C Farquhar

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc High uptake of postpartum hormonal contraception among HIV-1-seropositive women in Kenya
    Jennifer Balkus
    Department of Epidemiology, University of Washington, Seattle, Washington 98104, USA
    Sex Transm Dis 34:25-9. 2007
  2. pmc The role of G protein gene GNB3 C825T polymorphism in HIV-1 acquisition, progression and immune activation
    Jennifer Juno
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada
    Retrovirology 9:1. 2012
  3. pmc Uptake of prevention of mother to child transmission interventions in Kenya: health systems are more influential than stigma
    John Kinuthia
    Department of Obstetrics and Gynaecology, Kenyatta National Hospital University of Nairobi, Kenya
    J Int AIDS Soc 14:61. 2011
  4. pmc Medication diaries do not improve outcomes with highly active antiretroviral therapy in Kenyan children: a randomized clinical trial
    Dalton C Wamalwa
    Department of Paediatrics University of Nairobi, Nairobi, Kenya
    J Int AIDS Soc 12:8. 2009
  5. pmc Predictors of mortality in HIV-1 infected children on antiretroviral therapy in Kenya: a prospective cohort
    Dalton C Wamalwa
    Department of Paediatrics, University of Nairobi, Box 19676, Nairobi 00202, Kenya
    BMC Pediatr 10:33. 2010
  6. pmc The Afya Bora Consortium: an Africa-US partnership to train leaders in global health
    Carey Farquhar
    Division of Allergy and Infectious Disease, Departments of Medicine and Epidemiology and Global Health, University of Washington, 325 Ninth Avenue, Seattle, WA 98104, USA
    Infect Dis Clin North Am 25:399-409. 2011
  7. pmc Salivary secretory leukocyte protease inhibitor is associated with reduced transmission of human immunodeficiency virus type 1 through breast milk
    Carey Farquhar
    Departments of Medicine, Epidemiology, and Biostatistics, University of Washington, 325 Ninth Avenue, Seattle, WA 98104 2499, USA
    J Infect Dis 186:1173-6. 2002
  8. pmc Salivary human immunodeficiency virus (HIV)-1-specific immunoglobulin A in HIV-1-exposed infants in Kenya
    C Farquhar
    Department of Medicine, University of Washington, Seattle, Washington 98104 2499, USA
    Clin Exp Immunol 153:37-43. 2008
  9. pmc Illness during pregnancy and bacterial vaginosis are associated with in-utero HIV-1 transmission
    Carey Farquhar
    Department of Medicine, University of Washington, 325 Ninth Avenue, Box 359909, Seattle, WA 98104, USA
    AIDS 24:153-5. 2010
  10. pmc Immune responses to measles and tetanus vaccines among Kenyan human immunodeficiency virus type 1 (HIV-1)-infected children pre- and post-highly active antiretroviral therapy and revaccination
    Carey Farquhar
    Departments of Epidemiology, University of Washington, Seattle, WA, USA
    Pediatr Infect Dis J 28:295-9. 2009

Detail Information

Publications53

  1. pmc High uptake of postpartum hormonal contraception among HIV-1-seropositive women in Kenya
    Jennifer Balkus
    Department of Epidemiology, University of Washington, Seattle, Washington 98104, USA
    Sex Transm Dis 34:25-9. 2007
    ..The objectives of this study were to determine patterns of contraceptive utilization among sexually active HIV-1-seropositive women postpartum and to identify correlates of hormonal contraception uptake...
  2. pmc The role of G protein gene GNB3 C825T polymorphism in HIV-1 acquisition, progression and immune activation
    Jennifer Juno
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada
    Retrovirology 9:1. 2012
    ..Ex vivo immune activation was quantified by flow cytometry, and plasma chemokine levels were assessed by cytokine bead array...
  3. pmc Uptake of prevention of mother to child transmission interventions in Kenya: health systems are more influential than stigma
    John Kinuthia
    Department of Obstetrics and Gynaecology, Kenyatta National Hospital University of Nairobi, Kenya
    J Int AIDS Soc 14:61. 2011
    ....
  4. pmc Medication diaries do not improve outcomes with highly active antiretroviral therapy in Kenyan children: a randomized clinical trial
    Dalton C Wamalwa
    Department of Paediatrics University of Nairobi, Nairobi, Kenya
    J Int AIDS Soc 12:8. 2009
    ..abstract:..
  5. pmc Predictors of mortality in HIV-1 infected children on antiretroviral therapy in Kenya: a prospective cohort
    Dalton C Wamalwa
    Department of Paediatrics, University of Nairobi, Box 19676, Nairobi 00202, Kenya
    BMC Pediatr 10:33. 2010
    ..Among children, early mortality following highly active antiretroviral therapy (HAART) remains high. It is important to define correlates of mortality in order to improve outcome...
  6. pmc The Afya Bora Consortium: an Africa-US partnership to train leaders in global health
    Carey Farquhar
    Division of Allergy and Infectious Disease, Departments of Medicine and Epidemiology and Global Health, University of Washington, 325 Ninth Avenue, Seattle, WA 98104, USA
    Infect Dis Clin North Am 25:399-409. 2011
    ..This article describes a Pilot of the proposed program...
  7. pmc Salivary secretory leukocyte protease inhibitor is associated with reduced transmission of human immunodeficiency virus type 1 through breast milk
    Carey Farquhar
    Departments of Medicine, Epidemiology, and Biostatistics, University of Washington, 325 Ninth Avenue, Seattle, WA 98104 2499, USA
    J Infect Dis 186:1173-6. 2002
    ..5; 95% confidence interval, 0.3-0.9; P=.03). These results suggest that SLPI plays an important role in reducing HIV-1 transmission through breast milk...
  8. pmc Salivary human immunodeficiency virus (HIV)-1-specific immunoglobulin A in HIV-1-exposed infants in Kenya
    C Farquhar
    Department of Medicine, University of Washington, Seattle, Washington 98104 2499, USA
    Clin Exp Immunol 153:37-43. 2008
    ..Mucosal responses would be an appropriate target for paediatric vaccines against breast milk HIV-1 transmission...
  9. pmc Illness during pregnancy and bacterial vaginosis are associated with in-utero HIV-1 transmission
    Carey Farquhar
    Department of Medicine, University of Washington, 325 Ninth Avenue, Box 359909, Seattle, WA 98104, USA
    AIDS 24:153-5. 2010
    ..0-7.0) after adjusting for maternal HIV-1 viral load. Interventions targeting these novel risk factors could lead to more effective prevention of transmission during pregnancy...
  10. pmc Immune responses to measles and tetanus vaccines among Kenyan human immunodeficiency virus type 1 (HIV-1)-infected children pre- and post-highly active antiretroviral therapy and revaccination
    Carey Farquhar
    Departments of Epidemiology, University of Washington, Seattle, WA, USA
    Pediatr Infect Dis J 28:295-9. 2009
    ..We determined the extent to which highly active antiretroviral therapy (HAART) augments vaccine immunity and promotes responses to revaccination...
  11. pmc Pediatric HIV type 1 vaccine trial acceptability among mothers in Kenya
    Carey Farquhar
    Department of Medicine, University of Washington, Seattle, Washington 98104, USA
    AIDS Res Hum Retroviruses 22:491-5. 2006
    ..It will be important to address barriers identified in this study and to include male partners when mobilizing communities for pediatric HIV-1 vaccine trials and immunization programs...
  12. pmc Breast milk HIV-1 RNA levels and female sex are associated with HIV-1-specific CD8+ T-cell responses in HIV-1-exposed, uninfected infants in Kenya
    Carey Farquhar
    Department of Medicine, University of Washington, Seattle 98104 2499, USA
    J Infect Dis 204:1806-10. 2011
    ....
  13. pmc High maternal HIV-1 viral load during pregnancy is associated with reduced placental transfer of measles IgG antibody
    Carey Farquhar
    Department of Medicine, University of Washington, Seattle, WA 98104 2499, USA
    J Acquir Immune Defic Syndr 40:494-7. 2005
    ..As a result, infants born to women with HIV-1 infection may not acquire adequate passive immunity in utero and this could contribute to high infant morbidity and mortality in this vulnerable population...
  14. pmc The role of infant immune responses and genetic factors in preventing HIV-1 acquisition and disease progression
    C Farquhar
    Department of Medicine, University of Washington, Seattle 98104 2499, USA
    Clin Exp Immunol 134:367-77. 2003
  15. pmc Human leukocyte antigen (HLA) B*18 and protection against mother-to-child HIV type 1 transmission
    Carey Farquhar
    Department of Medicine, University of Washington, Seattle, Washington 98104, USA
    AIDS Res Hum Retroviruses 20:692-7. 2004
    ..HLA B*18 may protect breast-feeding infants against both early and late HIV-1 acquisition, a finding that could have implications for the design and monitoring of HIV-1 vaccines targeting cellular immune responses against HIV-1...
  16. pmc Antenatal couple counseling increases uptake of interventions to prevent HIV-1 transmission
    Carey Farquhar
    Department of Medicine, University of Washington, Seattle, WA 98104 249, USA
    J Acquir Immune Defic Syndr 37:1620-6. 2004
    ..004). Partner participation in VCT and couple counseling increased uptake of nevirapine and formula feeding. Antenatal couple counseling may be a useful strategy to promote HIV-1 prevention interventions...
  17. ncbi CC and CXC chemokines in breastmilk are associated with mother-to-child HIV-1 transmission
    Carey Farquhar
    Department of Medicine, University of Washington, Seattle, 98104, USA
    Curr HIV Res 3:361-9. 2005
    ..CC and CXC chemokines may play a role in mother-to-child HIV-1 transmission by blocking HIV-1 binding to chemokine receptors and impeding viral entry into cells...
  18. pmc CCR5, RANTES and SDF-1 polymorphisms and mother-to-child HIV-1 transmission
    D A Katz
    Department of Epidemiology, University of Washington, Seattle, WA 98104, USA
    Int J Immunogenet 37:301-5. 2010
    ....
  19. pmc Characteristics of HIV-1 discordant couples enrolled in a trial of HSV-2 suppression to reduce HIV-1 transmission: the partners study
    Jairam R Lingappa
    Department of Global Health, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 4:e5272. 2009
    ..We describe the baseline characteristics of this cohort...
  20. pmc Maternal HLA homozygosity and mother-child HLA concordance increase the risk of vertical transmission of HIV-1
    Romel D Mackelprang
    Department of Epidemiology, University of Washington, Seattle 98104, USA
    J Infect Dis 197:1156-61. 2008
    ..Mother-child human leukocyte antigen (HLA) concordance and maternal HLA homozygosity may increase the risk of vertical transmission of human immunodeficiency virus type 1 (HIV-1) risk by reducing infant immune responses...
  21. pmc Infant CD4 C868T polymorphism is associated with increased human immunodeficiency virus (HIV-1) acquisition
    R Y Choi
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    Clin Exp Immunol 160:461-5. 2010
    ..This SNP (an allele frequency of approximately 15% in our cohort) was associated with increased susceptibility to mother-to-child HIV-1 transmission, consistent with a previous study on this polymorphism among Nairobi sex workers...
  22. pmc Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2
    C Celum
    Department of Global Health, University of Washington, Harborview Medical Center, 325 Ninth Ave, Box 359927, Seattle, WA 98104, USA
    N Engl J Med 362:427-39. 2010
    ..Therapy to suppress HSV-2 reduces the frequency of reactivation of HSV-2 as well as HIV-1 levels, suggesting that suppression of HSV-2 may reduce the risk of transmission of HIV-1...
  23. pmc Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysis
    Deborah Donnell
    Statistical Center for HIV AIDS Research and Prevention and the Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Lancet 375:2092-8. 2010
    ..Initiation of antiretroviral therapy (ART) reduces plasma HIV-1 concentrations. We aimed to assess the effect of ART use by patients infected with HIV-1 on risk of transmission to their uninfected partners...
  24. pmc Daily acyclovir for HIV-1 disease progression in people dually infected with HIV-1 and herpes simplex virus type 2: a randomised placebo-controlled trial
    Jairam R Lingappa
    Department of Global Health, Seattle, WA, USA
    Lancet 375:824-33. 2010
    ..Daily suppression of this herpes virus reduces plasma HIV-1 concentrations, but whether it delays HIV-1 disease progression is unknown. We investigated the effect of acyclovir on HIV-1 progression...
  25. pmc Diagnosis of sexually transmitted infections and bacterial vaginosis among HIV-1-infected pregnant women in Nairobi
    G Marx
    Department of Medicine, University of Washington, Seattle, USA
    Int J STD AIDS 21:549-52. 2010
    ..Among these HIV-infected, pregnant women, STIs and vaginal infections were common and syndromic diagnosis was insensitive, resulting in missed opportunities to intervene and improve infant and maternal health...
  26. pmc HIV testing men in the antenatal setting: understanding male non-disclosure
    D A Katz
    Department of Epidemiology, University of Washington, Seattle, WA 98104, USA
    Int J STD AIDS 20:765-7. 2009
    ..Couple counselling models that incorporate disclosure may yield greater HIV prevention benefits than offering individual partner HIV testing services at ANC...
  27. pmc Sexually transmitted infections among HIV-1-discordant couples
    Brandon L Guthrie
    Department of Epidemiology, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 4:e8276. 2009
    ..Understanding correlates of STIs among discordant couples will aid in optimizing interventions to prevent HIV-1 transmission in these couples...
  28. pmc Male circumcision and risk of male-to-female HIV-1 transmission: a multinational prospective study in African HIV-1-serodiscordant couples
    Jared M Baeten
    University of Washington, WA, USA
    AIDS 24:737-44. 2010
    ....
  29. pmc Predicting pregnancy in HIV-1-discordant couples
    Brandon L Guthrie
    Department of Epidemiology, University of Washington, Seattle, WA 98104 2499, USA
    AIDS Behav 14:1066-71. 2010
    ..2%). Pregnancy rates may be high among discordant couples, indicating desire for children may override concerns of HIV-1 transmission and increase unprotected sex, and highlighting the need to make conception safer...
  30. pmc Male perspectives on incorporating men into antenatal HIV counseling and testing
    David A Katz
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    PLoS ONE 4:e7602. 2009
    ..We aimed to identify methods for increasing male involvement in antenatal VCT and determine male correlates of accepting couple counseling in these settings...
  31. pmc Cofactors for HIV-1 incidence during pregnancy and postpartum period
    John Kinuthia
    Department of Obstetrics and Gynaecology, Kenyatta National Hospital and University of Nairobi, Kenya
    Curr HIV Res 8:510-4. 2010
    ..to estimate HIV-1 incidence and cofactors for HIV-1 incidence during pregnancy and postpartum...
  32. pmc Morbidity among HIV-1-infected mothers in Kenya: prevalence and correlates of illness during 2-year postpartum follow-up
    Judd L Walson
    Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya
    J Acquir Immune Defic Syndr 46:208-15. 2007
    ..Understanding patterns of illness and determinants of disease in HIV-1-infected mothers may guide effective interventions to improve maternal health in this setting...
  33. pmc HV-1-specific cytotoxic T lymphocytes and breast milk HIV-1 transmission
    Grace C John-Stewart
    Department of Paediatrics, University of Nairobi, Nairobi, Kenya
    J Infect Dis 199:889-98. 2009
    ....
  34. ncbi Herpes simplex virus type 2 and risk of intrapartum human immunodeficiency virus transmission
    Alison L Drake
    Departments of Epidemiology and Medicine, University of Washington, Seattle, WA 98195, USA
    Obstet Gynecol 109:403-9. 2007
    ....
  35. pmc Hormonal contraception and HIV-1 disease progression among postpartum Kenyan women
    Barbra A Richardson
    Department of Biostatistics, University of Washington, Seattle, WA 98194 2499, USA
    AIDS 21:749-53. 2007
    ..To assess the immediate and longer-term effects of the use of hormonal contraception on the progression of HIV-1 disease in postpartum women...
  36. ncbi HIV-1-discordant couples in sub-Saharan Africa: explanations and implications for high rates of discordancy
    Brandon L Guthrie
    Department of Epidemiology, University of Washington, Seattle, WA 98104 2499, USA
    Curr HIV Res 5:416-29. 2007
    ....
  37. pmc Regional differences in prevalence of HIV-1 discordance in Africa and enrollment of HIV-1 discordant couples into an HIV-1 prevention trial
    Jairam R Lingappa
    University of Washington, Department of Medicine, Seattle, Washington, USA
    PLoS ONE 3:e1411. 2008
    ..Substantial regional differences exist in HIV-1 prevalence in Africa, but regional differences in HIV-1 discordance among African couples, has not previously been reported...
  38. pmc Comparison of CD4 cell count, viral load, and other markers for the prediction of mortality among HIV-1-infected Kenyan pregnant women
    Elizabeth R Brown
    Department of Biostatistics, University of Washington, Seattle, WA, USA
    J Infect Dis 199:1292-300. 2009
    ..There are limited data regarding the relative merits of biomarkers as predictors of mortality or time to initiation of antiretroviral therapy (ART)...
  39. pmc The detection of cytomegalovirus DNA in maternal plasma is associated with mortality in HIV-1-infected women and their infants
    Jennifer A Slyker
    MRC Human Immunology Unit, Oxford University, Oxford, UK
    AIDS 23:117-24. 2009
    ..The objective of this study was to determine whether the detection of CMV DNA (CMV DNAemia) in maternal plasma was associated with mortality in HIV-1-infected women or their infants...
  40. doi Predictive value of interferon-gamma release assays for postpartum active tuberculosis in HIV-1-infected women
    S R Jonnalagadda
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Int J Tuberc Lung Dis 17:1552-7. 2013
    ..Data on the prognostic utility of interferon-gamma release assays (IGRAs) for active tuberculosis (TB) among human immunodeficiency virus 1 (HIV-1) infected individuals are limited...
  41. pmc Latent tuberculosis detection by interferon γ release assay during pregnancy predicts active tuberculosis and mortality in human immunodeficiency virus type 1-infected women and their children
    Sasi Jonnalagadda
    Department of Epidemiology, University of Washington, Seattle, USA
    J Infect Dis 202:1826-35. 2010
    ..We evaluated the prognostic usefulness of interferon γ release assays (IGRAs) for active tuberculosis and mortality in Kenyan human immunodeficiency virus type 1 (HIV-1)-infected women and their infants...
  42. pmc Maternal human leukocyte antigen A*2301 is associated with increased mother-to-child HIV-1 transmission
    Romel D Mackelprang
    Departments of 1Epidemiology, 2Medicine, 3Global Health, and 4Biostatistics, University of Washington, Seattle, Washington 5Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, Inc, National Cancer Institute at Frederick, Maryland and 6Department of Paediatrics, University of Nairobi, Kenya
    J Infect Dis 202:1273-7. 2010
    ..26-7.51; P =.01; Pcorr is not significant). That maternal HLA-A*2301 was associated with transmission independent of plasma HIV-1 RNA levels suggests that HLA may alter infectivity through mechanisms other than influencing HIV-1 load...
  43. ncbi Biological mechanisms of vertical human immunodeficiency virus (HIV-1) transmission
    Dara A Lehman
    Department of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Rev Med Virol 17:381-403. 2007
    ..This review concludes with data on persistence of low-level resistance after delivery as well as recent guidelines for maternal and infant regimens designed to limit resistance...
  44. pmc Breast milk alpha-defensins are associated with HIV type 1 RNA and CC chemokines in breast milk but not vertical HIV type 1 transmission
    Rose Bosire
    Department of Pediatrics, University of Nairobi, Nairobi, Kenya
    AIDS Res Hum Retroviruses 23:198-203. 2007
    ..Despite these associations there was no significant relationship between breast milk alpha-defensins and mother-to-child transmission, suggesting a complex interplay between breast milk HIV-1, inflammation, and antiinfective factors...
  45. ncbi Prevalence and magnitude of human immunodeficiency virus (HIV) type 1-specific lymphocyte responses in breast milk from HIV-1-seropositive women
    Barbara L Lohman
    Department of Medical Microbiology, University of Nairobi, Kenya
    J Infect Dis 188:1666-74. 2003
    ..These results suggest that CD8+ lymphocytes present in breast milk have the capacity to recognize HIV-1-infected cells and may be selectively transported to breast milk to reduce either viral replication or transmission in breast milk...
  46. pmc Predictors of early mortality in a cohort of human immunodeficiency virus type 1-infected african children
    Elizabeth M Obimbo
    Department of Pediatrics, University of Nairobi, Nairobi, Kenya
    Pediatr Infect Dis J 23:536-43. 2004
    ..A prospective observational study was undertaken to determine predictors of mortality in HIV-1-infected African infants during the first 2 years of life...
  47. pmc Domestic violence and prevention of mother-to-child transmission of HIV-1
    James N Kiarie
    Department of Obstetrics Gynaecology, University of Nairobi, PO Box 3085 00506, Nairobi, Kenya
    AIDS 20:1763-9. 2006
    ..To determine the prevalence of life-time domestic violence by the current partner before HIV-1 testing, its impact on the uptake of prevention of mother-to-child transmission (PMTCT) interventions and frequency after testing...
  48. pmc Cost effectiveness of couple counselling to enhance infant HIV-1 prevention
    Francis N John
    Department of Obstetrics and Gynaecology, University of Nairobi, Nairobi, Kenya
    Int J STD AIDS 19:406-9. 2008
    ..Cost per disability-adjusted life year was similar to that of individual VCT. Sensitivity analyses found that couple VCT was more cost-effective in scenarios with increased uptake of couple counselling and higher HIV-1 prevalence...
  49. pmc Longitudinal assessment of human immunodeficiency virus type 1 (HIV-1)-specific gamma interferon responses during the first year of life in HIV-1-infected infants
    Barbara L Lohman
    Department of Paediatrics, University of Nairobi, Kenya
    J Virol 79:8121-30. 2005
    ....
  50. pmc HIV-1 disease progression in breast-feeding and formula-feeding mothers: a prospective 2-year comparison of T cell subsets, HIV-1 RNA levels, and mortality
    Phelgona A Otieno
    Centre for Clinical Research, Kenya Medical Research Institute, University of Nairobi, Nairobi, Kenya
    J Infect Dis 195:220-9. 2007
    ....
  51. pmc Early response to highly active antiretroviral therapy in HIV-1-infected Kenyan children
    Dalton C Wamalwa
    Department of Pediatrics, University of Nairobi, Nairobi, Kenya
    J Acquir Immune Defic Syndr 45:311-7. 2007
    ....
  52. ncbi Antiretroviral-associated toxicity among HIV-1-seropositive pregnant women in Mozambique receiving nevirapine-based regimens
    Lilia Jamisse
    Ministry of Health, Maputo, Mozambique
    J Acquir Immune Defic Syndr 44:371-6. 2007
    ..To assess toxicities associated with highly active antiretroviral therapy (HAART) among HIV-1-infected pregnant women treated with nevirapine-based regimens according to Mozambican national guidelines...
  53. pmc Longitudinal comparison of chemokines in breastmilk early postpartum among HIV-1-infected and uninfected Kenyan women
    Rose Bosire
    Center for Public Health Research, Kenya Medical Research Institute, Nairobi, Kenya
    Breastfeed Med 2:129-38. 2007
    ....

Research Grants7

  1. Protective Immune Responses in HIV-1 Exposed Infants
    Carey Farquhar; Fiscal Year: 2006
    ..Kreiss and John, will prepare her for the complex data analysis required by this study and contribute substantially to the development of her career as an independent clinical investigator. ..
  2. Protective cellular immune responses in HIV-1 discordant couples
    Carey Farquhar; Fiscal Year: 2007
    ....
  3. Protective cellular immune responses in HIV-1 discordant couples
    Carey Farquhar; Fiscal Year: 2010
    ....