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Genomes and GenesSpecies | M S FanselowSummaryAffiliation: University of California Country: USA Publications
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Contextual fear, gestalt memories, and the hippocampusM S Fanselow
Department of Psychology and Brain Research Institute, University of California, Los Angeles, CA 90095 1563, USA
Behav Brain Res 110:73-81. 2000..It also explains why retrograde amnesia of contextual fear is greater than anterograde amnesia...- The neuroscience of mammalian associative learningMichael S Fanselow
Department of Psychology and Brain Research Institute, University of California Los Angeles, Los Angeles, CA 90095 1563, USA
Annu Rev Psychol 56:207-34. 2005..In this chapter, we describe the orientation that the neuroscience of learning has taken and review some of the progress made within that orientation... - The amygdala, fear, and memoryMichael S Fanselow
Department of Psychology, University of California, Los Angeles, Los Angeles, California 90095 1563, USA
Ann N Y Acad Sci 985:125-34. 2003..Based on such findings we suggest that the frontotemporal amygdala permanently encodes a memory for the hedonic value of the aversive stimulus used to condition fear... 
From contextual fear to a dynamic view of memory systemsMichael S Fanselow
Department of Psychology, 405 Hilgard Avenue, University of California, Los Angeles, Los Angeles, CA 90095 1563, USA
Trends Cogn Sci 14:7-15. 2010..Potential circuits compete to form memories, with the most efficient circuits emerging as winners. However, alternate circuits compensate when these 'primary' circuits are compromised...- Are the dorsal and ventral hippocampus functionally distinct structures?Michael S Fanselow
Department of Psychology and the Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095 1563, USA
Neuron 65:7-19. 2010.... 
Trace and contextual fear conditioning is enhanced in mice lacking the alpha4 subunit of the GABA(A) receptorM D Moore
Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, CA, USA
Neurobiol Learn Mem 93:383-7. 2010....- Retrograde abolition of conditional fear after excitotoxic lesions in the basolateral amygdala of rats: absence of a temporal gradientS Maren
Department of Psychology, University of California, Los Angeles, USA
Behav Neurosci 110:718-26. 1996..These results reveal that neurons in the BLA have an enduring role in the expression of conditional fear... - Dorsal hippocampus involvement in delay fear conditioning depends upon the strength of the tone-footshock associationJennifer J Quinn
Department of Psychology and Brain Research Institute, University of California, Los Angeles, Los Angeles, California 90095, USA
Hippocampus 18:640-54. 2008..The results are discussed in terms of two parallel memory systems: a direct tone-footshock association that is independent of the hippocampus and a hippocampus-dependent memory for the conditioning session... - Bright light suppresses hyperactivity induced by excitotoxic dorsal hippocampus lesions in the ratBill P Godsil
Interdepartmental PhD Program in Neuroscience, University of California, Los Angeles, CA 90095, USA
Behav Neurosci 119:1339-52. 2005..These results demonstrate that a mild fear stimulus, such as bright light, can suppress DH lesion-evoked hyperactivity, and this hyperactivity results from impaired contextual processing... - Context fear learning in the absence of the hippocampusBrian J Wiltgen
Psychology and the Brain Research Institute, University of California, Los Angeles, California 90095, USA
J Neurosci 26:5484-91. 2006..These results demonstrate that alternative systems can acquire context fear but do so less efficiently than the hippocampus... - Amygdala-dependent and amygdala-independent pathways for contextual fear conditioningR Ponnusamy
Psychology and the Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA
Neuroscience 147:919-27. 2007..Normally, learning is dominated by the more efficient primary pathway, which prevents learning in the alternate pathway. However, alternate pathways compensate when the dominant pathway is compromised... - N-methyl-D-aspartate receptors in the basolateral amygdala are required for both acquisition and expression of conditional fear in ratsS Maren
Department of Psychology, University of California, Los Angeles
Behav Neurosci 110:1365-74. 1996..These results indicate that NMDA receptors in the BLA are necessary for both the acquisition and expression of Pavlovian fear conditioning to contextual cues in rats... - Testicular hormones do not regulate sexually dimorphic Pavlovian fear conditioning or perforant-path long-term potentiation in adult male ratsS G Anagnostaras
Department of Psychology, The University of California, Los Angeles 90095 1563, USA
Behav Brain Res 92:1-9. 1998..It is likely that sexual dimorphism in this system is established earlier in development by the organizational effects of gonadal hormones... - Immediate-early gene expression in the amygdala following footshock stress and contextual fear conditioningJ B Rosen
Department of Psychology, University of Delaware, Newark 19716, USA
Brain Res 796:132-42. 1998..This elevation in NGFI-A mRNA was not seen in the immediate-footshock group. This suggests that NGFI-A mRNA in the lateral nucleus of the amygdala may play a role in contextual fear conditioning... - Cholinergic modulation of pavlovian fear conditioning: effects of intrahippocampal scopolamine infusionG D Gale
Department of Psychology and Brain Research Institute, University of California, Los Angeles 90095-1563, USA
Hippocampus 11:371-6. 2001..These findings suggest that fear conditioning to context, but not discrete CS, requires intact cholinergic neurotransmission in the hippocampus... - Mice lacking the beta3 subunit of the GABAA receptor have the epilepsy phenotype and many of the behavioral characteristics of Angelman syndromeT M DeLorey
Department of Molecular and Medical Pharmacology, University of California, Los Angeles, California 90095, USA
J Neurosci 18:8505-14. 1998..At least one other gene, the E6-associated protein ubiquitin-protein ligase (UBE3A) gene, has been implicated in AS, so the relative contribution of the GABRB3 gene alone or in combination with other genes remains to be established... - Compensation in the neural circuitry of fear conditioning awakens learning circuits in the bed nuclei of the stria terminalisAndrew M Poulos
Department of Psychology, Brain Research Institute, University of California, Los Angeles, CA 90095 1563, USA
Proc Natl Acad Sci U S A 107:14881-6. 2010..Unlocking such neural compensation holds promise for understanding situations when brain damage impairs normal function or failure to regulate compensatory sites leads to anxiety disorders... - Long-term memory deficits in Pavlovian fear conditioning in Ca2+/calmodulin kinase kinase alpha-deficient miceFrank Blaeser
Department of Pediatrics, The David Geffen School of Medicine, University of California at Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095 1752, USA
Mol Cell Biol 26:9105-15. 2006..These results demonstrate a selective role for CaMKKalpha in contextual fear memory and suggest that different combinations of upstream and downstream components of the CaMK cascade may serve distinct physiological functions... - Dorsal hippocampus involvement in trace fear conditioning with long, but not short, trace intervals in miceNajwa Chowdhury
Department of Psychology, University of California, Los Angeles, 405 Hilgard Avenue, 90095 CA, USA
Behav Neurosci 119:1396-402. 2005..Given this difference in time scale along with the use of posttraining DH lesions, hippocampus dependency of trace conditioning is not related to a bridging function or response timing... - The accurate measurement of fear memory in Pavlovian conditioning: Resolving the baseline issueNathan S Jacobs
Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095, USA
J Neurosci Methods 190:235-9. 2010..We propose a methodological solution in which baseline fear is reduced to very low levels by first extinguishing fear to the training context and then pre-exposing to the testing context... - Body temperature as a conditional response measure for pavlovian fear conditioningB P Godsil
Department of Psychology, University of California, Los Angeles, California 90095 1563, USA
Learn Mem 7:353-6. 2000..Thus, body temperature can be used as a conditional response measure in Pavlovian fear conditioning experiments that use footshock as the unconditional stimulus... - Selective enhancement of emotional, but not motor, learning in monoamine oxidase A-deficient miceJ J Kim
Neuroscience Program, University of Southern California, Los Angeles, CA 90089 2520, USA
Proc Natl Acad Sci U S A 94:5929-33. 1997..These results suggest that chronic elevations of monoamines, due to a deletion of the gene encoding MAOA, lead to selective alterations in emotional behavior... - Hippocampus and contextual fear conditioning: recent controversies and advancesS G Anagnostaras
Department of Psychology and Brain Research Institute, University of California, Los Angeles 90095-1563, USA
Hippocampus 11:8-17. 2001..In summary, the data support a specific mnemonic role for the DH in the acquisition and consolidation of contextual representations... - NMDA receptor antagonism disrupts the development of morphine analgesic tolerance in male, but not female C57BL/6J miceCamron D Bryant
Interdepartmental Program in Neuroscience, Hatos Center for Neuropharmacology, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, CA 90024, USA
Am J Physiol Regul Integr Comp Physiol 291:R315-26. 2006..Furthermore, the underlying mechanisms are likely to be different from those mediating the sex difference in the modulation of acute morphine analgesia that has previously been reported... - Synapses, circuits, and the ontogeny of learningPamela S Hunt
Department of Psychology, College of William and Mary, PO Box 8795, Williamsburg, VA 23187 8795, USA
Dev Psychobiol 49:649-63. 2007.... - Inverse temporal contributions of the dorsal hippocampus and medial prefrontal cortex to the expression of long-term fear memoriesJennifer J Quinn
Department of Psychology and Brain Research Institute, UCLA, Los Angeles, California 90095 1563, USA
Learn Mem 15:368-72. 2008..These data strongly support the consolidation theory of hippocampus function and implicate the mPFC as a site of long-term memory storage/retrieval... - Exposure to a stressor produces a long lasting enhancement of fear learning in ratsVinuta Rau
Department of Anesthesia, University of California, San Francisco, CA 94143, USA
Stress 12:125-33. 2009..The time-course of the enhancement was examined in the next two experiments. These experiments show that SEFL persists for at least 3 months... - Opioid regulation of Pavlovian overshadowing in fear conditioningMoriel Zelikowsky
Department of Psychology and Brain Research Institute, University of California, Los Angeles, USA
Behav Neurosci 124:510-9. 2010..Collectively, these studies demonstrate an important role for both opioid- and dopamine-mediated processes in multiple-trial overshadowing... - Mouse model of Sanfilippo syndrome type B produced by targeted disruption of the gene encoding alpha-N-acetylglucosaminidaseH H Li
Department of Biological Chemistry, University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 96:14505-10. 1999.... - Sex differences, context preexposure, and the immediate shock deficit in Pavlovian context conditioning with miceB J Wiltgen
Department of Psychology, University of California, Los Angeles 90095 1563, USA
Behav Neurosci 115:26-32. 2001..The results are discussed in terms of configural learning theory and are argued to be contrary to the predictions of scalar expectancy theory... - Selective knockdown of NMDA receptors in primary afferent neurons decreases pain during phase 2 of the formalin testJ A McRoberts
Center for Neurobiology of Stress, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Neuroscience 172:474-82. 2011..001). There was no effect on phase 1 responses. These results suggest that NMDA receptors expressed by primary afferent nerves play an important role in the development of sensitized pain states... - Persistence of fear memory across time requires the basolateral amygdala complexAndrew M Poulos
Department of Psychology and Brain Research Institute, University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 106:11737-41. 2009..Collectively, these findings suggest that fear-related plasticity acquired by brain regions outside of the BLA, unlike those acquired in the intact animals, do so for a relatively time-limited period... - Isoflurane suppresses stress-enhanced fear learning in a rodent model of post-traumatic stress disorderVinuta Rau
Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0464, USA
Anesthesiology 110:487-95. 2009..Subsequent exposure to a single foot shock produces an enhanced fear response. This effect is akin to sensitized reactions shown by some post-traumatic stress disorder patients to cues previously associated with the traumatic event... - Morphine analgesic tolerance in 129P3/J and 129S6/SvEv miceCamron D Bryant
Shirley and Stefan Hatos Center for Neuropharmacology, USA
Pharmacol Biochem Behav 85:769-79. 2006..We conclude that the method of tolerance assessment affects the ability to detect tolerance and thus may affect the degree and pattern of heritability of this trait and this could have implications for gene mapping studies... - Stress-induced enhancement of fear learning: an animal model of posttraumatic stress disorderVinuta Rau
Department of Psychology, University of California, Los Angeles, 415 Hilgard Ave, Los Angeles, CA 90095 1563, USA
Neurosci Biobehav Rev 29:1207-23. 2005..This model can facilitate the study of neurobiological mechanisms underlying sensitization of responses observed in PTSD... - Role of the basolateral amygdala in the storage of fear memories across the adult lifetime of ratsGreg D Gale
Department of Psychology, University of California, Los Angeles, Los Angeles, California 90095 1563, USA
J Neurosci 24:3810-5. 2004..Rather, the consistent pattern of freezing deficits at both training-to-lesion intervals supports a role for the BLA in the permanent storage of fear memory... - NMDA receptor modulation of incidental learning in Pavlovian context conditioningDeborah L Stote
Department of Psychology, University of California, Los Angles, CA 90095-1563, USA
Behav Neurosci 118:253-7. 2004..The next day they were placed in the same chamber without drug and received shock 35 s later. APV blocked the facilitatory effect of preexposure. Therefore NMDA receptors are important for contextual latent learning... - The role of muscarinic and nicotinic cholinergic neurotransmission in aversive conditioning: comparing pavlovian fear conditioning and inhibitory avoidanceMatthew R Tinsley
Department of Psychology, University of California, Los Angeles, California 90095, USA
Learn Mem 11:35-42. 2004 - Alpha 1 subunit-containing GABA type A receptors in forebrain contribute to the effect of inhaled anesthetics on conditioned fearJames M Sonner
Department of Anesthesiology, University of California, San Francisco, San Francisco, California, USA
Mol Pharmacol 68:61-8. 2005..These results indicate that alpha1-containing GABA(A)-Rs in the hippocampus, amygdala, and/or cortex influence the amnestic effects of inhaled anesthetics and may be an important molecular target of the drug isoflurane... - The place of the hippocampus in fear conditioningMatthew J Sanders
UCLA Psychology Department, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095-1563, USA
Eur J Pharmacol 463:217-23. 2003..In this review, we examine the evidence that the hippocampus plays a role in fear conditioning. We then critically examine hypotheses concerning its exact role in learning and memory for cued and context fear conditioning... - Post-training excitotoxic lesions of the dorsal hippocampus attenuate forward trace, backward trace, and delay fear conditioning in a temporally specific mannerJennifer J Quinn
Department of Psychology, University of California, Los Angeles 90095, USA
Hippocampus 12:495-504. 2002..Hippocampal lesions also attenuated contextual conditioning. Thus, the hippocampus is critical for the consolidation and/or expression of a trace fear conditioned stimulus... - Genomic-anatomic evidence for distinct functional domains in hippocampal field CA1Hong Wei Dong
Department of Neurology, Laboratory of Neuro Imaging, School of Medicine, University of California, Los Angeles, CA 90095 7334, USA
Proc Natl Acad Sci U S A 106:11794-9. 2009..Insights emerging from this genomic-anatomic approach provide a starting point for a detailed analysis of differential hippocampal structure-function organization... - Deletion of the mu opioid receptor results in impaired acquisition of Pavlovian context fearMatthew J Sanders
UCLA Psychology Department, Los Angeles, CA, USA
Neurobiol Learn Mem 84:33-41. 2005..The conditioning deficit seen in this line of mice may be related to impairment in hippocampus function... - Pre-training prevents context fear conditioning deficits produced by hippocampal NMDA receptor blockadeMatthew J Sanders
UCLA Psychology Department, 1285 Franz Hall, Los Angeles, CA 90095 1563, USA
Neurobiol Learn Mem 80:123-9. 2003..The data thus suggest that the neurobiological substrates of context learning and place learning overlap... - Dorsal hippocampus NMDA receptors differentially mediate trace and contextual fear conditioningJennifer J Quinn
Department of Psychology and Brain Research Institute, University of California, Los Angeles, Los Angeles, California, USA
Hippocampus 15:665-74. 2005..By contrast, APV attenuated both acquisition and expression of trace fear memories. Thus, DH NMDA receptors appear to contribute to retrieval of some, but not all, fear memories... - Electrolytic lesions of the fimbria/fornix, dorsal hippocampus, or entorhinal cortex produce anterograde deficits in contextual fear conditioning in ratsS Maren
Department of Psychology, University of Michigan, Ann Arbor 48109 1109, USA
Neurobiol Learn Mem 67:142-9. 1997..The relationship of freezing deficits and locomotor hyperactivity in rats with hippocampal formation lesions is discussed... - Trace fear conditioning is enhanced in mice lacking the delta subunit of the GABAA receptorBrian J Wiltgen
Psychology Department, and the Brain Research Institute, UCLA, Los Angeles, California 90095, USA
Learn Mem 12:327-33. 2005..Knockouts are immune to this effect because of the reduced neurosteroid sensitivity that accompanies deletion of the delta subunit. Relationships between neurosteroids, hippocampal excitability, and memory are discussed... - Modulation of an activity response with associative and nonassociative fear in the rat: a lighting differential influences the form of defensive behavior evoked after fear conditioningBill P Godsil
Department of Psychology, University of California, Los Angeles, California 90095-1563, USA
Learn Behav 33:454-63. 2005..This procedure provides a means by which to examine learned and unlearned defensive responses to the same stimulus... - Amygdala and periaqueductal gray lesions only partially attenuate unconditional defensive responses in rats exposed to a catBeatrice M de Oca
University of California, Los Angeles, USA
Integr Physiol Behav Sci 39:318-33. 2004..Escapes from the apparatus were not significantly reduced by lesions of the vPAG and dlPAG. Thus, ACe lesions attenuated climbing and eliminated escapes, but did not impair locomotion of the rat away from the cat... - A high through-put reverse genetic screen identifies two genes involved in remote memory in miceAnna Matynia
Department of Neurobiology, University of California Los Angeles, Los Angeles, California, United States of America
PLoS ONE 3:e2121. 2008..This study identifies some of the first genes required for remote memory, and suggests that screens of targeted mutants may be an efficient strategy to identify molecular requirements for this process... - Short-term memory resists the depressant effect of the nonimmobilizer 1-2-dichlorohexafluorocyclobutane (2N) more than long-term memoryRobert C Dutton
Department of Anesthesia and Perioperative Care, University of California, San Francisco 94143 0464, USA
Anesth Analg 94:631-9; table of contents. 2002.... - Effect of isoflurane and other potent inhaled anesthetics on minimum alveolar concentration, learning, and the righting reflex in mice engineered to express alpha1 gamma-aminobutyric acid type A receptors unresponsive to isofluraneJames M Sonner
Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0464, USA
Anesthesiology 106:107-13. 2007..To test this, the authors created gene knock-in mice harboring mutations that render the receptors insensitive to isoflurane while preserving sensitivity to halothane... - Light stimulus change evokes an activity response in the ratBill P Godsil
University of California, Los Angeles, California 90095, USA
Learn Behav 32:299-310. 2004..This task is amenable to studying light-evoked defensive responses... - The hippocampus and Pavlovian fear conditioning: reply to Bast et alStephan G Anagnostaras
Hippocampus 12:561-5. 2002 - Isoflurane causes anterograde but not retrograde amnesia for pavlovian fear conditioningRobert C Dutton
Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California 94143 0464, USA
Anesthesiology 96:1223-9. 2002..Such disruption would allow suppression of memory of previous untoward events. The authors examined whether isoflurane provides retrograde amnesia for classic (Pavlovian) fear conditioning... - Differential effects of adding and removing components of a context on the generalization of conditional freezingFelisa González
Departamento de Psicologia Experimental y Fisiologia del Comportamiento, Facultad de Psicologia, Universidad de Granada, Campus La Cartuja, 18071 Granada, Spain
J Exp Psychol Anim Behav Process 29:78-83. 2003.... - Isoflurane antagonizes the capacity of flurothyl or 1,2-dichlorohexafluorocyclobutane to impair fear conditioning to context and toneEdmond I Eger
Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, CA 94143 0464
Anesth Analg 96:1010-8, table of contents. 2003..IMPLICATIONS: Conventional inhaled anesthetics and nonimmobilizers are antagonistic in their effects on learning and memory, and this finding suggests that they impair learning and memory, at least in part, by different mechanisms... - NF-kappa B functions in synaptic signaling and behaviorMollie K Meffert
Division of Biology, MC204 31 California Institute of Technology, Pasadena, California 91125, USA
Nat Neurosci 6:1072-8. 2003..These observations suggest that long-term changes to adult neuronal function caused by synaptic stimulation can be regulated by NF-kappa B nuclear translocation and gene activation... - Lesions of the dorsal hippocampus block trace fear conditioned potentiation of startleMarkus Fendt
Fakultat fur Biologie, Universität corrected Tübingen, Tubingen, Germany
Behav Neurosci 119:834-8. 2005..These data indicate that without a dorsal hippocampus rats are unable to acquire trace conditioning but can acquire contextual fear when fear is measured by potentiation of the startle response... - Brief flight to a familiar enclosure in response to a conditional stimulus in ratsBeatrice M de Oca
Psychology Program, California State University, Channel Islands CA 93012, USA
J Gen Psychol 134:153-72. 2007..The results of these 2 experiments support the idea that brief, directed flight in rats is a component of the postencounter stage of predatory imminence (M. S. Fanselow & L. S. Lester, 1988) and is compatible with freezing... - Immediate shock deficit in fear conditioning: effects of shock manipulationsJ Landeira-Fernandez
Departamento de Psicologia, Pontificia Universidade Catolico do Rio de Janeiro, Rio de Janeiro, Brazil
Behav Neurosci 120:873-9. 2006..However, immediate shock seems to sensitize subsequent context conditioning (Experiment 3). These findings suggest that the associative deficit produced by immediate shock is not related to the rat's ability to process the footshock US... - Trace but not delay fear conditioning requires attention and the anterior cingulate cortexC J Han
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
Proc Natl Acad Sci U S A 100:13087-92. 2003..These data suggest that trace conditioning may be useful for studying neural substrates of attention in mice, and implicate the ACC as one such substrate... - Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal networkThomas J McHugh
Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Science 317:94-9. 2007..These results provide evidence that NMDA receptors in the granule cells of the dentate gyrus play a crucial role in the process of pattern separation... - Dissecting the components of the central response to stressEmeran A Mayer
Nat Neurosci 6:1011-2. 2003 - Administration of epinephrine does not increase learning of fear to tone in rats anesthetized with isoflurane or desfluraneJames M Sonner
Department of Anesthesia and Perioperative Care S 455, University of California San Francisco, San Francisco, CA 94143 0464, USA
Anesth Analg 100:1333-7, table of contents. 2005..36 +/- 0.04 MAC in rats injected with 0.1 mg/kg of epinephrine i.p. We conclude that exogenous epinephrine does not decrease amnesia produced by inhaled isoflurane or desflurane, as assessed by fear conditioning to a tone in rats...