Research Topics
Genomes and Genes | Qi Wen FanSummaryAffiliation: University of California Country: USA Publications
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Publications
Chemical genetic blockade of transformation reveals dependence on aberrant oncogenic signalingQi-Wen Fan
Department of Neurology, University of California, San Francisco, CA 94143, USA
Curr Biol 12:1386-94. 2002..CONCLUSIONS: These data suggest that mammalian cells can become dependent on aberrant oncogenic signaling; this dependency renders them incapable of returning to a normal, proliferative phenotype...
Inhibition of PI3K-Akt-mTOR signaling in glioblastoma by mTORC1/2 inhibitorsQi Wen Fan
Department of Neurology, University of California, San Francisco, CA, USA
Methods Mol Biol 821:349-59. 2012....- A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant gliomaQi Wen Fan
Department of Neurology and Brain Tumor Research Center, Comprehensive Cancer Center, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA
Cancer Res 67:7960-5. 2007..These experiments show that a dual inhibitor of PI3Kalpha and mTOR augments the activity of EGFR blockade, offering a mechanistic rationale for targeting EGFR, PI3Kalpha, and mTOR in the treatment of EGFR-driven, PTEN-mutant glioma... - Akt and autophagy cooperate to promote survival of drug-resistant gliomaQi Wen Fan
Department of Neurology, University of California, 1450 Third Street, MC0520, San Francisco, CA 94158 9001, USA
Sci Signal 3:ra81. 2010.... - Kinetics of inhibitor cycling underlie therapeutic disparities between EGFR-driven lung and brain cancersKrister J Barkovich
Department of Neurology, Brain Tumor Research Center, San Francisco, CA 94143, USA
Cancer Discov 2:450-7. 2012.... - Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant gliomaChristine K Cheng
Department of Neurology, Dana Farber Cancer Institute, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 109:12722-7. 2012..We also tested clinical Akt and CDK inhibitors, demonstrating induction of apoptosis in vitro and providing a preclinical rationale to test this combination therapy in patients... - RNA interference against a glioma-derived allele of EGFR induces blockade at G2MQi Wen Fan
Department of Neurology, University of California, San Francisco, CA 94143 0663, USA
Oncogene 24:829-37. 2005.... - EGFR signals to mTOR through PKC and independently of Akt in gliomaQi Wen Fan
Department of Neurology, University of California, 533 Parnassus Avenue, San Francisco, CA 94143, USA
Sci Signal 2:ra4. 2009..These findings underline the importance of signaling between EGFR and mTOR in glioma, identify PKCalpha as essential to this network, and question the necessity of Akt as a critical intermediate coupling EGFR and mTOR in glioma... - Autophagy and Akt promote survival in gliomaQi Wen Fan
Department of Neurology, Neurological Surgery and Brain Tumor Research Center, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA
Autophagy 7:536-8. 2011.... - PI3K signaling in glioma--animal models and therapeutic challengesChristine K Cheng
Department of Neurology, University of California, San Francisco, CA 94143, USA
Brain Pathol 19:112-20. 2009..The engagement of other survival pathways in response to PI3K inhibition prompts the need to develop combination therapies that promote cytotoxicity in cancer cells... - Combinatorial efficacy achieved through two-point blockade within a signaling pathway-a chemical genetic approachQi-Wen Fan
Department of Neurology, University of California, San Francisco, California 94143-0663, USA
Cancer Res 63:8930-8. 2003..Our experiments provide a preclinical mechanistic basis for combining biologically based therapies directed against two targets within a complex signaling cascade... - Targeting the RTK-PI3K-mTOR axis in malignant glioma: overcoming resistanceQi Wen Fan
Department of Neurology, University of California, San Francisco, CA 94158 9001, USA
Curr Top Microbiol Immunol 347:279-96. 2010..Lastly, we discuss the need to combine targeted therapies with cytotoxic chemotherapy, radiation and with inhibitors of survival signaling to improve outcomes in glioma... - Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarityWei Yu
Department of Anatomy, Neurology, University of California, San Francisco, California 94143, USA
EMBO Rep 9:923-9. 2008..These results might be relevant to the hyperactivation of RhoA and disruption of normal polarity frequently observed in human epithelial cancers... - Structure-guided development of affinity probes for tyrosine kinases using chemical geneticsJimmy A Blair
Department of Chemistry, University of California, Berkeley, Berkeley, California 94720, USA
Nat Chem Biol 3:229-38. 2007.... - Pleiotropic role for MYCN in medulloblastomaFredrik J Swartling
University of California at San Francisco, San Francisco, California 94158, USA
Genes Dev 24:1059-72. 2010..Targeted expression of MYCN thus contributes to initiation, progression, and maintenance of MB, suggesting a central role for MYCN in pathogenesis... - A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in gliomaQi-Wen Fan
Department of Neurology, University of California, San Francisco, San Francisco, California 94143, USA
Cancer Cell 9:341-9. 2006..PI-103 showed significant activity in xenografted tumors with no observable toxicity. These data demonstrate an emergent efficacy due to combinatorial inhibition of mTOR and PI3 kinase alpha in malignant glioma... - Isoform specific inhibitors of PI3 kinase in gliomaQi-Wen Fan
Department of Neurology, Pediatrics, Neurological Surgery, and Brain Tumor Research Center, Comprehensive Cancer Center, San Francisco, California 94143, USA
Cell Cycle 5:2301-5. 2006..This result suggests a potentially effective strategy for cancer therapy based on dual inhibition of these two PI3K family members... - Chemical genetic approaches to the development of cancer therapeuticsQi-Wen Fan
Department of Neurology, 533 Parnassus Avenue, San Francisco, CA 94143, USA
Curr Opin Genet Dev 16:85-91. 2006..Elucidation of the mechanisms through which specific small molecule drug-like agents impact crucial cancer pathways should yield important and clinically translatable insights into the use of similar agents in patients...