John Fahy

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc A protective role for periostin and TGF-β in IgE-mediated allergy and airway hyperresponsiveness
    E D Gordon
    Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, CA, USA
    Clin Exp Allergy 42:144-55. 2012
  2. pmc Network analysis identifies a putative role for the PPAR and type 1 interferon pathways in glucocorticoid actions in asthmatics
    Diego Diez
    Laboratory of Bioinformatics and Genomics, World Premier International Immunology Frontier Research Center, Osaka University, Osaka 565 0871, Japan
    BMC Med Genomics 5:27. 2012
  3. doi request reprint Eosinophilic and neutrophilic inflammation in asthma: insights from clinical studies
    John V Fahy
    University of California at San Francisco, Box 0130, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    Proc Am Thorac Soc 6:256-9. 2009
  4. ncbi request reprint Anti-IgE: lessons learned from effects on airway inflammation and asthma exacerbation
    John V Fahy
    Division of Pulmonary and Critical Care Medicine, Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0130, USA
    J Allergy Clin Immunol 117:1230-2. 2006
  5. pmc The H antigen at epithelial surfaces is associated with susceptibility to asthma exacerbation
    Anh L Innes
    The Cardiovascular Research Institute, University of California, San Francisco, California, USA
    Am J Respir Crit Care Med 183:189-94. 2011
  6. ncbi request reprint Epithelial mucin stores are increased in the large airways of smokers with airflow obstruction
    Anh L Innes
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Cardiovascular Research Institute, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA 94143, USA
    Chest 130:1102-8. 2006
  7. pmc Chitotriosidase is the primary active chitinase in the human lung and is modulated by genotype and smoking habit
    Max A Seibold
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, CA 94143, USA
    J Allergy Clin Immunol 122:944-950.e3. 2008
  8. pmc Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids
    Prescott G Woodruff
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 104:15858-63. 2007
  9. ncbi request reprint Daily versus as-needed corticosteroids for mild persistent asthma
    Homer A Boushey
    University of California at San Francisco, San Francisco, USA
    N Engl J Med 352:1519-28. 2005
  10. ncbi request reprint Goblet cell and mucin gene abnormalities in asthma
    John V Fahy
    Division of Pulmonary and Critical Care Medicine, and the Cardiovascular Research Institute, University of California at San Francisco, San Francisco, CA 94143, USA
    Chest 122:320S-326S. 2002

Collaborators

Detail Information

Publications37

  1. pmc A protective role for periostin and TGF-β in IgE-mediated allergy and airway hyperresponsiveness
    E D Gordon
    Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, CA, USA
    Clin Exp Allergy 42:144-55. 2012
    ..Though one might expect periostin to play a deleterious role in asthma pathogenesis, to date its biological role in the airway is unknown...
  2. pmc Network analysis identifies a putative role for the PPAR and type 1 interferon pathways in glucocorticoid actions in asthmatics
    Diego Diez
    Laboratory of Bioinformatics and Genomics, World Premier International Immunology Frontier Research Center, Osaka University, Osaka 565 0871, Japan
    BMC Med Genomics 5:27. 2012
    ..While the role of GCs in disease management is well understood, few studies have examined the holistic effects on the airway epithelium...
  3. doi request reprint Eosinophilic and neutrophilic inflammation in asthma: insights from clinical studies
    John V Fahy
    University of California at San Francisco, Box 0130, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    Proc Am Thorac Soc 6:256-9. 2009
    ..The promise now is that these markers will ultimately guide personalized treatment programs...
  4. ncbi request reprint Anti-IgE: lessons learned from effects on airway inflammation and asthma exacerbation
    John V Fahy
    Division of Pulmonary and Critical Care Medicine, Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0130, USA
    J Allergy Clin Immunol 117:1230-2. 2006
    ..The unsuspected dissociations among asthma outcomes uncovered during clinical trials of omalizumab remind us that mysteries remain for how inflammation, remodeling, and airway function are linked in asthma...
  5. pmc The H antigen at epithelial surfaces is associated with susceptibility to asthma exacerbation
    Anh L Innes
    The Cardiovascular Research Institute, University of California, San Francisco, California, USA
    Am J Respir Crit Care Med 183:189-94. 2011
    ..Acute asthma exacerbations, precipitated by viral infections, are a significant cause of morbidity, but not all patients with asthma are equally susceptible...
  6. ncbi request reprint Epithelial mucin stores are increased in the large airways of smokers with airflow obstruction
    Anh L Innes
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Cardiovascular Research Institute, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA 94143, USA
    Chest 130:1102-8. 2006
    ..Habitual cigarette smoking is associated with chronic mucus hypersecretion, but the relationship between mucus abnormalities and airflow obstruction in smokers is uncertain...
  7. pmc Chitotriosidase is the primary active chitinase in the human lung and is modulated by genotype and smoking habit
    Max A Seibold
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, CA 94143, USA
    J Allergy Clin Immunol 122:944-950.e3. 2008
    ..Acidic mammalian chitinase (AMCase) and chitotriosidase (CHIT1) have chitinolytic activity, but relatively little is known about their expression in human asthma...
  8. pmc Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids
    Prescott G Woodruff
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 104:15858-63. 2007
    ....
  9. ncbi request reprint Daily versus as-needed corticosteroids for mild persistent asthma
    Homer A Boushey
    University of California at San Francisco, San Francisco, USA
    N Engl J Med 352:1519-28. 2005
    ....
  10. ncbi request reprint Goblet cell and mucin gene abnormalities in asthma
    John V Fahy
    Division of Pulmonary and Critical Care Medicine, and the Cardiovascular Research Institute, University of California at San Francisco, San Francisco, CA 94143, USA
    Chest 122:320S-326S. 2002
    ..Such new treatments are urgently needed, because mucus hypersecretion is an important cause of morbidity and mortality in patients with asthma, and no specific treatments are available...
  11. pmc Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthma
    Stephen C Lazarus
    University of California, San Francisco, 505 Parnassus Avenue, M 1083, San Francisco, CA 94143 0111, USA
    Am J Respir Crit Care Med 175:783-90. 2007
    ..One-quarter to one-third of individuals with asthma smoke, which may affect response to therapy and contribute to poor asthma control...
  12. pmc T-helper type 2-driven inflammation defines major subphenotypes of asthma
    Prescott G Woodruff
    Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, CA 94143 0111, USA
    Am J Respir Crit Care Med 180:388-95. 2009
    ..However, clinical studies increasingly suggest that asthma is heterogeneous...
  13. ncbi request reprint Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression
    Prescott G Woodruff
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, and Cardiovascular Research Institute, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    Am J Respir Crit Care Med 169:1001-6. 2004
    ..However, smooth muscle cells in mild to moderate asthma do not show hypertrophy or gene expression changes of a hypercontractile phenotype observed in vitro...
  14. ncbi request reprint Effects of individual self-management education on clinical, biological, and adherence outcomes in asthma
    Susan L Janson
    Department of Community Health Systems, School of Nursing, University of California, San Francisco 94143 0608, USA
    Am J Med 115:620-6. 2003
    ..Asthma guidelines urge teaching patients the knowledge and skills required for self-management, based on the assumption that education will lead to improved skills and better asthma control...
  15. doi request reprint Safety and efficacy of an inhaled epidermal growth factor receptor inhibitor (BIBW 2948 BS) in chronic obstructive pulmonary disease
    Prescott G Woodruff
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA
    Am J Respir Crit Care Med 181:438-45. 2010
    ..Epidermal growth factor receptor (EGFR) activation is implicated in mucin hypersecretion in chronic obstructive pulmonary disease (COPD)...
  16. pmc Accumulation of intraepithelial mast cells with a unique protease phenotype in T(H)2-high asthma
    Ryan H Dougherty
    Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, CA, USA
    J Allergy Clin Immunol 125:1046-1053.e8. 2010
    ..We also found that asthmatic subjects can be divided into 2 subgroups ("T(H)2 high" and "T(H)2 low" asthma) based on epithelial cell gene signatures for the activity of T(H)2 cytokines...
  17. pmc Ex vivo sputum analysis reveals impairment of protease-dependent mucus degradation by plasma proteins in acute asthma
    Anh L Innes
    Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA
    Am J Respir Crit Care Med 180:203-10. 2009
    ..Airway mucus plugs, composed of mucin glycoproteins mixed with plasma proteins, are an important cause of airway obstruction in acute severe asthma, and they are poorly treated with current therapies...
  18. pmc Distinct roles of FOXA2 and FOXA3 in allergic airway disease and asthma
    Sung Woo Park
    Lung Biology Center, University of California San Francisco, San Francisco, California 94143, USA
    Am J Respir Crit Care Med 180:603-10. 2009
    ..IL-13-driven mucous cell metaplasia is associated with decreased expression of the transcription factor FOXA2 and increased expression of the related transcription factor FOXA3 in animal and cell culture models...
  19. ncbi request reprint Practical management of acute asthma in adults
    Teal S Hallstrand
    Division of Pulmonary and Critical Care Medicine, University of Washington, Box 356522, Seattle WA 98195 6522, USA
    Respir Care 47:171-82. 2002
    ..After an episode of acute asthma, long-term preventive medications, especially inhaled corticosteroids, should be prescribed and education should be provided to prevent future episodes...
  20. pmc Characterizing mucous cell remodeling in cystic fibrosis: relationship to neutrophils
    Steven R Hays
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
    Am J Respir Crit Care Med 174:1018-24. 2006
    ..Relatively few studies have characterized mucous cells or mucins in detail in cystic fibrosis (CF), and the relationship between mucous cell abnormalities and neutrophilic inflammation is uncertain...
  21. pmc Effects of multiday exposure to ozone on airway inflammation as determined using sputum induction
    Jeffrey Ratto
    Lung Biology Center, University of California San Francisco, San Francisco, California 94143 0843, USA
    Environ Health Perspect 114:209-12. 2006
    ..Given that SI likely samples proximal airways better than distal lung, these results add to the body of evidence that differential airway compartmental responses to O3 occur in humans and other species...
  22. pmc Roles of epithelial cell-derived periostin in TGF-beta activation, collagen production, and collagen gel elasticity in asthma
    Sukhvinder S Sidhu
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 107:14170-5. 2010
    ..Epithelial cell-derived periostin in asthma has roles in TGF-beta activation and collagen gel elasticity in asthma...
  23. pmc Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein
    Max A Seibold
    Department of Medicine, Howard Hughes Medical Institute, University of California, San Francisco, California 94143, USA
    J Biol Chem 284:19650-8. 2009
    ..The structural, kinetic, and genetic data regarding the AMCase isoforms are consistent with the Th2-priming effects of environmental chitin and a role for AMCase in negatively regulating this stimulus...
  24. ncbi request reprint Significant variability in response to inhaled corticosteroids for persistent asthma
    Stanley J Szefler
    National Jewish Medical and Research Center, Department of Pediatrics, Denver, CO 80206, USA
    J Allergy Clin Immunol 109:410-8. 2002
    ..A clinical model is needed to compare inhaled corticosteroids (ICSs) with respect to efficacy...
  25. ncbi request reprint Airway tissue mast cells in persistent asthma: predictor of treatment failure when patients discontinue inhaled corticosteroids
    Monica Kraft
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    Chest 124:42-50. 2003
    ..To determine if persistent airway tissue mast cells are associated with treatment failure when patients discontinue inhaled corticosteroids (ICS)...
  26. ncbi request reprint The role of mucus in fatal asthma
    Steven R Hays
    Am J Med 115:68-9. 2003
  27. ncbi request reprint Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma
    Ratko Djukanovic
    Respiratory Cell and Molecular Biology, Division of Infection, Inflammation, and Repair, University of Southampton, Southampton, UK
    Am J Respir Crit Care Med 170:583-93. 2004
    ..The lack of effect of omalizumab on methacholine responsiveness suggests that IgE or eosinophils may not be causally linked to airway hyperresponsiveness to methacholine in mild to moderate asthma...
  28. ncbi request reprint Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial
    Elliot Israel
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Lancet 364:1505-12. 2004
    ..However, the existence of any genotype-dependent difference has not been tested in a prospective clinical trial...
  29. ncbi request reprint Systemic effect comparisons of six inhaled corticosteroid preparations
    Richard J Martin
    National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Respir Crit Care Med 165:1377-83. 2002
    ..This study represents the first step in evaluation of ICS efficacy based on equisystemic (cortisol suppression) effects of a given ICS, rather than doses judged arbitrarily to be comparable on a microgram basis...
  30. ncbi request reprint Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroids
    Aaron Deykin
    Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    J Allergy Clin Immunol 115:720-7. 2005
    ..Although inhaled corticosteroids (ICSs) are effective in preventing deterioration in asthma control, at least half of subjects with mild-to-moderate asthma will remain stable when these agents are discontinued...
  31. ncbi request reprint A role for neutrophils in asthma?
    Prescott G Woodruff
    Am J Med 112:498-500. 2002
  32. ncbi request reprint Dissecting asthma using focused transgenic modeling and functional genomics
    Douglas A Kuperman
    Department of Medicine, Allergy Immunology Division, Northwestern University Feinberg School of Medicine, Chicago, USA
    J Allergy Clin Immunol 116:305-11. 2005
    ..These mice develop airway hyperreactivity and mucus overproduction but not airway inflammation...
  33. pmc The Predicting Response to Inhaled Corticosteroid Efficacy (PRICE) trial
    Richard J Martin
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 119:73-80. 2007
    ..Although guidelines recommend anti-inflammatory therapy for persistent asthma, recent studies suggest that 25% to 35% of patients with asthma may not improve lung function with inhaled corticosteroids...
  34. pmc beta-Adrenergic receptor polymorphisms and response to salmeterol
    Michael E Wechsler
    Brigham and Women s Hospital, 75 Francis Street, Boston, MA, 02115, USA
    Am J Respir Crit Care Med 173:519-26. 2006
    ..Several studies suggest that patients with asthma who are homozygous for arginine at the 16th position of the beta2-adrenergic receptor may not benefit from short-acting beta-agonists...
  35. pmc Combination therapy with a long-acting beta-agonist and a leukotriene antagonist in moderate asthma
    Aaron Deykin
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 175:228-34. 2007
    ..The elements of asthma control achieved by LABAs (improved lung function) and leukotriene receptor antagonists (LTRAs; protection against exacerbations) may be complementary as well...
  36. ncbi request reprint Applying stereology to measure thickness of the basement membrane zone in bronchial biopsy specimens
    Ronald E Ferrando
    J Allergy Clin Immunol 112:1243-5. 2003
  37. ncbi request reprint Induced sputum evaluation in microwave popcorn production workers
    Muge Akpinar-Elci
    NIOSH Division of Respiratory Diseases Studies, Centers for Disease Control and Prevention National Institute for Occupational Safety and Health, Field Studies Branch, Mail Stop H 2800, 1095 Willowdale Rd, Morgantown, WV 26505, USA
    Chest 128:991-7. 2005
    ..We investigated whether exposure to flavoring agents is associated with airways inflammation in popcorn production workers...

Research Grants12

  1. GOBLET CELL DYSFUNCTION IN ASTHMA
    John Fahy; Fiscal Year: 2001
    ..The application of the methods described here provide the opportunity to begin to understand the relationship between goblet cell hypersecretion and airway obstruction in human asthma, and may suggest strategies for improving treatment. ..
  2. GOBLET CELL DYSFUNCTION IN ASTHMA
    John Fahy; Fiscal Year: 1999
    ..The application of the methods described here provide the opportunity to begin to understand the relationship between goblet cell hypersecretion and airway obstruction in human asthma, and may suggest strategies for improving treatment. ..
  3. Histoblood group antigens, viruses & asthma excerbation
    John Fahy; Fiscal Year: 2007
    ..These are novel lines of inquiry into the mechanisms of virus-induced asthma exacerbation and may prompt novel treatments. ..
  4. Histoblood group antigens, viruses & asthma excerbation
    John Fahy; Fiscal Year: 2006
    ..These are novel lines of inquiry into the mechanisms of virus-induced asthma exacerbation and may prompt novel treatments. ..
  5. Histoblood group antigens, viruses & asthma excerbation
    John Fahy; Fiscal Year: 2005
    ..These are novel lines of inquiry into the mechanisms of virus-induced asthma exacerbation and may prompt novel treatments. ..
  6. T CELL INFLAMMATION AND MUCIN HYPERSECRETION IN COPD
    John Fahy; Fiscal Year: 2004
    ..abstract_text> ..
  7. T CELL INFLAMMATION AND MUCIN HYPERSECRETION IN COPD
    John Fahy; Fiscal Year: 2003
    ..abstract_text> ..
  8. T CELL INFLAMMATION AND MUCIN HYPERSECRETION IN COPD
    John Fahy; Fiscal Year: 2002
    ..abstract_text> ..
  9. GOBLET CELL DYSFUNCTION IN ASTHMA
    John Fahy; Fiscal Year: 2002
    ..The application of the methods described here provide the opportunity to begin to understand the relationship between goblet cell hypersecretion and airway obstruction in human asthma, and may suggest strategies for improving treatment. ..
  10. T CELL INFLAMMATION AND MUCIN HYPERSECRETION IN COPD
    John Fahy; Fiscal Year: 2001
    ..abstract_text> ..
  11. GOBLET CELL DYSFUNCTION IN ASTHMA
    John Fahy; Fiscal Year: 2000
    ..The application of the methods described here provide the opportunity to begin to understand the relationship between goblet cell hypersecretion and airway obstruction in human asthma, and may suggest strategies for improving treatment. ..