Alan S Fanning

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Zonula occludens-1 and -2 regulate apical cell structure and the zonula adherens cytoskeleton in polarized epithelia
    Alan S Fanning
    Department of Cell and Molecular Physiology and the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7545, USA
    Mol Biol Cell 23:577-90. 2012
  2. ncbi request reprint Isolation and functional characterization of the actin binding region in the tight junction protein ZO-1
    Alan S Fanning
    Department of Cell and Molecular Physiology, The University of North Carolina at Chapel Hill, North Carolina 27599 7545, USA
    FASEB J 16:1835-7. 2002
  3. pmc Zonula occludens-1 and -2 are cytosolic scaffolds that regulate the assembly of cellular junctions
    Alan S Fanning
    The Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7545, USA
    Ann N Y Acad Sci 1165:113-20. 2009
  4. pmc A Laminin G-EGF-Laminin G module in Neurexin IV is essential for the apico-lateral localization of Contactin and organization of septate junctions
    Swati Banerjee
    Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America
    PLoS ONE 6:e25926. 2011
  5. pmc The single Drosophila ZO-1 protein Polychaetoid regulates embryonic morphogenesis in coordination with Canoe/afadin and Enabled
    Wangsun Choi
    Department of Biology, University of North Carolina at Chapel Hill, USA
    Mol Biol Cell 22:2010-30. 2011
  6. pmc ZO-1 stabilizes the tight junction solute barrier through coupling to the perijunctional cytoskeleton
    Christina M Van Itallie
    Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Mol Biol Cell 20:3930-40. 2009
  7. pmc The transforming Rho family GTPase Wrch-1 disrupts epithelial cell tight junctions and epithelial morphogenesis
    Donita C Brady
    Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7512, USA
    Mol Cell Biol 29:1035-49. 2009
  8. ncbi request reprint Setting up a selective barrier at the apical junction complex
    James Melvin Anderson
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Curr Opin Cell Biol 16:140-5. 2004
  9. pmc The unique-5 and -6 motifs of ZO-1 regulate tight junction strand localization and scaffolding properties
    Alan S Fanning
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7545, USA
    Mol Biol Cell 18:721-31. 2007
  10. pmc Domain swapping within PDZ2 is responsible for dimerization of ZO proteins
    Alan S Fanning
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7545, USA
    J Biol Chem 282:37710-6. 2007

Collaborators

  • Thomas Ma
  • James Anderson
  • Manzoor A Bhat
  • Adrienne D Cox
  • Stephen L Rogers
  • Arnon Lavie
  • A Forge
  • Zubair M Ahmed
  • Christina M Van Itallie
  • Laurel S Rodgers
  • Swati Banerjee
  • Katy C Liu
  • Wangsun Choi
  • Kevin Blauth
  • Donita C Brady
  • Darkhan I Utepbergenov
  • Saima Riazuddin
  • Yuanhe Li
  • Falak M Helwani
  • M Tanner Beam
  • Damon T Jacobs
  • Richard E Cheney
  • Brian D Dunn
  • Victoria J Madden
  • Greg J Beitel
  • Kevin S Nelson
  • Elizabeth S Fisher
  • Kuo Chen Jung
  • Mark Peifer
  • Raehum Paik
  • Rosa E Mino
  • Kimberly Peters
  • Jennifer Holmes
  • Jamie K Alan
  • James P Madigan
  • Arlene Bridges
  • Parna Chattaraj
  • Shin ichiro Kitajiri
  • Penelope L Friedman
  • Shaheen N Khan
  • Thomas B Friedman
  • Khushnooda Ramzan
  • Ayala Lagziel
  • Sheikh Riazuddin
  • Inna A Belyantseva
  • Eva M Kovacs
  • Suzie Verma
  • Alpha S Yap
  • Radiya G Ali
  • Scott A Weed
  • Andrew D Paterson

Detail Information

Publications20

  1. pmc Zonula occludens-1 and -2 regulate apical cell structure and the zonula adherens cytoskeleton in polarized epithelia
    Alan S Fanning
    Department of Cell and Molecular Physiology and the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7545, USA
    Mol Biol Cell 23:577-90. 2012
    ....
  2. ncbi request reprint Isolation and functional characterization of the actin binding region in the tight junction protein ZO-1
    Alan S Fanning
    Department of Cell and Molecular Physiology, The University of North Carolina at Chapel Hill, North Carolina 27599 7545, USA
    FASEB J 16:1835-7. 2002
    ..We conclude that direct interactions between ZO-1 and F-actin play a role in several different steps of junction assembly...
  3. pmc Zonula occludens-1 and -2 are cytosolic scaffolds that regulate the assembly of cellular junctions
    Alan S Fanning
    The Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7545, USA
    Ann N Y Acad Sci 1165:113-20. 2009
    ..Finally, we propose a model by which the functional activities of ZO proteins in the adherens junction and tight junction are differentiated by a novel regulatory motif known as the U6 or acidic motif...
  4. pmc A Laminin G-EGF-Laminin G module in Neurexin IV is essential for the apico-lateral localization of Contactin and organization of septate junctions
    Swati Banerjee
    Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America
    PLoS ONE 6:e25926. 2011
    ..Given the molecular conservation of SJ proteins across species, our studies may provide insights into how vertebrate axo-glial SJs are organized in myelinated axons...
  5. pmc The single Drosophila ZO-1 protein Polychaetoid regulates embryonic morphogenesis in coordination with Canoe/afadin and Enabled
    Wangsun Choi
    Department of Biology, University of North Carolina at Chapel Hill, USA
    Mol Biol Cell 22:2010-30. 2011
    ..Canoe (Cno) and Pyd are required for proper Ena localization during dorsal closure, and strong genetic interactions suggest that Cno, Pyd, and Ena act together in regulating or anchoring the actin cytoskeleton during dorsal closure...
  6. pmc ZO-1 stabilizes the tight junction solute barrier through coupling to the perijunctional cytoskeleton
    Christina M Van Itallie
    Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Mol Biol Cell 20:3930-40. 2009
    ..These studies are the first direct evidence that ZO-1 limits solute permeability in established tight junctions, perhaps by forming a stabilizing link between the barrier and perijunctional actomyosin...
  7. pmc The transforming Rho family GTPase Wrch-1 disrupts epithelial cell tight junctions and epithelial morphogenesis
    Donita C Brady
    Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7512, USA
    Mol Cell Biol 29:1035-49. 2009
    ..We hypothesize that Wrch-1-induced morphological and growth transformation may occur in part through Par6-mediated disruption of TJs and actin organization...
  8. ncbi request reprint Setting up a selective barrier at the apical junction complex
    James Melvin Anderson
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Curr Opin Cell Biol 16:140-5. 2004
    ..Similarly, assembly of the barriers requires a conserved set of polarity-generating protein complexes, particularly the PAR protein complexes...
  9. pmc The unique-5 and -6 motifs of ZO-1 regulate tight junction strand localization and scaffolding properties
    Alan S Fanning
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7545, USA
    Mol Biol Cell 18:721-31. 2007
    ..We review these findings in the context of regulated scaffolding functions of other MAGUK proteins...
  10. pmc Domain swapping within PDZ2 is responsible for dimerization of ZO proteins
    Alan S Fanning
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7545, USA
    J Biol Chem 282:37710-6. 2007
    ..This unique structure reveals an additional example of how PDZ domains dimerize and has multiple implications for both peptide binding and oligomerization in vivo...
  11. pmc Occludin is required for cytokine-induced regulation of tight junction barriers
    Christina M Van Itallie
    Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    J Cell Sci 123:2844-52. 2010
    ..These results demonstrate that occludin is required for cells to transduce cytokine-mediated signals that either increase the electrical barrier or decrease the large solute barrier, possibly by coordinating the functions of caveolin-1...
  12. pmc Epithelial barrier assembly requires coordinated activity of multiple domains of the tight junction protein ZO-1
    Laurel S Rodgers
    Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, CB7545, Chapel Hill, NC 27599 7545, USA
    J Cell Sci 126:1565-75. 2013
    ..Our results establish that ZO-1 acts as a true scaffolding protein and that the coordinated activity of multiple domains is required for normal TJ structure and function...
  13. pmc Myosin-X functions in polarized epithelial cells
    Katy C Liu
    Department of Cell and Molecular Physiology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Mol Biol Cell 23:1675-87. 2012
    ..Together these results reveal that Myo10 functions in polarized epithelial cells in junction formation, regulation of paracellular permeability, and epithelial morphogenesis...
  14. ncbi request reprint Dimerization of the scaffolding protein ZO-1 through the second PDZ domain
    Darkhan I Utepbergenov
    Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, North Carolina 27599 7545, USA
    J Biol Chem 281:24671-7. 2006
    ..We conclude that the dimerization of ZO proteins is unlike that of other MAGUKs and that the previously unrecognized ZO-1 homodimers may allow formation of protein networks distinct from those of heterodimers with ZO-2 and ZO-3...
  15. ncbi request reprint Reversal of charge selectivity in cation or anion-selective epithelial lines by expression of different claudins
    Christina M Van Itallie
    Department of Medicine, 6312 MBRB, CB 7545, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7545, USA
    Am J Physiol Renal Physiol 285:F1078-84. 2003
    ..Additionally, it is possible to rationalize the direction of charge selectivity conferred by the individual claudins on the basis of electrostatic effects of the charged amino acids in their first extracellular loops...
  16. pmc Regulation of epithelial permeability by the actin cytoskeleton
    Laurel S Rodgers
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, 27599 7545, USA
    Cytoskeleton (Hoboken) 68:653-60. 2011
    ..In this review, we explore the role of the actin cytoskeleton at TJ and present several areas for future study...
  17. pmc Drosophila neurexin IV interacts with Roundabout and is required for repulsive midline axon guidance
    Swati Banerjee
    Department of Cell and Molecular Physiology, University of North Carolina Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7545, USA
    J Neurosci 30:5653-67. 2010
    ..Together, our studies establish that Nrx IV is essential for proper Robo localization and identify Nrx IV as a novel interacting partner of the Slit/Robo signaling pathway...
  18. pmc Cortactin is necessary for E-cadherin-mediated contact formation and actin reorganization
    Falak M Helwani
    Institute for Molecular Bioscience, University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia
    J Cell Biol 164:899-910. 2004
    ..Together, our findings identify a necessary role for cortactin in the cadherin-actin cooperation that supports productive contact formation...
  19. pmc Tricellulin is a tight-junction protein necessary for hearing
    Saima Riazuddin
    Section on Human Genetics, Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850, USA
    Am J Hum Genet 79:1040-51. 2006
    ..A wild-type isoform of tricellulin, which lacks this conserved region, is unaffected by the mutant alleles and is hypothesized to be sufficient for structural and functional integrity of epithelial barriers outside the inner ear...
  20. ncbi request reprint Structure of the conserved cytoplasmic C-terminal domain of occludin: identification of the ZO-1 binding surface
    Yuanhe Li
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA
    J Mol Biol 352:151-64. 2005
    ..Our results provide a model to further test the function of occludin and its binding to other proteins...