Diana L Farmer

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint In utero repair of myelomeningocele: experimental pathophysiology, initial clinical experience, and outcomes
    Diana L Farmer
    Departments of Surgery and Neurosurgery and the Fetal Treatment Center, University of California, San Francisco, CA 94143 0570, USA
    Arch Surg 138:872-8. 2003
  2. ncbi request reprint Reliability of the lung-to-head ratio as a predictor of outcome in fetuses with isolated left congenital diaphragmatic hernia at gestation outside 24-26 weeks
    Soon Ha Yang
    Fetal Treatment Center, University of California, San Francisco, San Francisco, CA 94143 0570, USA
    Am J Obstet Gynecol 197:30.e1-7. 2007
  3. ncbi request reprint The ex utero intrapartum treatment procedure: Looking back at the EXIT
    Shinjiro Hirose
    Division of Pediatric Surgery and the Fetal Treatment Center, Department of Surgery, University of California, San Francisco, San Francisco, CA 94143 0570, USA
    J Pediatr Surg 39:375-80; discussion 375-80. 2004
  4. ncbi request reprint Fetal surgery for repair of myelomeningocele allows normal development of anal sphincter muscles in sheep
    Jyoji Yoshizawa
    Division of Pediatric Surgery and Fetal Treatment Center, Department of Surgery, University of California, San Francisco, CA, USA
    Pediatr Surg Int 20:14-8. 2004
  5. doi request reprint Does congenital diaphragmatic hernia associated with bronchopulmonary sequestration portend a better prognosis?
    Erich J Grethel
    Department of Pediatric Surgery, University of California, San Francisco, CA 94143 0570, USA
    Fetal Diagn Ther 23:250-3. 2008
  6. ncbi request reprint Efficacy of radiofrequency ablation for twin-reversed arterial perfusion sequence
    Hanmin Lee
    Fetal Treatment Center and the Department of Surgery, University of California, San Francisco, San Francisco, CA 94143 0570, USA
    Am J Obstet Gynecol 196:459.e1-4. 2007
  7. doi request reprint Human induced pluripotent stem cell-derived neural crest stem cells integrate into the injured spinal cord in the fetal lamb model of myelomeningocele
    Payam Saadai
    Division of Pediatric Surgery and Fetal Treatment Center, Department of Surgery, University of California, San Francisco, CA, USA
    J Pediatr Surg 48:158-63. 2013
  8. ncbi request reprint Recent advances in fetal surgery
    Raul A Cortes
    Division of Pediatric Surgery, The Fetal Treatment Center, University of California, San Frncisrco, CA 94143 0570, USA
    Semin Perinatol 28:199-211. 2004
  9. ncbi request reprint Infant pulmonary function in a randomized trial of fetal tracheal occlusion for severe congenital diaphragmatic hernia
    Roberta L Keller
    The Cardiovascular Research Institute and Department of Pediatrics, UCSF Box 0748, San Francisco, CA 94143, USA
    Pediatr Res 56:818-25. 2004
  10. ncbi request reprint Survival of severe congenital diaphragmatic hernia has morbid consequences
    Raul A Cortes
    Department of Surgery and Fetal Treatment Center, University of California in San Francisco Medical Center and Children s Hospital, San Francisco, CA 94143 0570, USA
    J Pediatr Surg 40:36-45; discussion 45-6. 2005

Research Grants

Collaborators

Detail Information

Publications45

  1. ncbi request reprint In utero repair of myelomeningocele: experimental pathophysiology, initial clinical experience, and outcomes
    Diana L Farmer
    Departments of Surgery and Neurosurgery and the Fetal Treatment Center, University of California, San Francisco, CA 94143 0570, USA
    Arch Surg 138:872-8. 2003
    ..Experimental work raises the possibility that in utero repair of myelomeningocele (MMC) may improve lower extremity, bladder, and bowel function, ameliorate the Arnold-Chiari malformation, and decrease the need for postnatal shunting...
  2. ncbi request reprint Reliability of the lung-to-head ratio as a predictor of outcome in fetuses with isolated left congenital diaphragmatic hernia at gestation outside 24-26 weeks
    Soon Ha Yang
    Fetal Treatment Center, University of California, San Francisco, San Francisco, CA 94143 0570, USA
    Am J Obstet Gynecol 197:30.e1-7. 2007
    ....
  3. ncbi request reprint The ex utero intrapartum treatment procedure: Looking back at the EXIT
    Shinjiro Hirose
    Division of Pediatric Surgery and the Fetal Treatment Center, Department of Surgery, University of California, San Francisco, San Francisco, CA 94143 0570, USA
    J Pediatr Surg 39:375-80; discussion 375-80. 2004
    ..The authors review their single-institution experience with EXIT...
  4. ncbi request reprint Fetal surgery for repair of myelomeningocele allows normal development of anal sphincter muscles in sheep
    Jyoji Yoshizawa
    Division of Pediatric Surgery and Fetal Treatment Center, Department of Surgery, University of California, San Francisco, CA, USA
    Pediatr Surg Int 20:14-8. 2004
    ..There was no difference in muscle development for the repair methods. Fetal surgery for repair of MMC allows normal development of anal sphincter muscles...
  5. doi request reprint Does congenital diaphragmatic hernia associated with bronchopulmonary sequestration portend a better prognosis?
    Erich J Grethel
    Department of Pediatric Surgery, University of California, San Francisco, CA 94143 0570, USA
    Fetal Diagn Ther 23:250-3. 2008
    ..We reviewed our experience to evaluate if prognosis was better in the CDH infants with associated bronchopulmonary sequestration...
  6. ncbi request reprint Efficacy of radiofrequency ablation for twin-reversed arterial perfusion sequence
    Hanmin Lee
    Fetal Treatment Center and the Department of Surgery, University of California, San Francisco, San Francisco, CA 94143 0570, USA
    Am J Obstet Gynecol 196:459.e1-4. 2007
    ..We report our experience in the treatment of patients with twin-reversed arterial perfusion (TRAP) sequence using radiofrequency ablation to stop perfusion to the acardiac twin and protect the pump twin...
  7. doi request reprint Human induced pluripotent stem cell-derived neural crest stem cells integrate into the injured spinal cord in the fetal lamb model of myelomeningocele
    Payam Saadai
    Division of Pediatric Surgery and Fetal Treatment Center, Department of Surgery, University of California, San Francisco, CA, USA
    J Pediatr Surg 48:158-63. 2013
    ..We aimed to evaluate the survival, integration, and differentiation of human NCSCs derived from induced pluripotent stem cells (iPSC-NCSCs) in the fetal lamb model of MMC...
  8. ncbi request reprint Recent advances in fetal surgery
    Raul A Cortes
    Division of Pediatric Surgery, The Fetal Treatment Center, University of California, San Frncisrco, CA 94143 0570, USA
    Semin Perinatol 28:199-211. 2004
    ..Fetal surgery as a (multi)discipline continues to strive to minimize maternal and fetal risk. Undoubtedly, as tocolytic therapy and neonatal intensive efforts improve, fetal therapy will expand...
  9. ncbi request reprint Infant pulmonary function in a randomized trial of fetal tracheal occlusion for severe congenital diaphragmatic hernia
    Roberta L Keller
    The Cardiovascular Research Institute and Department of Pediatrics, UCSF Box 0748, San Francisco, CA 94143, USA
    Pediatr Res 56:818-25. 2004
    ..We conclude that fetal TO for severe CDH results in modest improvements in neonatal pulmonary function that are of questionable clinical significance...
  10. ncbi request reprint Survival of severe congenital diaphragmatic hernia has morbid consequences
    Raul A Cortes
    Department of Surgery and Fetal Treatment Center, University of California in San Francisco Medical Center and Children s Hospital, San Francisco, CA 94143 0570, USA
    J Pediatr Surg 40:36-45; discussion 45-6. 2005
    ....
  11. ncbi request reprint A randomized trial of fetal endoscopic tracheal occlusion for severe fetal congenital diaphragmatic hernia
    Michael R Harrison
    Fetal Treatment Center, University of California, San Francisco, San Francisco, CA 94143 0570, USA
    N Engl J Med 349:1916-24. 2003
    ..We performed a randomized, controlled trial comparing fetal tracheal occlusion with standard postnatal care...
  12. pmc Alterations in maternal-fetal cellular trafficking after fetal surgery
    Payam Saadai
    Division of Pediatric Surgery and Fetal Treatment Center, Department of Surgery, University of California, San Francisco, CA 94143 0570, USA
    J Pediatr Surg 47:1089-94. 2012
    ..We hypothesized that patients undergoing open fetal surgery would have altered maternal-fetal cellular trafficking...
  13. ncbi request reprint Monochorionic twin gestation complicated by a sacrococcygeal teratoma with hydrops--optimal timing of delivery allows for survival of the unaffected twin
    Marsha Ayzen
    Division of Pediatric Surgery, Department of Surgery, University of California, San Francisco, CA 94143, USA
    J Pediatr Surg 41:e11-3. 2006
    ..In this case, serial ultrasound evaluations and timing of delivery optimized the outcome of the unaffected twin...
  14. ncbi request reprint Prosthetic patches for congenital diaphragmatic hernia repair: Surgisis vs Gore-Tex
    Erich J Grethel
    Division of Pediatric Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
    J Pediatr Surg 41:29-33; discussion 29-33. 2006
    ..A recent trend has been toward the use of bioactive prosthetic materials. We reviewed different patch closure techniques used for CDH repair at our institution and their association with these sequelae...
  15. ncbi request reprint Resolution of hydrops fetalis in congenital cystic adenomatoid malformation after prenatal steroid therapy
    KuoJen Tsao
    Fetal Treatment Center, Division of Pediatric Surgery, Department of Surgery, University of California, San Francisco, California 94143 0570, USA
    J Pediatr Surg 38:508-10. 2003
    ..Steroid therapy, utilized for lung maturity, has been postulated to accelerate this process. The natural history of hydropic fetuses with CCAM after receiving steroid therapy is presented...
  16. ncbi request reprint Surgical treatment of childhood recurrent pancreatitis
    Matthew S Clifton
    Division of Pediatric Surgery, Department of Surgery, University of California San Francisco, Box 0570, San Francisco, CA 94143 0570, USA
    J Pediatr Surg 42:1203-7. 2007
    ..Surgical intervention that improves pancreatic ductal drainage is a reasonable treatment strategy for recurrent pancreatitis in children...
  17. doi request reprint Thoracoscopic versus open resection for congenital cystic adenomatoid malformations of the lung
    Lan T Vu
    Division of Pediatric Surgery, Department of Surgery, University of California, San Francisco, CA 94131 0570, USA
    J Pediatr Surg 43:35-9. 2008
    ..This study evaluated the potential advantages of thoracoscopy compared to thoracotomy for resection of congenital cystic adenomatoid malformations (CCAM)...
  18. doi request reprint Determination of risk factors for deep venous thrombosis in hospitalized children
    Lan T Vu
    Division of Pediatric Surgery, Department of Surgery, University of California, Box 0570, San Francisco, CA 94143 0570, USA
    J Pediatr Surg 43:1095-9. 2008
    ..Our objective was to determine the time trend and risk factors for deep venous thrombosis (DVT) of the lower extremities among pediatric inpatients...
  19. ncbi request reprint Fetal intervention for mass lesions and hydrops improves outcome: a 15-year experience
    Erich J Grethel
    Division of Pediatric Surgery, Fetal Treatment Center, University of California, San Francisco, San Francisco, CA 94143 0570, USA
    J Pediatr Surg 42:117-23. 2007
    ..However, hydrops associated with fetal mass lesions can be halted and even reversed with fetal intervention and treatment of the underlying defect. We examined our patients with fetal mass lesions to evaluate survival after intervention...
  20. ncbi request reprint Maternal morbidity after maternal-fetal surgery
    Kirstin Golombeck
    Division of Pediatric Surgery, Department of Surgery, The Fetal Treatment Center, University of California, San Francisco, CA 94143 0570, USA
    Am J Obstet Gynecol 194:834-9. 2006
    ..We analyzed maternal morbidity and mortality that were associated with different types of fetal intervention (open hysterotomy, various endoscopic procedures and percutaneous techniques) to quantify this risk...
  21. ncbi request reprint Prenatal and postnatal management of a patient with pentalogy of Cantrell and left ventricular aneurysm. A case report and literature review
    Erich J Grethel
    Fetal Treatment Center, University of California, San Francisco, Calif 94143 0570, USA
    Fetal Diagn Ther 22:269-73. 2007
    ....
  22. ncbi request reprint Long-term follow-up after thymectomy for myasthenia gravis: thoracoscopic vs open
    Amy J Wagner
    Division of Pediatric Surgery, Department of Surgery, University of California, San Francisco, CA 94143, USA
    J Pediatr Surg 41:50-4; discussion 50-4. 2006
    ..The aim of this study was to determine if patients are in remission or weaning off medication after thymectomy for myasthenia gravis (MG) and to examine the thoracoscopic versus open approaches...
  23. ncbi request reprint Spontaneous rupture of fetal sacrococcygeal teratoma
    Edgar D Sy
    Fetal Treatment Center, University of California, San Francisco, Calif, USA
    Fetal Diagn Ther 21:424-7. 2006
    ..At 23 weeks, there was a sudden appearance of an additional lobular mass, consistent with intrauterine spontaneous ruptured of a sacrococcygeal teratoma mass...
  24. ncbi request reprint Fetal intervention for complications of monochorionic twinning
    Diana L Farmer
    The Fetal Treatment Center, Department of Surgery, Division of Pediatric Surgery, University of California, San Francisco, 513 Parnassus Avenue, Room HSW 1601, San Francisco, California 94143 4086, USA
    World J Surg 27:103-7. 2003
    ..A still greater danger exists when monochorionic twins also share a single amniotic sac. Fetal surgical interventions now exist to treat many of the complications associated with twin gestation pregnancies...
  25. ncbi request reprint Comparison of drainage techniques for biliary atresia
    KuoJen Tsao
    Fetal Treatment Center, Department of Surgery, Division of Pediatric Surgery, San Francisco, CA 94143 0570, USA
    J Pediatr Surg 38:1005-7. 2003
    ..Differences in outcome between patients who underwent either Kasai portoenterostomy or porto-appendiceal duodenostomy were compared...
  26. ncbi request reprint Spectrum of intrapartum management strategies for giant fetal cervical teratoma
    Shinjiro Hirose
    Department of Surgery, University of California, San Francisco, California 94143 0570, USA
    J Pediatr Surg 38:446-50; discussion 446-50. 2003
    ..The management of the fetus with a large neck mass that obstructs the airway remains a clinical challenge. The authors review their experience with giant fetal cervical teratoma and discuss options for management...
  27. pmc Fetal surgery for myelomeningocele
    Payam Saadai
    Division of Pediatric Surgery, Department of Surgery, Fetal Treatment Center, University of California, San Francisco, 513 Parnassus Avenue, HSW 16 01, Box 0570, San Francisco, CA 94143 0570, USA
    Clin Perinatol 39:279-88. 2012
    ....
  28. doi request reprint Fetal surgery for myelomeningocele
    Shinjiro Hirose
    Division of Pediatric Surgery, Department of Surgery, Fetal Treatment Center, University of California, San Francisco, CA 94143 0570, USA
    Clin Perinatol 36:431-8, xi. 2009
    ..MMC is the first nonlethal disease under consideration and study for fetal surgery. As a result, potential improvements in outcome must be balanced with maternal safety and well-being, in addition to that of the unborn patient...
  29. ncbi request reprint Selective reduction of acardiac twin by radiofrequency ablation
    KuoJen Tsao
    Fetal Treatment Center, Department of Surgery, University of California, San Francisco 94143 0570, USA
    Am J Obstet Gynecol 187:635-40. 2002
    ..A novel technique for selective reduction and obliteration of blood flow in the acardiac twin is described...
  30. doi request reprint Genetic analysis of congenital cystic adenomatoid malformation reveals a novel pulmonary gene: fatty acid binding protein-7 (brain type)
    Amy J Wagner
    Department of Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    Pediatr Res 64:11-6. 2008
    ..Decreased expression of FABP-7 in fetal CCAM compared with normal fetal lung at both the RNA and protein levels suggests FABP-7 may have a role in pulmonary development and in the pathogenesis of CCAM...
  31. ncbi request reprint Fetal endoscopic surgery: lessons learned and trends reviewed
    Steven F Fowler
    Department of Surgery, Division of Pediatric Surgery and Fetal Treatment Center, University of California, San Francisco, CA, USA
    J Pediatr Surg 37:1700-2. 2002
    ..Fetal surgery is performed increasingly with minimal access approaches. The authors report their experience with fetal endoscopic procedures (fetendo) with emphasis on changing techniques and outcome trends...
  32. ncbi request reprint Subcutaneous endoscopically assisted ligation (SEAL) of the internal ring for repair of inguinal hernias in children: a novel technique
    Michael R Harrison
    Division of Pediatric Surgery, Department of Surgery, University of California, San Francisco, CA 94143 0570, USA
    J Pediatr Surg 40:1177-80. 2005
    ..The safety, efficacy (recurrence risk), and cost-effectiveness of this unproven procedure must be tested against standard open repair in a trial...
  33. ncbi request reprint Fetal surgery for repair of myelomeningocele allows normal development of the rectum in sheep
    Jyoji Yoshizawa
    Department of Surgery, Division of Pediatric Surgery and Fetal Treatment Center, University of California San Francisco, San Francisco, California, USA
    Pediatr Surg Int 19:162-6. 2003
    ..There was no difference in muscle and nerve development of the rectum among the three repair methods. Fetal surgery for repair of MMC allows normal development of rectal muscles and nerves...
  34. ncbi request reprint Fetal relative lung volume: quantification by using prenatal MR imaging lung volumetry
    Gethin Williams
    Department of Radiology, University of California San Francisco, 505 Parnassus Ave, Box 0628, San Francisco, CA 94143 0628, USA
    Radiology 233:457-62. 2004
    ....
  35. ncbi request reprint Myelomeningocele: characterization of a surgically induced sheep model and its central nervous system similarities and differences to the human disease
    Cornelia S von Koch
    Department of Neurological Surgery, University of California, San Francisco, CA 94143 0570, USA
    Am J Obstet Gynecol 193:1456-62. 2005
    ....
  36. doi request reprint Conflicts in wound classification of neonatal operations
    Lan T Vu
    Department of Surgery, University of California, San Francisco, CA 94143 0570, USA
    J Pediatr Surg 44:1206-11. 2009
    ..This study sought to determine the reliability of wound classification guidelines when applied to neonatal operations...
  37. ncbi request reprint Fetal surgery for sacrococcygeal teratoma
    Shinjiro Hirose
    Fetal Treatment Center, University of California San Francisco, 513 Parnassus Avenue, HSW 1601, San Francisco, CA 94143 0570, USA
    Clin Perinatol 30:493-506. 2003
    ..Further study is required to determine the role of minimal access techniques in SCT. Future directions for treatment of fetal SCT with hydrops might include fetoscopic resection or high-intensity ultrasound ablation...
  38. ncbi request reprint Fetal therapy for giant hepatic cysts
    KuoJen Tsao
    Department of Surgery, University of California, San Francisco, CA 94143 0570, USA
    J Pediatr Surg 37:E31. 2002
    ..Decompression of giant hepatic cysts may reverse this phenomenon and allow normal fetal development...
  39. ncbi request reprint Fetal surgery for congenital diaphragmatic hernia and pulmonary sequestration complicated by postnatal diagnosis of transposition of the great arteries
    Shannon E G Hamrick
    Division of Neonatology, University of California San Francisco, San Francisco, Calif 94143, USA
    Fetal Diagn Ther 19:40-2. 2004
    ..This triad has not previously been documented in the literature. Clinicians should have a high index of suspicion for associated anomalies, especially cardiac, when evaluating and counseling a pregnancy complicated by CDH...
  40. doi request reprint Prenatal repair of myelomeningocele with aligned nanofibrous scaffolds-a pilot study in sheep
    Payam Saadai
    Department of Surgery, University of California, San Francisco, CA 94143 0570, USA
    J Pediatr Surg 46:2279-83. 2011
    ..The purpose of this pilot study was to evaluate the practicality and safety of using biodegradable NS as a regenerative device in prenatal MMC repair...
  41. doi request reprint Indication for pediatric muscle biopsy determines usefulness
    Ramin Jamshidi
    Department of Surgery, University of California, San Francisco, CA 94143 0570, USA
    J Pediatr Surg 43:2199-201. 2008
    ..Diagnostic skeletal muscle biopsy is an invasive procedure used for evaluation of neuromuscular disorders. We hypothesize that the yield of biopsy varies with its indication or suspected diagnosis...
  42. ncbi request reprint Chorioamniotic membrane separation following fetal surgery
    Roman M Sydorak
    Division of Pediatric Surgery, Department of Surgery, The Fetal Treatment Center, University of California San Francisco, San Francisco, CA 94143 0570, USA
    J Perinatol 22:407-10. 2002
    ..Due to the potential adverse consequences from this abnormality, we reviewed the last decade of experience with fetal intervention at our institution and examined the incidence and outcomes of fetuses given this diagnosis...
  43. doi request reprint Global health in general surgery residency: a national survey
    Sudha P Jayaraman
    Department of Surgery, University of California, San Francisco, CA, USA
    J Am Coll Surg 208:426-33. 2009
    ..There are limited data from surgery residency programs on their attitudes and scope of activities in this area. This study aims to understand how global health education fits into postgraduate surgical training in the US...
  44. ncbi request reprint Tissue ablation using high-intensity focused ultrasound in the fetal sheep model: potential for fetal treatment
    Bettina W Paek
    Department of Obstetrics and Gynecology, University of Washington, Seattle 98195 6460, USA
    Am J Obstet Gynecol 189:702-5. 2003
    ..In contrast to diagnostic ultrasound where intensity levels are below 0.1 W/cm(2), HIFU can deliver 1,000 to 10,000 W/cm(2) at the focal spot...
  45. ncbi request reprint Presumptive intrahepatic congenital cystic adenomatoid malformation
    B Keegan Markhardt
    University of Wisconsin, Madison, Wisconsin, USA
    J Ultrasound Med 22:531-6. 2003
    ..We present an interesting case of CCAM manifesting within the liver of a patient treated prenatally for a large pulmonary type II CCAM and review the reported cases of IEPS with CCAM...

Research Grants3

  1. Multicenter Trial of Fetal Myelomeningocele Repair
    Diana Farmer; Fiscal Year: 2006
    ..In summary, the proposed trial is expected to demonstrate whether fetal intervention offers improved outcome with a reasonable quality of life for spina bifida children. ..
  2. Multicenter Trial of Fetal Myelomeningocele Repair
    Diana Farmer; Fiscal Year: 2007
    ..In summary, the proposed trial will be able to demonstrate whether fetal intervention offers improved outcome with a reasonable quality of life for spina bifida children. ..