Marilyn Farquhar

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint A man for all seasons: reflections on the life and legacy of George Palade
    Marilyn G Farquhar
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Annu Rev Cell Dev Biol 28:1-28. 2012
  2. pmc Calnuc plays a role in dynamic distribution of Galphai but not Gbeta subunits and modulates ACTH secretion in AtT-20 neuroendocrine secretory cells
    Ping Lin
    Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093 0651, USA
    Mol Neurodegener 4:15. 2009
  3. ncbi request reprint The Golgi apparatus: 100 years of progress and controversy
    M G Farquhar
    Dept of Pathology, University of California, San Diego, USA
    Trends Cell Biol 8:2-10. 1998
  4. pmc The glomerular basement membrane: not gone, just forgotten
    Marilyn G Farquhar
    Department of Cellular and Molecular Medicine, UCSD, La Jolla, California 92093, USA
    J Clin Invest 116:2090-3. 2006
  5. ncbi request reprint GAIP, GIPC and Galphai3 are concentrated in endocytic compartments of proximal tubule cells: putative role in regulating megalin's function
    Xiaojing Lou
    Department of Cellular and Molecular Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    J Am Soc Nephrol 13:918-27. 2002
  6. pmc A G{alpha}i-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate
    Pradipta Ghosh
    Department of Cellular and Molecular Medicine and Medicine, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Mol Biol Cell 21:2338-54. 2010
  7. pmc A structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration
    Mikel Garcia-Marcos
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 285:12765-77. 2010
  8. ncbi request reprint Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles
    Helen Le-Niculescu
    Department of Cellular and Molecular Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    J Biol Chem 280:22012-20. 2005
  9. pmc GIV is a nonreceptor GEF for G alpha i with a unique motif that regulates Akt signaling
    Mikel Garcia-Marcos
    Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 106:3178-83. 2009
  10. pmc Activation of Galphai3 triggers cell migration via regulation of GIV
    Pradipta Ghosh
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 182:381-93. 2008

Research Grants

  1. Spatial Regulation of RGS and G Protein Signaling
    Marilyn Gist Farquhar; Fiscal Year: 2010
  2. Spatial Regulation of RGS and G Protein Signaling
    Marilyn Farquhar; Fiscal Year: 2007
  3. HORMONE SECRETION AND PROCESSING IN PITUITARY CELLS
    Marilyn Farquhar; Fiscal Year: 2007
  4. Glomerular Capillaries-- Normal and Pathologic
    Marilyn Farquhar; Fiscal Year: 2007
  5. HORMONE SECRETION AND PROCESSING IN PITUITARY CELLS
    Marilyn Gist Farquhar; Fiscal Year: 2010
  6. Spatial Regulation of RGS and G Protein Signaling
    Marilyn Farquhar; Fiscal Year: 2009
  7. HORMONE SECRETION AND PROCESSING IN PITUITARY CELLS
    Marilyn Farquhar; Fiscal Year: 2009
  8. Spatial Regulation of RGS and G Protein Signaling
    Marilyn Farquhar; Fiscal Year: 2007
  9. GRADUATE TRAINING IN CANCER CELL BIOLOGY
    Marilyn Farquhar; Fiscal Year: 2007
  10. HORMONE SECRETION AND PROCESSING IN PITUITARY CELLS
    Marilyn Farquhar; Fiscal Year: 2004

Collaborators

  • Pradipta Ghosh
  • Bin Zheng
  • Paul Insel
  • Patricia Thistlethwaite
  • MARK E VON ZASTROW
  • Seth Field
  • Tetsuro Takeda
  • Sanna Lehtonen
  • Mikel Garcia-Marcos
  • Thierry Fischer
  • Huilin Zhou
  • Krystyna Kudlicka
  • Ping Lin
  • Hemal H Patel
  • Brian P Head
  • Timo Meerloo
  • Hirotaka Fukasawa
  • Tingdong Tang
  • Holly C Dippold
  • Jennifer J Ryan
  • Noriaki Iino
  • James S Swaney
  • Ingrid R Niesman
  • Fiona Murray
  • Helen Le-Niculescu
  • Yun Wu Zhang
  • Ingrid Niesman
  • Masaaki Nagai
  • Eric Elenko
  • Tammie McQuistan
  • Xiaojing Lou
  • Jason Ear
  • Marshall C Peterman
  • Michelle M Ng
  • Anne N Murphy
  • Monica L Kerr
  • Scott Bornheimer
  • Ronald Sim
  • Sun Kyung Lee
  • Suzette E Farber-Katz
  • Swetha Madhavarapu
  • Patricia A Wiharto
  • Greg J Fuchs
  • Christine Lavoie
  • Haining Huang
  • Kenneth A Galbraith
  • Sheng Hong Chen
  • Rikke Nielsen
  • Mehul Shah
  • Shen Zhang
  • Ralph T Schermuly
  • Jason X J Yuan
  • Ryan Y S Suda
  • Atsushi Miyanohara
  • Utako Yokoyama
  • Soni Savai Pullamsetti
  • David M Roth
  • Gopal Thinakaran
  • Huaxi Xu
  • Kulandaivelu S Vetrivel
  • Feng Li
  • Wen Jie Luo
  • Fang Liao
  • Philip C Wong
  • Hong Wang
  • Luc DeVries
  • Eero Lehtonen
  • Harry Holthofer
  • Tim Harding
  • Luc De Vries
  • Robert A Orlando

Detail Information

Publications24

  1. doi request reprint A man for all seasons: reflections on the life and legacy of George Palade
    Marilyn G Farquhar
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Annu Rev Cell Dev Biol 28:1-28. 2012
    ....
  2. pmc Calnuc plays a role in dynamic distribution of Galphai but not Gbeta subunits and modulates ACTH secretion in AtT-20 neuroendocrine secretory cells
    Ping Lin
    Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093 0651, USA
    Mol Neurodegener 4:15. 2009
    ..Thus calnuc may connect G protein signaling and calcium signaling during regulated secretion...
  3. ncbi request reprint The Golgi apparatus: 100 years of progress and controversy
    M G Farquhar
    Dept of Pathology, University of California, San Diego, USA
    Trends Cell Biol 8:2-10. 1998
    ....
  4. pmc The glomerular basement membrane: not gone, just forgotten
    Marilyn G Farquhar
    Department of Cellular and Molecular Medicine, UCSD, La Jolla, California 92093, USA
    J Clin Invest 116:2090-3. 2006
    ..Changes in the permeability of the GBM and its organization were primary to changes in the epithelium, as they preceded foot process effacement and loss of slit diaphragms...
  5. ncbi request reprint GAIP, GIPC and Galphai3 are concentrated in endocytic compartments of proximal tubule cells: putative role in regulating megalin's function
    Xiaojing Lou
    Department of Cellular and Molecular Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    J Am Soc Nephrol 13:918-27. 2002
    ....
  6. pmc A G{alpha}i-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate
    Pradipta Ghosh
    Department of Cellular and Molecular Medicine and Medicine, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Mol Biol Cell 21:2338-54. 2010
    ..Thus, inclusion or exclusion of GIV's GEF motif, which activates Galphai, modulates EGFR signaling, generates migration-proliferation dichotomy, and most likely influences cancer progression...
  7. pmc A structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration
    Mikel Garcia-Marcos
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 285:12765-77. 2010
    ....
  8. ncbi request reprint Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles
    Helen Le-Niculescu
    Department of Cellular and Molecular Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    J Biol Chem 280:22012-20. 2005
    ....
  9. pmc GIV is a nonreceptor GEF for G alpha i with a unique motif that regulates Akt signaling
    Mikel Garcia-Marcos
    Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 106:3178-83. 2009
    ....
  10. pmc Activation of Galphai3 triggers cell migration via regulation of GIV
    Pradipta Ghosh
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 182:381-93. 2008
    ....
  11. pmc Cell junction-associated proteins IQGAP1, MAGI-2, CASK, spectrins, and alpha-actinin are components of the nephrin multiprotein complex
    Sanna Lehtonen
    Departments of Cellular and Molecular Medicine and Pathology, and Ludwig Institute for Cancer Research, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 102:9814-9. 2005
    ..Despite their special morphology and function, there is considerable compositional similarity between the podocyte slit diaphragm and typical junctional complexes of other epithelial cells...
  12. pmc Essential role of RGS-PX1/sorting nexin 13 in mouse development and regulation of endocytosis dynamics
    Bin Zheng
    Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093 0651, USA
    Proc Natl Acad Sci U S A 103:16776-81. 2006
    ..Taken together, our findings demonstrate an essential role for RGS-PX1/SNX13 in mouse development and provide previously undescribed insights into its cellular function in the regulation of endocytosis dynamics...
  13. pmc The endocytic adaptor protein ARH associates with motor and centrosomal proteins and is involved in centrosome assembly and cytokinesis
    Sanna Lehtonen
    Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Mol Biol Cell 19:2949-61. 2008
    ..We propose that ARH participates in centrosomal and mitotic dynamics by interacting with centrosomal proteins. Whether the centrosomal and mitotic functions of ARH are related to its endocytic role remains to be established...
  14. pmc Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components
    Yun Wu Zhang
    Center for Neuroscience and Aging, The Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 280:17020-6. 2005
    ....
  15. pmc Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin
    Sanna Lehtonen
    Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California, USA
    Am J Pathol 165:923-36. 2004
    ....
  16. pmc Regulation of epidermal growth factor receptor degradation by heterotrimeric Galphas protein
    Bin Zheng
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093 0651, USA
    Mol Biol Cell 15:5538-50. 2004
    ..These observations define a novel regulatory role for Galphas in EGF receptor degradation and provide mechanistic insights into the function of Galphas in endocytic sorting...
  17. ncbi request reprint Microtubules and actin microfilaments regulate lipid raft/caveolae localization of adenylyl cyclase signaling components
    Brian P Head
    Department of Pharmacology, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 281:26391-9. 2006
    ..We conclude that microtubules and actin filaments restrict cAMP formation by regulating the localization and interaction of GPCR-G(s)-AC in lipid rafts/caveolae...
  18. pmc GOLPH3 bridges phosphatidylinositol-4- phosphate and actomyosin to stretch and shape the Golgi to promote budding
    Holly C Dippold
    Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0707, USA
    Cell 139:337-51. 2009
    ..Consequently, this tensile force stretches the Golgi into the extended ribbon observed by fluorescence microscopy and the familiar flattened form observed by electron microscopy...
  19. pmc Slit diaphragms contain tight junction proteins
    Hirotaka Fukasawa
    Department of Cellular and Molecular Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 0651, USA
    J Am Soc Nephrol 20:1491-503. 2009
    ..The contribution of these proteins to the assembly of slit diaphragms and potential signaling cascades requires further investigation...
  20. ncbi request reprint Increased smooth muscle cell expression of caveolin-1 and caveolae contribute to the pathophysiology of idiopathic pulmonary arterial hypertension
    Hemal H Patel
    University of California, San Diego, Department of Pharmacology, 9500 Gilman Dr, La Jolla, CA 92093 0636, USA
    FASEB J 21:2970-9. 2007
    ..The results imply that disruption of caveolae in PASMC may provide a novel therapeutic approach to attenuate disease manifestations of IPAH...
  21. pmc hNOA1 interacts with complex I and DAP3 and regulates mitochondrial respiration and apoptosis
    Tingdong Tang
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093 0651, USA
    J Biol Chem 284:5414-24. 2009
    ..Thus, based on its interactions with both Complex I and DAP3, hNOA1 may play a role in mitochondrial respiration and apoptosis...
  22. ncbi request reprint Spatial regulation of Galphai protein signaling in clathrin-coated membrane microdomains containing GAIP
    Eric Elenko
    Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093 0651, USA
    Mol Pharmacol 64:11-20. 2003
    ..This constitutes a novel mechanism for regulation of Galpha signaling through spatial segregation of a GAP in clathrin-coated pits...
  23. pmc The adaptor protein ARH escorts megalin to and through endosomes
    Masaaki Nagai
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Mol Biol Cell 14:4984-96. 2003
    ....
  24. pmc Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP
    Thierry Fischer
    Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 100:8270-5. 2003
    ..RGS-GAIP functions as a bifunctional adaptor that binds to G alpha subunits through its RGS domain and to GIPN through its cysteine string motif...

Research Grants49

  1. Spatial Regulation of RGS and G Protein Signaling
    Marilyn Gist Farquhar; Fiscal Year: 2010
    ..Due to their crucial functions in cell regulation these new molecules represent attractive targets for development of pharmacologic and anti-tumor agents. ..
  2. Spatial Regulation of RGS and G Protein Signaling
    Marilyn Farquhar; Fiscal Year: 2007
    ..Due to their broad functions in regulation of cell functions, including cell growth, differentiation and mitogenesis, RGS proteins represent attractive targets for development of pharmacologic and anti-tumor agents. ..
  3. HORMONE SECRETION AND PROCESSING IN PITUITARY CELLS
    Marilyn Farquhar; Fiscal Year: 2007
    ..These studies can be expected to considerably expand knowledge of the role of G proteins in regulated secretion of hormones and in endocytosis and signaling of hormones by GPCR. ..
  4. Glomerular Capillaries-- Normal and Pathologic
    Marilyn Farquhar; Fiscal Year: 2007
    ..abstract_text> ..
  5. HORMONE SECRETION AND PROCESSING IN PITUITARY CELLS
    Marilyn Gist Farquhar; Fiscal Year: 2010
    ..These studies can be expected to considerably expand knowledge of the role of G proteins in regulated secretion of hormones and in endocytosis and signaling of hormones by GPCR. ..
  6. Spatial Regulation of RGS and G Protein Signaling
    Marilyn Farquhar; Fiscal Year: 2009
    ..Due to their crucial functions in cell regulation these new molecules represent attractive targets for development of pharmacologic and anti-tumor agents. ..
  7. HORMONE SECRETION AND PROCESSING IN PITUITARY CELLS
    Marilyn Farquhar; Fiscal Year: 2009
    ..These studies can be expected to considerably expand knowledge of the role of G proteins in regulated secretion of hormones and in endocytosis and signaling of hormones by GPCR. ..
  8. Spatial Regulation of RGS and G Protein Signaling
    Marilyn Farquhar; Fiscal Year: 2007
    ..1 ..
  9. GRADUATE TRAINING IN CANCER CELL BIOLOGY
    Marilyn Farquhar; Fiscal Year: 2007
    ....
  10. HORMONE SECRETION AND PROCESSING IN PITUITARY CELLS
    Marilyn Farquhar; Fiscal Year: 2004
    ..This work can be expected to provide novel findings and new insights into the mechanisms by which hormone uptake vin via GPCR is controlled and hormone processing and secretion are regulated. ..
  11. HORMONE SECRETION AND PROCESSING IN PITUITARY CELLS
    Marilyn Farquhar; Fiscal Year: 1999
    ..Fundamental information derived from these studies should provide new information on the molecular mechanisms of hormone secretion in neuroendocrine cells. ..
  12. GLOMERULAR CAPILLARIES --NORMAL AND PATHOLOGIC
    Marilyn Farquhar; Fiscal Year: 2003
    ..abstract_text> ..
  13. GLOMERULAR CAPILLARIES--NORMAL & PATHOLOGIC
    Marilyn Farquhar; Fiscal Year: 1993
    ..It is hoped that these studies will provide new insights into the cellular and molecular aspects of glomerular filtration and its alterations in various glomerular diseases...