Research Topics
| John T FarrarSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
Use of the cumulative proportion of responders analysis graph to present pain data over a range of cut-off points: making clinical trial data more understandableJohn T Farrar
Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Pain Symptom Manage 31:369-77. 2006..Whether as a primary or secondary approach to a clinical trial of pain therapy, the display of data in a CPRA format may be useful in the understanding of results and applicability to patient care...
What is clinically meaningful: outcome measures in pain clinical trialsJ T Farrar
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
Clin J Pain 16:S106-12. 2000....
Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scaleJ T Farrar
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Blockley Hall, Room 816, 423 Guardian Drive, Philadelphia, PA 19104, USA
Pain 94:149-58. 2001..Use of a standard outcome across chronic pain studies would greatly enhance the comparability, validity, and clinical applicability of these studies...
Neuropathic cancer pain: the role of adjuvant analgesicsJ T Farrar
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Health System, Philadelphia 19104 6021, USA
Oncology (Williston Park) 15:1435-42, 1445; discussion 1445, 1450-3. 2001..To optimize analgesic therapy in patients with neuropathic pain, both opioid and adjuvant analgesics must be used effectively...
Ability of the canine brief pain inventory to detect response to treatment in dogs with osteoarthritisDorothy Cimino Brown
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Am Vet Med Assoc 233:1278-83. 2008..To determine whether the Canine Brief Pain Inventory (CBPI) can detect changes in dogs with osteoarthritis treated with an NSAID or a placebo...
Moderate and high affinity serotonin reuptake inhibitors increase the risk of upper gastrointestinal toxicityJames D Lewis
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Pharmacoepidemiol Drug Saf 17:328-35. 2008..This study examined the effect of medications that inhibit serotonin uptake on upper gastrointestinal toxicity...
Double-blind, placebo-controlled, randomized pilot study of cerebral blood flow patterns employing SPECT imaging in dental postsurgical pain patients with and without pain reliefAndrew B Newberg
Division of Nuclear Medicine, Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
Clin Ther 33:1894-903. 2011..CBF patterns have not been evaluated in patients with acute postoperative pain...
Symptom burden among cancer survivors: impact of age and comorbidityJun J Mao
Department of Family Medicine and Community Health, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
J Am Board Fam Med 20:434-43. 2007....
Pain and neuropathy in cancer survivorsRosemary C Polomano
University of Pennsylvania School of Nursing, Philadelphia, USA
Cancer Nurs 29:39-47. 2006
A comparison of change in the 0-10 numeric rating scale to a pain relief scale and global medication performance scale in a short-term clinical trial of breakthrough pain intensityJohn T Farrar
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Anesthesiology 112:1464-72. 2010..The correlation of data from patients with breakthrough pain with a Pain Relief Scale and a different global outcome measures will extend our understanding of these measures...
Feasibility trial of electroacupuncture for aromatase inhibitor--related arthralgia in breast cancer survivorsJames J Mao
Department of Family Medicine and Community Health, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
Integr Cancer Ther 8:123-9. 2009..Given the existing evidence for electroacupuncture (EA) for treatment of osteoarthritis in the general population, this study aims to establish the feasibility of studying EA for treating AI-related arthralgia...
Use of an activity monitor to detect response to treatment in dogs with osteoarthritisDorothy Cimino Brown
Department of Clinical Studies Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Am Vet Med Assoc 237:66-70. 2010..To determine whether an activity monitor (AM) could be used to detect changes in activity in dogs with osteoarthritis treated with carprofen or a placebo...
De qi: Chinese acupuncture patients' experiences and beliefs regarding acupuncture needling sensation--an exploratory surveyJun J Mao
Department of Family Medicine and Community Health, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicne, USA
Acupunct Med 25:158-65. 2007..The aim of this study was to describe Chinese acupuncture patients' perceived sensations of, and beliefs about, acupuncture needling...
A novel approach to the use of animals in studies of pain: validation of the canine brief pain inventory in canine bone cancerDorothy Cimino Brown
Department of Clinical Studies, and Mari Lowe Center for Comparative Oncology Research, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6010, USA
Pain Med 10:133-42. 2009..To validate the Canine Brief Pain Inventory (CBPI), which is based on the human Brief Pain Inventory (BPI), in a canine model of spontaneous bone cancer...
Acupuncture expectancy scale: development and preliminary validation in ChinaJun J Mao
Department of Family Medicine and Community Health, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Explore (NY) 3:372-7. 2007....
Acupuncture for nonpalliative radiation therapy-related fatigue: feasibility studyJun James Mao
Department of Family Medicine and Community Health, Center for Clinical Epidemiology and Biostatistics, and Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA
J Soc Integr Oncol 7:52-8. 2009..Acupuncture has the potential to prevent RT-related fatigue, which will need to be confirmed by conducting a randomized controlled trial...
Prescribing NSAIDs to patients on SSRIs: possible adverse drug interaction of importance to dental practitionersAndres Pinto
Oral Medicine Clinical Center, Department of Oral Medicine, University of Pennsylvania, School of Dental Medicine, Philadelphia, Pennsylvania, USA
Compend Contin Educ Dent 30:142-51; quiz 152, 154. 2009..Nonetheless, a causal inference cannot be made based on the available evidence and the lack of randomized controlled clinical trials...
Development of and psychometric testing for the Brief Pain Inventory-Facial in patients with facial pain syndromesJohn Y K Lee
Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19107, USA
J Neurosurg 113:516-23. 2010..The complete 18-item instrument is referred to as the BPI-Facial...
The clinical importance of changes in the 0 to 10 numeric rating scale for worst, least, and average pain intensity: analyses of data from clinical trials of duloxetine in pain disordersJohn T Farrar
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA19041, USA
J Pain 11:109-18. 2010..Our findings support a standard definition of a clinically important difference in clinical trials of chronic-pain therapies...
Is satisfaction with pain management a valid and reliable quality indicator for use in nursing homes?David J Casarett
Philadelphia VA Medical Center, Pennsylvania, USA
J Am Geriatr Soc 50:2029-34. 2002..To determine whether satisfaction with pain management can be measured reliably in nursing homes and to gather preliminary data about the validity of satisfaction assessments in this population...
Oral transmucosal fentanyl citrate: randomized, double-blinded, placebo-controlled trial for treatment of breakthrough pain in cancer patientsJ T Farrar
University of Pennsylvania School of Medicine, Philadelphia 19104, USA
J Natl Cancer Inst 90:611-6. 1998..We conducted a multicenter, randomized, double-blinded, placebo-controlled trial of OTFC for cancer-related breakthrough pain...
Severe sudden visual loss caused by pseudotumor cerebri and lumboperitoneal shunt failureG T Liu
Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia 19104, USA
Am J Ophthalmol 122:129-31. 1996..Severe vistral acuity loss associated with pseudotumor cerebri is usually caused by chronic optic disk edema or a retinal abnormality...
Iyengar Yoga versus Enhanced Usual Care on Blood Pressure in Patients with Prehypertension to Stage I Hypertension: a Randomized Controlled TrialDebbie L Cohen
Renal Division, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Evid Based Complement Alternat Med 2011:546428. 2011..Twelve weeks of IY produces clinically meaningful improvements in 24 h SBP and DBP. Larger studies are needed to establish the long term efficacy, acceptability, utility and potential mechanisms of IY to control BP...
The master of science in clinical epidemiology degree program of the Perelman School of Medicine at the University of Pennsylvania: a model for clinical research trainingBrian L Strom
Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
Acad Med 87:74-80. 2012....
Patterns and risk factors associated with aromatase inhibitor-related arthralgia among breast cancer survivorsJun J Mao
Department of Family Medicine and Community Health, University of Pennsylvania Health System, Philadelphia, PA, USA
Cancer 115:3631-9. 2009..The objective of this study was to evaluate the perceived onset, characteristics, and risk factors for AI-related arthralgia (AIA)...
Cerebral blood flow effects of yoga training: preliminary evaluation of 4 casesDebbie L Cohen
Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
J Altern Complement Med 15:9-14. 2009..Experienced practitioners of yoga have been shown to alter brain function, but this case series measured cerebral blood flow before and after a 12-week training program in Iyengar yoga (IY) for naïve subjects...
A novel 12-week study, with three randomized, double-blind placebo-controlled periods to evaluate fentanyl buccal tablets for the relief of breakthrough pain in opioid-tolerant patients with noncancer-related chronic painJohn T Farrar
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
Pain Med 11:1313-27. 2010..To evaluate the time of onset, overall efficacy, and safety of fentanyl buccal tablet (FBT) for noncancer-related breakthrough pain (BTP) in opioid-tolerant adults over 12 weeks...
Advances in clinical research methodology for pain clinical trialsJohn T Farrar
University of Pennsylvania, Philadelphia, Pennsylvania, USA
Nat Med 16:1284-93. 2010....
Development and psychometric testing of an instrument designed to measure chronic pain in dogs with osteoarthritisDorothy Cimino Brown
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Am J Vet Res 68:631-7. 2007..To develop and psychometrically test an owner self-administered questionnaire designed to assess severity and impact of chronic pain in dogs with osteoarthritis...
Pain and neuropathy in cancer survivors. Surgery, radiation, and chemotherapy can cause pain; research could improve its detection and treatmentRosemary C Polomano
University of Pennsylvania School of Nursing, Philadelphia, USA
Am J Nurs 106:39-47. 2006
Use of complementary and alternative medicine and prayer among a national sample of cancer survivors compared to other populations without cancerJun J Mao
Department of Family Medicine and Community Health, University of Pennsylvania School of Medicine, 2 Gates Building 3400 Spruce Street, Philadelphia, PA 19104, USA
Complement Ther Med 15:21-9. 2007..Extensive use of complementary and alternative medicine (CAM) among cancer survivors has been described in literature, but the rate has not previously been compared to other groups in a true population sample...
Scope of symptoms and self-management strategies for chemotherapy-induced peripheral neuropathy in breast cancer patientsRebecca M Speck
Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, USA
Support Care Cancer 20:2433-9. 2012..We also examined the variety of taxane-related side effects in women with and without CIPN in order to discriminate the CIPN symptom experience...
Women suffer more short and long-term pain than men after major thoracotomyEdward A Ochroch
Department of Anesthesiology, University of Pennsylvania Health System, USA
Clin J Pain 22:491-8. 2006..We set out to determine whether sex affected pain and recovery after major surgery by analyzing data originally collected to determine the effect of the timing of epidural analgesia on long-term outcome after thoracotomy...
Validity, reliability, and clinical importance of change in a 0-10 numeric rating scale measure of spasticity: a post hoc analysis of a randomized, double-blind, placebo-controlled trialJohn T Farrar
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Blockley Hall, Room 816, 423 Guardian Drive, Philadelphia, PA 19104, USA
Clin Ther 30:974-85. 2008..In a patient with clinical spasticity, the best judge of the perceived severity of the symptom is the patient...
Cerebral blood flow effects of pain and acupuncture: a preliminary single-photon emission computed tomography imaging studyAndrew B Newberg
Department of Radiology, University of Pennsylvania Health System, Philadelphia, USA
J Neuroimaging 15:43-9. 2005..The purpose of this study was to investigate the cerebral blood flow changes associated with the analgesic effect of acupuncture in patients with chronic pain...
The influence of race and socioeconomic factors on patient acceptance of perioperative epidural analgesiaEdward Andrew Ochroch
Department of Anesthesiology and Critical Care, University of Pennsylvania Health System, University of Pennsylvania, Pennsylvania, USA
Anesth Analg 105:1787-92, table of contents. 2007....
Clinically important changes in acute pain outcome measures: a validation studyJohn T Farrar
University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Pain Symptom Manage 25:406-11. 2003..This provides support for the usefulness of these values in future clinical trials of pain therapy...
Hospitalization and mortality rates from peptic ulcer disease and GI bleeding in the 1990s: relationship to sales of nonsteroidal anti-inflammatory drugs and acid suppression medicationsJames D Lewis
Center for Clinical Epidemiology and Biostatistics, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104-6021, USA
Am J Gastroenterol 97:2540-9. 2002..Changing rates of peptic ulcer disease morbidity and mortality were temporally related to increasing sales of antiulcerants but not to change in sales of NSAIDs...
Tolerability of red yeast rice (2,400 mg twice daily) versus pravastatin (20 mg twice daily) in patients with previous statin intoleranceSteven C Halbert
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Am J Cardiol 105:198-204. 2010..In conclusion, red yeast rice was tolerated as well as pravastatin and achieved a comparable reduction of low-density lipoprotein cholesterol in a population previously intolerant to statins...
Risk of serious upper gastrointestinal toxicity with over-the-counter nonaspirin nonsteroidal anti-inflammatory drugsJames D Lewis
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Gastroenterology 129:1865-74. 2005..Less is known about over-the-counter (OTC) NANSAIDs, which are typically used at lower doses and for shorter durations. This study assessed the risk of toxicity with OTC NANSAIDs...
The effect of OPC Factor on energy levels in healthy adults ages 45-65: a phase IIb randomized controlled trialPatrick J Lariccia
Penn Presbyterian Medical Center, Philadelphia, PA, USA
J Altern Complement Med 14:723-32. 2008..To determine the efficacy of the food supplement OPC Factor to increase energy levels in healthy adults aged 45 to 65...
What postoperative outcomes matter to pediatric patients?Giovanni Cucchiaro
Department of Anesthesia and Critical Care Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Anesth Analg 102:1376-82. 2006..Children can express opinions about preferred postoperative outcomes and provide useful input about their care. Girls, more than boys, seem to perceive vomiting as less important than improved pain control in the postoperative period...
Core outcome measures for chronic pain clinical trials: IMMPACT recommendationsRobert H Dworkin
Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Pain 113:9-19. 2005
Core outcome domains for chronic pain clinical trials: IMMPACT recommendationsDennis C Turk
Department of Anesthesiology, University of Washington, Seattle, WA 98195, USA
Pain 106:337-45. 2003....
Long-term use of controlled-release oxycodone for noncancer pain: results of a 3-year registry studyRussell K Portenoy
Department of Pain Medicine and Palliative Care, Beth Israel Medical Center, New York, NY 10003, USA
Clin J Pain 23:287-99. 2007..To evaluate the outcomes associated with the use of controlled-release (CR) oxycodone for up to 3 years in the treatment of noncancer pain...
Spinal fusion or exercise and cognitive intervention? In search of the answersRosemary C Polomano
Pain 122:4-5. 2006
Duloxetine for the management of diabetic peripheral neuropathic pain: evidence-based findings from post hoc analysis of three multicenter, randomized, double-blind, placebo-controlled, parallel-group studiesDaniel K Kajdasz
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
Clin Ther 29:2536-46. 2007....
Interpreting the clinical importance of treatment outcomes in chronic pain clinical trials: IMMPACT recommendationsRobert H Dworkin
Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Pain 9:105-21. 2008....
Identifying important outcome domains for chronic pain clinical trials: an IMMPACT survey of people with painDennis C Turk
Department of Anesthesiology, University of Washington, Seattle, WA 98195, USA
Pain 137:276-85. 2008..These multiple outcomes should be considered when evaluating the efficacy and effectiveness of chronic pain treatments...
The effect of group aerobic exercise and t'ai chi on functional outcomes and quality of life for persons living with acquired immunodeficiency syndromeMary Lou Galantino
Richard Stockton College of New Jersey, Pomona, NJ 08240, USA
J Altern Complement Med 11:1085-92. 2005..Further research is warranted to evaluate additional exercise interventions that are accessible, safe, and cost-effective for the HIV population...
A titration strategy is needed to manage breakthrough cancer pain effectively: observations from data pooled from three clinical trialsNeil A Hagen
Department of Medicine, Tom Baker Cancer Centre, 1331 29 Street NW, Calgary, Alberta, Canada
J Palliat Med 10:47-55. 2007..Breakthrough pain is a prevalent and serious problem in patients with cancer. However, it is not known how best to predict the effective dose of breakthrough opioid for any given patient...
Comparison of logistic regression versus propensity score when the number of events is low and there are multiple confoundersM Soledad Cepeda
School of Medicine, Javeriana University, Bogota, Colombia
Am J Epidemiol 158:280-7. 2003..Logistic regression is the technique of choice when there are at least eight events per confounder...
Side effects of opioids during short-term administration: effect of age, gender, and raceM Soledad Cepeda
Department of Anesthesiology, and Clinical Epidemiology Unit. Javeriana Univeristy, Bogota, Colombia
Clin Pharmacol Ther 74:102-12. 2003..The risk of respiratory depression increases substantially after 60 years of age. Women have nausea and vomiting more often than men. The effect of race deserves further investigation...
Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendationsRobert H Dworkin
Department of Anesthesiology, University of Rochester School of Meedicine and Dentistry, Rochester, NY 14642
Arch Neurol 60:1524-34. 2003..Continued progress in basic and clinical research on the pathophysiologic mechanisms of neuropathic pain may make it possible to predict effective treatments for individual patients by application of a pain mechanism-based approach...
Pharmacologic management of neuropathic pain: evidence-based recommendationsRobert H Dworkin
University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Pain 132:237-51. 2007..Long-term studies, head-to-head comparisons between medications, studies involving combinations of medications, and RCTs examining treatment of central NP are lacking and should be a priority for future research...
The impact of modified Hatha yoga on chronic low back pain: a pilot studyMary Lou Galantino
Program in Physical Therapy, Richard Stockton College of New Jersey, USA
Altern Ther Health Med 10:56-9. 2004..Additional functional outcome measures should be explored. This pilot study supports the need for more research investigating the effect of yoga for this population...
Point of viewJohn T Farrar
Clin J Pain 20:367. 2004
Developing patient-reported outcome measures for pain clinical trials: IMMPACT recommendationsDennis C Turk
University of Washington, Seattle, WA 98195, USA
Pain 125:208-15. 2006
Economic evaluation of oral treatments for neuropathic painM Soledad Cepeda
Department of Anesthesia and Clinical Epidemiology Unit, Javeriana University School of Medicine, Bogota, Colombia
J Pain 7:119-28. 2006..We report a cost-effectiveness evaluation of treatments for neuropathic pain...
Research Grants
- Brain Imaging-Acupuncture and OsteoarthritisJohn Farrar; Fiscal Year: 2004..Defining the areas of interest and the techniques to use, will allow a comprehensive study of the effect on CBF of acupuncture therapy. ..
