Stefan S Fajans

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi Insufficient sensitivity of hemoglobin A(₁C) determination in diagnosis or screening of early diabetic states
    Stefan S Fajans
    Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Health System, Ann Arbor, MI 48106, USA
    Metabolism 60:86-91. 2011
  2. ncbi Obesity and hyperinsulinemia in a family with pancreatic agenesis and MODY caused by the IPF1 mutation Pro63fsX60
    Stefan S Fajans
    Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan Health System, Ann Arbor, MI 48105 9484, USA
    Transl Res 156:7-14. 2010
  3. ncbi Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young
    S S Fajans
    Department of Internal Medicine, University of Michigan Health System, Ann Arbor, USA
    N Engl J Med 345:971-80. 2001
  4. ncbi Neonatal diabetes mellitus with pancreatic agenesis in an infant with homozygous IPF-1 Pro63fsX60 mutation
    Inas H Thomas
    Department of Pediatrics and Communicable Diseases, Division of Pediatric Endocrinology, University of Michigan Health Center, Ann Arbor, MI 48109, USA
    Pediatr Diabetes 10:492-6. 2009
  5. ncbi Diminished insulin and glucagon secretory responses to arginine in nondiabetic subjects with a mutation in the hepatocyte nuclear factor-4alpha/MODY1 gene
    W H Herman
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109 0354, USA
    Diabetes 46:1749-54. 1997
  6. ncbi Hemoglobin A1c for the diagnosis of diabetes: practical considerations
    William H Herman
    Department of Internal Medicine, University of Michigan, Michigan, USA
    Pol Arch Med Wewn 120:37-40. 2010
  7. ncbi Administration of sulfonylureas can increase glucose-induced insulin secretion for decades in patients with maturity-onset diabetes of the young
    S S Fajans
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor
    Diabetes Care 16:1254-61. 1993
  8. ncbi Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)
    K Yamagata
    Howard Hughes Medical Institute, The University of Chicago, Illinois 60637, USA
    Nature 384:455-8. 1996
  9. ncbi Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)
    K Yamagata
    Howard Hughes Medical Institute, The University of Chicago, Illinois 60637, USA
    Nature 384:458-60. 1996
  10. ncbi A yeast artificial chromosome-based map of the region of chromosome 20 containing the diabetes-susceptibility gene, MODY1, and a myeloid leukemia related gene
    M Stoffel
    Howard Hughes Medical Institute, University of Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 93:3937-41. 1996

Collaborators

Detail Information

Publications14

  1. ncbi Insufficient sensitivity of hemoglobin A(₁C) determination in diagnosis or screening of early diabetic states
    Stefan S Fajans
    Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Health System, Ann Arbor, MI 48106, USA
    Metabolism 60:86-91. 2011
    ..A combination of A1C and plasma glucose determinations, where necessary, is recommended for diagnosis or screening of diabetes or IGT...
  2. ncbi Obesity and hyperinsulinemia in a family with pancreatic agenesis and MODY caused by the IPF1 mutation Pro63fsX60
    Stefan S Fajans
    Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan Health System, Ann Arbor, MI 48105 9484, USA
    Transl Res 156:7-14. 2010
    ..Genetic testing should be considered in multigenerational obese diabetic subjects, particularly when such families contain young diabetic members...
  3. ncbi Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young
    S S Fajans
    Department of Internal Medicine, University of Michigan Health System, Ann Arbor, USA
    N Engl J Med 345:971-80. 2001
  4. ncbi Neonatal diabetes mellitus with pancreatic agenesis in an infant with homozygous IPF-1 Pro63fsX60 mutation
    Inas H Thomas
    Department of Pediatrics and Communicable Diseases, Division of Pediatric Endocrinology, University of Michigan Health Center, Ann Arbor, MI 48109, USA
    Pediatr Diabetes 10:492-6. 2009
    ..This is the second reported case of neonatal diabetes mellitus secondary to a homozygous mutation in the IPF-1 gene and supports the previously proposed biological role of IPF-1 in the pancreatic development in human...
  5. ncbi Diminished insulin and glucagon secretory responses to arginine in nondiabetic subjects with a mutation in the hepatocyte nuclear factor-4alpha/MODY1 gene
    W H Herman
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109 0354, USA
    Diabetes 46:1749-54. 1997
    ..The decrease in glucagon AUC and decreased suppression of glucagon AUC with hyperglycemia suggest that mutations in HNF-4alpha may lead to alpha-cell as well as beta-cell secretory defects or a reduction in pancreatic islet mass...
  6. ncbi Hemoglobin A1c for the diagnosis of diabetes: practical considerations
    William H Herman
    Department of Internal Medicine, University of Michigan, Michigan, USA
    Pol Arch Med Wewn 120:37-40. 2010
    ..Combining the use of HbA1c and plasma glucose measurements for the diagnosis of diabetes offers the benefits of each test and reduces the risk of systematic bias inherent in HbA1c testing alone...
  7. ncbi Administration of sulfonylureas can increase glucose-induced insulin secretion for decades in patients with maturity-onset diabetes of the young
    S S Fajans
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor
    Diabetes Care 16:1254-61. 1993
    ..To ascertain whether the effect of sulfonylureas on glucose-mediated insulin release persists for years to decades in patients with maturity-onset diabetes of the young...
  8. ncbi Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)
    K Yamagata
    Howard Hughes Medical Institute, The University of Chicago, Illinois 60637, USA
    Nature 384:455-8. 1996
    ..HNF-1alpha is a transcription factor that helps in the tissue-specific regulation of the expression of several liver genes and also functions as a weak transactivator of the rat insulin-I gene...
  9. ncbi Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)
    K Yamagata
    Howard Hughes Medical Institute, The University of Chicago, Illinois 60637, USA
    Nature 384:458-60. 1996
    ..Here we show that MODY1 is the gene encoding HNF-4alpha (gene symbol, TCF14), a member of the steroid/thyroid hormone receptor superfamily and an upstream regulator of HNF-1alpha expression...
  10. ncbi A yeast artificial chromosome-based map of the region of chromosome 20 containing the diabetes-susceptibility gene, MODY1, and a myeloid leukemia related gene
    M Stoffel
    Howard Hughes Medical Institute, University of Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 93:3937-41. 1996
    ..The myeloid tumor suppressor gene was localized to an 18-centimorgan interval (approximately equal to 13 Mb) between RPN2 and D20S17. This physical map will facilitate the isolation of MODY1 and the myeloid tumor suppressor gene...
  11. ncbi Fructose-1,6-bisphosphatase: genetic and physical mapping to human chromosome 9q22.3 and evaluation in non-insulin-dependent diabetes mellitus
    C B Rothschild
    Department of Biochemistry, Bowman Gray School of Medicine, Wake Forest University, Winston Salem, North Carolina 27157, USA
    Genomics 29:187-94. 1995
    ..Although FBP is a rate-limiting enzyme in gluconeogenesis, using both parametric and nonparametric analysis there was no evidence for linkage of FBP to diabetes in these families...
  12. ncbi Phenotypic heterogeneity between different mutations of MODY subtypes and within MODY pedigrees
    S S Fajans
    Diabetologia 49:1106-8. 2006
  13. ncbi Gene for non-insulin-dependent diabetes mellitus (maturity-onset diabetes of the young subtype) is linked to DNA polymorphism on human chromosome 20q
    G I Bell
    Howard Hughes Medical Institute, University of Chicago, IL 60637
    Proc Natl Acad Sci U S A 88:1484-8. 1991
    ..25 at a recombination fraction of 0.00. These results indicate that the odds are greater than 178,000:1 that the gene responsible for MODY in this family is tightly linked to the ADA gene on chromosome 20q...
  14. ncbi A microsatellite polymorphism associated with the PLC1 (phospholipase C) locus: identification, mapping, and linkage to the MODY locus on chromosome 20
    C B Rothschild
    Department of Biochemistry, Bowman Gray School of Medicine, Winston Salem, North Carolina 27157
    Genomics 13:560-4. 1992
    ..2 and 6.6 cM, respectively, from these loci (sex-averaged distances). In addition, the PLC1 gene shows linkage to the maturity-onset diabetes of the young (MODY) locus on chromosome 20 with a lod score of 4.57 at theta = 0.089...