Research Topics
Species | Philip M FarrellSummaryAffiliation: University of Wisconsin Country: USA Publications
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Publications
The meaning of "early" diagnosis in a new era of cystic fibrosis carePhilip M Farrell
Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, 610 Walnut St, Madison, WI 53726, USA
Pediatrics 119:156-7. 2007
The prevalence of cystic fibrosis in the European UnionPhilip M Farrell
The School of Medicine and Public Health, University of Wisconsin Madison, 610 Walnut Street, 785 WARF, Madison, WI 53726 2397, United States
J Cyst Fibros 7:450-3. 2008..737/10,000 in the 27 EU countries, which is similar to the value of 0.797 in the United States, and only one outlier, namely the Republic of Ireland at 2.98...
Is newborn screening for cystic fibrosis a basic human right?Philip M Farrell
The School of Medicine and Public Health, University of Wisconsin Madison, 610 Walnut Street, 785 WARF, Madison, WI 53726 2397, USA
J Cyst Fibros 7:262-5. 2008..However, if more harm than good is likely, or if regional "readiness" does not exist, newborn screening should be deferred...- Newborn screening for cystic fibrosis in Wisconsin: nine-year experience with routine trypsinogen/DNA testingMichael J Rock
Department of Pediatrics and State Laboratory of Hygiene, University of Wisconsin, Madison, Wisconsin 53792, USA
J Pediatr 147:S73-7. 2005..To describe the development and follow-up confirmatory results of the routine cystic fibrosis (CF) newborn screening (NBS) program in Wisconsin... - Evidence on improved outcomes with early diagnosis of cystic fibrosis through neonatal screening: enough is enough!Philip M Farrell
Department of Pediatrics, Biostatistics Medical Informatics, Radiology, Nutritional Sciences, and the State Laboratory of Hygiene, University of Wisconsin, Madison, WI 53706 1532, USA
J Pediatr 147:S30-6. 2005..To generate and examine evidence in support of diagnosing cystic fibrosis (CF) early through newborn screening (NBS)... - Quality of life of children with cystic fibrosisRebecca L Koscik
Department of Biostatistics and Medical Informatics, Madison, WI 53792, USA
J Pediatr 147:S64-8. 2005.... - Regional differences in the evolution of lung disease in children with cystic fibrosisZhanhai Li
Department of Pediatrics, University of Wisconsin Madison, Madison, Wisconsin 53792 9988, USA
Pediatr Pulmonol 47:635-40. 2012..A variety of potential explanations such as aspiration episodes may be clinically relevant and provide insights regarding therapies... - Preventing early, prolonged vitamin E deficiency: an opportunity for better cognitive outcomes via early diagnosis through neonatal screeningRebecca L Koscik
Department of Biostatistics Medical Informatics, Nutritional Sciences, and Pediatrics, University of Wisconsin, Madison, WI 53792, USA
J Pediatr 147:S51-6. 2005..To evaluate whether early diagnosis of cystic fibrosis (CF) through newborn screening (NBS) and early vitamin E status are associated with cognitive function... - A decision-tree approach to cost comparison of newborn screening strategies for cystic fibrosisJanelle Wells
Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA
Pediatrics 129:e339-47. 2012..We therefore investigated the costs and consequences or specific outcomes of the 2 most commonly used methods... - Newborn screening for cystic fibrosis: parents' preferences regarding counseling at the time of infants' sweat testAudrey Tluczek
School of Nursing, University of Wisconsin Madison, 600 Highland Ave, Madison, Wisconsin 53792, USA
J Genet Couns 15:277-91. 2006..Counseling that matched parents preferences reduced parents' distress while mismatched counseling tended to increase parents' worry about their infant... - Bronchopulmonary disease in children with cystic fibrosis after early or delayed diagnosisPhilip M Farrell
Department of Pediatrics, University of Wisconsin Medical School, Madison, WI 53706 1532, USA
Am J Respir Crit Care Med 168:1100-8. 2003..Although CF neonatal screening provides a potential opportunity for better pulmonary outcomes, it appears that respiratory infections and pancreatic status are the dominant factors in pulmonary prognosis... - Longitudinal development of mucoid Pseudomonas aeruginosa infection and lung disease progression in children with cystic fibrosisZhanhai Li
Department of Pediatrics, University of Wisconsin, Madison 53705-2221, USA
JAMA 293:581-8. 2005..Antibody titers, cough scores, and chest radiographs are early signs of nonmucoid P aeruginosa and especially mucoid P aeruginosa stages... - Cystic fibrosis mutations and genotype-pulmonary phenotype analysisAndrew T Braun
Department of Pediatrics and Biostatistics Medical Informatics, University of Wisconsin, Madison, WI 53705 2221, USA
J Cyst Fibros 5:33-41. 2006..Although there are more than 1000 mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, most of them are uncommon and only limited information exists regarding genotype-pulmonary phenotype relationships... - Relationships among health-related quality of life, pulmonary health, and newborn screening for cystic fibrosisAudrey Tluczek
School of Nursing, University of Wisconsin, Madison, WI 53792, USA
Chest 140:170-7. 2011..The objective of this study was to examine relationships between pulmonary health and health-related quality of life (HRQOL) in patients with cystic fibrosis (CF) evaluated longitudinally in the Wisconsin Newborn Screening Project... - The survival advantage of patients with cystic fibrosis diagnosed through neonatal screening: evidence from the United States Cystic Fibrosis Foundation registry dataHuiChuan J Lai
Department of Nutritional Sciences, University of Wisconsin Madison, WI 53706 1562, USA
J Pediatr 147:S57-63. 2005..To determine the impact of age and condition at the time of diagnosis on survival of patients with cystic fibrosis (CF)... - Pulmonary outcome differences in U.S. and French cystic fibrosis cohorts diagnosed through newborn screeningAimee C Walsh
School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA
J Cyst Fibros 9:44-50. 2010.... - Growth and pulmonary outcomes during the first 2 y of life of breastfed and formula-fed infants diagnosed with cystic fibrosis through the Wisconsin Routine Newborn Screening ProgramSarah A Jadin
Department of Nutritional Sciences, College of Agriculture and Life Sciences, University of Wisconsin, Madison, WI 53706, USA
Am J Clin Nutr 93:1038-47. 2011..The optimal feeding (breast milk, formula, or a combination) for infants with cystic fibrosis (CF) is unknown. Recommendations from the CF Foundation are based on limited data... - Longitudinal pulmonary status of cystic fibrosis children with meconium ileusZhanhai Li
Department of Pediatrics, University of Wisconsin, Madison, Wisconsin, USA
Pediatr Pulmonol 38:277-84. 2004..In conclusion, MI children have worse lung function and more obstructive lung disease than those without MI. Such abnormalities are accompanied by reduced lung volume. MI is a distinct CF phenotype with more severe pulmonary dysfunction... - The sensitivity of lung disease surrogates in detecting chest CT abnormalities in children with cystic fibrosisDon B Sanders
Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
Pediatr Pulmonol 47:567-73. 2012..Quantitative chest radiography scores are useful in detecting mild lung disease, but whether they are sensitive to the presence of CT scan abnormalities has not been evaluated... - Comparing age of cystic fibrosis diagnosis and treatment initiation after newborn screening with two common strategiesDon B Sanders
Department of Pediatrics, University of Wisconsin, Madison, WI, United States
J Cyst Fibros 11:150-3. 2012..Newborn screening (NBS) for CF has become widespread, although there are multiple strategies. Little is known about outcomes such as age of diagnosis after different NBS methods... - Assessing the cost of cystic fibrosis diagnosis and treatmentMarjorie A Rosenberg
University of Wisconsin, Madison, Wisconsin 53705-2221, USA
J Pediatr 147:S101-5. 2005..Individual-level modeling of CF costs must include factors contributing to the severity of the disease and allow for consideration of individual-level utilization, such as the number of hospitalizations... - Association between mucoid Pseudomonas infection and bronchiectasis in children with cystic fibrosisPhilip M Farrell
Department of Pediatrics, University of Wisconsin, Madison, Wis, USA
Radiology 252:534-43. 2009..To correlate the severity of bronchiectasis in children with cystic fibrosis with clinical and microbiologic variables in order to clarify risk factors for the development of irreversible lung disease... - Psychosocial risk associated with newborn screening for cystic fibrosis: parents' experience while awaiting the sweat-test appointmentAudrey Tluczek
Department of Psychiatry, University of Wisconsin, 6001 Research Park Blvd, Madison, WI 53719 1179, USA
Pediatrics 115:1692-703. 2005..The psychosocial effects on parents of infants with abnormal results in cystic fibrosis (CF) newborn screening (NBS) that uses genetic testing remain unclear... - Factors accounting for a missed diagnosis of cystic fibrosis after newborn screeningMichael J Rock
School of Medicine and Public Health, University of Wisconsin Madison, Madison, Wisconsin 53792, USA
Pediatr Pulmonol 46:1166-74. 2011.... - Optimal DNA tier for the IRT/DNA algorithm determined by CFTR mutation results over 14 years of newborn screeningMei W Baker
School of Medicine and Public Health, Newborn Screening Laboratory, Wisconsin State Laboratory of Hygiene, University of Wisconsin Madison, Madison, WI 53706, USA
J Cyst Fibros 10:278-81. 2011..There has been great variation and uncertainty about how many and what CFTR mutations to include in cystic fibrosis (CF) newborn screening algorithms, and very little research on this topic using large populations of newborns... - Chest computed tomography scores of severity are associated with future lung disease progression in children with cystic fibrosisDon B Sanders
Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
Am J Respir Crit Care Med 184:816-21. 2011..Chest computed tomography (CT) scans have been shown to be more sensitive to changes in lung disease than spirometry and may provide a means for predicting future lung disease progression... - Guidelines for diagnosis of cystic fibrosis in newborns through older adults: Cystic Fibrosis Foundation consensus reportPhilip M Farrell
Department of Pediatrics and Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
J Pediatr 153:S4-S14. 2008..Their recommendations, presented herein, involve a combination of clinical presentation, laboratory testing, and genetics to confirm a diagnosis of CF... - Clarification of laboratory and clinical variables that influence cystic fibrosis newborn screening with initial analysis of immunoreactive trypsinogenMolly Kloosterboer
Departments of Population Health Sciences, University of Wisconsin, Madison, WI 53726 2397, USA
Pediatrics 123:e338-46. 2009..Our objectives included clarification of various factors that influence immunoreactive trypsinogen concentrations and resolution of long-standing questions about variations in immunoreactive trypsinogen levels among newborns... - Applying CFTR molecular genetics to facilitate the diagnosis of cystic fibrosis through screeningJoseph L Bobadilla
Department of Pediatrics, University of Wisconsin, USA
Adv Pediatr 49:131-90. 2002 - Association between initial disease presentation, lung disease outcomes, and survival in patients with cystic fibrosisHuiChuan J Lai
Department of Nutritional Sciences, University of Wisconsin College of Agriculture and Life Sciences, 1415 Linden Drive, Madison, WI 53706 1562, USA
Am J Epidemiol 159:537-46. 2004..aeruginosa acquisition compared with patients with presumably "mild" genotypes (class IV or V mutations in one or both alleles)... - Proteomic identification of OprL as a seromarker for initial diagnosis of Pseudomonas aeruginosa infection of patients with cystic fibrosisAparna R Rao
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, 5322 0509, USA
J Clin Microbiol 47:2483-8. 2009..aeruginosa infections during initial infections. Detection of serum reactivity to OprL, along with proteins of the TTSS, and in conjunction with microbiology may diagnose initial P. aeruginosa infections in patients with CF... - Prenatal screening for cystic fibrosis: where are we now?Philip M Farrell
Department of Pediatrics, University of Wisconsin Madison, USA
J Pediatr 141:758-63. 2002 - Multiplexed genetic analysis using an expanded genetic alphabetScott C Johnson
Eragen Biosciences, Inc, Madison, WI 53717, USA
Clin Chem 50:2019-27. 2004..CONCLUSIONS: The unique genetic multiplexing platform was successfully able to test for 31 targets within the CFTR gene and provides accurate genotype assignments in a clinical setting... - Recovery of birth weight z score within 2 years of diagnosis is positively associated with pulmonary status at 6 years of age in children with cystic fibrosisHuiChuan J Lai
Departments of Nutritional Sciences, University of Wisconsin, Madison, WI 53706, USA
Pediatrics 123:714-22. 2009..The present study examined the impact of this early weight recovery on subsequent growth pattern and pulmonary status at 6 years of age... - Enhanced methods for assessment of the trace element composition of Iron Age boneMartin M Shafer
State Laboratory of Hygiene, University of Wisconsin Madison, 2601 Agriculture Drive, Madison, WI 53707 7996, United States
Sci Total Environ 401:144-61. 2008..Large variations in bone core concentrations between the 80 Iron Age specimens examined were observed for all the primary trace elements and in many of the supporting elements, even after correction for major contaminant components... - Cystic fibrosis newborn screening: shifting the key question from "should we screen?" to "how should we screen?"Philip M Farrell
Department of Pediatrics, University of Wisconsin Medical School, Madison, WI 53706, USA
Pediatrics 113:1811-2. 2004 - Delayed diagnosis of US females with cystic fibrosisHui Chuan Lai
Department of Pediatrics, University of Wisconsin School of Medicine, Madison, WI 53792 9988, USA
Am J Epidemiol 156:165-73. 2002..A delay in diagnosis of females with cystic fibrosis was discovered, suggesting either differential recognition of respiratory symptoms or a gender bias... - Associations between academic achievement and psychosocial variables in adolescents with cystic fibrosisAdam J Grieve
School of Medicine and Public Health, University of Wisconsin, Madison, USA
J Sch Health 81:713-20. 2011..This cross-sectional, correlational study examined the potential effects of CF on students' psychosocial and academic development... - Opportunities for quality improvement in cystic fibrosis newborn screeningMolly K Groose
Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53726, USA
J Cyst Fibros 9:284-7. 2010..Using Process Failure Modes and Effects Analysis (PFMEA), we adapted this method to determine if it could be applied to discover and rank high priority QI opportunities... - Longitudinal evaluation of bronchopulmonary disease in children with cystic fibrosisPhilip M Farrell
Department of Pediatrics, University of Wisconsin, Madison, Wisconsin, USA
Pediatr Pulmonol 36:230-40. 2003..Our results also suggest that bronchiectasis and other radiographic evidence of chronic infection are apparent prior to airways obstruction in young CF patients... - A fruitful and gratifying collaborationPhilip M Farrell
University of Wisconsin Medical School, Madison, USA
WMJ 102:89-90. 2003 - Using the power of genetics, genomics and molecular biology to fight cancerPhilip M Farrell
University of Wisconsin Medical School, Madison, USA
WMJ 102:51-2. 2003 - Analysis of the costs of diagnosing cystic fibrosis with a newborn screening programDon S Lee
University of Wisconsin, Madison, Wisconsin, USA
J Pediatr 142:617-23. 2003..66 per newborn and $2.47 per newborn for a national CF newborn screening program. CONCLUSIONS: A CF newborn screening program provides a potentially cost-saving alternative to the traditional method of diagnosis of CF... - Cystic fibrosis: a worldwide analysis of CFTR mutations--correlation with incidence data and application to screeningJoseph L Bobadilla
Department of Pediatrics, University of Wisconsin, Madison, Wisconsin, USA
Hum Mutat 19:575-606. 2002.... - Respiratory infections with Pseudomonas aeruginosa in children with cystic fibrosis: early detection by serology and assessment of risk factorsSusan E H West
Department of Pathobiological Sciences and School of Veterinary Medicine, University of Wisconsin, 1300 University Ave, Madison, WI 53706, USA
JAMA 287:2958-67. 2002..The longitudinal monitoring of P aeruginosa antibody titers, in concert with WCXR score, should facilitate diagnosis and treatment of P aeruginosa pulmonary infections in young children with CF... - Matriculating student perceptions of changes to the admissions interview process at the University of Wisconsin Medical School: a prospective, controlled comparisonMark A Albanese
Office of Medical Education Research and Development, University of Wisconsin Medical School, Madison, Wis, USA
WMJ 102:30-3. 2003..The manner in which interviews are conducted should be critically reviewed periodically to ensure that the interview continues to meet its intended needs... - Welcoming incremental, measurable changePhilip M Farrell
University of Wisconsin Medical School, Madison, USA
WMJ 103:67-8. 2004 - Mission aligned management and allocation: a successfully implemented model of mission-based budgetingGordon T Ridley
Administration and finance, University of Wisconsin Medical School, Madison, Wisconsin 52706-1532, USA
Acad Med 77:124-9. 2002..Finally, they discuss outcomes tracked during two years of full implementation to assess the success of the new MAMA budget process... - Cognitive function of children with cystic fibrosis: deleterious effect of early malnutritionRebecca L Koscik
Department of Biostatistics/Medical Informatics, University of Wisconsin, Madison 53706-1532, USA
Pediatrics 113:1549-58. 2004.... - Potential impact of newborn screening for cystic fibrosis on child survival: a systematic review and analysisScott D Grosse
National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
J Pediatr 149:362-6. 2006..To estimate the population impact of child mortality as a result of cystic fibrosis (CF) potentially preventable by newborn screening... - Gross genomic rearrangements involving deletions in the CFTR gene: characterization of six new events from a large cohort of hitherto unidentified cystic fibrosis chromosomes and meta-analysis of the underlying mechanismsClaude Ferec
INSERM, U613 Génétique Moléculaire et Génétique Epidémiologique, Brest, France
Eur J Hum Genet 14:567-76. 2006.... - Guidelines for implementation of cystic fibrosis newborn screening programs: Cystic Fibrosis Foundation workshop reportAnne Marie Comeau
New England Newborn Screening Program and Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, USA
Pediatrics 119:e495-518. 2007.... - Using science to improve health care delivery and patient carePhilip M Farrell
University of Wisconsin Medical School, UW-Madison, USA
WMJ 103:87-8. 2004 - Plan to address physician shortage requires proper supportPhilip M Farrell
University of Wisconsin Medical School, USA
WMJ 104:73-4. 2005 - Celebrating the importance of medical historyPhilip M Farrell
University of Wisconsin Medical School, USA
WMJ 103:76. 2004 - Much more research needed on injury preventionPhilip M Farrell
WMJ 104:55-6. 2005 - Reproducibility of a scoring system for computed tomography scanning in cystic fibrosisAlan S Brody
Department of Radiology, Cincinnati Children s Hospital, Cincinnati, OH 45229 3039, USA
J Thorac Imaging 21:14-21. 2006..The scoring system used to convert the CT image to numeric data is an essential determinant of the performance of CT scanning... - Excellent progress has been made but significant challenges remainPhilip M Farrell
University of Wisconsin Medical School, USA
WMJ 103:91-2. 2004 - Children with cystic fibrosis produce an immune response against exoenzyme S, a type III cytotoxin of Pseudomonas aeruginosaBruce Banwart
J Infect Dis 185:269-70. 2002 - Enhancing men's urologic healthPhilip M Farrell
University of Wisconsin Medical School, USA
WMJ 101:46-7. 2002 - Newborn screening for cystic fibrosis: ensuring more good than harmMichael H Farrell
Departments of Pediatrics and Internal Medicine, Yale University Medical School, New Haven, Connecticut, USA
J Pediatr 143:707-12. 2003 - New research, perspectives required to understand impact of gender on healthPhilip M Farrell
University of Wisconsin Medical School, USA
WMJ 102:57-8. 2003
Research Grants
- PULMONARY BENEFITS OF CYSTIC FIBROSIS NEONATAL SCREENINGPhilip Farrell; Fiscal Year: 2000..The state that this project will generate that important information. ..
- PULMONARY BENEFITS OF CYSTIC FIBROSIS NEONATAL SCREENINGPhilip Farrell; Fiscal Year: 2005..We will also clarify the risks of screening and delineate for the first time the costs of diagnosis and treatment of CF throughout childhood as well as the cost-effectiveness of screening. ..
- PULMONARY BENEFITS OF CYSTIC FIBROSIS NEONATAL SCREENINGPhilip Farrell; Fiscal Year: 2007..This project has the potential to impact healthcare quite significantly by promoting molecular genetics screening of all newborn infants. ..
- PULMONARY BENEFITS OF CYSTIC FIBROSIS NEONATAL SCREENINGPhilip Farrell; Fiscal Year: 2009..This project has the potential to impact healthcare quite significantly by promoting molecular genetics screening of all newborn infants. ..
- PULMONARY BENEFITS OF CYSTIC FIBROSIS NEONATAL SCREENINGPhilip M Farrell; Fiscal Year: 2010..This project has the potential to impact healthcare quite significantly by promoting molecular genetics screening of all newborn infants. ..
- PULMONARY BENEFITS OF CYSTIC FIBROSIS NEONATAL SCREENINGPhilip Farrell; Fiscal Year: 1993....
- PULMONARY BENEFITS OF CYSTIC FIBROSIS NEONATAL SCREENINGPhilip Farrell; Fiscal Year: 1990....
- PULMONARY BENEFITS OF CYSTIC FIBROSIS NEONATAL SCREENINGPhilip M Farrell; Fiscal Year: 2010..This project has the potential to impact healthcare quite significantly by promoting molecular genetics screening of all newborn infants. ..