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Genomes and Genes | G FantuzziSummaryAffiliation: University of Colorado Health Sciences Center Country: USA Publications
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Publications
Generation and characterization of mice transgenic for human IL-18-binding protein isoform aGiamila Fantuzzi
Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Leukoc Biol 74:889-96. 2003..These results indicate that high endogenous levels of IL-18BP in trangenic mice effectively neutralize IL-18 and are protective in response to different inflammatory stimuli...- Role of interferon regulatory factor-1 in the regulation of IL-18 production and activityG Fantuzzi
Department of Medicine, University of Colorado Health Sciences Center, Denver, USA
Eur J Immunol 31:369-75. 2001..In conclusion, IRF-1 regulates IL-18 production and activity mostly by modulating expression of caspase-1 and IL-18BP. In addition, IRF-1 participates in the induction of IFN-gamma by IL-18... - Leptin in the regulation of immunity, inflammation, and hematopoiesisG Fantuzzi
Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
J Leukoc Biol 68:437-46. 2000..Moreover, leptin production is acutely increased during infection and inflammation. This review focuses on the role of leptin in the modulation of the innate immune response, inflammation, and hematopoiesis... 
IL-12-induced IFN-gamma is dependent on caspase-1 processing of the IL-18 precursorG Fantuzzi
Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Clin Invest 104:761-7. 1999..Furthermore, administration of IL-12 significantly increased liver-associated IL-18 levels. These data demonstrate that endogenous, ICE-cleaved IL-18 significantly contributes to induction of IFN-gamma by IL-12...- Interleukin-18 regulation of interferon gamma production and cell proliferation as shown in interleukin-1beta-converting enzyme (caspase-1)-deficient miceG Fantuzzi
Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Blood 91:2118-25. 1998..Our results show that IL-18 is an IL-12-independent regulator of IFNgamma production and of cell proliferation induced by microbial stimuli. However, ICE-dependent processing of IL-18 is not needed for response to mitogens or antigens... - Neutralization of IL-18 reduces neutrophil tissue accumulation and protects mice against lethal Escherichia coli and Salmonella typhimurium endotoxemiaM G Netea
Departments ofMedicine and Surgery, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Immunol 164:2644-9. 2000..coli LPS) or TNF (S. typhimurium LPS) synthesis by anti-IL-18 treatment may also be involved... - Functional reconstitution and regulation of IL-18 activity by the IL-18R beta chainS H Kim
Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Immunol 166:148-54. 2001..The synergism of IL-18 plus IL-12 for IFN-gamma production is, in part, due to IL-12 up-regulation of both IL-18R alpha and IL-18R beta chains, although postreceptor events likely contribute to IFN-gamma production... - Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha productionB Siegmund
Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
Am J Physiol Regul Integr Comp Physiol 281:R1264-73. 2001..The stimulation of lamina propria mononuclear cells by IL-18 and IL-12 resulted in a synergistic increase in IFN-gamma synthesis. These findings suggest that IL-18 is a pivotal mediator in experimental colitis... - Response to local inflammation of IL-1 beta-converting enzyme- deficient miceG Fantuzzi
Department of Medicine, Tufts University School of Medicine and New England Medical Center, Boston, MA 02111, USA
J Immunol 158:1818-24. 1997..Our results demonstrate that in turpentine-induced tissue necrosis, precursor IL-1 beta is processed by non-ICE proteases, but in complement-mediated inflammation, ICE participates in the processing of the IL-1 beta precursor... - IL-18 binding protein increases spontaneous and IL-1-induced prostaglandin production via inhibition of IFN-gammaL L Reznikov
Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Proc Natl Acad Sci U S A 97:2174-9. 2000..These studies demonstrate that IL-18BP decreases endogenous IL-18 activity by reducing IFN-gamma-mediated responses... - Physiological and cytokine responses in IL-1 beta-deficient mice after zymosan-induced inflammationG Fantuzzi
Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver 80262, USA
Am J Physiol 273:R400-6. 1997..Our results demonstrate that IL-1 beta plays a significant, although not exclusive, role in the physiological and cytokine responses to zymosan-mediated inflammation... - Impaired IL-18 processing protects caspase-1-deficient mice from ischemic acute renal failureV Y Melnikov
Department of Medicine, University of Colorado School of Medicine, Denver, Colorado 80262, USA
J Clin Invest 107:1145-52. 2001..Finally, we confirmed histologically that caspase-1(-/-) mice show decreased neutrophil infiltration, indicating that the deleterious role of IL-18 in ischemic ARF may be due to increased neutrophil infiltration... - Utilization of endoscopic inoculation in a mouse model of intrauterine infection-induced preterm birth: role of interleukin 1betaL L Reznikov
Division of Infectious Diseases, University of Colorado Health SciencesCenter, Denver 80262, USA
Biol Reprod 60:1231-8. 1999..This model using direct intracervical bacterial or LPS inoculation is useful for studying preterm pregnancy loss in genetically altered mice in order to develop novel interventions for infection-associated preterm labor... - IL-1 beta -converting enzyme (caspase-1) in intestinal inflammationB Siegmund
Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Proc Natl Acad Sci U S A 98:13249-54. 2001..We conclude that inhibition of ICE represents a novel anti-inflammatory strategy for intestinal inflammation... - Effect of endotoxin in IL-1 beta-deficient miceG Fantuzzi
Department of Medicine, Tufts University School of Medicine, Boston, MA 02111, USA
J Immunol 157:291-6. 1996..In summary, our results suggest that either IL-1 beta is not essential for the in vivo systemic response to LPS or that its role can be fulfilled by other cytokines with overlapping activities... - Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18S H Kim
University of Colorado Health Sciences Center, Denver, CO 80262, USA
Proc Natl Acad Sci U S A 97:1190-5. 2000..It is likely that preferential secretion of functional and nonfunctional isoforms of IL-18BP affect the immune response... - Lessons from interleukin-deficient mice: the interleukin-1 systemG Fantuzzi
University of Colorado Health Sciences Center, Denver, CO 80262, USA
Acta Physiol Scand 173:5-9. 2001..Because some of the components of the IL-1 system are shared with IL-18, similarities between IL-1beta and IL-18 are also discussed... - Interleukin-1beta deficiency results in reduced NF-kappaB levels in pregnant miceL L Reznikov
Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Am J Physiol Regul Integr Comp Physiol 278:R263-70. 2000..This suppression was 25% greater in IL-1beta(-/-) than in IL-1beta(+/+) mice. These data suggest that constitutive NF-kappaB p65 protein synthesis is regulated by IL-1beta, particularly during pregnancy... - The inflammatory response in interleukin-1 beta-deficient mice: comparison with other cytokine-related knock-out miceG Fantuzzi
Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA
J Leukoc Biol 59:489-93. 1996.... - Mouse IL-1 receptor antagonist isoforms: complementary DNA cloning and protein expression of intracellular isoform and tissue distribution of secreted and intracellular IL-1 receptor antagonist in vivoC Gabay
Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
J Immunol 159:5905-13. 1997..Using RPA, primer extension assay and 5' rapid amplification of cDNA ends, we were able to demonstrate the presence of different transcription start sites for murine sIL-1Ra mRNA... - Defective localization of the NADPH phagocyte oxidase to Salmonella-containing phagosomes in tumor necrosis factor p55 receptor-deficient macrophagesA Vazquez-Torres
Department of Medicine, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
Proc Natl Acad Sci U S A 98:2561-5. 2001..TNFalpha-TNFRp55 signaling plays a critical role in the immediate innate immune response to an intracellular pathogen by optimizing the delivery of toxic reactive oxygen species to the phagosome... - Elevated circulating levels of soluble interleukin-1 receptor type II during interleukin-2 immunotherapyE Vannier
Department of Medicine, Division of Geographic Medicine and Infectious Diseases, New England Medical Center and Tufts University School of Medicine, Boston, MA, USA
Eur Cytokine Netw 10:37-42. 1999..IL-1sRI levels did not increase during immunotherapy with IL-2 or IL-6. Our results indicate that IL-1sRII, unlike IL-1Ra, remains a modest, natural, anti-inflammatory mechanism triggered by immunotherapy with IL-2, but not with IL-6... - Adipose tissue, adipokines, and inflammationGiamila Fantuzzi
Department of Human Nutrition, University of Illinois at Chicago, USA
J Allergy Clin Immunol 115:911-9; quiz 920. 2005..Altered adipokine levels have been observed in a variety of inflammatory conditions, although their pathogenic role has not been completely clarified... - Induction of thymocyte apoptosis by systemic administration of concanavalin A in mice: role of TNF-alpha, IFN-gamma and glucocorticoidsRaja Fayad
Department of Human Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA
Eur J Immunol 35:2304-12. 2005..These data demonstrate that the thymus is a critical target organ of Con A-induced inflammation; the effects of Con A on the thymus are mediated by extrathymic production of TNF-alpha and IFN-gamma, but not by glucocorticoids... - Suppressor alphabeta T lymphocytes control innate resistance to endotoxic shockJessica Jones-Carson
Departments of Medicine, and Microbiology, University of Colorado Health Sciences Center, Denver, USA
J Infect Dis 192:1039-46. 2005..These observations suggest that suppressor alphabeta T lymphocytes protect against the proinflammatory cascade unleashed during the innate stages of endotoxemia... - Pulmonary Mycobacterium tuberculosis infection in leptin-deficient ob/ob miceCatharina W Wieland
Laboratory of Experimental Internal Medicine, and Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
Int Immunol 17:1399-408. 2005..Leptin replacement restored the reduced IFNgamma response observed in ob/ob mice. Mortality did not differ between ob/ob and Wt mice. These data suggest that leptin plays a role in the early immune response to pulmonary tuberculosis... - T cell-mediated hepatic inflammation modulates adiponectin levels in mice: role of tumor necrosis factor alphaAlison M Morris
Division of Endocrinology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Metabolism 55:555-9. 2006..These findings indicate that inflammation-induced TNF-alpha is a critical mediator of adipose-tissue-derived adiponectin in vivo... - Histone hyperacetylation is associated with amelioration of experimental colitis in miceRainer Glauben
Department of Medicine I, Charit, Campus Benjamin Franklin, Berlin, Germany
J Immunol 176:5015-22. 2006.... - Leptin and host defense against Gram-positive and Gram-negative pneumonia in miceCatharina W Wieland
Center of Infection and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, The Netherlands
Shock 25:414-9. 2006..pneumoniae or K. pneumoniae in the lower airways... - Adiponectin deficiency does not affect the inflammatory response to endotoxin or concanavalin a in miceMaria Pini
Department of Human Nutrition, University of Illinois at Chicago, 1919 West Taylor Street, MC 517, Chicago, Illinois 60612, USA
Endocrinology 147:5019-22. 2006..These data indicate that--despite its well-described role as an antiinflammatory molecule--endogenous APN does not play a critical role in modulating the inflammatory responses to LPS and ConA in mice... - Soluble human p55 and p75 tumor necrosis factor receptors reverse spontaneous arthritis in transgenic mice expressing transmembrane tumor necrosis factor alphaCarl K Edwards
Amgen, Inc, Thousand Oaks, California, USA
Arthritis Rheum 54:2872-85. 2006.... - Adiponectin deficiency protects mice from chemically induced colonic inflammationRaja Fayad
Department of Human Nutrition, University of Illinois at Chicago, 60612, USA
Gastroenterology 132:601-14. 2007..Adiponectin (APN) is an adipokine that regulates insulin sensitivity and is anti-inflammatory in atherosclerosis. The goal of this study was to investigate the role of APN in intestinal inflammation... - Adipose tissue and atherosclerosis: exploring the connectionGiamila Fantuzzi
Department of Human Nutrition, University of Illinois at Chicago, USA
Arterioscler Thromb Vasc Biol 27:996-1003. 2007..The unfolding role of adipose tissue as an important metabolic and secretory organ provides new opportunities for developing more effective approaches for preventing obesity and its atherosclerotic complications... 
Endogenous interferon-gamma is required for efficient skeletal muscle regenerationMing Cheng
Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA
Am J Physiol Cell Physiol 294:C1183-91. 2008..In summary, our results indicate that IFN-gamma promotes muscle healing, in part, by stimulating formation of new muscle fibers...- Role and regulation of adipokines during zymosan-induced peritoneal inflammation in miceMaria Pini
Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Endocrinology 149:4080-5. 2008..These findings point to a complex role for adipokines in ZY-induced peritonitis and further emphasize the interplay between obesity and inflammation... - Interleukin-18, together with interleukin-12, induces severe acute pancreatitis in obese but not in nonobese leptin-deficient miceJoseph A Sennello
Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA
Proc Natl Acad Sci U S A 105:8085-90. 2008..In conclusion, we developed a pathologically relevant model of AP in which obesity per se is associated with increased severity... - Acute leptin deficiency, leptin resistance, and the physiologic response to leptin withdrawalJason M Montez
Chromocell Corporation, 675 US Highway One, North Brunswick, NJ 08902 USA
Proc Natl Acad Sci U S A 102:2537-42. 2005.... - Regulation of T cell-mediated hepatic inflammation by adiponectin and leptinJoseph A Sennello
Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Endocrinology 146:2157-64. 2005..In conclusion, although leptin increases susceptibility to hepatotoxicity by regulating cytokine production and T cell activation, adiponectin protects hepatocytes from TNF alpha-induced death... - Frontline: interferon regulatory factor-1 as a protective gene in intestinal inflammation: role of TCR gamma delta T cells and interleukin-18-binding proteinBritta Siegmund
Department of Medicine, University of Colorado Health Sciences Center, Denver, USA
Eur J Immunol 34:2356-64. 2004..IL-18BP and TCR gamma delta cells appear to be critical factors in the anti-inflammatory effects of IRF-1... - Effect of interleukin-18 on mouse core body temperatureSilvia Gatti
Pharmaceutical Division, CNS Preclinical Research, F Hoffmann LaRoche, CH 4070 Basel, Switzerland
Am J Physiol Regul Integr Comp Physiol 282:R702-9. 2002..We conclude that IL-18 is not pyrogenic when injected intraperitoneally in C57BL/6 mice. Furthermore, a pretreatment with IL-18, 30 min before IL-1beta, attenuates the febrile response induced by IL-1beta... - Pulmonary inflammation induced by Pseudomonas aeruginosa lipopolysaccharide, phospholipase C, and exotoxin A: role of interferon regulatory factor 1Catharina W Wieland
Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Infect Immun 70:1352-8. 2002..These data indicate that different virulence factors from P. aeruginosa induce pulmonary inflammation in vivo and that IRF-1 is involved in some of the cytokine responses to LPS and ETA... - The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokinesFlavio Leoni
Italfarmaco, SPA, 20092 Cinisello Balsamo, Italy
Proc Natl Acad Sci U S A 99:2995-3000. 2002..Because SAHA exhibits antiinflammatory properties in vivo and in vitro, inhibitors of histone deacetylase may stimulate the expression of genes that control the synthesis of cytokines and nitric oxide or hyperacetylate other targets... - Role of interleukin-18 in host defense against disseminated Candida albicans infectionRogier J L Stuyt
Department of Medicine, University Medical Center St. Radboud, Nijmegen, The Netherlands
Infect Immun 70:3284-6. 2002..There was no effect on the organ load with Candida when gamma interferon (IFN-gamma)-deficient mice were treated with anti-IL-18 antibodies, suggesting that the protective effect of IL-18 is mediated through endogenous IFN-gamma... - Leptin: a pivotal mediator of intestinal inflammation in miceBritta Siegmund
Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Gastroenterology 122:2011-25. 2002..In addition to acting as a regulator of food intake and energy expenditure, leptin can also modulate immune and inflammatory responses. The role of leptin in intestinal inflammation is the focus of the present study... - Regulation of Staphylococcus epidermidis-induced IFN-gamma in whole human blood: the role of endogenous IL-18, IL-12, IL-1, and TNFRogier J L Stuyt
Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
Cytokine 21:65-73. 2003..In conclusion, S. epidermidis stimulates IFN-gamma which is IL-18, IL-12 and TNF-dependent, but IL-1 independent... - Leptin deficiency, not obesity, protects mice from Con A-induced hepatitisBritta Siegmund
Department of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
Eur J Immunol 32:552-60. 2002..Furthermore, no decrease in NK T cells was observed in Con A-injected ob/ob mice. We conclude that leptin-deficiency, not obesity, is responsible for protection from Con A-induced hepatitis... - GM-CSF DNA induces specific patterns of cytokines and chemokines in the skin: implications for DNA vaccinesMiguel Angel Perales
The Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Cytokines Cell Mol Ther 7:125-33. 2002..These results have implications for understanding early events in the immune response to DNA vaccines, and provide a basis for development of new approaches to cancer vaccines, including the use of cytokine genes as adjuvants... - IL-18 cDNA vaccination protects mice from spontaneous lupus-like autoimmune diseasePaola Bossù
Laboratory of Clinical and Behavioral Neurology, Istituto di Ricovero e Cura a Carattere Scientifico Fondazione Santa Lucia, 00179 Rome, Italy
Proc Natl Acad Sci U S A 100:14181-6. 2003..These studies support the concept that IL-18 plays a major role in the pathogenesis of the autoimmune syndrome of lpr mice and that a reduction in IL-18 activity could be a therapeutic strategy in autoimmune diseases... - Development of intestinal inflammation in double IL-10- and leptin-deficient miceBritta Siegmund
Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Germany
J Leukoc Biol 76:782-6. 2004.... - Pretreatment with granulocyte-colony stimulating factor decreases lipopolysaccharide-induced interferon-gamma production in mice in association with the production of interleukin-18Christine L Shaklee
Amgen Inc, Thousand Oaks, CA 94555, USA
Cytokine 25:119-26. 2004..G-CSF decrease of IL-18 production may be a major mechanism explaining the effects of G-CSF on the production of IFN-gamma... - Role of leptin deficiency in early acute renal failure during endotoxemia in ob/ob miceWei Wang
Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Am Soc Nephrol 15:645-9. 2004..5 mg/kg). In summary, the previously reported increased susceptibility to LPS of ob/ob mice, compared with db/db mice, may be attributable at least in part to increased susceptibility to ARF... - Urokinase-type plasminogen activator plays essential roles in macrophage chemotaxis and skeletal muscle regenerationScott C Bryer
Department of Movement Sciences, University of Illinois, Chicago 60612, USA
J Immunol 180:1179-88. 2008..Overall, the results indicate that uPA plays a fundamental role in macrophage chemotaxis and that macrophage-derived uPA promotes efficient muscle regeneration... - Adiponectin and inflammation: consensus and controversyGiamila Fantuzzi
Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA
J Allergy Clin Immunol 121:326-30. 2008..This article discusses this apparent paradox and presents possible alternative and/or complementary explanations... - Transplantation of wild-type white adipose tissue normalizes metabolic, immune and inflammatory alterations in leptin-deficient ob/ob miceJoseph A Sennello
Department of Human Nutrition, University of Illinois at Chicago, 1919 W. Taylor Street M/C517, Chicago, IL 60612, USA
Cytokine 36:261-6. 2006..Finally, leptin derived exclusively from WAT is sufficient to normalize metabolic, immune and inflammatory parameters in ob/ob mice... - Interleukin-18 expression in cystic fibrosis lungsEdward D Chan
Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, 80262, USA
Chest 121:84S-85S. 2002 - Leptin: nourishment for the immune systemGiamila Fantuzzi
Department of Human Nutrition, University of Illinois at Chicago, Chicago 60612, USA
Eur J Immunol 36:3101-4. 2006..These exciting novel data add an important piece of evidence to the picture of the role of leptin in immunity and inflammation and generate the possibility that many of the effects of leptin on T lymphocytes might be mediated through DC... - Interleukin-18 and host defense against infectionCharles A Dinarello
Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Infect Dis 187:S370-84. 2003..Thus, blockade of IL-18 appears to be a viable clinical target to combat the pathologic consequences of sepsis via IFN-gamma mechanisms...