Research Topics
| Jie FanSummaryAffiliation: University of Illinois at Chicago Country: USA Publications
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Detail Information
Publications
Transcriptional mechanisms of acute lung injuryJ Fan
Department of Pharmacology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Am J Physiol Lung Cell Mol Physiol 281:L1037-50. 2001..NF-kappa B can interact with other transcription factors, and these interactions thereby lead to greater transcriptional selectivity. Modification of transcription is likely to be a logical therapeutic target for acute lung injury...- Role of neutrophil NADPH oxidase in the mechanism of tumor necrosis factor-alpha -induced NF-kappa B activation and intercellular adhesion molecule-1 expression in endothelial cellsJie Fan
Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
J Biol Chem 277:3404-11. 2002..Thus, oxidant signaling by the PMN NAD(P)H oxidase complex is an important determinant of TNFalpha-induced NF-kappaB activation and ICAM-1 expression in endothelial cells... 
TLR4 signaling induces TLR2 expression in endothelial cells via neutrophil NADPH oxidaseJie Fan
Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
J Clin Invest 112:1234-43. 2003..Thus, PMN NADPH oxidase-derived oxidant signaling is an important determinant of the cross talk between TLR4 and TLR2 and the control of endothelial cell activation...- LPS activation of Toll-like receptor 4 signals CD11b/CD18 expression in neutrophilsXiming Zhou
Department of Pharmacology, College of Medicine, University of Illinois, 835 So Wolcott Ave, Chicago, IL 60612, USA
Am J Physiol Lung Cell Mol Physiol 288:L655-62. 2005..Our data suggest an important role of TLR4-activated CD11b expression in the mechanism of the PMN host-defense response to LPS... - Toll-like receptor-4 (TLR4) signaling augments chemokine-induced neutrophil migration by modulating cell surface expression of chemokine receptorsJie Fan
Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois, USA
Nat Med 9:315-21. 2003..These data indicate that TLR4 modulation of PMN surface chemokine receptor expression subsequent to the downregulation of GRK2 and GRK5 expression is a critical determinant of PMN migration... - Dissection of a complex enhancer element: maintenance of keratinocyte specificity but loss of differentiation specificityCharles K Kaufman
Department of Molecular Genetics and Cell Biology, Howard Hughes Medical Institute, The University of Chicago, Chicago, Illinois 60637, USA
Mol Cell Biol 22:4293-308. 2002..Through mixing and matching of these modules, additional levels of specificity are obtained, indicating that both transcriptional repressors and activators govern the specificity... - Hemorrhagic shock-activated neutrophils augment TLR4 signaling-induced TLR2 upregulation in alveolar macrophages: role in hemorrhage-primed lung inflammationJie Fan
Department of Surgery, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15240, USA
Am J Physiol Lung Cell Mol Physiol 290:L738-L746. 2006..Thus TLR2 expression in AMphi, signaled by TLR4 and regulated by shock-activated PMN, is an important positive-feedback mechanism responsible for shock-primed PMN infiltration into the lung after primary PMN sequestration... - Regulation of Toll-like receptor 4 expression in the lung following hemorrhagic shock and lipopolysaccharideJie Fan
Department of Surgery, University Health Network, St Michael s Hospital and University of Toronto, Toronto, Ontario, Canada
J Immunol 168:5252-9. 2002.... - Impaired induction of IL-10 expression in the lung following hemorrhagic shockRachel G Khadaroo
Departments of Surgery, University Health Network and University of Toronto, Toronto, Ontario, Canada
Shock 22:333-9. 2004..Failed up-regulation of counter inflammatory cytokines may contribute to augmented organ dysfunction in trauma patients... - Neutrophil NAD(P)H oxidase is required for hemorrhagic shock-enhanced TLR2 up-regulation in alveolar macrophages in response to LPSJie Fan
Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15240, USA
Shock 28:213-8. 2007..Thus, PMN nicotinamide adenine dinucleotide phosphate (reduced form) oxidase sensitizes hemorrhagic shock-primed AM to LPS, at least in part via enhancing IL-1 receptor associated kinase 4 activity... - Rpe65-/- and Lrat-/- mice: comparable models of leber congenital amaurosisJie Fan
Department of Ophthalmology, Medical University of South Carolina, Charleston, South Carolina 29402, USA
Invest Ophthalmol Vis Sci 49:2384-9. 2008.... - Hemorrhagic shock induces NAD(P)H oxidase activation in neutrophils: role of HMGB1-TLR4 signalingJie Fan
Department of Surgery, School of Medicine, University of Pittsburgh, and Division of Pediatric Surgery, Children s Hospital of Pittsburgh, PA 15213, USA
J Immunol 178:6573-80. 2007..Thus, PMN NAD(P)H oxidase activation, induced by HS/R and as mediated by HMGB1/TLR4 signaling, is an important mechanism responsible for PMN-mediated inflammation and organ injury after hemorrhage... - 9-cis Retinal increased in retina of RPE65 knockout mice with decrease in coat pigmentationJie Fan
Department of Ophthalmology, Medical University of South Carolina, Charleston, SC, USA
Photochem Photobiol 82:1461-7. 2006..Therefore, photoreceptor damage correlates with the amount of the apoprotein present, supporting findings that the activity from unregenerated opsin can lead to photoreceptor degeneration... - Cloning and characterization of a novel all-trans retinol short-chain dehydrogenase/reductase from the RPEBill X Wu
Department of Ophthalmology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Invest Ophthalmol Vis Sci 43:3365-72. 2002..This study was conducted to identify the atRDH that generates all-trans retinal in the RPE... - Vascular endothelial growth factor expression in the retinal pigment epithelium is essential for choriocapillaris development and visual functionAlexander G Marneros
Department of Cell Biology, Harvard Medical School, 188 Longwood Ave, Boston, MA 02115, USA
Am J Pathol 167:1451-9. 2005..Thus, hypoxia-inducible factor-1alpha-independent expression of VEGF is essential for choroid development... - Opsin activation of transduction in the rods of dark-reared Rpe65 knockout miceJie Fan
Department of Ophthalmology, Medical University of South Carolina, Charleston 29425, USA
J Physiol 568:83-95. 2005..Both also have shorter outer segments and a lower free-Ca2+ concentration. These experiments provide the first quantitative measurement of opsin activation in physiologically responding mammalian rods... - The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junctionHaijuan Yang
Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
Nature 433:653-7. 2005..These results establish a BRCA2 function in RAD51-mediated DSB repair and explain the loss of this repair capacity in BRCA2-associated cancers... - Hypertonic preconditioning prevents hepatocellular injury following ischemia/reperfusion in mice: a role for interleukin 10George D Oreopoulos
Department of Surgery, University Health Network and University of Toronto, Toronto, Ontario, Canada
Hepatology 40:211-20. 2004.... - Isorhodopsin rather than rhodopsin mediates rod function in RPE65 knock-out miceJie Fan
Department of Ophthalmology, Medical University of South Carolina, 167 Ashley Avenue, Charleston, SC 29425, USA
Proc Natl Acad Sci U S A 100:13662-7. 2003..These studies demonstrate that a pathway exists in the eye for the generation of 9-cis-retinal that is independent of RPE65 and light... - Trafficking of membrane-associated proteins to cone photoreceptor outer segments requires the chromophore 11-cis-retinalHoubin Zhang
Department of Ophthalmology, University of Utah Health Science Center, Salt Lake City, Utah 84132, USA
J Neurosci 28:4008-14. 2008..Furthermore, the presence of 11-cis-retinal is essential for proper transport of several membrane-associated cone phototransduction polypeptides in these cones...