... - Seeing the light with celiacCarol E Semrad
University of Chicago, Section of Gastroenterology, Chicago, Illinois, USA
Clin Immunol 115:236-9. 2005 - Effect of the biologically active fragment of zonula occludens toxin, delta G, on the intestinal paracellular transport and oral absorption of mannitolNoha N Salama
Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland at Baltimore, 100 Penn Street, Baltimore, MD 21201, USA
Int J Pharm 251:113-21. 2003..CONCLUSIONS: The 12 kDa fragment of Zot, deltaG, enhanced the in vitro transport and oral absorption of the paracellular marker, mannitol, in the presence of protease inhibitors (PI)... - Enhanced nasal absorption of hydrophilic markers after dosing with AT1002, a tight junction modulatorKeon Hyoung Song
Department of Pharmaceutical Science, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
Eur J Pharm Biopharm 69:231-7. 2008..AT1002 significantly increased the nasal absorption of molecular weight markers, PEG4000 and inulin. This study suggests that AT1002 may be used to enhance the systemic availability of macromolecules when administered concurrently... - Latest developments in the pathogenesis and treatment of celiac diseaseDavid Branski
Department of Pediatrics, Hadassah University Hospitals, Hadassah Medical Organization, 91120 Jerusalem, Israel
J Pediatr 149:295-300. 2006 - Infectious diarrhea in children: Working Group Report of the First World Congress of Pediatric Gastroenterology, Hepatology, and NutritionGeoffrey Davidson
Commonwealth Association of Paediatric Gastroenterology and Nutrition, USA
J Pediatr Gastroenterol Nutr 35:S143-50. 2002 - New developments in childhood celiac diseaseCarlo Catassi
Center for Celiac Research, Division of Pediatric Gastroenterology and Nutrition, University of Maryland School of Medicine, 685 West Baltimore Street, HSF Building, Room 465, Baltimore, MD 21201, USA
Curr Gastroenterol Rep 4:238-43. 2002..The epidemiology, pathophysiology, diagnosis, and clinical spectrum of CD in children are highlighted... - Mechanisms of disease: protease functions in intestinal mucosal pathobiologyToni M Antalis
Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Nat Clin Pract Gastroenterol Hepatol 4:393-402. 2007.... - Ganglioside reactive antibodies in the neuropathy associated with celiac diseaseArmin Alaedini
Department of Neurology and Neuroscience, Cornell University, 525 E 68th St, LC 807, New York, NY 10021, USA
J Neuroimmunol 127:145-8. 2002..The neuropathy of celiac disease may be autoimmune and associated with anti-ganglioside antibodies. The presence of IgG reactivity furthermore implicates a T cell-mediated response to ganglioside antigens... - Structural and functional alterations of the gastrointestinal tract following radiation-induced injury in the rhesus monkeyRoy M Vigneulle
Department of Radiation Oncology, Greenebaum Cancer Center, Baltimore, Maryland 21201, USA
Dig Dis Sci 47:1480-91. 2002..Our integrated approach allowed a comprehensive study of the relationship between postirradiation tissue injury and changes in function over time in the gastrointestinal tract of the nonhuman primate... - Celiac disease in the pediatric populationDaniel Gelfond
Division of Pediatric Gastroenterology and Nutrition, University of Maryland School of Medicine, Baltimore 21201, USA
Pediatr Ann 35:275-9. 2006 - Tight junction modulation and its relationship to drug deliveryNoha N Salama
Pharmacokinetics-Biopharmaceutics Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland at Baltimore, 100 Penn Street, Baltimore, Maryland 21201, USA
Adv Drug Deliv Rev 58:15-28. 2006..Above all, the transient opening of the TJs by Zot suggests that it could be used as a novel approach for the safe drug delivery of therapeutic agents... - Dual sugar gut-permeability testing on blood drop in animal modelsFourogh Katouzian
Department of Reproductive and Development Science and IRCCS, Instituto per I'Infanzia Burlo Garofolo Clinica Pediatrica University of Trieste, Via dell'Istria 65/1, IT-34100, Trieste, Italy
Clin Chim Acta 352:191-7. 2005..This cheap simple method allows us to measure in vivo the biological activity of other molecules which modulate the paracellular pathway... - The impact of DeltaG on the oral bioavailability of low bioavailable therapeutic agentsNoha N Salama
Pharmacokinetics-Biopharmaceutics Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland at Baltimore, 20 Penn Street, Baltimore, MD 21201, USA
J Pharmacol Exp Ther 312:199-205. 2005..This study suggests that DeltaG-mediated tight junction modulation, combined with metabolic protection, may be used to enhance the low oral bioavailability of certain drugs when administered concurrently... - Celiac disease as a cause of growth retardation in childhoodCarlo Catassi
Center for Celiac Research, Division of Pediatric Gastroenterology and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Curr Opin Pediatr 16:445-9. 2004..The keystone treatment of celiac disease patients is a lifelong elimination diet in which food products containing gluten are avoided... - Intestinal infections and environmental enteropathy: Working Group report of the second World Congress of Pediatric Gastroenterology, Hepatology, and NutritionEduardo Salazar-Lindo
J Pediatr Gastroenterol Nutr 39:S662-9. 2004 - The effect of delta G on the transport and oral absorption of macromoleculesNoha N Salama
Pharmacokinetics-Biopharmaceutics Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland at Baltimore, 20 Penn Street, Baltimore, Maryland 21201, USA
J Pharm Sci 93:1310-9. 2004..This study suggests that DeltaG may be used to enhance the oral bioavailability of macromolecules (e.g., proteins) after coadministration through modulation of paracellular transport... - Secreted autotransporter toxin produced by a diffusely adhering Escherichia coli strain causes intestinal damage in animal model assaysCarla R Taddei
, , Clinicas e Toxicologicas, , Av. Prof. Lineu Prestes, 580 - bl. 17, CEP 05508-900, , Brazil
FEMS Microbiol Lett 250:263-9. 2005..Our results suggest that DAEC strains may be involved in diarrhea... - Current concepts in the evaluation, diagnosis and management of acute infectious diarrheaSwati Gadewar
Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, University of Maryland School of Medicine, 22 S. Greene St. N5W70, Baltimore, Maryland 21201-1595, USA
Curr Opin Pharmacol 5:559-65. 2005..For this reason, development of vaccines against the most important gastrointestinal infections remains a high priority... - Enhancement of brain distribution of anticancer agents using DeltaG, the 12 kDa active fragment of ZOTDivya Menon
Pharmacokinetics Biopharmaceutics Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20 Penn Street, HSF II 543, Baltimore, MD 21201-6808, USA
Int J Pharm 306:122-31. 2005.... - Zonula occludens toxin acts as an adjuvant through different mucosal routes and induces protective immune responsesMariarosaria Marinaro
Laboratory of Bacteriology and Medical Mycology, Istituto Superiore di Sanit, Viale Regina Elena 299, 00161 Rome, Italy
Infect Immun 71:1897-902. 2003..In conclusion, Zot is a novel and effective mucosal adjuvant that may be useful for the development of mucosal vaccines... - Celiac disease: is the atypical really typical? Summary of the recent National Institutes of Health Consensus Conference and latest advancesSwati Gadewar
Department of Pediatrics, Mucosal Biology Research Center, University of Maryland School of Medicine, Health Science Facility II Room 8345, 20 Penn Street, Baltimore, MD 21201, USA
Curr Gastroenterol Rep 7:455-61. 2005..There are several targets for new treatments. This article briefly summarizes the National Institutes of Health Consensus Statement and gives an overview of new findings in recent years and of future therapeutic options for CD... - Zonula occludens toxin synthetic peptide derivative AT1002 enhances in vitro and in vivo intestinal absorption of low molecular weight heparinNusrat A Motlekar
Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, School of Pharmacy, Amarillo, TX 79106, USA
J Drug Target 14:321-9. 2006..These in vivo and in vitro results suggest that the co-administration of LMWH with AT1002 may be a useful delivery strategy to increase its permeability and hence oral absorption...
Research Grants
- Gut permeability in the pathogenesis of Type 1 diabetesAlessio Fasano; Fiscal Year: 2004....