J V Fahy

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Effect of aerosolized anti-IgE (E25) on airway responses to inhaled allergen in asthmatic subjects
    J V Fahy
    The Cardiovascular Research Institute and the Department of Medicine, University of California, San Francisco, California, USA
    Am J Respir Crit Care Med 160:1023-7. 1999
  2. ncbi request reprint Goblet cell and mucin gene abnormalities in asthma
    John V Fahy
    Division of Pulmonary and Critical Care Medicine, and the Cardiovascular Research Institute, University of California at San Francisco, San Francisco, CA 94143, USA
    Chest 122:320S-326S. 2002
  3. ncbi request reprint Safety and reproducibility of sputum induction in asthmatic subjects in a multicenter study
    J V Fahy
    Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
    Am J Respir Crit Care Med 163:1470-5. 2001
  4. ncbi request reprint Remodeling of the airway epithelium in asthma
    J V Fahy
    Pulmonary and Critical Care Division, Department of Medicine and the Cardiovascular Research Institute, University of California at San Francisco, San Francisco, California 94143, USA
    Am J Respir Crit Care Med 164:S46-51. 2001
  5. ncbi request reprint Allergen challenge causes inflammation but not goblet cell degranulation in asthmatic subjects
    S R Hays
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco 94143, USA
    J Allergy Clin Immunol 108:784-90. 2001
  6. ncbi request reprint Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression
    C L Ordoñez
    Department of Pediatrics and Cardiovascular Research Institute, University of California at San Francisco, San Francisco, California 94143, USA
    Am J Respir Crit Care Med 163:517-23. 2001
  7. pmc Allergen-induced IL-9 directly stimulates mucin transcription in respiratory epithelial cells
    M Longphre
    Department of Anatomy and Cardiovascular Research Institute, School of Medicine, University of California San Francisco, San Francisco, California 94143, USA
    J Clin Invest 104:1375-82. 1999
  8. ncbi request reprint Long-acting beta2-agonist monotherapy vs continued therapy with inhaled corticosteroids in patients with persistent asthma: a randomized controlled trial
    S C Lazarus
    University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA 94143 0111, USA
    JAMA 285:2583-93. 2001
  9. ncbi request reprint Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma
    P G Woodruff
    Department of Medicine, University of California, San Francisco 94143, USA
    J Allergy Clin Immunol 108:753-8. 2001
  10. pmc A protective role for periostin and TGF-β in IgE-mediated allergy and airway hyperresponsiveness
    E D Gordon
    Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, CA, USA
    Clin Exp Allergy 42:144-55. 2012

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Effect of aerosolized anti-IgE (E25) on airway responses to inhaled allergen in asthmatic subjects
    J V Fahy
    The Cardiovascular Research Institute and the Department of Medicine, University of California, San Francisco, California, USA
    Am J Respir Crit Care Med 160:1023-7. 1999
    ..Additionally, the aerosol route of delivery of monoclonal antibodies may be more immunogenic than the parenteral route...
  2. ncbi request reprint Goblet cell and mucin gene abnormalities in asthma
    John V Fahy
    Division of Pulmonary and Critical Care Medicine, and the Cardiovascular Research Institute, University of California at San Francisco, San Francisco, CA 94143, USA
    Chest 122:320S-326S. 2002
    ..Such new treatments are urgently needed, because mucus hypersecretion is an important cause of morbidity and mortality in patients with asthma, and no specific treatments are available...
  3. ncbi request reprint Safety and reproducibility of sputum induction in asthmatic subjects in a multicenter study
    J V Fahy
    Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
    Am J Respir Crit Care Med 163:1470-5. 2001
    ..Importantly, we demonstrate that measurement of markers of inflammation in induced sputum is as reproducible as methacholine PC(20) and should prove useful in the assessment of airway inflammation in multicenter clinical trials...
  4. ncbi request reprint Remodeling of the airway epithelium in asthma
    J V Fahy
    Pulmonary and Critical Care Division, Department of Medicine and the Cardiovascular Research Institute, University of California at San Francisco, San Francisco, California 94143, USA
    Am J Respir Crit Care Med 164:S46-51. 2001
    ..Improved understanding of epithelial goblet cell abnormalities in asthma will hopefully lead to novel therapies for mucin hypersecretion, which is an important cause of morbidity and mortality...
  5. ncbi request reprint Allergen challenge causes inflammation but not goblet cell degranulation in asthmatic subjects
    S R Hays
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco 94143, USA
    J Allergy Clin Immunol 108:784-90. 2001
    ..In fact, in subjects with normal baseline mucin stores, allergen challenge increases goblet cell mucin stores...
  6. ncbi request reprint Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression
    C L Ordoñez
    Department of Pediatrics and Cardiovascular Research Institute, University of California at San Francisco, San Francisco, California 94143, USA
    Am J Respir Crit Care Med 163:517-23. 2001
    ....
  7. pmc Allergen-induced IL-9 directly stimulates mucin transcription in respiratory epithelial cells
    M Longphre
    Department of Anatomy and Cardiovascular Research Institute, School of Medicine, University of California San Francisco, San Francisco, California 94143, USA
    J Clin Invest 104:1375-82. 1999
    ..Furthermore, recombinant IL-9, but not IL-5 or IL-13, stimulated mucin synthesis. These results indicate that IL-9 may account for as much as 50-60% of the mucin-stimulating activity of lung fluids in allergic airway disease...
  8. ncbi request reprint Long-acting beta2-agonist monotherapy vs continued therapy with inhaled corticosteroids in patients with persistent asthma: a randomized controlled trial
    S C Lazarus
    University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA 94143 0111, USA
    JAMA 285:2583-93. 2001
    ..No evidence exists, however, to support their use as monotherapy in adults with persistent asthma...
  9. ncbi request reprint Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma
    P G Woodruff
    Department of Medicine, University of California, San Francisco 94143, USA
    J Allergy Clin Immunol 108:753-8. 2001
    ..Therapies directed specifically at control of neutrophilic inflammation might be useful in improving airway caliber in patients with chronic asthma...
  10. pmc A protective role for periostin and TGF-β in IgE-mediated allergy and airway hyperresponsiveness
    E D Gordon
    Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, CA, USA
    Clin Exp Allergy 42:144-55. 2012
    ..Though one might expect periostin to play a deleterious role in asthma pathogenesis, to date its biological role in the airway is unknown...
  11. ncbi request reprint Relationship of epidermal growth factor receptors to goblet cell production in human bronchi
    K Takeyama
    Cardiovascular Research Institute and Department of Medicine, University of California San Francisco, San Francisco, California 94143-0130, USA
    Am J Respir Crit Care Med 163:511-6. 2001
    ..These findings suggest a sequence of events by which EGFR activation is involved in mucin expression in asthmatic airway epithelium...
  12. ncbi request reprint Effect of a single dose of the selectin inhibitor TBC1269 on early and late asthmatic responses
    P C Avila
    Department of Medicine and Cardiovascular Research Institute, University of California at San Francisco, San Francisco, CA 94143 0130, USA
    Clin Exp Allergy 34:77-84. 2004
    ..In the sheep asthma model, TBC1269, a pan-selectin antagonist, reduced late allergen response by 74%...
  13. ncbi request reprint A novel method of gene transcript profiling in airway biopsy homogenates reveals increased expression of a Na+-K+-Cl- cotransporter (NKCC1) in asthmatic subjects
    G M Dolganov
    Genelabs Technologies, Inc, Redwood City, California 94063, USA
    Genome Res 11:1473-83. 2001
    ..Potential applications for this method include transcriptional profiling in limited numbers of laser captured cells and validation of DNA microarray data in clinical specimens...
  14. pmc Predicting worsening asthma control following the common cold
    M J Walter
    Division of Pulmonary and Critical Care Medicine, Campus Box 8052, 660 South Euclid Ave, St Louis, MO 63110, USA
    Eur Respir J 32:1548-54. 2008
    ..In asthmatic subjects, cold severity within the first 2 days can be used to predict subsequent changes in asthma control. This information may help clinicians prevent deterioration in asthma control following a cold...
  15. pmc Acute exacerbations of asthma: epidemiology, biology and the exacerbation-prone phenotype
    R H Dougherty
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, CA 94143, USA
    Clin Exp Allergy 39:193-202. 2009
    ....
  16. pmc Negative methacholine challenge tests in subjects who report physician-diagnosed asthma
    K W McGrath
    UCSF School of Nursing, University of California, San Francisco, CA, USA
    Clin Exp Allergy 41:46-51. 2011
    ..The frequency of adults reporting a history of asthma is rising. However, it is unclear whether this increased prevalence accurately demonstrates a rising trend or if it reflects an overall increase in asthma awareness...
  17. pmc Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma
    Yvonne J Huang
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, Calif, USA
    J Allergy Clin Immunol 127:372-381.e1-3. 2011
    ..However, the airway might be populated by a more diverse microbiota, and clinical features of asthma might be associated with characteristics of the airway microbiota present...
  18. ncbi request reprint Anti-IgE: lessons learned from effects on airway inflammation and asthma exacerbation
    John V Fahy
    Division of Pulmonary and Critical Care Medicine, Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0130, USA
    J Allergy Clin Immunol 117:1230-2. 2006
    ..The unsuspected dissociations among asthma outcomes uncovered during clinical trials of omalizumab remind us that mysteries remain for how inflammation, remodeling, and airway function are linked in asthma...
  19. pmc Combination therapy with a long-acting beta-agonist and a leukotriene antagonist in moderate asthma
    Aaron Deykin
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 175:228-34. 2007
    ..The elements of asthma control achieved by LABAs (improved lung function) and leukotriene receptor antagonists (LTRAs; protection against exacerbations) may be complementary as well...
  20. ncbi request reprint Epithelial mucin stores are increased in the large airways of smokers with airflow obstruction
    Anh L Innes
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Cardiovascular Research Institute, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA 94143, USA
    Chest 130:1102-8. 2006
    ..Habitual cigarette smoking is associated with chronic mucus hypersecretion, but the relationship between mucus abnormalities and airflow obstruction in smokers is uncertain...
  21. ncbi request reprint Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression
    Prescott G Woodruff
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, and Cardiovascular Research Institute, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    Am J Respir Crit Care Med 169:1001-6. 2004
    ..However, smooth muscle cells in mild to moderate asthma do not show hypertrophy or gene expression changes of a hypercontractile phenotype observed in vitro...
  22. pmc Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthma
    Stephen C Lazarus
    University of California, San Francisco, 505 Parnassus Avenue, M 1083, San Francisco, CA 94143 0111, USA
    Am J Respir Crit Care Med 175:783-90. 2007
    ..One-quarter to one-third of individuals with asthma smoke, which may affect response to therapy and contribute to poor asthma control...
  23. pmc The Predicting Response to Inhaled Corticosteroid Efficacy (PRICE) trial
    Richard J Martin
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 119:73-80. 2007
    ..Although guidelines recommend anti-inflammatory therapy for persistent asthma, recent studies suggest that 25% to 35% of patients with asthma may not improve lung function with inhaled corticosteroids...
  24. pmc Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids
    Prescott G Woodruff
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 104:15858-63. 2007
    ....
  25. pmc beta-Adrenergic receptor polymorphisms and response to salmeterol
    Michael E Wechsler
    Brigham and Women s Hospital, 75 Francis Street, Boston, MA, 02115, USA
    Am J Respir Crit Care Med 173:519-26. 2006
    ..Several studies suggest that patients with asthma who are homozygous for arginine at the 16th position of the beta2-adrenergic receptor may not benefit from short-acting beta-agonists...
  26. ncbi request reprint Dissecting asthma using focused transgenic modeling and functional genomics
    Douglas A Kuperman
    Department of Medicine, Allergy Immunology Division, Northwestern University Feinberg School of Medicine, Chicago, USA
    J Allergy Clin Immunol 116:305-11. 2005
    ..These mice develop airway hyperreactivity and mucus overproduction but not airway inflammation...
  27. ncbi request reprint Effects of individual self-management education on clinical, biological, and adherence outcomes in asthma
    Susan L Janson
    Department of Community Health Systems, School of Nursing, University of California, San Francisco 94143 0608, USA
    Am J Med 115:620-6. 2003
    ..Asthma guidelines urge teaching patients the knowledge and skills required for self-management, based on the assumption that education will lead to improved skills and better asthma control...
  28. ncbi request reprint The role of mucus in fatal asthma
    Steven R Hays
    Am J Med 115:68-9. 2003
  29. ncbi request reprint Systemic effect comparisons of six inhaled corticosteroid preparations
    Richard J Martin
    National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Respir Crit Care Med 165:1377-83. 2002
    ..This study represents the first step in evaluation of ICS efficacy based on equisystemic (cortisol suppression) effects of a given ICS, rather than doses judged arbitrarily to be comparable on a microgram basis...
  30. ncbi request reprint A role for neutrophils in asthma?
    Prescott G Woodruff
    Am J Med 112:498-500. 2002
  31. ncbi request reprint Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma
    Ratko Djukanovic
    Respiratory Cell and Molecular Biology, Division of Infection, Inflammation, and Repair, University of Southampton, Southampton, UK
    Am J Respir Crit Care Med 170:583-93. 2004
    ..The lack of effect of omalizumab on methacholine responsiveness suggests that IgE or eosinophils may not be causally linked to airway hyperresponsiveness to methacholine in mild to moderate asthma...
  32. ncbi request reprint Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial
    Elliot Israel
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Lancet 364:1505-12. 2004
    ..However, the existence of any genotype-dependent difference has not been tested in a prospective clinical trial...
  33. ncbi request reprint Significant variability in response to inhaled corticosteroids for persistent asthma
    Stanley J Szefler
    National Jewish Medical and Research Center, Department of Pediatrics, Denver, CO 80206, USA
    J Allergy Clin Immunol 109:410-8. 2002
    ..A clinical model is needed to compare inhaled corticosteroids (ICSs) with respect to efficacy...
  34. ncbi request reprint Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroids
    Aaron Deykin
    Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    J Allergy Clin Immunol 115:720-7. 2005
    ..Although inhaled corticosteroids (ICSs) are effective in preventing deterioration in asthma control, at least half of subjects with mild-to-moderate asthma will remain stable when these agents are discontinued...
  35. ncbi request reprint Daily versus as-needed corticosteroids for mild persistent asthma
    Homer A Boushey
    University of California at San Francisco, San Francisco, USA
    N Engl J Med 352:1519-28. 2005
    ....
  36. ncbi request reprint Airway tissue mast cells in persistent asthma: predictor of treatment failure when patients discontinue inhaled corticosteroids
    Monica Kraft
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    Chest 124:42-50. 2003
    ..To determine if persistent airway tissue mast cells are associated with treatment failure when patients discontinue inhaled corticosteroids (ICS)...
  37. ncbi request reprint Induced sputum evaluation in microwave popcorn production workers
    Muge Akpinar-Elci
    NIOSH Division of Respiratory Diseases Studies, Centers for Disease Control and Prevention National Institute for Occupational Safety and Health, Field Studies Branch, Mail Stop H 2800, 1095 Willowdale Rd, Morgantown, WV 26505, USA
    Chest 128:991-7. 2005
    ..We investigated whether exposure to flavoring agents is associated with airways inflammation in popcorn production workers...
  38. ncbi request reprint Applying stereology to measure thickness of the basement membrane zone in bronchial biopsy specimens
    Ronald E Ferrando
    J Allergy Clin Immunol 112:1243-5. 2003
  39. pmc Characterizing mucous cell remodeling in cystic fibrosis: relationship to neutrophils
    Steven R Hays
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
    Am J Respir Crit Care Med 174:1018-24. 2006
    ..Relatively few studies have characterized mucous cells or mucins in detail in cystic fibrosis (CF), and the relationship between mucous cell abnormalities and neutrophilic inflammation is uncertain...
  40. ncbi request reprint Practical management of acute asthma in adults
    Teal S Hallstrand
    Division of Pulmonary and Critical Care Medicine, University of Washington, Box 356522, Seattle WA 98195 6522, USA
    Respir Care 47:171-82. 2002
    ..After an episode of acute asthma, long-term preventive medications, especially inhaled corticosteroids, should be prescribed and education should be provided to prevent future episodes...