P M Farrell

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Evidence on improved outcomes with early diagnosis of cystic fibrosis through neonatal screening: enough is enough!
    Philip M Farrell
    Department of Pediatrics, Biostatistics Medical Informatics, Radiology, Nutritional Sciences, and the State Laboratory of Hygiene, University of Wisconsin, Madison, WI 53706 1532, USA
    J Pediatr 147:S30-6. 2005
  2. ncbi request reprint Cystic fibrosis newborn screening: shifting the key question from "should we screen?" to "how should we screen?"
    Philip M Farrell
    Department of Pediatrics, University of Wisconsin Medical School, Madison, WI 53706, USA
    Pediatrics 113:1811-2. 2004
  3. ncbi request reprint Bronchopulmonary disease in children with cystic fibrosis after early or delayed diagnosis
    Philip M Farrell
    Department of Pediatrics, University of Wisconsin Medical School, Madison, WI 53706 1532, USA
    Am J Respir Crit Care Med 168:1100-8. 2003
  4. ncbi request reprint Early diagnosis of cystic fibrosis through neonatal screening prevents severe malnutrition and improves long-term growth. Wisconsin Cystic Fibrosis Neonatal Screening Study Group
    P M Farrell
    University of Wisconsin Medical School, Madison, Wisconsin, USA
    Pediatrics 107:1-13. 2001
  5. ncbi request reprint Comparison of growth status of patients with cystic fibrosis between the United States and Canada
    H C Lai
    Department of Pediatrics, University of Wisconsin School of Medicine, Madison 53792, USA
    Am J Clin Nutr 69:531-8. 1999
  6. ncbi request reprint Acceleration of lung disease in children with cystic fibrosis after Pseudomonas aeruginosa acquisition
    M R Kosorok
    Department of Pediatrics, University of Wisconsin Medical School, Madison, Wisconsin 53706-1532, USA
    Pediatr Pulmonol 32:277-87. 2001
  7. ncbi request reprint Nutritional status of patients with cystic fibrosis with meconium ileus: a comparison with patients without meconium ileus and diagnosed early through neonatal screening
    H C Lai
    Departments of Pediatrics and Biostatistics, University of Wisconsin School of Medicine, Madison, Wisconsin 53792, USA
    Pediatrics 105:53-61. 2000
  8. ncbi request reprint Risk of persistent growth impairment after alternate-day prednisone treatment in children with cystic fibrosis
    H C Lai
    Department of Pediatrics, University of Wisconsin School of Medicine, Madison 53792, USA
    N Engl J Med 342:851-9. 2000
  9. ncbi request reprint Genetic counseling and neonatal screening for cystic fibrosis: an assessment of the communication process
    D J Ciske
    Department of Pediatrics, University of Wisconsin, Madison, Wisconsin, USA
    Pediatrics 107:699-705. 2001
  10. ncbi request reprint Assessing the quality of life in children with cystic fibrosis
    R J Kotwicki
    University of Wisconsin Medical School, School of Pharmacy, University of Wisconsin Hospital and Clinics, Madison, WI, USA
    WMJ 100:50-4. 2001

Research Grants

  1. EXTRAMURAL FACILITIES IMPROVEMENT PROGRAM
    Robert Golden; Fiscal Year: 2004

Collaborators

Detail Information

Publications52

  1. ncbi request reprint Evidence on improved outcomes with early diagnosis of cystic fibrosis through neonatal screening: enough is enough!
    Philip M Farrell
    Department of Pediatrics, Biostatistics Medical Informatics, Radiology, Nutritional Sciences, and the State Laboratory of Hygiene, University of Wisconsin, Madison, WI 53706 1532, USA
    J Pediatr 147:S30-6. 2005
    ..To generate and examine evidence in support of diagnosing cystic fibrosis (CF) early through newborn screening (NBS)...
  2. ncbi request reprint Cystic fibrosis newborn screening: shifting the key question from "should we screen?" to "how should we screen?"
    Philip M Farrell
    Department of Pediatrics, University of Wisconsin Medical School, Madison, WI 53706, USA
    Pediatrics 113:1811-2. 2004
  3. ncbi request reprint Bronchopulmonary disease in children with cystic fibrosis after early or delayed diagnosis
    Philip M Farrell
    Department of Pediatrics, University of Wisconsin Medical School, Madison, WI 53706 1532, USA
    Am J Respir Crit Care Med 168:1100-8. 2003
    ..Although CF neonatal screening provides a potential opportunity for better pulmonary outcomes, it appears that respiratory infections and pancreatic status are the dominant factors in pulmonary prognosis...
  4. ncbi request reprint Early diagnosis of cystic fibrosis through neonatal screening prevents severe malnutrition and improves long-term growth. Wisconsin Cystic Fibrosis Neonatal Screening Study Group
    P M Farrell
    University of Wisconsin Medical School, Madison, Wisconsin, USA
    Pediatrics 107:1-13. 2001
    ..In addition, the incidence of CF was determined, and the validity of our randomization method assessed by comparing 16 demographic variables...
  5. ncbi request reprint Comparison of growth status of patients with cystic fibrosis between the United States and Canada
    H C Lai
    Department of Pediatrics, University of Wisconsin School of Medicine, Madison 53792, USA
    Am J Clin Nutr 69:531-8. 1999
    ..Differences in growth status of patients with cystic fibrosis (CF) between the United States and Canada were reported in the 1980s based on analysis of data from 2 regional CF centers...
  6. ncbi request reprint Acceleration of lung disease in children with cystic fibrosis after Pseudomonas aeruginosa acquisition
    M R Kosorok
    Department of Pediatrics, University of Wisconsin Medical School, Madison, Wisconsin 53706-1532, USA
    Pediatr Pulmonol 32:277-87. 2001
    ..We also conclude that the WCXR appears to be more sensitive than FEV(1)/FVC in detecting early changes in lung disease associated with CF...
  7. ncbi request reprint Nutritional status of patients with cystic fibrosis with meconium ileus: a comparison with patients without meconium ileus and diagnosed early through neonatal screening
    H C Lai
    Departments of Pediatrics and Biostatistics, University of Wisconsin School of Medicine, Madison, Wisconsin 53792, USA
    Pediatrics 105:53-61. 2000
    ..The objective was to determine if CF patients with meconium ileus (MI) were more likely to be malnourished compared with those without MI who were diagnosed during early infancy through neonatal screening...
  8. ncbi request reprint Risk of persistent growth impairment after alternate-day prednisone treatment in children with cystic fibrosis
    H C Lai
    Department of Pediatrics, University of Wisconsin School of Medicine, Madison 53792, USA
    N Engl J Med 342:851-9. 2000
    ..It is uncertain whether the growth impairment that occurs in children during long-term treatment with glucocorticoids persists after the medication is discontinued and ultimately affects adult height...
  9. ncbi request reprint Genetic counseling and neonatal screening for cystic fibrosis: an assessment of the communication process
    D J Ciske
    Department of Pediatrics, University of Wisconsin, Madison, Wisconsin, USA
    Pediatrics 107:699-705. 2001
    ....
  10. ncbi request reprint Assessing the quality of life in children with cystic fibrosis
    R J Kotwicki
    University of Wisconsin Medical School, School of Pharmacy, University of Wisconsin Hospital and Clinics, Madison, WI, USA
    WMJ 100:50-4. 2001
    ..In fact, the QWB instrument has limited sensitivity and responds more to the extent of physician-determined treatment than to QoL. There is a need for more QoL assessment and better instruments, particularly in young children with CF...
  11. ncbi request reprint Preventing early, prolonged vitamin E deficiency: an opportunity for better cognitive outcomes via early diagnosis through neonatal screening
    Rebecca L Koscik
    Department of Biostatistics Medical Informatics, Nutritional Sciences, and Pediatrics, University of Wisconsin, Madison, WI 53792, USA
    J Pediatr 147:S51-6. 2005
    ..To evaluate whether early diagnosis of cystic fibrosis (CF) through newborn screening (NBS) and early vitamin E status are associated with cognitive function...
  12. ncbi request reprint Assessing the cost of cystic fibrosis diagnosis and treatment
    Marjorie A Rosenberg
    University of Wisconsin, Madison, Wisconsin 53705 2221, USA
    J Pediatr 147:S101-5. 2005
    ..To extend previous evaluations of costs of cystic fibrosis (CF) diagnosis and examine key issues in assessing the CF cost of care...
  13. ncbi request reprint Psychosocial risk associated with newborn screening for cystic fibrosis: parents' experience while awaiting the sweat-test appointment
    Audrey Tluczek
    Department of Psychiatry, University of Wisconsin, 6001 Research Park Blvd, Madison, WI 53719 1179, USA
    Pediatrics 115:1692-703. 2005
    ..The psychosocial effects on parents of infants with abnormal results in cystic fibrosis (CF) newborn screening (NBS) that uses genetic testing remain unclear...
  14. ncbi request reprint Longitudinal development of mucoid Pseudomonas aeruginosa infection and lung disease progression in children with cystic fibrosis
    Zhanhai Li
    Department of Pediatrics, University of Wisconsin, Madison 53705 2221, USA
    JAMA 293:581-8. 2005
    ....
  15. ncbi request reprint Longitudinal pulmonary status of cystic fibrosis children with meconium ileus
    Zhanhai Li
    Department of Pediatrics, University of Wisconsin, Madison, Wisconsin, USA
    Pediatr Pulmonol 38:277-84. 2004
    ..In conclusion, MI children have worse lung function and more obstructive lung disease than those without MI. Such abnormalities are accompanied by reduced lung volume. MI is a distinct CF phenotype with more severe pulmonary dysfunction...
  16. ncbi request reprint The survival advantage of patients with cystic fibrosis diagnosed through neonatal screening: evidence from the United States Cystic Fibrosis Foundation registry data
    HuiChuan J Lai
    Department of Nutritional Sciences, University of Wisconsin Madison, WI 53706 1562, USA
    J Pediatr 147:S57-63. 2005
    ..To determine the impact of age and condition at the time of diagnosis on survival of patients with cystic fibrosis (CF)...
  17. ncbi request reprint Quality of life of children with cystic fibrosis
    Rebecca L Koscik
    Department of Biostatistics and Medical Informatics, Madison, WI 53792, USA
    J Pediatr 147:S64-8. 2005
    ....
  18. ncbi request reprint Newborn screening for cystic fibrosis in Wisconsin: nine-year experience with routine trypsinogen/DNA testing
    Michael J Rock
    Department of Pediatrics and State Laboratory of Hygiene, University of Wisconsin, Madison, Wisconsin 53792, USA
    J Pediatr 147:S73-7. 2005
    ..To describe the development and follow-up confirmatory results of the routine cystic fibrosis (CF) newborn screening (NBS) program in Wisconsin...
  19. pmc Guidelines for diagnosis of cystic fibrosis in newborns through older adults: Cystic Fibrosis Foundation consensus report
    Philip M Farrell
    Department of Pediatrics and Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    J Pediatr 153:S4-S14. 2008
    ..Their recommendations, presented herein, involve a combination of clinical presentation, laboratory testing, and genetics to confirm a diagnosis of CF...
  20. doi request reprint Enhanced methods for assessment of the trace element composition of Iron Age bone
    Martin M Shafer
    State Laboratory of Hygiene, University of Wisconsin Madison, 2601 Agriculture Drive, Madison, WI 53707 7996, United States
    Sci Total Environ 401:144-61. 2008
    ..Large variations in bone core concentrations between the 80 Iron Age specimens examined were observed for all the primary trace elements and in many of the supporting elements, even after correction for major contaminant components...
  21. pmc Is newborn screening for cystic fibrosis a basic human right?
    Philip M Farrell
    The School of Medicine and Public Health, University of Wisconsin Madison, 610 Walnut Street, 785 WARF, Madison, WI 53726 2397, USA
    J Cyst Fibros 7:262-5. 2008
    ..However, if more harm than good is likely, or if regional "readiness" does not exist, newborn screening should be deferred...
  22. ncbi request reprint Guidelines for implementation of cystic fibrosis newborn screening programs: Cystic Fibrosis Foundation workshop report
    Anne Marie Comeau
    New England Newborn Screening Program and Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Pediatrics 119:e495-518. 2007
    ....
  23. ncbi request reprint The meaning of "early" diagnosis in a new era of cystic fibrosis care
    Philip M Farrell
    Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, 610 Walnut St, Madison, WI 53726, USA
    Pediatrics 119:156-7. 2007
  24. ncbi request reprint Potential impact of newborn screening for cystic fibrosis on child survival: a systematic review and analysis
    Scott D Grosse
    National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
    J Pediatr 149:362-6. 2006
    ..To estimate the population impact of child mortality as a result of cystic fibrosis (CF) potentially preventable by newborn screening...
  25. ncbi request reprint Gross genomic rearrangements involving deletions in the CFTR gene: characterization of six new events from a large cohort of hitherto unidentified cystic fibrosis chromosomes and meta-analysis of the underlying mechanisms
    Claude Ferec
    INSERM, U613 Génétique Moléculaire et Génétique Epidémiologique, Brest, France
    Eur J Hum Genet 14:567-76. 2006
    ....
  26. ncbi request reprint Cystic fibrosis mutations and genotype-pulmonary phenotype analysis
    Andrew T Braun
    Department of Pediatrics and Biostatistics Medical Informatics, University of Wisconsin, Madison, WI 53705 2221, USA
    J Cyst Fibros 5:33-41. 2006
    ..Although there are more than 1000 mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, most of them are uncommon and only limited information exists regarding genotype-pulmonary phenotype relationships...
  27. pmc Multiplexed genetic analysis using an expanded genetic alphabet
    Scott C Johnson
    Eragen Biosciences, Inc, Madison, WI 53717, USA
    Clin Chem 50:2019-27. 2004
    ..We describe the development and technical evaluation of a multiplex platform that may foster increased newborn genetic screening...
  28. ncbi request reprint Prenatal screening for cystic fibrosis: where are we now?
    Philip M Farrell
    Department of Pediatrics, University of Wisconsin Madison, USA
    J Pediatr 141:758-63. 2002
  29. ncbi request reprint Applying CFTR molecular genetics to facilitate the diagnosis of cystic fibrosis through screening
    Joseph L Bobadilla
    Department of Pediatrics, University of Wisconsin, USA
    Adv Pediatr 49:131-90. 2002
  30. ncbi request reprint Analysis of the costs of diagnosing cystic fibrosis with a newborn screening program
    Don S Lee
    University of Wisconsin, Madison, Wisconsin, USA
    J Pediatr 142:617-23. 2003
    ..To compare the cost of diagnosing cystic fibrosis (CF) through a newborn screening program with the traditional method and to estimate the cost of CF diagnosis if a national newborn screening program is implemented...
  31. ncbi request reprint Longitudinal evaluation of bronchopulmonary disease in children with cystic fibrosis
    Philip M Farrell
    Department of Pediatrics, University of Wisconsin, Madison, Wisconsin, USA
    Pediatr Pulmonol 36:230-40. 2003
    ..Our results also suggest that bronchiectasis and other radiographic evidence of chronic infection are apparent prior to airways obstruction in young CF patients...
  32. ncbi request reprint Association between initial disease presentation, lung disease outcomes, and survival in patients with cystic fibrosis
    HuiChuan J Lai
    Department of Nutritional Sciences, University of Wisconsin College of Agriculture and Life Sciences, 1415 Linden Drive, Madison, WI 53706 1562, USA
    Am J Epidemiol 159:537-46. 2004
    ..aeruginosa acquisition compared with patients with presumably "mild" genotypes (class IV or V mutations in one or both alleles)...
  33. ncbi request reprint Delayed diagnosis of US females with cystic fibrosis
    Hui Chuan Lai
    Department of Pediatrics, University of Wisconsin School of Medicine, Madison, WI 53792 9988, USA
    Am J Epidemiol 156:165-73. 2002
    ..A delay in diagnosis of females with cystic fibrosis was discovered, suggesting either differential recognition of respiratory symptoms or a gender bias...
  34. ncbi request reprint Respiratory infections with Pseudomonas aeruginosa in children with cystic fibrosis: early detection by serology and assessment of risk factors
    Susan E H West
    Department of Pathobiological Sciences and School of Veterinary Medicine, University of Wisconsin, 1300 University Ave, Madison, WI 53706, USA
    JAMA 287:2958-67. 2002
    ..The ability to diagnose CF by genetic testing at birth makes it possible to determine the temporal sequence of events that result in P aeruginosa-associated pulmonary infections...
  35. ncbi request reprint Cystic fibrosis: a worldwide analysis of CFTR mutations--correlation with incidence data and application to screening
    Joseph L Bobadilla
    Department of Pediatrics, University of Wisconsin, Madison, Wisconsin, USA
    Hum Mutat 19:575-606. 2002
    ....
  36. ncbi request reprint Cognitive function of children with cystic fibrosis: deleterious effect of early malnutrition
    Rebecca L Koscik
    Department of Biostatistics Medical Informatics, University of Wisconsin, Madison 53706 1532, USA
    Pediatrics 113:1549-58. 2004
    ..The objective of this study was to evaluate cognitive function in children with CF and the influence of both early diagnosis through neonatal screening and the potential effect of early malnutrition...
  37. ncbi request reprint Newborn screening for cystic fibrosis: parents' preferences regarding counseling at the time of infants' sweat test
    Audrey Tluczek
    School of Nursing, University of Wisconsin Madison, 600 Highland Ave, Madison, Wisconsin 53792, USA
    J Genet Couns 15:277-91. 2006
    ..Counseling that matched parents preferences reduced parents' distress while mismatched counseling tended to increase parents' worry about their infant...
  38. ncbi request reprint Enhancing men's urologic health
    Philip M Farrell
    University of Wisconsin Medical School, USA
    WMJ 101:46-7. 2002
  39. ncbi request reprint Using the power of genetics, genomics and molecular biology to fight cancer
    Philip M Farrell
    University of Wisconsin Medical School, Madison, USA
    WMJ 102:51-2. 2003
  40. ncbi request reprint Mission aligned management and allocation: a successfully implemented model of mission-based budgeting
    Gordon T Ridley
    Administration and finance, University of Wisconsin Medical School, Madison, Wisconsin 52706 1532, USA
    Acad Med 77:124-9. 2002
    ..Finally, they discuss outcomes tracked during two years of full implementation to assess the success of the new MAMA budget process...
  41. ncbi request reprint Reproducibility of a scoring system for computed tomography scanning in cystic fibrosis
    Alan S Brody
    Department of Radiology, Cincinnati Children s Hospital, Cincinnati, OH 45229 3039, USA
    J Thorac Imaging 21:14-21. 2006
    ..The scoring system used to convert the CT image to numeric data is an essential determinant of the performance of CT scanning...
  42. ncbi request reprint Using science to improve health care delivery and patient care
    Philip M Farrell
    University of Wisconsin Medical School, UW Madison, USA
    WMJ 103:87-8. 2004
  43. ncbi request reprint Plan to address physician shortage requires proper support
    Philip M Farrell
    University of Wisconsin Medical School, USA
    WMJ 104:73-4. 2005
  44. ncbi request reprint Excellent progress has been made but significant challenges remain
    Philip M Farrell
    University of Wisconsin Medical School, USA
    WMJ 103:91-2. 2004
  45. ncbi request reprint Welcoming incremental, measurable change
    Philip M Farrell
    University of Wisconsin Medical School, Madison, USA
    WMJ 103:67-8. 2004
  46. ncbi request reprint Celebrating the importance of medical history
    Philip M Farrell
    University of Wisconsin Medical School, USA
    WMJ 103:76. 2004
  47. ncbi request reprint Much more research needed on injury prevention
    Philip M Farrell
    WMJ 104:55-6. 2005
  48. ncbi request reprint A fruitful and gratifying collaboration
    Philip M Farrell
    University of Wisconsin Medical School, Madison, USA
    WMJ 102:89-90. 2003
  49. ncbi request reprint Newborn screening for cystic fibrosis: ensuring more good than harm
    Michael H Farrell
    Departments of Pediatrics and Internal Medicine, Yale University Medical School, New Haven, Connecticut, USA
    J Pediatr 143:707-12. 2003
  50. ncbi request reprint New research, perspectives required to understand impact of gender on health
    Philip M Farrell
    University of Wisconsin Medical School, USA
    WMJ 102:57-8. 2003
  51. ncbi request reprint Matriculating student perceptions of changes to the admissions interview process at the University of Wisconsin Medical School: a prospective, controlled comparison
    Mark A Albanese
    Office of Medical Education Research and Development, University of Wisconsin Medical School, Madison, Wis, USA
    WMJ 102:30-3. 2003
    ..The purpose of this study was to assess whether changes in the admissions interview process improved matriculating students' perceptions of the quality of the admissions interview process...
  52. ncbi request reprint Children with cystic fibrosis produce an immune response against exoenzyme S, a type III cytotoxin of Pseudomonas aeruginosa
    Bruce Banwart
    J Infect Dis 185:269-70. 2002

Research Grants1

  1. EXTRAMURAL FACILITIES IMPROVEMENT PROGRAM
    Robert Golden; Fiscal Year: 2004
    ....