L A Fairbanks

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Effects of age and sex on hematologic and serum biochemical values of vervet monkeys (Chlorocebus aethiops sabaeus)
    Akiko Sato
    Division of Laboratory Animal Medicine, David Geffen School of Medicine, UCLA, Box 951718, Los Angeles, California 90095 17181, USA
    Contemp Top Lab Anim Sci 44:29-34. 2005
  2. pmc A quantitative trait locus for variation in dopamine metabolism mapped in a primate model using reference sequences from related species
    Nelson B Freimer
    Center for Neurobehavioral Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 104:15811-6. 2007
  3. doi request reprint Maternal and offspring dopamine D4 receptor genotypes interact to influence juvenile impulsivity in vervet monkeys
    Lynn A Fairbanks
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Psychol Sci 23:1099-104. 2012
  4. pmc Environmental stress alters genetic regulation of novelty seeking in vervet monkeys
    L A Fairbanks
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute, University of California, Los Angeles UCLA
    Genes Brain Behav 10:683-8. 2011
  5. pmc Heritability and genetic correlation of hair cortisol in vervet monkeys in low and higher stress environments
    Lynn A Fairbanks
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Psychoneuroendocrinology 36:1201-8. 2011
  6. doi request reprint High-fiber diet promotes weight loss and affects maternal behavior in vervet monkeys
    Lynn A Fairbanks
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute, University of California at Los Angeles, USA
    Am J Primatol 72:234-41. 2010
  7. ncbi request reprint CSF monoamines, age and impulsivity in wild grivet monkeys (Cercopithecus aethiops aethiops)
    L A Fairbanks
    Neuropsychiatric Institute, University of California, Los Angeles, CA 90024, USA
    Brain Behav Evol 53:305-12. 1999
  8. ncbi request reprint Adolescent impulsivity predicts adult dominance attainment in male vervet monkeys
    Lynn A Fairbanks
    Neuropsychiatric Institute, University of California Los Angeles, Los Angeles, California 90024, USA
    Am J Primatol 64:1-17. 2004
  9. ncbi request reprint Individual differences in response to a stranger: social impulsivity as a dimension of temperament in vervet monkeys (Cercopithecus aethiops sabaeus)
    L A Fairbanks
    Neuropsychiatric Institute, University of California, Los Angeles, 90024, USA
    J Comp Psychol 115:22-8. 2001
  10. ncbi request reprint Social impulsivity inversely associated with CSF 5-HIAA and fluoxetine exposure in vervet monkeys
    L A Fairbanks
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA
    Neuropsychopharmacology 24:370-8. 2001

Research Grants

  1. QTL Mapping of Impulsivity-related Traits Before and After a Stressful Life Chang
    Lynn Fairbanks; Fiscal Year: 2007
  2. Behavioral Genetics of Impulsivity
    Lynn Fairbanks; Fiscal Year: 2001
  3. Vervet Research Colony as a Biomedical Resource
    Lynn Fairbanks; Fiscal Year: 2006
  4. Vervet Research Colony as a Biomedical Resource
    Lynn Fairbanks; Fiscal Year: 2005
  5. Behavioral Genetics of Impulsivity
    Lynn Fairbanks; Fiscal Year: 2005
  6. Behavioral Genetics of Impulsivity
    Lynn Fairbanks; Fiscal Year: 2004
  7. Behavioral Genetics of Impulsivity
    Lynn Fairbanks; Fiscal Year: 2003
  8. Behavioral Genetics of Impulsivity
    Lynn Fairbanks; Fiscal Year: 2002
  9. QTL Mapping of Impulsivity-related Traits Before and After a Stressful Life Chang
    Lynn Fairbanks; Fiscal Year: 2009

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Effects of age and sex on hematologic and serum biochemical values of vervet monkeys (Chlorocebus aethiops sabaeus)
    Akiko Sato
    Division of Laboratory Animal Medicine, David Geffen School of Medicine, UCLA, Box 951718, Los Angeles, California 90095 17181, USA
    Contemp Top Lab Anim Sci 44:29-34. 2005
    ....
  2. pmc A quantitative trait locus for variation in dopamine metabolism mapped in a primate model using reference sequences from related species
    Nelson B Freimer
    Center for Neurobehavioral Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 104:15811-6. 2007
    ....
  3. doi request reprint Maternal and offspring dopamine D4 receptor genotypes interact to influence juvenile impulsivity in vervet monkeys
    Lynn A Fairbanks
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Psychol Sci 23:1099-104. 2012
    ..These results highlight the importance of considering the genotype of the parents in studies of early experience and vulnerability genes for impulsivity-related traits...
  4. pmc Environmental stress alters genetic regulation of novelty seeking in vervet monkeys
    L A Fairbanks
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute, University of California, Los Angeles UCLA
    Genes Brain Behav 10:683-8. 2011
    ..48). These results indicate that genetic regulation of novelty seeking was modified by the level of environmental stress, and they support a role for gene-environment interactions in a behavioural trait with relevance for mental health...
  5. pmc Heritability and genetic correlation of hair cortisol in vervet monkeys in low and higher stress environments
    Lynn A Fairbanks
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Psychoneuroendocrinology 36:1201-8. 2011
    ..The results provide support for an additive model of the effects of genes and environment on this measure of long term HPA activity...
  6. doi request reprint High-fiber diet promotes weight loss and affects maternal behavior in vervet monkeys
    Lynn A Fairbanks
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute, University of California at Los Angeles, USA
    Am J Primatol 72:234-41. 2010
    ..These results demonstrate that maternal behavior is responsive to changes in maternal condition, and that beneficial changes in the diet may have unintended consequences on behavior...
  7. ncbi request reprint CSF monoamines, age and impulsivity in wild grivet monkeys (Cercopithecus aethiops aethiops)
    L A Fairbanks
    Neuropsychiatric Institute, University of California, Los Angeles, CA 90024, USA
    Brain Behav Evol 53:305-12. 1999
    ..The results suggest that normal variation in central monoaminergic activity may have functional consequences in wild populations...
  8. ncbi request reprint Adolescent impulsivity predicts adult dominance attainment in male vervet monkeys
    Lynn A Fairbanks
    Neuropsychiatric Institute, University of California Los Angeles, Los Angeles, California 90024, USA
    Am J Primatol 64:1-17. 2004
    ..They also demonstrate that adolescent impulsivity is age-limited. Males that achieved high rank moderated their behavior as adults, and no longer scored high in impulsivity relative to their age peers...
  9. ncbi request reprint Individual differences in response to a stranger: social impulsivity as a dimension of temperament in vervet monkeys (Cercopithecus aethiops sabaeus)
    L A Fairbanks
    Neuropsychiatric Institute, University of California, Los Angeles, 90024, USA
    J Comp Psychol 115:22-8. 2001
    ..The highest ranking males in each group were more likely to score in the moderate range, whereas lower ranking males were more likely to score in the highest (impulsive) or lowest (inhibited) quartiles...
  10. ncbi request reprint Social impulsivity inversely associated with CSF 5-HIAA and fluoxetine exposure in vervet monkeys
    L A Fairbanks
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA
    Neuropsychopharmacology 24:370-8. 2001
    ..m.) or vehicle. Fluoxetine-treated subjects (n = 6) had significantly lower Impulsivity Index scores than controls (n = 12). The results from these two investigations provide evidence for serotonergic influences on social impulsivity...
  11. ncbi request reprint Brain metabolic changes in major depressive disorder from pre- to post-treatment with paroxetine
    A L Brody
    UCLA Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute and Hospital, Los Angeles, CA 90024, USA
    Psychiatry Res 91:127-39. 1999
    ..These findings implicate ventral prefrontal-subcortical brain circuitry in the mediation of response to serotonin reuptake inhibitors in MDD...
  12. ncbi request reprint Personality changes in adult subjects with major depressive disorder or obsessive-compulsive disorder treated with paroxetine
    A L Brody
    University of California at Los Angeles, Department of Psychiatry and Biobehavioral Sciences, USA
    J Clin Psychiatry 61:349-55. 2000
    ..We also sought to determine whether or not these personality changes were associated with disease state (MDD vs. OCD) or treatment response (responders vs. nonresponders)...
  13. ncbi request reprint Regional brain metabolic changes in patients with major depression treated with either paroxetine or interpersonal therapy: preliminary findings
    A L Brody
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, CA, USA
    Arch Gen Psychiatry 58:631-40. 2001
    ..We also performed a preliminary comparison of regional changes with 2 distinct forms of treatment (paroxetine and interpersonal psychotherapy)...
  14. ncbi request reprint Frequency and characteristics of anxiety among patients with Alzheimer's disease and related dementias
    Verna R Porter
    Department of Neurology, University of California, Los Angeles, School of Medicine, USA
    J Neuropsychiatry Clin Neurosci 15:180-6. 2003
    ..These data suggest that anxiety is common among patients with diverse forms of dementia. In AD, anxiety is most common in those with more severe cognitive deterioration and an earlier age at onset...
  15. ncbi request reprint Posttraumatic stress and depressive reactions among Nicaraguan adolescents after hurricane Mitch
    A K Goenjian
    Trauma Psychiatry Program, Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, CA, USA
    Am J Psychiatry 158:788-94. 2001
    ....
  16. ncbi request reprint Long-term methamphetamine administration in the vervet monkey models aspects of a human exposure: brain neurotoxicity and behavioral profiles
    William P Melega
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095 1735, USA
    Neuropsychopharmacology 33:1441-52. 2008
    ....
  17. pmc A web-based brain atlas of the vervet monkey, Chlorocebus aethiops
    Roger P Woods
    Ahmanson Lovelace Brain Mapping Center, University of California, Los Angeles UCLA, Los Angeles, CA 90095 7085, USA
    Neuroimage 54:1872-80. 2011
    ..Despite the extended time period since their divergence, the major sulcal and subcortical landmarks in vervets are highly conserved relative to those described in macaques...
  18. ncbi request reprint Early-onset Alzheimer's disease is associated with greater pathologic burden
    Gad A Marshall
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, USA
    J Geriatr Psychiatry Neurol 20:29-33. 2007
    ..This suggests that late-onset AD patients have less cognitive reserve than early-onset patients and require fewer pathologic changes to exhibit cognitive deterioration...
  19. ncbi request reprint The association of DRD4 and novelty seeking is found in a nonhuman primate model
    Julia N Bailey
    Center for Primate Neuroethology, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, California 90095, USA
    Psychiatr Genet 17:23-7. 2007
    ..The objective of this study was to test the generality of the association in a captive nonhuman primate population of known history, using objective methods for assessing novelty seeking and a pedigree-based association design...
  20. ncbi request reprint Dimensions of impulsivity are associated with poor spatial working memory performance in monkeys
    Alex S James
    Department of Psychology, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 27:14358-64. 2007
    ..These data indicate that dimensions of impulsivity may impact on working memory performance in qualitatively similar ways but through different mechanisms...
  21. ncbi request reprint Neuropathologic correlates of activities of daily living in Alzheimer disease
    Gad A Marshall
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 1769, USA
    Alzheimer Dis Assoc Disord 20:56-9. 2006
    ..Deteriorating activities of daily living in Alzheimer Disease subjects correlate with greater overall pathologic burden and possibly selectively with involvement of the medial temporal, occipital, and orbital frontal regions...
  22. ncbi request reprint Neuropathologic correlates of apathy in Alzheimer's disease
    Gad A Marshall
    Department of Neurology, University of California at Los Angeles, Reed Neurological Research Center, 2 238, 710 Westwood Plaza, CA 90095 1769, USA
    Dement Geriatr Cogn Disord 21:144-7. 2006
    ..01, and r = 0.438, p = 0.032). This analysis suggests that chronic apathy in AD correlates with a greater anterior cingulate NFT burden and that chronic behavioral changes are more reflective than acute changes of disease pathology...
  23. ncbi request reprint Genetic contributions to social impulsivity and aggressiveness in vervet monkeys
    Lynn A Fairbanks
    Neuropsychiatric Institute, University of California Los Angeles, California 90024, USA
    Biol Psychiatry 55:642-7. 2004
    ..This study assessed the genetic contribution to impulsivity and aggressiveness in a social context using a nonhuman primate model...
  24. ncbi request reprint Mood symptoms and cognitive performance in women estrogen users and nonusers and men
    Karen J Miller
    Department of Psychiatry and Biobehavioral Sciences, The Neuropsychiatric Institute, University of California, Los Angeles, CA 90024, USA
    J Am Geriatr Soc 50:1826-30. 2002
    ..In this study, we explore sex differences for a range of mood symptoms and for neuropsychological performance in men and postmenopausal women and assess the potential influence of estrogen on these measures...
  25. pmc Architectonic distribution of the serotonin transporter within the orbitofrontal cortex of the vervet monkey
    B M Way
    Department of Molecular and Medical Pharmacology, 23 120 CHS, David Geffen School of Medicine at the University of California at Los Angeles, Box 951735, Los Angeles, CA 90095 1735, USA
    Neuroscience 148:937-48. 2007
    ..Collectively, these results suggest that the serotoninergic innervation is organized according to both cortical type and area, and is thus structured to differentially modulate information processing within the OFC...
  26. ncbi request reprint Mild cognitive impairment is associated with characteristic neuropsychiatric symptoms
    Tzung J Hwang
    Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 1769, USA
    Alzheimer Dis Assoc Disord 18:17-21. 2004
    ..Psychotic symptoms are significantly more common in the early stage of AD than in MCI. These results are derived from a limited clinical sample and require confirmation in longitudinal community-based investigations...
  27. pmc Identifying heritable brain phenotypes in an extended pedigree of vervet monkeys
    Scott C Fears
    Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 29:2867-75. 2009
    ....
  28. ncbi request reprint Brain metabolic changes associated with symptom factor improvement in major depressive disorder
    A L Brody
    Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, California 90095, USA
    Biol Psychiatry 50:171-8. 2001
    ..CONCLUSIONS: Brain regions that show significant relationships with symptom provocation in normal control subjects have similar relationships with MDD symptoms as they improve with treatment...
  29. pmc Identification of brain transcriptional variation reproduced in peripheral blood: an approach for mapping brain expression traits
    Anna J Jasinska
    Center for Neurobehavioral Genetics, University of California, Los Angeles, CA 90095, USA
    Hum Mol Genet 18:4415-27. 2009
    ....
  30. ncbi request reprint Estrogen replacement therapy in the treatment of major depressive disorder in perimenopausal women
    Natalie L Rasgon
    Department of Psychiatry and Biobehavioral Science, University of California, Los Angeles, USA
    J Clin Psychiatry 63:45-8. 2002
    ..Fluctuating estrogen levels accompany the perimenopausal transition. Thus, estrogen replacement therapy (ERT) has been proposed as a potentially effective treatment for mood disorders occurring during perimenopause...
  31. ncbi request reprint Considerations in the selection and conditioning of Old World monkeys for laboratory research: animals from domestic sources
    John P Capitanio
    California National Primate Research Center, University of California, Davis, CA, USA
    ILAR J 47:294-306. 2006
    ..Attention to issues of animal selection and conditioning by both researchers and colony managers can lead to the shared goal of high-quality research that utilizes the minimal number of animals...
  32. ncbi request reprint A genetic linkage map of the vervet monkey (Chlorocebus aethiops sabaeus)
    Anna J Jasinska
    Center for Neurobehavioral Genetics, The Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California 90095, USA
    Mamm Genome 18:347-60. 2007
    ..Our results support the notion that large inversions played a less prominent role in the evolution within the group of the Old World monkeys compared to the human and chimpanzee lineages...
  33. ncbi request reprint Vitamin E as a treatment for ulcerative dermatitis in C57BL/6 mice and strains with a C57BL/6 background
    Gregory W Lawson
    Division of Laboratory Animal Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095 1718, USA
    Contemp Top Lab Anim Sci 44:18-21. 2005
    ..The positive response to vitamin E suggests that protection from oxidative injury may play a role in the resolution of UD lesions and offers veterinarians and investigators a new treatment option with ease of compliance...
  34. ncbi request reprint Characterization and heritability of obesity and associated risk factors in vervet monkeys
    Kylie Kavanagh
    Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Obesity (Silver Spring) 15:1666-74. 2007
    ..The objective was to determine the prevalence and heritability of obesity and risk factors associated with metabolic syndrome (MS) in a pedigreed colony of vervet monkeys...
  35. ncbi request reprint Effectiveness of human microsatellite loci for assessing paternity in a captive colony of vervets (Chlorocebus aethiops sabaeus)
    Timothy K Newman
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Am J Primatol 56:237-43. 2002
    ..Our results provide a panel of markers derived from the human genome that is suitable for assessing genetic variation and paternity in vervets...
  36. ncbi request reprint Approach to a social stranger is associated with low central nervous system serotonergic responsivity in female cynomolgus monkeys (Macaca fascicularis)
    Stephen B Manuck
    Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Primatol 61:187-94. 2003
    ..We conclude that in female cynomolgus monkeys, social impulsivity (vs. inhibition) correlates inversely with individual differences in CNS serotonergic activity, as assessed by neuroendocrine challenge...

Research Grants10

  1. QTL Mapping of Impulsivity-related Traits Before and After a Stressful Life Chang
    Lynn Fairbanks; Fiscal Year: 2007
    ..This is a novel way of assessing the role of the gene-environment interactions in measuring effects of genetic variation on behavior traits ..
  2. Behavioral Genetics of Impulsivity
    Lynn Fairbanks; Fiscal Year: 2001
    ....
  3. Vervet Research Colony as a Biomedical Resource
    Lynn Fairbanks; Fiscal Year: 2006
    ..abstract_text> ..
  4. Vervet Research Colony as a Biomedical Resource
    Lynn Fairbanks; Fiscal Year: 2005
    ..These efforts will generate critical information and provide access to animals and research opportunities that will expand the use of the vervet as an alternative nonhuman primate model for the study of human diseases and disorders. ..
  5. Behavioral Genetics of Impulsivity
    Lynn Fairbanks; Fiscal Year: 2005
    ....
  6. Behavioral Genetics of Impulsivity
    Lynn Fairbanks; Fiscal Year: 2004
    ....
  7. Behavioral Genetics of Impulsivity
    Lynn Fairbanks; Fiscal Year: 2003
    ....
  8. Behavioral Genetics of Impulsivity
    Lynn Fairbanks; Fiscal Year: 2002
    ....
  9. QTL Mapping of Impulsivity-related Traits Before and After a Stressful Life Chang
    Lynn Fairbanks; Fiscal Year: 2009
    ..This is a novel way of assessing the role of the gene-environment interactions in measuring effects of genetic variation on behavior traits ..