Research Topics
Species | J V FahySummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Effect of aerosolized anti-IgE (E25) on airway responses to inhaled allergen in asthmatic subjectsJ V Fahy
The Cardiovascular Research Institute and the Department of Medicine, University of California, San Francisco, California, USA
Am J Respir Crit Care Med 160:1023-7. 1999..Additionally, the aerosol route of delivery of monoclonal antibodies may be more immunogenic than the parenteral route...- Goblet cell and mucin gene abnormalities in asthmaJohn V Fahy
Division of Pulmonary and Critical Care Medicine, and the Cardiovascular Research Institute, University of California at San Francisco, San Francisco, CA 94143, USA
Chest 122:320S-326S. 2002..Such new treatments are urgently needed, because mucus hypersecretion is an important cause of morbidity and mortality in patients with asthma, and no specific treatments are available... - Safety and reproducibility of sputum induction in asthmatic subjects in a multicenter studyJ V Fahy
Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
Am J Respir Crit Care Med 163:1470-5. 2001..Importantly, we demonstrate that measurement of markers of inflammation in induced sputum is as reproducible as methacholine PC(20) and should prove useful in the assessment of airway inflammation in multicenter clinical trials... - Remodeling of the airway epithelium in asthmaJ V Fahy
Pulmonary and Critical Care Division, Department of Medicine and the Cardiovascular Research Institute, University of California at San Francisco, San Francisco, California 94143, USA
Am J Respir Crit Care Med 164:S46-51. 2001..Improved understanding of epithelial goblet cell abnormalities in asthma will hopefully lead to novel therapies for mucin hypersecretion, which is an important cause of morbidity and mortality... - Allergen challenge causes inflammation but not goblet cell degranulation in asthmatic subjectsS R Hays
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco 94143, USA
J Allergy Clin Immunol 108:784-90. 2001..In fact, in subjects with normal baseline mucin stores, allergen challenge increases goblet cell mucin stores... - Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expressionC L Ordoñez
Department of Pediatrics and Cardiovascular Research Institute, University of California at San Francisco, San Francisco, California 94143, USA
Am J Respir Crit Care Med 163:517-23. 2001.... 
Allergen-induced IL-9 directly stimulates mucin transcription in respiratory epithelial cellsM Longphre
Department of Anatomy and Cardiovascular Research Institute, School of Medicine, University of California San Francisco, San Francisco, California 94143, USA
J Clin Invest 104:1375-82. 1999..Furthermore, recombinant IL-9, but not IL-5 or IL-13, stimulated mucin synthesis. These results indicate that IL-9 may account for as much as 50-60% of the mucin-stimulating activity of lung fluids in allergic airway disease...- Long-acting beta2-agonist monotherapy vs continued therapy with inhaled corticosteroids in patients with persistent asthma: a randomized controlled trialS C Lazarus
University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA 94143 0111, USA
JAMA 285:2583-93. 2001..No evidence exists, however, to support their use as monotherapy in adults with persistent asthma... - Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthmaP G Woodruff
Department of Medicine, University of California, San Francisco 94143, USA
J Allergy Clin Immunol 108:753-8. 2001..Therapies directed specifically at control of neutrophilic inflammation might be useful in improving airway caliber in patients with chronic asthma... - A protective role for periostin and TGF-β in IgE-mediated allergy and airway hyperresponsivenessE D Gordon
Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, CA, USA
Clin Exp Allergy 42:144-55. 2012..Though one might expect periostin to play a deleterious role in asthma pathogenesis, to date its biological role in the airway is unknown... - Relationship of epidermal growth factor receptors to goblet cell production in human bronchiK Takeyama
Cardiovascular Research Institute and Department of Medicine, University of California San Francisco, San Francisco, California 94143-0130, USA
Am J Respir Crit Care Med 163:511-6. 2001..These findings suggest a sequence of events by which EGFR activation is involved in mucin expression in asthmatic airway epithelium... - Effect of a single dose of the selectin inhibitor TBC1269 on early and late asthmatic responsesP C Avila
Department of Medicine and Cardiovascular Research Institute, University of California at San Francisco, San Francisco, CA 94143 0130, USA
Clin Exp Allergy 34:77-84. 2004..In the sheep asthma model, TBC1269, a pan-selectin antagonist, reduced late allergen response by 74%... - A novel method of gene transcript profiling in airway biopsy homogenates reveals increased expression of a Na+-K+-Cl- cotransporter (NKCC1) in asthmatic subjectsG M Dolganov
Genelabs Technologies, Inc, Redwood City, California 94063, USA
Genome Res 11:1473-83. 2001..Potential applications for this method include transcriptional profiling in limited numbers of laser captured cells and validation of DNA microarray data in clinical specimens... - Predicting worsening asthma control following the common coldM J Walter
Division of Pulmonary and Critical Care Medicine, Campus Box 8052, 660 South Euclid Ave, St Louis, MO 63110, USA
Eur Respir J 32:1548-54. 2008..In asthmatic subjects, cold severity within the first 2 days can be used to predict subsequent changes in asthma control. This information may help clinicians prevent deterioration in asthma control following a cold... - Acute exacerbations of asthma: epidemiology, biology and the exacerbation-prone phenotypeR H Dougherty
Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, CA 94143, USA
Clin Exp Allergy 39:193-202. 2009.... - Negative methacholine challenge tests in subjects who report physician-diagnosed asthmaK W McGrath
UCSF School of Nursing, University of California, San Francisco, CA, USA
Clin Exp Allergy 41:46-51. 2011..The frequency of adults reporting a history of asthma is rising. However, it is unclear whether this increased prevalence accurately demonstrates a rising trend or if it reflects an overall increase in asthma awareness... - Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthmaYvonne J Huang
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, Calif, USA
J Allergy Clin Immunol 127:372-381.e1-3. 2011..However, the airway might be populated by a more diverse microbiota, and clinical features of asthma might be associated with characteristics of the airway microbiota present... - Anti-IgE: lessons learned from effects on airway inflammation and asthma exacerbationJohn V Fahy
Division of Pulmonary and Critical Care Medicine, Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0130, USA
J Allergy Clin Immunol 117:1230-2. 2006..The unsuspected dissociations among asthma outcomes uncovered during clinical trials of omalizumab remind us that mysteries remain for how inflammation, remodeling, and airway function are linked in asthma... - Combination therapy with a long-acting beta-agonist and a leukotriene antagonist in moderate asthmaAaron Deykin
Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Respir Crit Care Med 175:228-34. 2007..The elements of asthma control achieved by LABAs (improved lung function) and leukotriene receptor antagonists (LTRAs; protection against exacerbations) may be complementary as well... - Epithelial mucin stores are increased in the large airways of smokers with airflow obstructionAnh L Innes
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Cardiovascular Research Institute, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA 94143, USA
Chest 130:1102-8. 2006..The highest epithelial mucin stores are found in smokers with airflow obstruction, suggesting a mechanistic link between epithelial mucin dysregulation and airflow obstruction... - Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expressionPrescott G Woodruff
Division of Pulmonary and Critical Care Medicine, Department of Medicine, and Cardiovascular Research Institute, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
Am J Respir Crit Care Med 169:1001-6. 2004..However, smooth muscle cells in mild to moderate asthma do not show hypertrophy or gene expression changes of a hypercontractile phenotype observed in vitro... - Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthmaStephen C Lazarus
University of California, San Francisco, 505 Parnassus Avenue, M 1083, San Francisco, CA 94143 0111, USA
Am J Respir Crit Care Med 175:783-90. 2007..One-quarter to one-third of individuals with asthma smoke, which may affect response to therapy and contribute to poor asthma control... - The Predicting Response to Inhaled Corticosteroid Efficacy (PRICE) trialRichard J Martin
National Jewish Medical and Research Center, Denver, CO 80206, USA
J Allergy Clin Immunol 119:73-80. 2007..Although guidelines recommend anti-inflammatory therapy for persistent asthma, recent studies suggest that 25% to 35% of patients with asthma may not improve lung function with inhaled corticosteroids... - Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroidsPrescott G Woodruff
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 104:15858-63. 2007.... - beta-Adrenergic receptor polymorphisms and response to salmeterolMichael E Wechsler
Brigham and Women s Hospital, 75 Francis Street, Boston, MA, 02115, USA
Am J Respir Crit Care Med 173:519-26. 2006..Several studies suggest that patients with asthma who are homozygous for arginine at the 16th position of the beta2-adrenergic receptor may not benefit from short-acting beta-agonists... - Dissecting asthma using focused transgenic modeling and functional genomicsDouglas A Kuperman
Department of Medicine, Allergy-Immunology Division, Northwestern University Feinberg School of Medicine, Chicago, USA
J Allergy Clin Immunol 116:305-11. 2005.... - Effects of individual self-management education on clinical, biological, and adherence outcomes in asthmaSusan L Janson
Department of Community Health Systems, School of Nursing, University of California, San Francisco 94143 0608, USA
Am J Med 115:620-6. 2003..Asthma guidelines urge teaching patients the knowledge and skills required for self-management, based on the assumption that education will lead to improved skills and better asthma control... - The role of mucus in fatal asthmaSteven R Hays
Am J Med 115:68-9. 2003 - Systemic effect comparisons of six inhaled corticosteroid preparationsRichard J Martin
National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Am J Respir Crit Care Med 165:1377-83. 2002..This study represents the first step in evaluation of ICS efficacy based on equisystemic (cortisol suppression) effects of a given ICS, rather than doses judged arbitrarily to be comparable on a microgram basis... - A role for neutrophils in asthma?Prescott G Woodruff
Am J Med 112:498-500. 2002 - Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthmaRatko Djukanovic
Respiratory Cell and Molecular Biology, Division of Infection, Inflammation, and Repair, University of Southampton, Southampton, UK
Am J Respir Crit Care Med 170:583-93. 2004..The lack of effect of omalizumab on methacholine responsiveness suggests that IgE or eosinophils may not be causally linked to airway hyperresponsiveness to methacholine in mild to moderate asthma... - Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trialElliot Israel
Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Lancet 364:1505-12. 2004..However, the existence of any genotype-dependent difference has not been tested in a prospective clinical trial... - Significant variability in response to inhaled corticosteroids for persistent asthmaStanley J Szefler
National Jewish Medical and Research Center, Department of Pediatrics, Denver, CO 80206, USA
J Allergy Clin Immunol 109:410-8. 2002..It is possible that higher doses of ICSs are necessary to manage more severe patients or to achieve goals of therapy not evaluated in this study, such as prevention of asthma exacerbations... - Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroidsAaron Deykin
Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
J Allergy Clin Immunol 115:720-7. 2005..Although inhaled corticosteroids (ICSs) are effective in preventing deterioration in asthma control, at least half of subjects with mild-to-moderate asthma will remain stable when these agents are discontinued... - Daily versus as-needed corticosteroids for mild persistent asthmaHomer A Boushey
University of California at San Francisco, San Francisco, USA
N Engl J Med 352:1519-28. 2005..Further studies are required to determine whether this novel approach to treatment should be recommended... - Airway tissue mast cells in persistent asthma: predictor of treatment failure when patients discontinue inhaled corticosteroidsMonica Kraft
National Jewish Medical and Research Center, Denver, CO 80206, USA
Chest 124:42-50. 2003..To determine if persistent airway tissue mast cells are associated with treatment failure when patients discontinue inhaled corticosteroids (ICS)... - Induced sputum evaluation in microwave popcorn production workersMuge Akpinar-Elci
NIOSH Division of Respiratory Diseases Studies, Centers for Disease Control and Prevention National Institute for Occupational Safety and Health, Field Studies Branch, Mail Stop H 2800, 1095 Willowdale Rd, Morgantown, WV 26505, USA
Chest 128:991-7. 2005..We investigated whether exposure to flavoring agents is associated with airways inflammation in popcorn production workers... - Applying stereology to measure thickness of the basement membrane zone in bronchial biopsy specimensRonald E Ferrando
J Allergy Clin Immunol 112:1243-5. 2003 - Characterizing mucous cell remodeling in cystic fibrosis: relationship to neutrophilsSteven R Hays
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
Am J Respir Crit Care Med 174:1018-24. 2006..The mechanism for increased submucosal gland volume in CF deserves further study... - Practical management of acute asthma in adultsTeal S Hallstrand
Division of Pulmonary and Critical Care Medicine, University of Washington, Box 356522, Seattle WA 98195 6522, USA
Respir Care 47:171-82. 2002..After an episode of acute asthma, long-term preventive medications, especially inhaled corticosteroids, should be prescribed and education should be provided to prevent future episodes...