Jie Fan

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. ncbi request reprint Transcriptional mechanisms of acute lung injury
    J Fan
    Department of Pharmacology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Am J Physiol Lung Cell Mol Physiol 281:L1037-50. 2001
  2. ncbi request reprint Role of neutrophil NADPH oxidase in the mechanism of tumor necrosis factor-alpha -induced NF-kappa B activation and intercellular adhesion molecule-1 expression in endothelial cells
    Jie Fan
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    J Biol Chem 277:3404-11. 2002
  3. pmc TLR4 signaling induces TLR2 expression in endothelial cells via neutrophil NADPH oxidase
    Jie Fan
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    J Clin Invest 112:1234-43. 2003
  4. ncbi request reprint LPS activation of Toll-like receptor 4 signals CD11b/CD18 expression in neutrophils
    Ximing Zhou
    Department of Pharmacology, College of Medicine, University of Illinois, 835 So Wolcott Ave, Chicago, IL 60612, USA
    Am J Physiol Lung Cell Mol Physiol 288:L655-62. 2005
  5. ncbi request reprint Toll-like receptor-4 (TLR4) signaling augments chemokine-induced neutrophil migration by modulating cell surface expression of chemokine receptors
    Jie Fan
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois, USA
    Nat Med 9:315-21. 2003
  6. pmc Dissection of a complex enhancer element: maintenance of keratinocyte specificity but loss of differentiation specificity
    Charles K Kaufman
    Department of Molecular Genetics and Cell Biology, Howard Hughes Medical Institute, The University of Chicago, Chicago, Illinois 60637, USA
    Mol Cell Biol 22:4293-308. 2002
  7. ncbi request reprint Hemorrhagic shock-activated neutrophils augment TLR4 signaling-induced TLR2 upregulation in alveolar macrophages: role in hemorrhage-primed lung inflammation
    Jie Fan
    Department of Surgery, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15240, USA
    Am J Physiol Lung Cell Mol Physiol 290:L738-L746. 2006
  8. ncbi request reprint Regulation of Toll-like receptor 4 expression in the lung following hemorrhagic shock and lipopolysaccharide
    Jie Fan
    Department of Surgery, University Health Network, St Michael s Hospital and University of Toronto, Toronto, Ontario, Canada
    J Immunol 168:5252-9. 2002
  9. ncbi request reprint Impaired induction of IL-10 expression in the lung following hemorrhagic shock
    Rachel G Khadaroo
    Departments of Surgery, University Health Network and University of Toronto, Toronto, Ontario, Canada
    Shock 22:333-9. 2004
  10. ncbi request reprint Neutrophil NAD(P)H oxidase is required for hemorrhagic shock-enhanced TLR2 up-regulation in alveolar macrophages in response to LPS
    Jie Fan
    Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15240, USA
    Shock 28:213-8. 2007

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Transcriptional mechanisms of acute lung injury
    J Fan
    Department of Pharmacology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Am J Physiol Lung Cell Mol Physiol 281:L1037-50. 2001
    ..NF-kappa B can interact with other transcription factors, and these interactions thereby lead to greater transcriptional selectivity. Modification of transcription is likely to be a logical therapeutic target for acute lung injury...
  2. ncbi request reprint Role of neutrophil NADPH oxidase in the mechanism of tumor necrosis factor-alpha -induced NF-kappa B activation and intercellular adhesion molecule-1 expression in endothelial cells
    Jie Fan
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    J Biol Chem 277:3404-11. 2002
    ..Thus, oxidant signaling by the PMN NAD(P)H oxidase complex is an important determinant of TNFalpha-induced NF-kappaB activation and ICAM-1 expression in endothelial cells...
  3. pmc TLR4 signaling induces TLR2 expression in endothelial cells via neutrophil NADPH oxidase
    Jie Fan
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    J Clin Invest 112:1234-43. 2003
    ..Thus, PMN NADPH oxidase-derived oxidant signaling is an important determinant of the cross talk between TLR4 and TLR2 and the control of endothelial cell activation...
  4. ncbi request reprint LPS activation of Toll-like receptor 4 signals CD11b/CD18 expression in neutrophils
    Ximing Zhou
    Department of Pharmacology, College of Medicine, University of Illinois, 835 So Wolcott Ave, Chicago, IL 60612, USA
    Am J Physiol Lung Cell Mol Physiol 288:L655-62. 2005
    ..Our data suggest an important role of TLR4-activated CD11b expression in the mechanism of the PMN host-defense response to LPS...
  5. ncbi request reprint Toll-like receptor-4 (TLR4) signaling augments chemokine-induced neutrophil migration by modulating cell surface expression of chemokine receptors
    Jie Fan
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois, USA
    Nat Med 9:315-21. 2003
    ..These data indicate that TLR4 modulation of PMN surface chemokine receptor expression subsequent to the downregulation of GRK2 and GRK5 expression is a critical determinant of PMN migration...
  6. pmc Dissection of a complex enhancer element: maintenance of keratinocyte specificity but loss of differentiation specificity
    Charles K Kaufman
    Department of Molecular Genetics and Cell Biology, Howard Hughes Medical Institute, The University of Chicago, Chicago, Illinois 60637, USA
    Mol Cell Biol 22:4293-308. 2002
    ..Through mixing and matching of these modules, additional levels of specificity are obtained, indicating that both transcriptional repressors and activators govern the specificity...
  7. ncbi request reprint Hemorrhagic shock-activated neutrophils augment TLR4 signaling-induced TLR2 upregulation in alveolar macrophages: role in hemorrhage-primed lung inflammation
    Jie Fan
    Department of Surgery, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15240, USA
    Am J Physiol Lung Cell Mol Physiol 290:L738-L746. 2006
    ..Thus TLR2 expression in AMphi, signaled by TLR4 and regulated by shock-activated PMN, is an important positive-feedback mechanism responsible for shock-primed PMN infiltration into the lung after primary PMN sequestration...
  8. ncbi request reprint Regulation of Toll-like receptor 4 expression in the lung following hemorrhagic shock and lipopolysaccharide
    Jie Fan
    Department of Surgery, University Health Network, St Michael s Hospital and University of Toronto, Toronto, Ontario, Canada
    J Immunol 168:5252-9. 2002
    ....
  9. ncbi request reprint Impaired induction of IL-10 expression in the lung following hemorrhagic shock
    Rachel G Khadaroo
    Departments of Surgery, University Health Network and University of Toronto, Toronto, Ontario, Canada
    Shock 22:333-9. 2004
    ..Failed up-regulation of counter inflammatory cytokines may contribute to augmented organ dysfunction in trauma patients...
  10. ncbi request reprint Neutrophil NAD(P)H oxidase is required for hemorrhagic shock-enhanced TLR2 up-regulation in alveolar macrophages in response to LPS
    Jie Fan
    Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15240, USA
    Shock 28:213-8. 2007
    ..Thus, PMN nicotinamide adenine dinucleotide phosphate (reduced form) oxidase sensitizes hemorrhagic shock-primed AM to LPS, at least in part via enhancing IL-1 receptor associated kinase 4 activity...
  11. pmc Rpe65-/- and Lrat-/- mice: comparable models of leber congenital amaurosis
    Jie Fan
    Department of Ophthalmology, Medical University of South Carolina, Charleston, South Carolina 29402, USA
    Invest Ophthalmol Vis Sci 49:2384-9. 2008
    ....
  12. ncbi request reprint Hemorrhagic shock induces NAD(P)H oxidase activation in neutrophils: role of HMGB1-TLR4 signaling
    Jie Fan
    Department of Surgery, School of Medicine, University of Pittsburgh, and Division of Pediatric Surgery, Children s Hospital of Pittsburgh, PA 15213, USA
    J Immunol 178:6573-80. 2007
    ..Thus, PMN NAD(P)H oxidase activation, induced by HS/R and as mediated by HMGB1/TLR4 signaling, is an important mechanism responsible for PMN-mediated inflammation and organ injury after hemorrhage...
  13. ncbi request reprint 9-cis Retinal increased in retina of RPE65 knockout mice with decrease in coat pigmentation
    Jie Fan
    Department of Ophthalmology, Medical University of South Carolina, Charleston, SC, USA
    Photochem Photobiol 82:1461-7. 2006
    ..Therefore, photoreceptor damage correlates with the amount of the apoprotein present, supporting findings that the activity from unregenerated opsin can lead to photoreceptor degeneration...
  14. ncbi request reprint Cloning and characterization of a novel all-trans retinol short-chain dehydrogenase/reductase from the RPE
    Bill X Wu
    Department of Ophthalmology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Invest Ophthalmol Vis Sci 43:3365-72. 2002
    ..This study was conducted to identify the atRDH that generates all-trans retinal in the RPE...
  15. pmc Vascular endothelial growth factor expression in the retinal pigment epithelium is essential for choriocapillaris development and visual function
    Alexander G Marneros
    Department of Cell Biology, Harvard Medical School, 188 Longwood Ave, Boston, MA 02115, USA
    Am J Pathol 167:1451-9. 2005
    ..Thus, hypoxia-inducible factor-1alpha-independent expression of VEGF is essential for choroid development...
  16. pmc Opsin activation of transduction in the rods of dark-reared Rpe65 knockout mice
    Jie Fan
    Department of Ophthalmology, Medical University of South Carolina, Charleston 29425, USA
    J Physiol 568:83-95. 2005
    ..Both also have shorter outer segments and a lower free-Ca2+ concentration. These experiments provide the first quantitative measurement of opsin activation in physiologically responding mammalian rods...
  17. ncbi request reprint The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction
    Haijuan Yang
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nature 433:653-7. 2005
    ..These results establish a BRCA2 function in RAD51-mediated DSB repair and explain the loss of this repair capacity in BRCA2-associated cancers...
  18. ncbi request reprint Hypertonic preconditioning prevents hepatocellular injury following ischemia/reperfusion in mice: a role for interleukin 10
    George D Oreopoulos
    Department of Surgery, University Health Network and University of Toronto, Toronto, Ontario, Canada
    Hepatology 40:211-20. 2004
    ....
  19. pmc Isorhodopsin rather than rhodopsin mediates rod function in RPE65 knock-out mice
    Jie Fan
    Department of Ophthalmology, Medical University of South Carolina, 167 Ashley Avenue, Charleston, SC 29425, USA
    Proc Natl Acad Sci U S A 100:13662-7. 2003
    ..These studies demonstrate that a pathway exists in the eye for the generation of 9-cis-retinal that is independent of RPE65 and light...
  20. pmc Trafficking of membrane-associated proteins to cone photoreceptor outer segments requires the chromophore 11-cis-retinal
    Houbin Zhang
    Department of Ophthalmology, University of Utah Health Science Center, Salt Lake City, Utah 84132, USA
    J Neurosci 28:4008-14. 2008
    ..Furthermore, the presence of 11-cis-retinal is essential for proper transport of several membrane-associated cone phototransduction polypeptides in these cones...