Research Topics
| L A FairbanksSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
A quantitative trait locus for variation in dopamine metabolism mapped in a primate model using reference sequences from related speciesNelson B Freimer
Center for Neurobehavioral Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 104:15811-6. 2007....
CSF monoamines, age and impulsivity in wild grivet monkeys (Cercopithecus aethiops aethiops)L A Fairbanks
Neuropsychiatric Institute, University of California, Los Angeles, CA 90024, USA
Brain Behav Evol 53:305-12. 1999..The results suggest that normal variation in central monoaminergic activity may have functional consequences in wild populations...- Heritability and genetic correlation of hair cortisol in vervet monkeys in low and higher stress environmentsLynn A Fairbanks
Department of Psychiatry and Biobehavioral Sciences, Semel Institute, University of California at Los Angeles, Los Angeles, CA 90095, USA
Psychoneuroendocrinology 36:1201-8. 2011..The results provide support for an additive model of the effects of genes and environment on this measure of long term HPA activity... 
High-fiber diet promotes weight loss and affects maternal behavior in vervet monkeysLynn A Fairbanks
Department of Psychiatry and Biobehavioral Sciences, Semel Institute, University of California at Los Angeles, USA
Am J Primatol 72:234-41. 2010..These results demonstrate that maternal behavior is responsive to changes in maternal condition, and that beneficial changes in the diet may have unintended consequences on behavior...- Environmental stress alters genetic regulation of novelty seeking in vervet monkeysL A Fairbanks
Department of Psychiatry and Biobehavioral Sciences, Semel Institute, University of California, Los Angeles UCLA
Genes Brain Behav 10:683-8. 2011..48). These results indicate that genetic regulation of novelty seeking was modified by the level of environmental stress, and they support a role for gene-environment interactions in a behavioural trait with relevance for mental health... - Adolescent impulsivity predicts adult dominance attainment in male vervet monkeysLynn A Fairbanks
Neuropsychiatric Institute, University of California Los Angeles, Los Angeles, California 90024, USA
Am J Primatol 64:1-17. 2004..They also demonstrate that adolescent impulsivity is age-limited. Males that achieved high rank moderated their behavior as adults, and no longer scored high in impulsivity relative to their age peers... - Individual differences in response to a stranger: social impulsivity as a dimension of temperament in vervet monkeys (Cercopithecus aethiops sabaeus)L A Fairbanks
Neuropsychiatric Institute, University of California, Los Angeles, 90024, USA
J Comp Psychol 115:22-8. 2001..The highest ranking males in each group were more likely to score in the moderate range, whereas lower ranking males were more likely to score in the highest (impulsive) or lowest (inhibited) quartiles... - Social impulsivity inversely associated with CSF 5-HIAA and fluoxetine exposure in vervet monkeysL A Fairbanks
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA
Neuropsychopharmacology 24:370-8. 2001..m.) or vehicle. Fluoxetine-treated subjects (n = 6) had significantly lower Impulsivity Index scores than controls (n = 12). The results from these two investigations provide evidence for serotonergic influences on social impulsivity... - Brain metabolic changes in major depressive disorder from pre- to post-treatment with paroxetineA L Brody
UCLA Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute and Hospital, Los Angeles, CA 90024, USA
Psychiatry Res 91:127-39. 1999..These findings implicate ventral prefrontal-subcortical brain circuitry in the mediation of response to serotonin reuptake inhibitors in MDD... - Personality changes in adult subjects with major depressive disorder or obsessive-compulsive disorder treated with paroxetineA L Brody
University of California at Los Angeles, Department of Psychiatry and Biobehavioral Sciences, USA
J Clin Psychiatry 61:349-55. 2000..We also sought to determine whether or not these personality changes were associated with disease state (MDD vs. OCD) or treatment response (responders vs. nonresponders)... - Regional brain metabolic changes in patients with major depression treated with either paroxetine or interpersonal therapy: preliminary findingsA L Brody
Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, CA, USA
Arch Gen Psychiatry 58:631-40. 2001..We also performed a preliminary comparison of regional changes with 2 distinct forms of treatment (paroxetine and interpersonal psychotherapy)... - Frequency and characteristics of anxiety among patients with Alzheimer's disease and related dementiasVerna R Porter
Department of Neurology, University of California, Los Angeles, School of Medicine, USA
J Neuropsychiatry Clin Neurosci 15:180-6. 2003..These data suggest that anxiety is common among patients with diverse forms of dementia. In AD, anxiety is most common in those with more severe cognitive deterioration and an earlier age at onset... - Posttraumatic stress and depressive reactions among Nicaraguan adolescents after hurricane MitchA K Goenjian
Trauma Psychiatry Program, Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, CA, USA
Am J Psychiatry 158:788-94. 2001.... - Mood symptoms and cognitive performance in women estrogen users and nonusers and menKaren J Miller
Department of Psychiatry and Biobehavioral Sciences, The Neuropsychiatric Institute, University of California, Los Angeles, CA 90024, USA
J Am Geriatr Soc 50:1826-30. 2002..In this study, we explore sex differences for a range of mood symptoms and for neuropsychological performance in men and postmenopausal women and assess the potential influence of estrogen on these measures... - Dimensions of impulsivity are associated with poor spatial working memory performance in monkeysAlex S James
Department of Psychology, University of California, Los Angeles, Los Angeles, California 90095, USA
J Neurosci 27:14358-64. 2007..These data indicate that dimensions of impulsivity may impact on working memory performance in qualitatively similar ways but through different mechanisms... - Long-term methamphetamine administration in the vervet monkey models aspects of a human exposure: brain neurotoxicity and behavioral profilesWilliam P Melega
Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095 1735, USA
Neuropsychopharmacology 33:1441-52. 2008.... - Early-onset Alzheimer's disease is associated with greater pathologic burdenGad A Marshall
Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, USA
J Geriatr Psychiatry Neurol 20:29-33. 2007..This suggests that late-onset AD patients have less cognitive reserve than early-onset patients and require fewer pathologic changes to exhibit cognitive deterioration... - The association of DRD4 and novelty seeking is found in a nonhuman primate modelJulia N Bailey
Center for Primate Neuroethology, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, California 90095, USA
Psychiatr Genet 17:23-7. 2007..The objective of this study was to test the generality of the association in a captive nonhuman primate population of known history, using objective methods for assessing novelty seeking and a pedigree-based association design... - Neuropathologic correlates of activities of daily living in Alzheimer diseaseGad A Marshall
Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095-1769, USA
Alzheimer Dis Assoc Disord 20:56-9. 2006..Deteriorating activities of daily living in Alzheimer Disease subjects correlate with greater overall pathologic burden and possibly selectively with involvement of the medial temporal, occipital, and orbital frontal regions... - Neuropathologic correlates of apathy in Alzheimer's diseaseGad A Marshall
Department of Neurology, University of California at Los Angeles, Reed Neurological Research Center, 2 238, 710 Westwood Plaza, CA 90095 1769, USA
Dement Geriatr Cogn Disord 21:144-7. 2006..01, and r = 0.438, p = 0.032). This analysis suggests that chronic apathy in AD correlates with a greater anterior cingulate NFT burden and that chronic behavioral changes are more reflective than acute changes of disease pathology... - Genetic contributions to social impulsivity and aggressiveness in vervet monkeysLynn A Fairbanks
Neuropsychiatric Institute, University of California-Los Angeles, California 90024, USA
Biol Psychiatry 55:642-7. 2004..The high genetic correlation suggests the same genes may influence variation in both impulsive approach and aggression. These results provide a promising basis for identification of susceptibility loci for impulsivity and aggressiveness... - A web-based brain atlas of the vervet monkey, Chlorocebus aethiopsRoger P Woods
Ahmanson Lovelace Brain Mapping Center, University of California, Los Angeles UCLA, Los Angeles, CA 90095 7085, USA
Neuroimage 54:1872-80. 2011..Despite the extended time period since their divergence, the major sulcal and subcortical landmarks in vervets are highly conserved relative to those described in macaques... - Architectonic distribution of the serotonin transporter within the orbitofrontal cortex of the vervet monkeyB M Way
Department of Molecular and Medical Pharmacology, 23 120 CHS, David Geffen School of Medicine at the University of California at Los Angeles, Box 951735, Los Angeles, CA 90095 1735, USA
Neuroscience 148:937-48. 2007..Collectively, these results suggest that the serotoninergic innervation is organized according to both cortical type and area, and is thus structured to differentially modulate information processing within the OFC... - Mild cognitive impairment is associated with characteristic neuropsychiatric symptomsTzung J Hwang
Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095-1769, USA
Alzheimer Dis Assoc Disord 18:17-21. 2004..Psychotic symptoms are significantly more common in the early stage of AD than in MCI. These results are derived from a limited clinical sample and require confirmation in longitudinal community-based investigations... - Identifying heritable brain phenotypes in an extended pedigree of vervet monkeysScott C Fears
Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, California 90095, USA
J Neurosci 29:2867-75. 2009.... - Brain metabolic changes associated with symptom factor improvement in major depressive disorderA L Brody
Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, California 90095, USA
Biol Psychiatry 50:171-8. 2001..CONCLUSIONS: Brain regions that show significant relationships with symptom provocation in normal control subjects have similar relationships with MDD symptoms as they improve with treatment... - Identification of brain transcriptional variation reproduced in peripheral blood: an approach for mapping brain expression traitsAnna J Jasinska
Center for Neurobehavioral Genetics, University of California, Los Angeles, CA 90095, USA
Hum Mol Genet 18:4415-27. 2009.... - Effects of age and sex on hematologic and serum biochemical values of vervet monkeys (Chlorocebus aethiops sabaeus)Akiko Sato
Division of Laboratory Animal Medicine, David Geffen School of Medicine, UCLA, Box 951718, Los Angeles, California 90095-17181, USA
Contemp Top Lab Anim Sci 44:29-34. 2005.... - A genetic linkage map of the vervet monkey (Chlorocebus aethiops sabaeus)Anna J Jasinska
Center for Neurobehavioral Genetics, The Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California 90095, USA
Mamm Genome 18:347-60. 2007..Our results support the notion that large inversions played a less prominent role in the evolution within the group of the Old World monkeys compared to the human and chimpanzee lineages... - Considerations in the selection and conditioning of Old World monkeys for laboratory research: animals from domestic sourcesJohn P Capitanio
California National Primate Research Center, University of California, Davis, CA, USA
ILAR J 47:294-306. 2006..Attention to issues of animal selection and conditioning by both researchers and colony managers can lead to the shared goal of high-quality research that utilizes the minimal number of animals... - Estrogen replacement therapy in the treatment of major depressive disorder in perimenopausal womenNatalie L Rasgon
Department of Psychiatry and Biobehavioral Science, University of California, Los Angeles, USA
J Clin Psychiatry 63:45-8. 2002..In depressed women who have minimal response to a selective serotonin reuptake inhibitor, ERT may augment response. Further controlled trials are needed... - Vitamin E as a treatment for ulcerative dermatitis in C57BL/6 mice and strains with a C57BL/6 backgroundGregory W Lawson
Division of Laboratory Animal Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California 90095-1718, USA
Contemp Top Lab Anim Sci 44:18-21. 2005..The positive response to vitamin E suggests that protection from oxidative injury may play a role in the resolution of UD lesions and offers veterinarians and investigators a new treatment option with ease of compliance... - Characterization and heritability of obesity and associated risk factors in vervet monkeysKylie Kavanagh
Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
Obesity (Silver Spring) 15:1666-74. 2007..The objective was to determine the prevalence and heritability of obesity and risk factors associated with metabolic syndrome (MS) in a pedigreed colony of vervet monkeys... - Approach to a social stranger is associated with low central nervous system serotonergic responsivity in female cynomolgus monkeys (Macaca fascicularis)Stephen B Manuck
Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA
Am J Primatol 61:187-94. 2003..We conclude that in female cynomolgus monkeys, social impulsivity (vs. inhibition) correlates inversely with individual differences in CNS serotonergic activity, as assessed by neuroendocrine challenge... - Effectiveness of human microsatellite loci for assessing paternity in a captive colony of vervets (Chlorocebus aethiops sabaeus)Timothy K Newman
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
Am J Primatol 56:237-43. 2002..Our results provide a panel of markers derived from the human genome that is suitable for assessing genetic variation and paternity in vervets...
Research Grants
- QTL Mapping of Impulsivity-related Traits Before and After a Stressful Life ChangLynn Fairbanks; Fiscal Year: 2007..This is a novel way of assessing the role of the gene-environment interactions in measuring effects of genetic variation on behavior traits ..
- Vervet Research Colony as a Biomedical ResourceLynn Fairbanks; Fiscal Year: 2006..abstract_text> ..
- Vervet Research Colony as a Biomedical ResourceLynn Fairbanks; Fiscal Year: 2005..These efforts will generate critical information and provide access to animals and research opportunities that will expand the use of the vervet as an alternative nonhuman primate model for the study of human diseases and disorders. ..
- Behavioral Genetics of ImpulsivityLynn Fairbanks; Fiscal Year: 2005....
- QTL Mapping of Impulsivity-related Traits Before and After a Stressful Life ChangLynn Fairbanks; Fiscal Year: 2009..This is a novel way of assessing the role of the gene-environment interactions in measuring effects of genetic variation on behavior traits ..