Anna Marie Fairhurst

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Rheumatoid peripheral blood phagocytes are primed for activation but have impaired Fc-mediated generation of reactive oxygen species
    Anna Marie Fairhurst
    William Harvey Research Institute, Barts and The London, Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    Arthritis Res Ther 9:R29. 2007
  2. pmc Yaa autoimmune phenotypes are conferred by overexpression of TLR7
    Anna Marie Fairhurst
    Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Eur J Immunol 38:1971-8. 2008
  3. pmc Systemic IFN-alpha drives kidney nephritis in B6.Sle123 mice
    Anna Marie Fairhurst
    Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Eur J Immunol 38:1948-60. 2008
  4. pmc Type I interferons produced by resident renal cells may promote end-organ disease in autoantibody-mediated glomerulonephritis
    Anna Marie Fairhurst
    Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8884, USA
    J Immunol 183:6831-8. 2009
  5. doi Dysregulated expression of CXCR4/CXCL12 in subsets of patients with systemic lupus erythematosus
    Andrew Wang
    University of Texas Southwestern Medical Center, Dallas, TX 75390 8884, USA
    Arthritis Rheum 62:3436-46. 2010
  6. pmc Regulation and localization of endogenous human tristetraprolin
    Anna Marie Fairhurst
    William Harvey Research Institute, University of London, London, UK
    Arthritis Res Ther 5:R214-25. 2003
  7. ncbi Systemic lupus erythematosus: multiple immunological phenotypes in a complex genetic disease
    Anna Marie Fairhurst
    Center for Immunology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Adv Immunol 92:1-69. 2006
  8. pmc CXCR4/CXCL12 hyperexpression plays a pivotal role in the pathogenesis of lupus
    Andrew Wang
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    J Immunol 182:4448-58. 2009
  9. pmc B cell TLR7 expression drives anti-RNA autoantibody production and exacerbates disease in systemic lupus erythematosus-prone mice
    Sun Hee Hwang
    Department of Immunology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    J Immunol 189:5786-96. 2012
  10. pmc Temporal changes in myeloid cells in the cervix during pregnancy and parturition
    Brenda C Timmons
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 182:2700-7. 2009

Collaborators

Detail Information

Publications11

  1. pmc Rheumatoid peripheral blood phagocytes are primed for activation but have impaired Fc-mediated generation of reactive oxygen species
    Anna Marie Fairhurst
    William Harvey Research Institute, Barts and The London, Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    Arthritis Res Ther 9:R29. 2007
    ..This may account for the increased susceptibility to bacterial infection that arises in patients with severe disease...
  2. pmc Yaa autoimmune phenotypes are conferred by overexpression of TLR7
    Anna Marie Fairhurst
    Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Eur J Immunol 38:1971-8. 2008
    ..However, the resolution of TLR7 up-regulation did not eliminate the enhanced humoral autoimmunity observed in B6.SleYaa, suggesting that additional elements in the translocation may contribute to the disease phenotype...
  3. pmc Systemic IFN-alpha drives kidney nephritis in B6.Sle123 mice
    Anna Marie Fairhurst
    Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Eur J Immunol 38:1948-60. 2008
    ..In summary, the predominant impact of systemic IFN-alpha in this murine model is an exacerbation of mechanisms mediating end organ damage...
  4. pmc Type I interferons produced by resident renal cells may promote end-organ disease in autoantibody-mediated glomerulonephritis
    Anna Marie Fairhurst
    Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8884, USA
    J Immunol 183:6831-8. 2009
    ..Collectively, these studies indicate that an important contribution of IFN-I toward the disease pathology seen in systemic autoimmunity may be exercised at the level of the end-organ...
  5. doi Dysregulated expression of CXCR4/CXCL12 in subsets of patients with systemic lupus erythematosus
    Andrew Wang
    University of Texas Southwestern Medical Center, Dallas, TX 75390 8884, USA
    Arthritis Rheum 62:3436-46. 2010
    ....
  6. pmc Regulation and localization of endogenous human tristetraprolin
    Anna Marie Fairhurst
    William Harvey Research Institute, University of London, London, UK
    Arthritis Res Ther 5:R214-25. 2003
    ..These data establish the cytoplasmic location of TTP, supporting a major role for this protein in regulating TNF production, and suggest that TTP levels are not regulated solely by TNF...
  7. ncbi Systemic lupus erythematosus: multiple immunological phenotypes in a complex genetic disease
    Anna Marie Fairhurst
    Center for Immunology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Adv Immunol 92:1-69. 2006
    ....
  8. pmc CXCR4/CXCL12 hyperexpression plays a pivotal role in the pathogenesis of lupus
    Andrew Wang
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    J Immunol 182:4448-58. 2009
    ..These findings underscore the pathogenic role of CXCR4/CXCL12 in lymphoproliferative lupus and lupus nephritis and highlight this axis as a promising therapeutic target in this disease...
  9. pmc B cell TLR7 expression drives anti-RNA autoantibody production and exacerbates disease in systemic lupus erythematosus-prone mice
    Sun Hee Hwang
    Department of Immunology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    J Immunol 189:5786-96. 2012
    ..Moreover, this enhanced B cell TLR7 expression permits the specific development of Abs to RNA/protein complexes and exacerbates SLE disease...
  10. pmc Temporal changes in myeloid cells in the cervix during pregnancy and parturition
    Brenda C Timmons
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 182:2700-7. 2009
    ..Additionally, macrophages with diverse phenotypes (M1 and M2) are present in the cervix and are most likely involved in the postpartum repair of tissue...
  11. ncbi IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells
    Rachel Ettinger
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA
    J Immunol 175:7867-79. 2005
    ..Taken together, our data show that IL-21 plays a central role in CSR and plasma cell differentiation during T cell-dependent B cell responses...