ROBERT FAHEY

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Bacillithiol is an antioxidant thiol produced in Bacilli
    Gerald L Newton
    Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, USA
    Nat Chem Biol 5:625-7. 2009
  2. doi request reprint Glutathione analogs in prokaryotes
    Robert C Fahey
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA
    Biochim Biophys Acta 1830:3182-98. 2013
  3. ncbi request reprint Novel thiols of prokaryotes
    R C Fahey
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA
    Annu Rev Microbiol 55:333-56. 2001
  4. pmc Organic hydroperoxide resistance protein and ergothioneine compensate for loss of mycothiol in Mycobacterium smegmatis mutants
    Philong Ta
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093 0314, USA
    J Bacteriol 193:1981-90. 2011

Collaborators

Detail Information

Publications4

  1. pmc Bacillithiol is an antioxidant thiol produced in Bacilli
    Gerald L Newton
    Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, USA
    Nat Chem Biol 5:625-7. 2009
    ..Bacillithiol is the alpha-anomeric glycoside of L-cysteinyl-D-glucosamine with L-malic acid and most probably functions as an antioxidant. Bacillithiol, like the structurally similar mycothiol, may serve as a substitute for glutathione...
  2. doi request reprint Glutathione analogs in prokaryotes
    Robert C Fahey
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA
    Biochim Biophys Acta 1830:3182-98. 2013
    ..Low-molecular-weight thiols provide protective buffers against the hazards of ROS toxicity. Glutathione is the small protective thiol in nearly all eukaryotes but in prokaryotes the situation is far more complex...
  3. ncbi request reprint Novel thiols of prokaryotes
    R C Fahey
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA
    Annu Rev Microbiol 55:333-56. 2001
    ..Available data on the biosynthesis and metabolism of these and other novel thiols is summarized and key areas for additional study are identified...
  4. pmc Organic hydroperoxide resistance protein and ergothioneine compensate for loss of mycothiol in Mycobacterium smegmatis mutants
    Philong Ta
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093 0314, USA
    J Bacteriol 193:1981-90. 2011
    ..The finding of multiple Ohr homologs with various sequence identities in some bacterial genomes indicates that there may be multiple physiologic targets for Ohr proteins...

Research Grants9

  1. MYCOTHIOL BIOSYNTHESIS AND METABOLISM AS TB DRUG TARGETS
    ROBERT FAHEY; Fiscal Year: 2004
    ..abstract_text> ..
  2. MYCOTHIOL BIOSYNTHESIS AND METABOLISM AS TB DRUG TARGETS
    ROBERT FAHEY; Fiscal Year: 2005
    ..abstract_text> ..
  3. Whole cell and essential enzyme screening assays for mycothiol biosynthesis
    ROBERT FAHEY; Fiscal Year: 2009
    ..These HTS assays are designed to meet the goals of PA-04-068 and will be proposed for screening of libraries available under the Molecular Libraries Initiative. ..
  4. MYCOTHIOL BIOSYNTHESIS AND METABOLISM AS TB DRUG TARGETS
    ROBERT FAHEY; Fiscal Year: 2006
    ..abstract_text> ..
  5. Whole cell and essential enzyme screening assays for mycothiol biosynthesis
    ROBERT FAHEY; Fiscal Year: 2007
    ..These HTS assays are designed to meet the goals of PA-04-068 and will be proposed for screening of libraries available under the Molecular Libraries Initiative. ..