Research Topics
Species | Diana L FarmerSummaryAffiliation: University of California Country: USA Publications
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Publications
In utero repair of myelomeningocele: experimental pathophysiology, initial clinical experience, and outcomesDiana L Farmer
Departments of Surgery and Neurosurgery and the Fetal Treatment Center, University of California, San Francisco, CA 94143 0570, USA
Arch Surg 138:872-8. 2003..Experimental work raises the possibility that in utero repair of myelomeningocele (MMC) may improve lower extremity, bladder, and bowel function, ameliorate the Arnold-Chiari malformation, and decrease the need for postnatal shunting...- Reliability of the lung-to-head ratio as a predictor of outcome in fetuses with isolated left congenital diaphragmatic hernia at gestation outside 24-26 weeksSoon Ha Yang
Fetal Treatment Center, University of California, San Francisco, San Francisco, CA 94143 0570, USA
Am J Obstet Gynecol 197:30.e1-7. 2007.... - The ex utero intrapartum treatment procedure: Looking back at the EXITShinjiro Hirose
Division of Pediatric Surgery and the Fetal Treatment Center, Department of Surgery, University of California, San Francisco, San Francisco, CA 94143-0570, USA
J Pediatr Surg 39:375-80; discussion 375-80. 2004..EXIT procedures have evolved from an adjunct to fetal surgery to a potentially life-saving procedure in fetuses with airway compromise at birth... 
Does congenital diaphragmatic hernia associated with bronchopulmonary sequestration portend a better prognosis?Erich J Grethel
Department of Pediatric Surgery, University of California, San Francisco, CA 94143 0570, USA
Fetal Diagn Ther 23:250-3. 2008..We reviewed our experience to evaluate if prognosis was better in the CDH infants with associated bronchopulmonary sequestration...- Fetal surgery for repair of myelomeningocele allows normal development of anal sphincter muscles in sheepJyoji Yoshizawa
Division of Pediatric Surgery and Fetal Treatment Center, Department of Surgery, University of California, San Francisco, CA, USA
Pediatr Surg Int 20:14-8. 2004..There was no difference in muscle development for the repair methods. Fetal surgery for repair of MMC allows normal development of anal sphincter muscles... - Efficacy of radiofrequency ablation for twin-reversed arterial perfusion sequenceHanmin Lee
Fetal Treatment Center and the Department of Surgery, University of California, San Francisco, San Francisco, CA 94143 0570, USA
Am J Obstet Gynecol 196:459.e1-4. 2007..We report our experience in the treatment of patients with twin-reversed arterial perfusion (TRAP) sequence using radiofrequency ablation to stop perfusion to the acardiac twin and protect the pump twin... - Recent advances in fetal surgeryRaul A Cortes
Division of Pediatric Surgery, The Fetal Treatment Center, University of California, San Frncisrco, CA 94143-0570, USA
Semin Perinatol 28:199-211. 2004..Fetal surgery as a (multi)discipline continues to strive to minimize maternal and fetal risk. Undoubtedly, as tocolytic therapy and neonatal intensive efforts improve, fetal therapy will expand... - Infant pulmonary function in a randomized trial of fetal tracheal occlusion for severe congenital diaphragmatic herniaRoberta L Keller
The Cardiovascular Research Institute and Department of Pediatrics, UCSF Box 0748, San Francisco, CA 94143, USA
Pediatr Res 56:818-25. 2004..We conclude that fetal TO for severe CDH results in modest improvements in neonatal pulmonary function that are of questionable clinical significance... - Survival of severe congenital diaphragmatic hernia has morbid consequencesRaul A Cortes
Department of Surgery and Fetal Treatment Center, University of California in San Francisco Medical Center and Children's Hospital, San Francisco, CA 94143-0570, USA
J Pediatr Surg 40:36-45; discussion 45-6. 2005..Severe CDH carries significant risk of chronic morbidity... - A randomized trial of fetal endoscopic tracheal occlusion for severe fetal congenital diaphragmatic herniaMichael R Harrison
Fetal Treatment Center, University of California, San Francisco, San Francisco, CA 94143-0570, USA
N Engl J Med 349:1916-24. 2003..37.0+/-1.5 weeks; P<0.001). The rates of neonatal morbidity did not differ between the groups. CONCLUSIONS: Tracheal occlusion did not improve survival or morbidity rates in this cohort of fetuses with congenital diaphragmatic hernia... 
Alterations in maternal-fetal cellular trafficking after fetal surgeryPayam Saadai
Division of Pediatric Surgery and Fetal Treatment Center, Department of Surgery, University of California, San Francisco, CA 94143 0570, USA
J Pediatr Surg 47:1089-94. 2012..We hypothesized that patients undergoing open fetal surgery would have altered maternal-fetal cellular trafficking...- Monochorionic twin gestation complicated by a sacrococcygeal teratoma with hydrops--optimal timing of delivery allows for survival of the unaffected twinMarsha Ayzen
Division of Pediatric Surgery, Department of Surgery, University of California, San Francisco, CA 94143, USA
J Pediatr Surg 41:e11-3. 2006..In this case, serial ultrasound evaluations and timing of delivery optimized the outcome of the unaffected twin... - Prosthetic patches for congenital diaphragmatic hernia repair: Surgisis vs Gore-TexErich J Grethel
Division of Pediatric Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
J Pediatr Surg 41:29-33; discussion 29-33. 2006..A recent trend has been toward the use of bioactive prosthetic materials. We reviewed different patch closure techniques used for CDH repair at our institution and their association with these sequelae... - Resolution of hydrops fetalis in congenital cystic adenomatoid malformation after prenatal steroid therapyKuoJen Tsao
Fetal Treatment Center, Division of Pediatric Surgery, Department of Surgery, University of California, San Francisco, California 94143-0570, USA
J Pediatr Surg 38:508-10. 2003..Because the mechanism of this process is speculative, further studies are needed to elucidate the relationship between antenatal steroids and maturation of congenital cystic adenomatoid malformation... - Determination of risk factors for deep venous thrombosis in hospitalized childrenLan T Vu
Division of Pediatric Surgery, Department of Surgery, University of California, Box 0570, San Francisco, CA 94143 0570, USA
J Pediatr Surg 43:1095-9. 2008..Our objective was to determine the time trend and risk factors for deep venous thrombosis (DVT) of the lower extremities among pediatric inpatients... - Thoracoscopic versus open resection for congenital cystic adenomatoid malformations of the lungLan T Vu
Division of Pediatric Surgery, Department of Surgery, University of California, San Francisco, CA 94131 0570, USA
J Pediatr Surg 43:35-9. 2008..This study evaluated the potential advantages of thoracoscopy compared to thoracotomy for resection of congenital cystic adenomatoid malformations (CCAM)... - Surgical treatment of childhood recurrent pancreatitisMatthew S Clifton
Division of Pediatric Surgery, Department of Surgery, University of California San Francisco, Box 0570, San Francisco, CA 94143 0570, USA
J Pediatr Surg 42:1203-7. 2007..Surgical intervention that improves pancreatic ductal drainage is a reasonable treatment strategy for recurrent pancreatitis in children... - Fetal intervention for mass lesions and hydrops improves outcome: a 15-year experienceErich J Grethel
Division of Pediatric Surgery, Fetal Treatment Center, University of California, San Francisco, San Francisco, CA 94143 0570, USA
J Pediatr Surg 42:117-23. 2007..However, hydrops associated with fetal mass lesions can be halted and even reversed with fetal intervention and treatment of the underlying defect. We examined our patients with fetal mass lesions to evaluate survival after intervention... - Maternal morbidity after maternal-fetal surgeryKirstin Golombeck
Division of Pediatric Surgery, Department of Surgery, The Fetal Treatment Center, University of California, San Francisco, CA 94143-0570, USA
Am J Obstet Gynecol 194:834-9. 2006..Maternal-fetal surgery can be performed without maternal death. Results from this study provide helpful data for counseling prospective patients... - Prenatal and postnatal management of a patient with pentalogy of Cantrell and left ventricular aneurysm. A case report and literature reviewErich J Grethel
Fetal Treatment Center, University of California, San Francisco, Calif 94143 0570, USA
Fetal Diagn Ther 22:269-73. 2007.... - Long-term follow-up after thymectomy for myasthenia gravis: thoracoscopic vs openAmy J Wagner
Division of Pediatric Surgery, Department of Surgery, University of California, San Francisco, CA 94143, USA
J Pediatr Surg 41:50-4; discussion 50-4. 2006..The thoracoscopic group has the added benefits of decreased estimated blood loss, decreased length of hospital stay, and improved cosmesis. We advocate the thoracoscopic approach for thymectomy in the treatment of juvenile MG... - Spectrum of intrapartum management strategies for giant fetal cervical teratomaShinjiro Hirose
Department of Surgery, University of California, San Francisco, California 94143-0570, USA
J Pediatr Surg 38:446-50; discussion 446-50. 2003..In patients with airway obstruction, EXIT procedure provides the luxury of time to obtain airway control either by intubation, tracheostomy, or, if necessary, tumor resection on placental support... - Spontaneous rupture of fetal sacrococcygeal teratomaEdgar D Sy
Fetal Treatment Center, University of California, San Francisco, Calif, USA
Fetal Diagn Ther 21:424-7. 2006..At 23 weeks, there was a sudden appearance of an additional lobular mass, consistent with intrauterine spontaneous ruptured of a sacrococcygeal teratoma mass... - Fetal intervention for complications of monochorionic twinningDiana L Farmer
The Fetal Treatment Center, Department of Surgery, Division of Pediatric Surgery, University of California, San Francisco, 513 Parnassus Avenue, Room HSW 1601, San Francisco, California 94143-4086, USA
World J Surg 27:103-7. 2003..A still greater danger exists when monochorionic twins also share a single amniotic sac. Fetal surgical interventions now exist to treat many of the complications associated with twin gestation pregnancies... - Comparison of drainage techniques for biliary atresiaKuoJen Tsao
Fetal Treatment Center, Department of Surgery, Division of Pediatric Surgery, San Francisco, CA 94143-0570, USA
J Pediatr Surg 38:1005-7. 2003..Although the appendix may serve as an alternative biliary conduit, traditional Kasai portoenterostomy appears to achieve better biliary drainage... - Fetal surgery for myelomeningocelePayam Saadai
Division of Pediatric Surgery, Department of Surgery, Fetal Treatment Center, University of California, San Francisco, 513 Parnassus Avenue, HSW 16 01, Box 0570, San Francisco, CA 94143 0570, USA
Clin Perinatol 39:279-88. 2012.... - Fetal surgery for myelomeningoceleShinjiro Hirose
Division of Pediatric Surgery, Department of Surgery, Fetal Treatment Center, University of California, San Francisco, CA 94143 0570, USA
Clin Perinatol 36:431-8, xi. 2009..MMC is the first nonlethal disease under consideration and study for fetal surgery. As a result, potential improvements in outcome must be balanced with maternal safety and well-being, in addition to that of the unborn patient... - Selective reduction of acardiac twin by radiofrequency ablationKuoJen Tsao
Fetal Treatment Center, Department of Surgery, University of California, San Francisco 94143-0570, USA
Am J Obstet Gynecol 187:635-40. 2002..2 weeks. CONCLUSION: Radiofrequency ablation is a minimally invasive, percutaneous technique that can effectively obliterate blood supply to an acardiac twin to preserve and protect the pump twin... - Fetal endoscopic surgery: lessons learned and trends reviewedSteven F Fowler
Department of Surgery, Division of Pediatric Surgery and Fetal Treatment Center, University of California, San Francisco, CA, USA
J Pediatr Surg 37:1700-2. 2002.... - Genetic analysis of congenital cystic adenomatoid malformation reveals a novel pulmonary gene: fatty acid binding protein-7 (brain type)Amy J Wagner
Department of Surgery, University of California, San Francisco, San Francisco, California 94143, USA
Pediatr Res 64:11-6. 2008..Decreased expression of FABP-7 in fetal CCAM compared with normal fetal lung at both the RNA and protein levels suggests FABP-7 may have a role in pulmonary development and in the pathogenesis of CCAM... - Subcutaneous endoscopically assisted ligation (SEAL) of the internal ring for repair of inguinal hernias in children: a novel techniqueMichael R Harrison
Division of Pediatric Surgery, Department of Surgery, University of California, San Francisco, CA 94143 0570, USA
J Pediatr Surg 40:1177-80. 2005..The safety, efficacy (recurrence risk), and cost-effectiveness of this unproven procedure must be tested against standard open repair in a trial... - Fetal surgery for repair of myelomeningocele allows normal development of the rectum in sheepJyoji Yoshizawa
Department of Surgery, Division of Pediatric Surgery and Fetal Treatment Center, University of California San Francisco, San Francisco, California, USA
Pediatr Surg Int 19:162-6. 2003..There was no difference in muscle and nerve development of the rectum among the three repair methods. Fetal surgery for repair of MMC allows normal development of rectal muscles and nerves... - Fetal relative lung volume: quantification by using prenatal MR imaging lung volumetryGethin Williams
Department of Radiology, University of California San Francisco, 505 Parnassus Ave, Box 0628, San Francisco, CA 94143-0628, USA
Radiology 233:457-62. 2004.... - Myelomeningocele: characterization of a surgically induced sheep model and its central nervous system similarities and differences to the human diseaseCornelia S von Koch
Department of Neurological Surgery, University of California, San Francisco, CA 94143-0570, USA
Am J Obstet Gynecol 193:1456-62. 2005..This model may be useful to develop new minimally invasive techniques to halt CSF leak in utero... - Fetal surgery for sacrococcygeal teratomaShinjiro Hirose
Fetal Treatment Center, University of California-San Francisco, 513 Parnassus Avenue, HSW 1601, San Francisco, CA 94143-0570, USA
Clin Perinatol 30:493-506. 2003..Further study is required to determine the role of minimal access techniques in SCT. Future directions for treatment of fetal SCT with hydrops might include fetoscopic resection or high-intensity ultrasound ablation... - Fetal therapy for giant hepatic cystsKuoJen Tsao
Department of Surgery, University of California, San Francisco, CA 94143-0570, USA
J Pediatr Surg 37:E31. 2002..Decompression of giant hepatic cysts may reverse this phenomenon and allow normal fetal development... - Conflicts in wound classification of neonatal operationsLan T Vu
Department of Surgery, University of California, San Francisco, CA 94143 0570, USA
J Pediatr Surg 44:1206-11. 2009..This study sought to determine the reliability of wound classification guidelines when applied to neonatal operations... - Fetal surgery for congenital diaphragmatic hernia and pulmonary sequestration complicated by postnatal diagnosis of transposition of the great arteriesShannon E G Hamrick
Division of Neonatology, University of California San Francisco, San Francisco, Calif 94143, USA
Fetal Diagn Ther 19:40-2. 2004..This triad has not previously been documented in the literature. Clinicians should have a high index of suspicion for associated anomalies, especially cardiac, when evaluating and counseling a pregnancy complicated by CDH... - Prenatal repair of myelomeningocele with aligned nanofibrous scaffolds-a pilot study in sheepPayam Saadai
Department of Surgery, University of California, San Francisco, CA 94143 0570, USA
J Pediatr Surg 46:2279-83. 2011..The purpose of this pilot study was to evaluate the practicality and safety of using biodegradable NS as a regenerative device in prenatal MMC repair... - Indication for pediatric muscle biopsy determines usefulnessRamin Jamshidi
Department of Surgery, University of California, San Francisco, CA 94143 0570, USA
J Pediatr Surg 43:2199-201. 2008..Diagnostic skeletal muscle biopsy is an invasive procedure used for evaluation of neuromuscular disorders. We hypothesize that the yield of biopsy varies with its indication or suspected diagnosis... - Chorioamniotic membrane separation following fetal surgeryRoman M Sydorak
Division of Pediatric Surgery, Department of Surgery, The Fetal Treatment Center, University of California San Francisco, San Francisco, CA 94143-0570, USA
J Perinatol 22:407-10. 2002..Following fetal surgery, the finding of CMS can be a life-threatening complication that warrants further study to understand its etiology and prevention... - Global health in general surgery residency: a national surveySudha P Jayaraman
Department of Surgery, University of California, San Francisco, CA, USA
J Am Coll Surg 208:426-33. 2009..There are limited data from surgery residency programs on their attitudes and scope of activities in this area. This study aims to understand how global health education fits into postgraduate surgical training in the US... - Tissue ablation using high-intensity focused ultrasound in the fetal sheep model: potential for fetal treatmentBettina W Paek
Department of Obstetrics and Gynecology, University of Washington, Seattle 98195 6460, USA
Am J Obstet Gynecol 189:702-5. 2003..In contrast to diagnostic ultrasound where intensity levels are below 0.1 W/cm(2), HIFU can deliver 1,000 to 10,000 W/cm(2) at the focal spot... - Presumptive intrahepatic congenital cystic adenomatoid malformationB Keegan Markhardt
University of Wisconsin, Madison, Wisconsin, USA
J Ultrasound Med 22:531-6. 2003..We present an interesting case of CCAM manifesting within the liver of a patient treated prenatally for a large pulmonary type II CCAM and review the reported cases of IEPS with CCAM...
Research Grants
- Multicenter Trial of Fetal Myelomeningocele RepairDiana Farmer; Fiscal Year: 2006..In summary, the proposed trial is expected to demonstrate whether fetal intervention offers improved outcome with a reasonable quality of life for spina bifida children. ..
- Multicenter Trial of Fetal Myelomeningocele RepairDiana Farmer; Fiscal Year: 2007..In summary, the proposed trial will be able to demonstrate whether fetal intervention offers improved outcome with a reasonable quality of life for spina bifida children. ..