Qi Wen Fan

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Chemical genetic blockade of transformation reveals dependence on aberrant oncogenic signaling
    Qi Wen Fan
    Department of Neurology, University of California, San Francisco, CA 94143, USA
    Curr Biol 12:1386-94. 2002
  2. pmc EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma
    Qi Wen Fan
    Department of Neurology, University of California, San Francisco, 1450 Third Street, MC0520, San Francisco, CA 94158 9001, USA Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, 1450 Third Street, MC0520, San Francisco, CA 94158 9001, USA Electronic address
    Cancer Cell 24:438-49. 2013
  3. pmc Inhibition of PI3K-Akt-mTOR signaling in glioblastoma by mTORC1/2 inhibitors
    Qi Wen Fan
    Department of Neurology, University of California, San Francisco, CA, USA
    Methods Mol Biol 821:349-59. 2012
  4. pmc A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma
    Qi Wen Fan
    Department of Neurology and Brain Tumor Research Center, Comprehensive Cancer Center, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA
    Cancer Res 67:7960-5. 2007
  5. ncbi request reprint Combinatorial efficacy achieved through two-point blockade within a signaling pathway-a chemical genetic approach
    Qi Wen Fan
    Department of Neurology, University of California, San Francisco, California 94143 0663, USA
    Cancer Res 63:8930-8. 2003
  6. pmc A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma
    Qi Wen Fan
    Department of Neurology, University of California, San Francisco, San Francisco, California 94143, USA
    Cancer Cell 9:341-9. 2006
  7. pmc Akt and autophagy cooperate to promote survival of drug-resistant glioma
    Qi Wen Fan
    Department of Neurology, University of California, 1450 Third Street, MC0520, San Francisco, CA 94158 9001, USA
    Sci Signal 3:ra81. 2010
  8. pmc EGFR signals to mTOR through PKC and independently of Akt in glioma
    Qi Wen Fan
    Department of Neurology, University of California, 533 Parnassus Avenue, San Francisco, CA 94143, USA
    Sci Signal 2:ra4. 2009
  9. pmc Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma
    Christine K Cheng
    Department of Neurology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 109:12722-7. 2012
  10. ncbi request reprint RNA interference against a glioma-derived allele of EGFR induces blockade at G2M
    Qi Wen Fan
    Department of Neurology, University of California, San Francisco, CA 94143 0663, USA
    Oncogene 24:829-37. 2005

Detail Information

Publications19

  1. ncbi request reprint Chemical genetic blockade of transformation reveals dependence on aberrant oncogenic signaling
    Qi Wen Fan
    Department of Neurology, University of California, San Francisco, CA 94143, USA
    Curr Biol 12:1386-94. 2002
    ..Because it is implicated in a large number of malignancies, EGFR provides an attractive target for such selective kinase inhibition...
  2. pmc EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma
    Qi Wen Fan
    Department of Neurology, University of California, San Francisco, 1450 Third Street, MC0520, San Francisco, CA 94158 9001, USA Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, 1450 Third Street, MC0520, San Francisco, CA 94158 9001, USA Electronic address
    Cancer Cell 24:438-49. 2013
    ..Subsequent phosphorylation of STAT3 requires nuclear entry of EGFRvIII and formation of an EGFRvIII-STAT3 nuclear complex. Our findings clarify specific oncogenic signaling relationships between EGFR and EGFRvIII in glioblastoma. ..
  3. pmc Inhibition of PI3K-Akt-mTOR signaling in glioblastoma by mTORC1/2 inhibitors
    Qi Wen Fan
    Department of Neurology, University of California, San Francisco, CA, USA
    Methods Mol Biol 821:349-59. 2012
    ....
  4. pmc A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma
    Qi Wen Fan
    Department of Neurology and Brain Tumor Research Center, Comprehensive Cancer Center, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA
    Cancer Res 67:7960-5. 2007
    ..These experiments show that a dual inhibitor of PI3Kalpha and mTOR augments the activity of EGFR blockade, offering a mechanistic rationale for targeting EGFR, PI3Kalpha, and mTOR in the treatment of EGFR-driven, PTEN-mutant glioma...
  5. ncbi request reprint Combinatorial efficacy achieved through two-point blockade within a signaling pathway-a chemical genetic approach
    Qi Wen Fan
    Department of Neurology, University of California, San Francisco, California 94143 0663, USA
    Cancer Res 63:8930-8. 2003
    ..Our experiments provide a preclinical mechanistic basis for combining biologically based therapies directed against two targets within a complex signaling cascade...
  6. pmc A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma
    Qi Wen Fan
    Department of Neurology, University of California, San Francisco, San Francisco, California 94143, USA
    Cancer Cell 9:341-9. 2006
    ..PI-103 showed significant activity in xenografted tumors with no observable toxicity. These data demonstrate an emergent efficacy due to combinatorial inhibition of mTOR and PI3 kinase alpha in malignant glioma...
  7. pmc Akt and autophagy cooperate to promote survival of drug-resistant glioma
    Qi Wen Fan
    Department of Neurology, University of California, 1450 Third Street, MC0520, San Francisco, CA 94158 9001, USA
    Sci Signal 3:ra81. 2010
    ....
  8. pmc EGFR signals to mTOR through PKC and independently of Akt in glioma
    Qi Wen Fan
    Department of Neurology, University of California, 533 Parnassus Avenue, San Francisco, CA 94143, USA
    Sci Signal 2:ra4. 2009
    ..These findings underline the importance of signaling between EGFR and mTOR in glioma, identify PKCalpha as essential to this network, and question the necessity of Akt as a critical intermediate coupling EGFR and mTOR in glioma...
  9. pmc Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma
    Christine K Cheng
    Department of Neurology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 109:12722-7. 2012
    ..We also tested clinical Akt and CDK inhibitors, demonstrating induction of apoptosis in vitro and providing a preclinical rationale to test this combination therapy in patients...
  10. ncbi request reprint RNA interference against a glioma-derived allele of EGFR induces blockade at G2M
    Qi Wen Fan
    Department of Neurology, University of California, San Francisco, CA 94143 0663, USA
    Oncogene 24:829-37. 2005
    ....
  11. pmc Kinetics of inhibitor cycling underlie therapeutic disparities between EGFR-driven lung and brain cancers
    Krister J Barkovich
    Department of Neurology, Brain Tumor Research Center, San Francisco, CA 94143, USA
    Cancer Discov 2:450-7. 2012
    ..Kinase-site occupancy correlated directly with cell-cycle arrest. EGFRvIII released erlotinib rapidly compared with wild-type EGFR, whereas NSCLC-derived mutants released erlotinib slowly...
  12. ncbi request reprint Isoform specific inhibitors of PI3 kinase in glioma
    Qi Wen Fan
    Department of Neurology, Pediatrics, Neurological Surgery, and Brain Tumor Research Center, Comprehensive Cancer Center, San Francisco, California 94143, USA
    Cell Cycle 5:2301-5. 2006
    ..This result suggests a potentially effective strategy for cancer therapy based on dual inhibition of these two PI3K family members...
  13. ncbi request reprint Structure-guided development of affinity probes for tyrosine kinases using chemical genetics
    Jimmy A Blair
    Department of Chemistry, University of California, Berkeley, Berkeley, California 94720, USA
    Nat Chem Biol 3:229-38. 2007
    ....
  14. pmc Autophagy and Akt promote survival in glioma
    Qi Wen Fan
    Department of Neurology, Neurological Surgery and Brain Tumor Research Center, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA
    Autophagy 7:536-8. 2011
    ....
  15. pmc PI3K signaling in glioma--animal models and therapeutic challenges
    Christine K Cheng
    Department of Neurology, University of California, San Francisco, CA 94143, USA
    Brain Pathol 19:112-20. 2009
    ..The engagement of other survival pathways in response to PI3K inhibition prompts the need to develop combination therapies that promote cytotoxicity in cancer cells...
  16. pmc Pleiotropic role for MYCN in medulloblastoma
    Fredrik J Swartling
    University of California at San Francisco, San Francisco, California 94158, USA
    Genes Dev 24:1059-72. 2010
    ..Targeted expression of MYCN thus contributes to initiation, progression, and maintenance of MB, suggesting a central role for MYCN in pathogenesis...
  17. pmc Targeting the RTK-PI3K-mTOR axis in malignant glioma: overcoming resistance
    Qi Wen Fan
    Department of Neurology, University of California, San Francisco, CA 94158 9001, USA
    Curr Top Microbiol Immunol 347:279-96. 2010
    ..Lastly, we discuss the need to combine targeted therapies with cytotoxic chemotherapy, radiation and with inhibitors of survival signaling to improve outcomes in glioma...
  18. ncbi request reprint Chemical genetic approaches to the development of cancer therapeutics
    Qi Wen Fan
    Department of Neurology, 533 Parnassus Avenue, San Francisco, CA 94143, USA
    Curr Opin Genet Dev 16:85-91. 2006
    ..Elucidation of the mechanisms through which specific small molecule drug-like agents impact crucial cancer pathways should yield important and clinically translatable insights into the use of similar agents in patients...
  19. pmc Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarity
    Wei Yu
    Department of Anatomy, Neurology, University of California, San Francisco, California 94143, USA
    EMBO Rep 9:923-9. 2008
    ..These results might be relevant to the hyperactivation of RhoA and disruption of normal polarity frequently observed in human epithelial cancers...