Ferric Fang

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Antimicrobial reactive oxygen and nitrogen species: concepts and controversies
    Ferric C Fang
    Department of Laboratory Medicine, University of Washington School of Medicine, 1959 North East Pacific Street, Box 357242, Seattle, Washington 98195 7242, USA
    Nat Rev Microbiol 2:820-32. 2004
  2. ncbi request reprint Salmonella selectively stops traffic
    Ferric Fang
    Depts of Laboratory Medicine and Microbiology, University of Washington School of Medicine, Seattle, WA 98195 7242, USA
    Trends Microbiol 10:391-2. 2002
  3. pmc Liver abscess caused by magA+ Klebsiella pneumoniae in North America
    Ferric C Fang
    Department of Medicine, University of Washington School of Medicine and Harborview Medical Center, Box 357242, Seattle, WA 98195, USA
    J Clin Microbiol 43:991-2. 2005
  4. pmc Isocitrate lyase (AceA) is required for Salmonella persistence but not for acute lethal infection in mice
    Ferric C Fang
    Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, WA 98195 7242, USA
    Infect Immun 73:2547-9. 2005
  5. pmc Sigma cascades in prokaryotic regulatory networks
    Ferric C Fang
    Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 102:4933-4. 2005
  6. ncbi request reprint Alternative sigma factor interactions in Salmonella: sigma and sigma promote antioxidant defences by enhancing sigma levels
    Iel Soo Bang
    Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA
    Mol Microbiol 56:811-23. 2005
  7. ncbi request reprint Compensatory role of PspA, a member of the phage shock protein operon, in rpoE mutant Salmonella enterica serovar Typhimurium
    Lynne A Becker
    Departments of Laboratory Medicine and Microbiology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Mol Microbiol 56:1004-16. 2005
  8. ncbi request reprint The role of ferritins in the physiology of Salmonella enterica sv. Typhimurium: a unique role for ferritin B in iron-sulphur cluster repair and virulence
    Jyoti Velayudhan
    Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA
    Mol Microbiol 63:1495-507. 2007
  9. pmc On rejection
    Ferric C Fang
    Mailing address Departments of Laboratory Medicine and Microbiology, University of Washington School of Medicine, 1959 NE Pacific Street, Box 357242, Seattle, WA 98195 7242
    Infect Immun 76:1802-3. 2008
  10. pmc New insights into transcriptional regulation by H-NS
    Ferric C Fang
    Department of Laboratory Medicine, University of Washington School of Medicine, 1959 NE Pacific Street, Box 357242, Seattle, WA 98195 7242 USA
    Curr Opin Microbiol 11:113-20. 2008

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Antimicrobial reactive oxygen and nitrogen species: concepts and controversies
    Ferric C Fang
    Department of Laboratory Medicine, University of Washington School of Medicine, 1959 North East Pacific Street, Box 357242, Seattle, Washington 98195 7242, USA
    Nat Rev Microbiol 2:820-32. 2004
    ..This review updates the reader on these concepts and the topical questions in the field...
  2. ncbi request reprint Salmonella selectively stops traffic
    Ferric Fang
    Depts of Laboratory Medicine and Microbiology, University of Washington School of Medicine, Seattle, WA 98195 7242, USA
    Trends Microbiol 10:391-2. 2002
    ..New research has now revealed that SPI-2 effectors also interfere with the colocalization of inducible nitric oxide synthase (iNOS) to SCVs, thus protecting the pathogen from the antimicrobial actions of reactive nitrogen species...
  3. pmc Liver abscess caused by magA+ Klebsiella pneumoniae in North America
    Ferric C Fang
    Department of Medicine, University of Washington School of Medicine and Harborview Medical Center, Box 357242, Seattle, WA 98195, USA
    J Clin Microbiol 43:991-2. 2005
    ..We report a patient transferred from Alaska to Washington State with a magA(+) K. pneumoniae liver abscess and describe a simple approach for recognition of these hypervirulent strains...
  4. pmc Isocitrate lyase (AceA) is required for Salmonella persistence but not for acute lethal infection in mice
    Ferric C Fang
    Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, WA 98195 7242, USA
    Infect Immun 73:2547-9. 2005
    ..Substrate availability in the phagosome appears to evolve over time, with increasing fatty acid dependence during chronic infection...
  5. pmc Sigma cascades in prokaryotic regulatory networks
    Ferric C Fang
    Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 102:4933-4. 2005
  6. ncbi request reprint Alternative sigma factor interactions in Salmonella: sigma and sigma promote antioxidant defences by enhancing sigma levels
    Iel Soo Bang
    Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA
    Mol Microbiol 56:811-23. 2005
    ..Interactions between alternative sigma factors permit the integration of diverse stress signals to produce coordinated genetic responses...
  7. ncbi request reprint Compensatory role of PspA, a member of the phage shock protein operon, in rpoE mutant Salmonella enterica serovar Typhimurium
    Lynne A Becker
    Departments of Laboratory Medicine and Microbiology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Mol Microbiol 56:1004-16. 2005
    ..These findings suggest that pspA expression in S. Typhimurium is induced by alterations in PMF and a functional sigma(E) regulon is essential for the maintenance of PMF...
  8. ncbi request reprint The role of ferritins in the physiology of Salmonella enterica sv. Typhimurium: a unique role for ferritin B in iron-sulphur cluster repair and virulence
    Jyoti Velayudhan
    Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA
    Mol Microbiol 63:1495-507. 2007
    ..The absence of a conserved ferroxidase domain and the potentiation of oxidative stress by FtnB in some strains lacking Dps suggest that FtnB serves as a facile cellular reservoir of Fe2+...
  9. pmc On rejection
    Ferric C Fang
    Mailing address Departments of Laboratory Medicine and Microbiology, University of Washington School of Medicine, 1959 NE Pacific Street, Box 357242, Seattle, WA 98195 7242
    Infect Immun 76:1802-3. 2008
  10. pmc New insights into transcriptional regulation by H-NS
    Ferric C Fang
    Department of Laboratory Medicine, University of Washington School of Medicine, 1959 NE Pacific Street, Box 357242, Seattle, WA 98195 7242 USA
    Curr Opin Microbiol 11:113-20. 2008
    ..This review will highlight recent insights into the mechanism and biological importance of H-NS-DNA interactions...
  11. ncbi request reprint The nitrosative stress response of Staphylococcus aureus is required for resistance to innate immunity
    Anthony R Richardson
    Department of Laboratory Medicine, University of Washington, School of Medicine, Seattle, WA 98185, USA
    Mol Microbiol 61:927-39. 2006
    ..production. Thus, the S. aureus Hmp protein has evolved to serve as an iNOS-dependent virulence determinant...
  12. ncbi request reprint Silencing of xenogeneic DNA by H-NS-facilitation of lateral gene transfer in bacteria by a defense system that recognizes foreign DNA
    William Wiley Navarre
    Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195, USA
    Genes Dev 21:1456-71. 2007
    ..The possibility that microorganisms maintain and exploit their characteristic genomic GC ratios for the purpose of self/non-self-discrimination is discussed...
  13. ncbi request reprint Selective silencing of foreign DNA with low GC content by the H-NS protein in Salmonella
    William Wiley Navarre
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    Science 313:236-8. 2006
    ..Characteristic GC/AT ratios of bacterial genomes may facilitate discrimination between a cell's own DNA and foreign DNA...
  14. doi request reprint Acid stress activation of the sigma(E) stress response in Salmonella enterica serovar Typhimurium
    Cecile Muller
    Departments of Laboratory Medicine, University o9f Washington School of Medicine, Seattle, WA 98121, USA
    Mol Microbiol 71:1228-38. 2009
    ..These observations demonstrate a novel environmental stimulus and activation pathway for the sigma(E) regulon that appear to be critically important during Salmonella-host cell interactions...
  15. pmc Coordinate regulation of Salmonella pathogenicity island 1 (SPI1) and SPI4 in Salmonella enterica serovar Typhimurium
    Kara L Main-Hester
    Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Infect Immun 76:1024-35. 2008
    ..Coordinate regulation suggests that SPI1 and SPI4 play complementary roles in the interaction of S. enterica serovar Typhimurium with the host intestinal mucosa...
  16. ncbi request reprint Regulation of Salmonella typhimurium virulence gene expression by cationic antimicrobial peptides
    Martin W Bader
    Departments of Microbiology and Laboratory Medicine, University of Washington Medical School, Seattle, WA 98195, USA
    Mol Microbiol 50:219-30. 2003
    ..Because bacterial resistance to oxidative stress and CAMP are induced during infection of animals, CAMP may be an important signal recognized by bacteria on colonization of animal tissues...
  17. ncbi request reprint The alternative sigma factor sigma is required for resistance of Salmonella enterica serovar Typhimurium to anti-microbial peptides
    Marie Laure Crouch
    Department of Laboratory Medicine, Universit of Washington School of Medicine, Seattle, WA 98195, USA
    Mol Microbiol 56:789-99. 2005
    ..In contrast to P2, Crp4 does not inhibit bacterial respiration at lethal concentrations. However, both peptides induce expression of rpoE, suggesting that they trigger a common mechanism for sensing extracytoplasmic stress...
  18. doi request reprint Biosynthesis and IroC-dependent export of the siderophore salmochelin are essential for virulence of Salmonella enterica serovar Typhimurium
    Marie Laure V Crouch
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    Mol Microbiol 67:971-83. 2008
    ..Salmonella mutants deficient in salmochelin synthesis or secretion exhibit reduced virulence during systemic infection of mice...
  19. pmc The Base Excision Repair system of Salmonella enterica serovar typhimurium counteracts DNA damage by host nitric oxide
    Anthony R Richardson
    Department of Laboratory Medicine, University of Washington, Seattle, WA, USA
    PLoS Pathog 5:e1000451. 2009
    ..These observations demonstrate that host-derived NO. damages Salmonella DNA in vivo, and the BER system is required to maintain bacterial genomic integrity...
  20. ncbi request reprint Co-regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ
    William Wiley Navarre
    Department of Microbiology, University of Washington, Seattle, WA 98195, USA
    Mol Microbiol 56:492-508. 2005
    ..The absence of almost all SlyA-activated genes from the Escherichia coli K12 genome suggests that the functional linkage between the SlyA and PhoP/PhoQ regulatory systems arose as Salmonella evolved its distinctive pathogenic lifestyle...
  21. pmc Nutrient availability as a mechanism for selection of antibiotic tolerant Pseudomonas aeruginosa within the CF airway
    Lucas R Hoffman
    Department of Pediatrics, University of Washington, Seattle, Washington, USA
    PLoS Pathog 6:e1000712. 2010
    ....
  22. ncbi request reprint Maintenance of nitric oxide and redox homeostasis by the salmonella flavohemoglobin hmp
    Iel Soo Bang
    Departments of Microbiology and Laboratory Medicine, University of Washington School of Medicine, Seattle, 98195, USA
    J Biol Chem 281:28039-47. 2006
    ..The Hmp flavohemoglobin plays a central role in the response of Salmonella to nitrosative stress but requires precise regulation to avoid the exacerbation of oxidative stress that can result if electrons are shuttled to extraneous iron...
  23. pmc Inhibition of bacterial DNA replication by zinc mobilization during nitrosative stress
    Jeffrey M Schapiro
    Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, WA 98195 7242, USA
    Proc Natl Acad Sci U S A 100:8496-501. 2003
    ..Inhibition of DNA replication during nitrosative stress is invariably accompanied by zinc mobilization, implicating DNA-binding zinc metalloproteins as critical targets of NO-related antimicrobial activity...
  24. doi request reprint A nitric oxide-inducible lactate dehydrogenase enables Staphylococcus aureus to resist innate immunity
    Anthony R Richardson
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    Science 319:1672-6. 2008
    ..NO.-inducible lactate dehydrogenase activity and NO. resistance distinguish S. aureus from the closely related commensal species S. epidermidis and S. saprophyticus...
  25. pmc Isolation of metronidazole-resistant Bacteroides fragilis carrying the nimA nitroreductase gene from a patient in Washington State
    Jeffrey M Schapiro
    Department of Laboratory Medicine, University of Washington Medical Center, Box 357110, 1959 NE Pacific St, Seattle, WA 98195, USA
    J Clin Microbiol 42:4127-9. 2004
    ..fragilis strains in the United States and the importance of susceptibility testing in selected situations...
  26. pmc Evaluation of tcdB real-time PCR in a three-step diagnostic algorithm for detection of toxigenic Clostridium difficile
    Ann M Larson
    Clinical Microbiology Laboratory, Harborview Medical Center, Seattle, Washington 98104, USA
    J Clin Microbiol 48:124-30. 2010
    ..7% of specimens, although this approach is less sensitive than performing DPCR on all specimens...
  27. pmc Humanized nonobese diabetic-scid IL2rgammanull mice are susceptible to lethal Salmonella Typhi infection
    Stephen J Libby
    Departments of Laboratory Medicine and Microbiology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 107:15589-94. 2010
    ..Typhi in mice. The hu-SRC-SCID mouse provides an unprecedented opportunity to gain insights into S. Typhi pathogenesis and devise strategies for the prevention of typhoid fever...
  28. ncbi request reprint The response regulator SsrB activates expression of diverse Salmonella pathogenicity island 2 promoters and counters silencing by the nucleoid-associated protein H-NS
    Don Walthers
    University of Illinois at Chicago, Department of Microbiology and Immunology, 835 S Wolcott Ave M C 790, Chicago, IL 60612, USA
    Mol Microbiol 65:477-93. 2007
    ..SsrB appears to possess dual activities to promote SPI-2 gene expression: activation of transcription and relief of H-NS-mediated repression...
  29. pmc The ferritin-like Dps protein is required for Salmonella enterica serovar Typhimurium oxidative stress resistance and virulence
    Thomas A Halsey
    Department of Microbiology, North Carolina State University, Raleigh, North Carolina 27695, USA
    Infect Immun 72:1155-8. 2004
    ..Reduced numbers of dps mutant bacteria in the livers and spleens of infected mice are consistent with a role of Dps in protecting Salmonella from oxidative stress encountered during infection...
  30. ncbi request reprint The alternative sigma factor sigmaE controls antioxidant defences required for Salmonella virulence and stationary-phase survival
    Traci L Testerman
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Mol Microbiol 43:771-82. 2002
    ....
  31. ncbi request reprint Toll-like receptor 4 dependence of innate and adaptive immunity to Salmonella: importance of the Kupffer cell network
    Andres Vazquez-Torres
    Department of Microbiology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 172:6202-8. 2004
    ..Alternative pattern-recognition receptors cannot completely compensate for the loss of TLR4, and compensation occurs at the expense of an increased microbial burden...
  32. pmc Descriptive science
    Arturo Casadevall
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461 1975, USA
    Infect Immun 76:3835-6. 2008
  33. pmc Analysis of nitric oxide-dependent antimicrobial actions in macrophages and mice
    Andres Vazquez-Torres
    University of Colorado Health Sciences Center, Aurora, Colorado, USA
    Methods Enzymol 437:521-38. 2008
    ..This chapter describes techniques with which to analyze the antimicrobial actions of nitric oxide in murine and human macrophages and in laboratory mice...
  34. pmc Regulatory and structural differences in the Cu,Zn-superoxide dismutases of Salmonella enterica and their significance for virulence
    Serena Ammendola
    Dipartimento di Biologia, Universita di Roma Tor Vergata, 00133 Rome, Italy
    J Biol Chem 283:13688-99. 2008
    ..Our observations demonstrate that differences in expression, activity, and stability help to account for the unique contribution of the bacteriophage-encoded SodCI enzyme to Salmonella virulence...
  35. ncbi request reprint Suppressor alphabeta T lymphocytes control innate resistance to endotoxic shock
    Jessica Jones-Carson
    Departments of Medicine, and Microbiology, University of Colorado Health Sciences Center, Denver, USA
    J Infect Dis 192:1039-46. 2005
    ..These observations suggest that suppressor alphabeta T lymphocytes protect against the proinflammatory cascade unleashed during the innate stages of endotoxemia...
  36. pmc Characterization of six lipoproteins in the sigmaE regulon
    Christina Onufryk
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143, USA
    J Bacteriol 187:4552-61. 2005
    ..We suggest that this lipoprotein performs a very important but as-yet-unknown function in maintaining the integrity of the cell envelope...
  37. ncbi request reprint Comparison of the PhoPQ regulon in Escherichia coli and Salmonella typhimurium
    Pieter Monsieurs
    ESAT SCD, K U Leuven, Kasteelpark Arenberg 10, 3001, Leuven Heverlee, Belgium
    J Mol Evol 60:462-74. 2005
    ..g., pathogenesis in S. typhimurium)...
  38. pmc The Salmonella enterica serovar typhimurium divalent cation transport systems MntH and SitABCD are essential for virulence in an Nramp1G169 murine typhoid model
    Michelle L Zaharik
    Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3 Canada
    Infect Immun 72:5522-5. 2004
    ....
  39. pmc The global regulator ArcA controls resistance to reactive nitrogen and oxygen intermediates in Salmonella enterica serovar Enteritidis
    Sangwei Lu
    Program in Infectious Diseases and Immunity, School of Public Health, University of California at Berkeley, Berkeley, California 94720, USA
    Infect Immun 70:451-61. 2002
    ..enterica serovar Enteritidis to nitrosative and oxidative stress. However, additional genetic loci may contribute to the resistance to RNI/ROI and unusually high virulence for mice of SE2472...