Giamila Fantuzzi

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. pmc Adiponectin in inflammatory and immune-mediated diseases
    Giamila Fantuzzi
    Department of Kinesiology and Nutrition, University of Illinois at Chicago, 1919 W Taylor Street MC517, Chicago, IL 60613, United States Electronic address
    Cytokine 64:1-10. 2013
  2. ncbi request reprint Adiponectin and inflammation: consensus and controversy
    Giamila Fantuzzi
    Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Allergy Clin Immunol 121:326-30. 2008
  3. pmc Three questions about leptin and immunity
    Giamila Fantuzzi
    Department of Kinesiology and Nutrition, University of Illinois at Chicago, 1919 W Taylor Street MC517, Chicago, IL 60612, USA
    Brain Behav Immun 23:405-10. 2009
  4. ncbi request reprint Leptin: nourishment for the immune system
    Giamila Fantuzzi
    Department of Human Nutrition, University of Illinois at Chicago, Chicago 60612, USA
    Eur J Immunol 36:3101-4. 2006
  5. ncbi request reprint Adipose tissue, adipokines, and inflammation
    Giamila Fantuzzi
    Department of Human Nutrition, University of Illinois at Chicago, USA
    J Allergy Clin Immunol 115:911-9; quiz 920. 2005
  6. pmc Adiponectin deficiency does not affect development and progression of spontaneous colitis in IL-10 knockout mice
    Maria Pini
    Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA
    Am J Physiol Gastrointest Liver Physiol 296:G382-7. 2009
  7. pmc Effect of diet-induced obesity on acute pancreatitis induced by administration of interleukin-12 plus interleukin-18 in mice
    Maria Pini
    Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA
    Obesity (Silver Spring) 18:476-81. 2010
  8. pmc Increased adiposity, dysregulated glucose metabolism and systemic inflammation in Galectin-3 KO mice
    Jingbo Pang
    Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS ONE 8:e57915. 2013
  9. pmc Enhanced production of IL-17A during zymosan-induced peritonitis in obese mice
    Maria Pini
    Department of Kinesiology, University of Illinois, Chicago, IL 60612, USA
    J Leukoc Biol 87:51-8. 2010
  10. pmc Adiponectin deficiency modulates adhesion molecules expression and cytokine production but does not affect disease severity in the transfer model of colitis
    Melissa E Gove
    Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA
    Cytokine 47:119-25. 2009

Research Grants

  1. A model of obesity-associated severe acute pancreatitis
    Giamila Fantuzzi; Fiscal Year: 2007
  2. Role of Leptin in murine modeles of IBD
    Giamila Fantuzzi; Fiscal Year: 2007
  3. Acute pancreatitis and obesity
    Giamila Fantuzzi; Fiscal Year: 2010

Collaborators

Detail Information

Publications53

  1. pmc Adiponectin in inflammatory and immune-mediated diseases
    Giamila Fantuzzi
    Department of Kinesiology and Nutrition, University of Illinois at Chicago, 1919 W Taylor Street MC517, Chicago, IL 60613, United States Electronic address
    Cytokine 64:1-10. 2013
    ....
  2. ncbi request reprint Adiponectin and inflammation: consensus and controversy
    Giamila Fantuzzi
    Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Allergy Clin Immunol 121:326-30. 2008
    ..This article discusses this apparent paradox and presents possible alternative and/or complementary explanations...
  3. pmc Three questions about leptin and immunity
    Giamila Fantuzzi
    Department of Kinesiology and Nutrition, University of Illinois at Chicago, 1919 W Taylor Street MC517, Chicago, IL 60612, USA
    Brain Behav Immun 23:405-10. 2009
    ..of immune responses?; (2) Where am I coming from, or Is the cellular source important in determining leptin's effects on immune responses? and (3) What am I doing, or What are leptin's effects on immune and inflammatory responses?..
  4. ncbi request reprint Leptin: nourishment for the immune system
    Giamila Fantuzzi
    Department of Human Nutrition, University of Illinois at Chicago, Chicago 60612, USA
    Eur J Immunol 36:3101-4. 2006
    ..These exciting novel data add an important piece of evidence to the picture of the role of leptin in immunity and inflammation and generate the possibility that many of the effects of leptin on T lymphocytes might be mediated through DC...
  5. ncbi request reprint Adipose tissue, adipokines, and inflammation
    Giamila Fantuzzi
    Department of Human Nutrition, University of Illinois at Chicago, USA
    J Allergy Clin Immunol 115:911-9; quiz 920. 2005
    ..Altered adipokine levels have been observed in a variety of inflammatory conditions, although their pathogenic role has not been completely clarified...
  6. pmc Adiponectin deficiency does not affect development and progression of spontaneous colitis in IL-10 knockout mice
    Maria Pini
    Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA
    Am J Physiol Gastrointest Liver Physiol 296:G382-7. 2009
    ..In conclusion, lack of APN does not play a significant role in the pathogenesis of spontaneous colonic inflammation in the IL-10 KO model...
  7. pmc Effect of diet-induced obesity on acute pancreatitis induced by administration of interleukin-12 plus interleukin-18 in mice
    Maria Pini
    Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA
    Obesity (Silver Spring) 18:476-81. 2010
    ..In conclusion, obesity induced by high-fat diet is associated with increased disease severity and duration in the model of AP induced by administration of IL-12+IL-18...
  8. pmc Increased adiposity, dysregulated glucose metabolism and systemic inflammation in Galectin-3 KO mice
    Jingbo Pang
    Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS ONE 8:e57915. 2013
    ..In conclusion, Gal-3 is an important modulator of glucose metabolism, adiposity and inflammation...
  9. pmc Enhanced production of IL-17A during zymosan-induced peritonitis in obese mice
    Maria Pini
    Department of Kinesiology, University of Illinois, Chicago, IL 60612, USA
    J Leukoc Biol 87:51-8. 2010
    ..These data demonstrate that neutrophil-derived IL-17A is increased in obese mice during acute inflammation and contributes to exacerbation of inflammatory responses...
  10. pmc Adiponectin deficiency modulates adhesion molecules expression and cytokine production but does not affect disease severity in the transfer model of colitis
    Melissa E Gove
    Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA
    Cytokine 47:119-25. 2009
    ..In conclusion, although APN regulates expression of cytokines and adhesion molecules in the colon, this does not result in alteration of overall colitis severity in the CD4(+)CD45RB(high) transfer model...
  11. pmc Interleukin-18, together with interleukin-12, induces severe acute pancreatitis in obese but not in nonobese leptin-deficient mice
    Joseph A Sennello
    Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 105:8085-90. 2008
    ..In conclusion, we developed a pathologically relevant model of AP in which obesity per se is associated with increased severity...
  12. pmc Adipose tissue-specific modulation of galectin expression in lean and obese mice: evidence for regulatory function
    Davina H Rhodes
    Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA
    Obesity (Silver Spring) 21:310-9. 2013
    ..Galectins (Gal) exert many activities, including regulation of inflammation and adipogenesis. We evaluated modulation of Gal-1, -3, -9 and -12 in visceral (VAT) and subcutaneous (SAT) adipose tissue in mice...
  13. pmc Obesity and IL-6 interact in modulating the response to endotoxemia in mice
    Maria Pini
    Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60612, United States
    Cytokine 61:71-7. 2013
    ..Thus, both IL-6 and obesity modulate the response to endotoxemia, suggesting a complex interaction that needs to be considered when evaluating the effect of obesity on the outcome of septic patients...
  14. pmc Rosiglitazone improves survival and hastens recovery from pancreatic inflammation in obese mice
    Maria Pini
    Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS ONE 7:e40944. 2012
    ..However, RGZ worsens selective parameters of AP severity in LFD mice...
  15. pmc Role of leptin receptor-induced STAT3 signaling in modulation of intestinal and hepatic inflammation in mice
    Melissa E Gove
    Kinesiology and Nutrition Department, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Leukoc Biol 85:491-6. 2009
    ..In conclusion, lack of leptin-induced STAT3 signaling is associated with reduced cytokine production following DSS and Con A administration, but it appears to sensitize mice to the effects of proinflammatory mediators...
  16. pmc Role and regulation of adipokines during zymosan-induced peritoneal inflammation in mice
    Maria Pini
    Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Endocrinology 149:4080-5. 2008
    ..These findings point to a complex role for adipokines in ZY-induced peritonitis and further emphasize the interplay between obesity and inflammation...
  17. pmc Effect of adiponectin deficiency on intestinal damage and hematopoietic responses of mice exposed to gamma radiation
    Venkatesh Ponemone
    Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA
    Mutat Res 690:102-7. 2010
    ..Our data indicate that APN deficiency does not play a significant role in modulating radiation-induced gastrointestinal injury in mice, while it may participate in regulation of damage to the hematopoietic system...
  18. pmc Role of IL-6 in the resolution of pancreatitis in obese mice
    Maria Pini
    Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA
    J Leukoc Biol 91:957-66. 2012
    ....
  19. pmc Hematological and acute-phase responses to diet-induced obesity in IL-6 KO mice
    Maria Pini
    Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60612, United States
    Cytokine 56:708-16. 2011
    ..In conclusion, in the absence of overt metabolic alterations, IL-6 modulates leukocytosis, thrombopoiesis and induction of SAA-1, but not other acute-phase proteins in obese mice...
  20. pmc Generation of leptin receptor bone marrow chimeras: recovery from irradiation, immune cellularity, cytokine expression, and metabolic parameters
    Melissa E Gove
    Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA
    Obesity (Silver Spring) 18:2274-81. 2010
    ..Therefore, interpretation of results obtained using BM chimeras between WT and db mice should take into account the difference in radiation sensitivity between the two types of animals...
  21. pmc Transplantation of wild-type white adipose tissue normalizes metabolic, immune and inflammatory alterations in leptin-deficient ob/ob mice
    Joseph A Sennello
    Department of Human Nutrition, University of Illinois at Chicago, 1919 W Taylor Street M C517, Chicago, IL 60612, USA
    Cytokine 36:261-6. 2006
    ..Finally, leptin derived exclusively from WAT is sufficient to normalize metabolic, immune and inflammatory parameters in ob/ob mice...
  22. pmc Homocysteine suppresses lipolysis in adipocytes by activating the AMPK pathway
    Zhigang Wang
    Department of Kinesiology and Nutrition, University of Illinois at Chicago, USA
    Am J Physiol Endocrinol Metab 301:E703-12. 2011
    ..Moreover, Hcy supplementation was associated with elevated leptin levels and reduced adiponectin levels in plasma. These results show that Hcy inhibits lipolysis through a pathway that involves AMPK activation...
  23. doi request reprint Endogenous interferon-gamma is required for efficient skeletal muscle regeneration
    Ming Cheng
    Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA
    Am J Physiol Cell Physiol 294:C1183-91. 2008
    ..In summary, our results indicate that IFN-gamma promotes muscle healing, in part, by stimulating formation of new muscle fibers...
  24. pmc Betaine improved adipose tissue function in mice fed a high-fat diet: a mechanism for hepatoprotective effect of betaine in nonalcoholic fatty liver disease
    Zhigang Wang
    Dept of Human Nutrition, Univ of Illinois at Chicago, IL 60612, USA
    Am J Physiol Gastrointest Liver Physiol 298:G634-42. 2010
    ..Our findings suggest that betaine might serve as a safe and efficacious therapeutic tool for NAFLD by improving adipose tissue function...
  25. doi request reprint Associations between obesity and asthma in a low-income, urban, minority population
    Samuel Dorevitch
    Division of Environmental and Occupational Health Sciences, University of Illinois at Chicago School of Public Health, Chicago, IL 60612, USA
    Ann Allergy Asthma Immunol 110:340-6. 2013
    ..Oxidative stress, perhaps modulated by adipokines, may increase airway inflammation in obese individuals...
  26. pmc PCOS is associated with increased CD11c expression and crown-like structures in adipose tissue and increased central abdominal fat depots independent of obesity
    Zhi Hua Huang
    Department of Medicine, Section of Endocrinology, Diabetes, and Metabolism MC 797, University of Illinois at Chicago, 1819 West Polk Street, Chicago, Illinois 60612, USA
    J Clin Endocrinol Metab 98:E17-24. 2013
    ..Adipose tissue macrophage (ATM) infiltration is a major pathway for obesity-induced insulin resistance but has not been studied as a mechanism for insulin resistance in PCOS...
  27. ncbi request reprint Adipose tissue and atherosclerosis: exploring the connection
    Giamila Fantuzzi
    Department of Human Nutrition, University of Illinois at Chicago, USA
    Arterioscler Thromb Vasc Biol 27:996-1003. 2007
    ..The unfolding role of adipose tissue as an important metabolic and secretory organ provides new opportunities for developing more effective approaches for preventing obesity and its atherosclerotic complications...
  28. pmc Increased adiposity in annexin A1-deficient mice
    Rand T Akasheh
    Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS ONE 8:e82608. 2013
    ....
  29. pmc Fatigue, inflammation, and projected mortality in heart failure
    Anne M Fink
    Department of Biobehavioral Health Science, College of Nursing, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Card Fail 18:711-6. 2012
    ..Fatigue is a prominent and poorly understood symptom of heart failure with reduced ejection fraction (HFrEF). The purpose of this study was to determine whether fatigue correlated with immune biomarkers and prognosis...
  30. doi request reprint Elevated systemic hepcidin and iron depletion in obese premenopausal females
    Lisa M Tussing-Humphreys
    Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA
    Obesity (Silver Spring) 18:1449-56. 2010
    ..However, these findings suggest inflammation may perpetuate this condition by hepcidin-mediated inhibition of dietary iron absorption...
  31. pmc New pathways to control inflammatory responses in adipose tissue
    Rand T Akasheh
    Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA
    Curr Opin Pharmacol 13:613-7. 2013
    ....
  32. pmc Apoptosis and inflammation: role of adipokines in inflammatory bowel disease
    Venkatesh Ponemone
    Kinesiology and Nutrition Department, University of Illinois at Chicago, Chicago, Illinois, USA
    Clin Transl Gastroenterol 1:e1. 2010
    ..We addressed the mechanism by which leptin and APN regulate inflammation and apoptosis in IBD...
  33. ncbi request reprint Urokinase-type plasminogen activator plays essential roles in macrophage chemotaxis and skeletal muscle regeneration
    Scott C Bryer
    Department of Movement Sciences, University of Illinois, Chicago 60612, USA
    J Immunol 180:1179-88. 2008
    ..Overall, the results indicate that uPA plays a fundamental role in macrophage chemotaxis and that macrophage-derived uPA promotes efficient muscle regeneration...
  34. ncbi request reprint Adiponectin deficiency protects mice from chemically induced colonic inflammation
    Raja Fayad
    Department of Human Nutrition, University of Illinois at Chicago, 60612, USA
    Gastroenterology 132:601-14. 2007
    ..Adiponectin (APN) is an adipokine that regulates insulin sensitivity and is anti-inflammatory in atherosclerosis. The goal of this study was to investigate the role of APN in intestinal inflammation...
  35. ncbi request reprint Adiponectin deficiency does not affect the inflammatory response to endotoxin or concanavalin a in mice
    Maria Pini
    Department of Human Nutrition, University of Illinois at Chicago, 1919 West Taylor Street, MC 517, Chicago, Illinois 60612, USA
    Endocrinology 147:5019-22. 2006
    ..These data indicate that--despite its well-described role as an antiinflammatory molecule--endogenous APN does not play a critical role in modulating the inflammatory responses to LPS and ConA in mice...
  36. ncbi request reprint Development of intestinal inflammation in double IL-10- and leptin-deficient mice
    Britta Siegmund
    Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Germany
    J Leukoc Biol 76:782-6. 2004
    ....
  37. ncbi request reprint Leptin: a pivotal mediator of intestinal inflammation in mice
    Britta Siegmund
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Gastroenterology 122:2011-25. 2002
    ..In addition to acting as a regulator of food intake and energy expenditure, leptin can also modulate immune and inflammatory responses. The role of leptin in intestinal inflammation is the focus of the present study...
  38. ncbi request reprint Leptin and host defense against Gram-positive and Gram-negative pneumonia in mice
    Catharina W Wieland
    Center of Infection and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, The Netherlands
    Shock 25:414-9. 2006
    ..pneumoniae or K. pneumoniae in the lower airways...
  39. ncbi request reprint Regulation of T cell-mediated hepatic inflammation by adiponectin and leptin
    Joseph A Sennello
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Endocrinology 146:2157-64. 2005
    ..In conclusion, although leptin increases susceptibility to hepatotoxicity by regulating cytokine production and T cell activation, adiponectin protects hepatocytes from TNF alpha-induced death...
  40. pmc The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines
    Flavio Leoni
    Italfarmaco, SPA, 20092 Cinisello Balsamo, Italy
    Proc Natl Acad Sci U S A 99:2995-3000. 2002
    ..Because SAHA exhibits antiinflammatory properties in vivo and in vitro, inhibitors of histone deacetylase may stimulate the expression of genes that control the synthesis of cytokines and nitric oxide or hyperacetylate other targets...
  41. pmc Pulmonary inflammation induced by Pseudomonas aeruginosa lipopolysaccharide, phospholipase C, and exotoxin A: role of interferon regulatory factor 1
    Catharina W Wieland
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Infect Immun 70:1352-8. 2002
    ..These data indicate that different virulence factors from P. aeruginosa induce pulmonary inflammation in vivo and that IRF-1 is involved in some of the cytokine responses to LPS and ETA...
  42. ncbi request reprint Generation and characterization of mice transgenic for human IL-18-binding protein isoform a
    Giamila Fantuzzi
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Leukoc Biol 74:889-96. 2003
    ..These results indicate that high endogenous levels of IL-18BP in trangenic mice effectively neutralize IL-18 and are protective in response to different inflammatory stimuli...
  43. ncbi request reprint Mycoplasma pneumoniae antigens stimulate interleukin-8
    Kathryn Chmura
    Department of Medicine, National Jewish Medical and Research Center, Denver CO 80206, USA
    Chest 123:425S. 2003
  44. ncbi request reprint Histone hyperacetylation is associated with amelioration of experimental colitis in mice
    Rainer Glauben
    Department of Medicine I, Charite, Campus Benjamin Franklin, Berlin, Germany
    J Immunol 176:5015-22. 2006
    ....
  45. ncbi request reprint GM-CSF DNA induces specific patterns of cytokines and chemokines in the skin: implications for DNA vaccines
    Miguel Angel Perales
    The Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cytokines Cell Mol Ther 7:125-33. 2002
    ..These results have implications for understanding early events in the immune response to DNA vaccines, and provide a basis for development of new approaches to cancer vaccines, including the use of cytokine genes as adjuvants...
  46. pmc IL-18 cDNA vaccination protects mice from spontaneous lupus-like autoimmune disease
    Paola Bossù
    Laboratory of Clinical and Behavioral Neurology, Istituto di Ricovero e Cura a Carattere Scientifico Fondazione Santa Lucia, 00179 Rome, Italy
    Proc Natl Acad Sci U S A 100:14181-6. 2003
    ..These studies support the concept that IL-18 plays a major role in the pathogenesis of the autoimmune syndrome of lpr mice and that a reduction in IL-18 activity could be a therapeutic strategy in autoimmune diseases...
  47. ncbi request reprint Pretreatment with granulocyte-colony stimulating factor decreases lipopolysaccharide-induced interferon-gamma production in mice in association with the production of interleukin-18
    Christine L Shaklee
    Amgen Inc, Thousand Oaks, CA 94555, USA
    Cytokine 25:119-26. 2004
    ..G-CSF decrease of IL-18 production may be a major mechanism explaining the effects of G-CSF on the production of IFN-gamma...
  48. ncbi request reprint Frontline: interferon regulatory factor-1 as a protective gene in intestinal inflammation: role of TCR gamma delta T cells and interleukin-18-binding protein
    Britta Siegmund
    Department of Medicine, University of Colorado Health Sciences Center, Denver, USA
    Eur J Immunol 34:2356-64. 2004
    ..IL-18BP and TCR gamma delta cells appear to be critical factors in the anti-inflammatory effects of IRF-1...
  49. ncbi request reprint Leptin deficiency, not obesity, protects mice from Con A-induced hepatitis
    Britta Siegmund
    Department of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Eur J Immunol 32:552-60. 2002
    ..Furthermore, no decrease in NK T cells was observed in Con A-injected ob/ob mice. We conclude that leptin-deficiency, not obesity, is responsible for protection from Con A-induced hepatitis...
  50. pmc Acute leptin deficiency, leptin resistance, and the physiologic response to leptin withdrawal
    Jason M Montez
    Chromocell Corporation, 675 US Highway One, North Brunswick, NJ 08902 USA
    Proc Natl Acad Sci U S A 102:2537-42. 2005
    ....
  51. ncbi request reprint Pulmonary Mycobacterium tuberculosis infection in leptin-deficient ob/ob mice
    Catharina W Wieland
    Laboratory of Experimental Internal Medicine, and Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Int Immunol 17:1399-408. 2005
    ..Leptin replacement restored the reduced IFNgamma response observed in ob/ob mice. Mortality did not differ between ob/ob and Wt mice. These data suggest that leptin plays a role in the early immune response to pulmonary tuberculosis...
  52. ncbi request reprint T cell-mediated hepatic inflammation modulates adiponectin levels in mice: role of tumor necrosis factor alpha
    Alison M Morris
    Division of Endocrinology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Metabolism 55:555-9. 2006
    ..These findings indicate that inflammation-induced TNF-alpha is a critical mediator of adipose-tissue-derived adiponectin in vivo...
  53. ncbi request reprint Role of leptin deficiency in early acute renal failure during endotoxemia in ob/ob mice
    Wei Wang
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Am Soc Nephrol 15:645-9. 2004
    ..5 mg/kg). In summary, the previously reported increased susceptibility to LPS of ob/ob mice, compared with db/db mice, may be attributable at least in part to increased susceptibility to ARF...

Research Grants7

  1. A model of obesity-associated severe acute pancreatitis
    Giamila Fantuzzi; Fiscal Year: 2007
    ....
  2. Role of Leptin in murine modeles of IBD
    Giamila Fantuzzi; Fiscal Year: 2007
    ..The possible participation of immune-derived leptin in the local inflammatory network will also be investigated. ..
  3. Acute pancreatitis and obesity
    Giamila Fantuzzi; Fiscal Year: 2010
    ....