Research Topics
Genomes and Genes | Alan S FanningSummaryAffiliation: University of North Carolina Country: USA Publications
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Publications
Zonula occludens-1 and -2 regulate apical cell structure and the zonula adherens cytoskeleton in polarized epitheliaAlan S Fanning
Department of Cell and Molecular Physiology and the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7545, USA
Mol Biol Cell 23:577-90. 2012....
Isolation and functional characterization of the actin binding region in the tight junction protein ZO-1Alan S Fanning
Department of Cell and Molecular Physiology, The University of North Carolina at Chapel Hill, North Carolina 27599 7545, USA
FASEB J 16:1835-7. 2002..We conclude that direct interactions between ZO-1 and F-actin play a role in several different steps of junction assembly...
Zonula occludens-1 and -2 are cytosolic scaffolds that regulate the assembly of cellular junctionsAlan S Fanning
The Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7545, USA
Ann N Y Acad Sci 1165:113-20. 2009..Finally, we propose a model by which the functional activities of ZO proteins in the adherens junction and tight junction are differentiated by a novel regulatory motif known as the U6 or acidic motif...- A Laminin G-EGF-Laminin G module in Neurexin IV is essential for the apico-lateral localization of Contactin and organization of septate junctionsSwati Banerjee
Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America
PLoS ONE 6:e25926. 2011..Given the molecular conservation of SJ proteins across species, our studies may provide insights into how vertebrate axo-glial SJs are organized in myelinated axons... - The single Drosophila ZO-1 protein Polychaetoid regulates embryonic morphogenesis in coordination with Canoe/afadin and EnabledWangsun Choi
Department of Biology, University of North Carolina at Chapel Hill, USA
Mol Biol Cell 22:2010-30. 2011..Canoe (Cno) and Pyd are required for proper Ena localization during dorsal closure, and strong genetic interactions suggest that Cno, Pyd, and Ena act together in regulating or anchoring the actin cytoskeleton during dorsal closure... - ZO-1 stabilizes the tight junction solute barrier through coupling to the perijunctional cytoskeletonChristina M Van Itallie
Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Mol Biol Cell 20:3930-40. 2009..These studies are the first direct evidence that ZO-1 limits solute permeability in established tight junctions, perhaps by forming a stabilizing link between the barrier and perijunctional actomyosin... - The transforming Rho family GTPase Wrch-1 disrupts epithelial cell tight junctions and epithelial morphogenesisDonita C Brady
Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7512, USA
Mol Cell Biol 29:1035-49. 2009..We hypothesize that Wrch-1-induced morphological and growth transformation may occur in part through Par6-mediated disruption of TJs and actin organization... - Setting up a selective barrier at the apical junction complexJames Melvin Anderson
Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Curr Opin Cell Biol 16:140-5. 2004..Similarly, assembly of the barriers requires a conserved set of polarity-generating protein complexes, particularly the PAR protein complexes... - The unique-5 and -6 motifs of ZO-1 regulate tight junction strand localization and scaffolding propertiesAlan S Fanning
Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7545, USA
Mol Biol Cell 18:721-31. 2007..We review these findings in the context of regulated scaffolding functions of other MAGUK proteins... - Occludin is required for cytokine-induced regulation of tight junction barriersChristina M Van Itallie
Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
J Cell Sci 123:2844-52. 2010..These results demonstrate that occludin is required for cells to transduce cytokine-mediated signals that either increase the electrical barrier or decrease the large solute barrier, possibly by coordinating the functions of caveolin-1... - Domain swapping within PDZ2 is responsible for dimerization of ZO proteinsAlan S Fanning
Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7545, USA
J Biol Chem 282:37710-6. 2007..This unique structure reveals an additional example of how PDZ domains dimerize and has multiple implications for both peptide binding and oligomerization in vivo... - Myosin-X functions in polarized epithelial cellsKaty C Liu
Department of Cell and Molecular Physiology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Mol Biol Cell 23:1675-87. 2012..Together these results reveal that Myo10 functions in polarized epithelial cells in junction formation, regulation of paracellular permeability, and epithelial morphogenesis... - Dimerization of the scaffolding protein ZO-1 through the second PDZ domainDarkhan I Utepbergenov
Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, North Carolina 27599-7545, USA
J Biol Chem 281:24671-7. 2006..We conclude that the dimerization of ZO proteins is unlike that of other MAGUKs and that the previously unrecognized ZO-1 homodimers may allow formation of protein networks distinct from those of heterodimers with ZO-2 and ZO-3... - Reversal of charge selectivity in cation or anion-selective epithelial lines by expression of different claudinsChristina M Van Itallie
Department of Medicine, 6312 MBRB, CB 7545, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7545, USA
Am J Physiol Renal Physiol 285:F1078-84. 2003..Additionally, it is possible to rationalize the direction of charge selectivity conferred by the individual claudins on the basis of electrostatic effects of the charged amino acids in their first extracellular loops... - Regulation of epithelial permeability by the actin cytoskeletonLaurel S Rodgers
Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, 27599 7545, USA
Cytoskeleton (Hoboken) 68:653-60. 2011..In this review, we explore the role of the actin cytoskeleton at TJ and present several areas for future study... - Drosophila neurexin IV interacts with Roundabout and is required for repulsive midline axon guidanceSwati Banerjee
Department of Cell and Molecular Physiology, University of North Carolina Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7545, USA
J Neurosci 30:5653-67. 2010..Together, our studies establish that Nrx IV is essential for proper Robo localization and identify Nrx IV as a novel interacting partner of the Slit/Robo signaling pathway... - Structure of the conserved cytoplasmic C-terminal domain of occludin: identification of the ZO-1 binding surfaceYuanhe Li
Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA
J Mol Biol 352:151-64. 2005..Our results provide a model to further test the function of occludin and its binding to other proteins... - Cortactin is necessary for E-cadherin-mediated contact formation and actin reorganizationFalak M Helwani
Institute for Molecular Bioscience, University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia
J Cell Biol 164:899-910. 2004..Together, our findings identify a necessary role for cortactin in the cadherin-actin cooperation that supports productive contact formation... - Tricellulin is a tight-junction protein necessary for hearingSaima Riazuddin
Section on Human Genetics, Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850, USA
Am J Hum Genet 79:1040-51. 2006..A wild-type isoform of tricellulin, which lacks this conserved region, is unaffected by the mutant alleles and is hypothesized to be sufficient for structural and functional integrity of epithelial barriers outside the inner ear...