Research Topics
Genomes and Genes
Species | Andrea FagioliniSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
Functional impairment in the remission phase of bipolar disorderAndrea Fagiolini
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Bipolar Disord 7:281-5. 2005....
The long term--maximising potential for rehabilitation in patients with schizophreniaAndrea Fagiolini
Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Eur Neuropsychopharmacol 17:S123-9. 2007..In summary, newer, atypical agents may improve efficacy, patient satisfaction, and aid long-term rehabilitation...
Weight gain and metabolic issues of medicines used for bipolar disorderAndrea Fagiolini
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 2593, USA
Curr Psychiatry Rep 9:521-8. 2007....
Metabolic syndrome in bipolar disorder: findings from the Bipolar Disorder Center for PennsylvaniansAndrea Fagiolini
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
Bipolar Disord 7:424-30. 2005..This study sought to evaluate the presence of the metabolic syndrome in a group of 171 patients with bipolar disorder who were consecutively recruited in the Bipolar Disorder Center for Pennsylvanians...
Physical health considerations in psychiatry: european views on recognition, monitoring and managementAndrea Fagiolini
Eur Neuropsychopharmacol 18:iii. 2008
Overcoming hurdles to achieving good physical health in patients treated with atypical antipsychoticsAndrea Fagiolini
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Eur Neuropsychopharmacol 18:S102-7. 2008....
Mood and anxiety spectrum as a means to identify clinically relevant subtypes of bipolar I disorderAndrea Fagiolini
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Bipolar Disord 9:462-7. 2007..We examine the structure of mood and anxiety spectrum features in patients with BD I to identify subtypes with similar profiles...
Bipolar disorder and the metabolic syndrome: causal factors, psychiatric outcomes and economic burdenAndrea Fagiolini
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA
CNS Drugs 22:655-69. 2008..Prevention of weight gain and metabolic disturbances or early intervention when these are present in bipolar disorder could result in significant health and economic benefits...
Practical guidance for prescribing with aripiprazole in bipolar disorderAndrea Fagiolini
Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Curr Med Res Opin 24:2691-702. 2008..Aripiprazole differs from other atypical antipsychotics in its pharmacological and clinical profile...
Suicide attempts and ideation in patients with bipolar I disorderAndrea Fagiolini
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
J Clin Psychiatry 65:509-14. 2004..Suicidal thinking and behavior are common in individuals with bipolar disorder...
Clinical significance of lifetime panic spectrum symptoms in the treatment of patients with bipolar I disorderEllen Frank
Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Arch Gen Psychiatry 59:905-11. 2002..We hypothesized that lifetime panic spectrum features would be associated with higher levels of suicidal ideation and a poorer response to acute treatment of the index mood episode in this patient population...
Effect of age, weight, and CYP2C19 genotype on escitalopram exposureYuyan Jin
Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
J Clin Pharmacol 50:62-72. 2010..These variables may affect patient tolerance of this antidepressant and may provide important information in the effort to tailor treatments to patients' individual needs...
Prevalence and correlates of eating disorder co-morbidity in patients with bipolar disorderJennifer E Wildes
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
Psychiatry Res 161:51-8. 2008..Screening for eating disorders in bipolar patients is warranted, as intervention may minimize distress and improve treatment outcome...
Prevalence and clinical correlates of medical comorbidities in patients with bipolar I disorder: analysis of acute-phase data from a randomized controlled trialWesley K Thompson
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15260, USA
J Clin Psychiatry 67:783-8. 2006..We studied the relationship between number of medical comorbidities in patients with bipolar I disorder and their demographic and clinical characteristics...
Bipolar disorder center for Pennsylvanians: implementing an effectiveness trial to improve treatment for at-risk patientsDavid J Kupfer
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
Psychiatr Serv 60:888-97. 2009..This report highlights the methods used to recruit, screen, and enroll a cohort of difficult-to-recruit individuals with bipolar disorder...
Development and preliminary testing of the General 5-Spectrum Measure (GSM-V)Paola Rucci
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, Pennsylvania 15213-2593, USA
Depress Anxiety 18:109-17. 2003..Additionally, it could provide a better characterization of patients with a syndromal level Axis-I disorder, who might require specific treatment strategies targeted to co-occurring subsyndromal conditions...
Cross-cultural validity of the structured clinical interview for panic-agoraphobic spectrumEllen Frank
Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Soc Psychiatry Psychiatr Epidemiol 40:283-90. 2005....
Interpersonal psychotherapy for depression with panic spectrum symptoms: a pilot studyJill M Cyranowski
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
Depress Anxiety 21:140-2. 2005..A newly adapted psychosocial treatment for depression with lifetime panic spectrum symptoms was evaluated in an open pilot study...
Sensitivity to change and predictive validity of the MOODS-SR questionnaire, last-month versionMario Miniati
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Psychother Psychosom 78:116-24. 2009....
Addressing the challenges of a cross-national investigation: lessons from the Pittsburgh-Pisa study of treatment-relevant phenotypes of unipolar depressionEllen Frank
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Clin Trials 5:253-61. 2008..A multi-site clinical trial that includes psychotherapy as one of the treatments presents numerous challenges related to cross-site consistency and communication...
Medical burden in late-life bipolar and major depressive disordersAriel G Gildengers
Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, The Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA
Am J Geriatr Psychiatry 16:194-200. 2008..The authors compare medical burden in elderly patients with bipolar disorder with that in those with major depressive disorder...
Relationship of general medical burden, duration of illness and age in patients with bipolar I disorderIsabella Soreca
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, Pennsylvania 15213, USA
J Psychiatr Res 42:956-61. 2008..This study was aimed at evaluating general medical burden in a group of 111 patients with bipolar I disorder...
Chronotype and body composition in bipolar disorderIsabella Soreca
Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania, USA
Chronobiol Int 26:780-8. 2009..Evening chronotype could be a proxy for as yet unknown specific causes of the high rate of obesity and obesity-related diseases in bipolar disorder...
Eating disorders and illness burden in patients with bipolar spectrum disordersJennifer E Wildes
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Compr Psychiatry 48:516-21. 2007....
Obesity as a correlate of outcome in patients with bipolar I disorderAndrea Fagiolini
Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, USA
Am J Psychiatry 160:112-7. 2003....
The panic-agoraphobic spectrum: development, description, and clinical significanceM Katherine Shear
Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Psychiatr Clin North Am 25:739-56. 2002..Such an approach holds some promise for progress in studies of neurobiologic basis of panic and may be useful in further efforts to overcome the nagging problem of the ambiguous boundaries of DSM diagnostic categories [53]...
Enhancing outcomes in patients with bipolar disorder: results from the Bipolar Disorder Center for Pennsylvanians StudyAndrea Fagiolini
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Bipolar Disord 11:382-90. 2009..We investigated whether SCBD and ECI + SCBD are able to improve outcomes and reduce health disparities for young and elderly individuals, African Americans, and rural residents with bipolar disorder...
Hypothyroidism in patients with bipolar I disorder treated primarily with lithiumAndrea Fagiolini
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA
Epidemiol Psichiatr Soc 15:123-7. 2006..This study evaluated the frequency and clinical significance of abnormal Thyroid Stimulating Hormone (TSH) and Free Thyroxine Index (FTI) in patients with bipolar I disorder treated primarily with lithium...
Suicide attempts in patients with bipolar I disorder during acute and maintenance phases of intensive treatment with pharmacotherapy and adjunctive psychotherapyPaola Rucci
Department of Psychiatry, Western Psychiatric Institite and Clinic, 3811 O'Hara Street, Pittsburgh, PA 15213, USA
Am J Psychiatry 159:1160-4. 2002..CONCLUSIONS: A treatment program in a maximally supportive clinical environment can significantly reduce suicidal behavior in high-risk patients with bipolar I disorder...
Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophreniaHader A Mansour
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Bipolar Disord 11:701-10. 2009..The results are plausible, based on prior studies of circadian abnormalities. As replications have not been attempted uniformly, we evaluated representative, common polymorphisms in all three disorders...
Adherence to escitalopram treatment in depression: a study of electronically compiled dosing histories in the 'Depression: the search for phenotypes' studyAlette M Wessels
Department of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Int Clin Psychopharmacol 27:291-7. 2012..IPT+escitalopram. Early discontinuation of treatment and suboptimal daily execution of the prescribed regimen are the most common facets of poor adherence in this study population...
Prevalence of obesity and weight change during treatment in patients with bipolar I disorderAndrea Fagiolini
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
J Clin Psychiatry 63:528-33. 2002....
Medication effects in neuroimaging studies of bipolar disorderMary L Phillips
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Am J Psychiatry 165:313-20. 2008..Withdrawing all individuals from medication and examining only unmedicated individuals may be clinically unfeasible, and examining only unmedicated individuals may render findings less generalizable...
Cardiovascular disease and hypertension among adults with bipolar I disorder in the United StatesBenjamin I Goldstein
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Bipolar Disord 11:657-62. 2009..We therefore examined this topic in a representative epidemiologic sample...
Season of birth is associated with adult body mass index in patients with bipolar disorderIsabella Soreca
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Chronobiol Int 30:577-82. 2013..Author correspondence: sorecai@upmc.edu )...
Persistent posttraumatic stress disorder following September 11 in patients with bipolar disorderMark H Pollack
Department of Psychiatry, Massachusetts General Hospital, Boston, Mass, USA
J Clin Psychiatry 67:394-9. 2006....
The effect of reporting methods for dosing times on the estimation of pharmacokinetic parameters of escitalopramYuyan Jin
University of Pittsburgh Medical Center, Department of Pharmaceutical Sciences and Psychiatry, 805 Salk Hall, Pittsburgh, PA 15261, USA
J Clin Pharmacol 49:176-84. 2009..Furthermore, the parameters estimated from the MEMS method were similar to literature reported values for V/F ( approximately 1100 L) and K(a) ( approximately 0.8-0.9 h(-1)) arising from traditional pharmacokinetic approaches...
A pilot study of standardized treatment in geriatric bipolar disorderAriel G Gildengers
Intervention Research Center for Late-Life Mood Disorders, Department of Psychiatry, the Bipolar Disorder Center for Pennsylvanians, University of Pittsburgh School of Medicine 15213, USA
Am J Geriatr Psychiatry 13:319-23. 2005..CONCLUSIONS: Treating older adults with bipolar disorder under standardized treatment is feasible and is associated with low symptom levels. However, most older adults with bipolar disorder do not experience sustained recovery...
The importance of routine for preventing recurrence in bipolar disorderEllen Frank
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara St, Pittsburgh, PA 15213, USA
Am J Psychiatry 163:981-5. 2006
Adult separation anxiety: psychometric properties of a new structured clinical interviewJill M Cyranowski
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O'Hara Street, Pittsburgh, PA 15213, USA
J Psychiatr Res 36:77-86. 2002..These results highlight the feasibility and potential clinical utility of assessing age-appropriate symptoms of separation anxiety experienced during adulthood...
Medical monitoring in patients with bipolar disorder: a review of dataAndrea Fagiolini
Department of Psychiatry, University of Pittsburgh Medical Center and Western Psychiatric Institute and Clinic, Pittsburgh, PA, USA
J Clin Psychiatry 69:e16. 2008..To optimize care and achieve the best possible treatment outcomes, integrated psychiatric and medical care is needed...
Obesity in patients with bipolar disorder: a biopsychosocial-behavioral modelJennifer E Wildes
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
J Clin Psychiatry 67:904-15. 2006..We provide a model to explicate how factors representing different levels of analysis (i.e., biology, psychology, sociodemographics, and behavior) interact to influence the onset and maintenance of obesity in bipolar disorder...
Diagnostic guidelines for bipolar disorder: a summary of the International Society for Bipolar Disorders Diagnostic Guidelines Task Force ReportS Nassir Ghaemi
Bipolar Disorder Research Program, Department of Psychiatry, Emory University, Atlanta, GA 30322, USA
Bipolar Disord 10:117-28. 2008....
Is treatment-resistant depression a unique subtype of depression?Andrea Fagiolini
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 53:640-8. 2003..This in turn may facilitate the identification of more effective treatment strategies...
Changes in metabolic syndrome parameters in patients with schizoaffective disorder who participated in a randomized, placebo-controlled trial of topiramateRanita Basu
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA Veterans Administration Health System, Highland Drive, Pittsburgh, PA, USA
Asian J Psychiatr 2:106-11. 2009..Furthermore, lower thresholds for waist circumference have also been recommended for Asians...
Serotonin gene polymorphisms and bipolar I disorder: focus on the serotonin transporterHader A Mansour
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, U S A
Ann Med 37:590-602. 2005..Our analyses do not support association between SLC6A4 and BDI families. Further studies using sub-groups of BDI are worthwhile...
Conceptual underpinnings and empirical support for the mood spectrumGiovanni B Cassano
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Via Roma 67, 56100 Pisa, Italy
Psychiatr Clin North Am 25:699-712, v. 2002..Finally, they summarize the clinical utility of such an approach to the description and assessment of patients with mood disorders...
Measuring mood spectrum: comparison of interview (SCI-MOODS) and self-report (MOODS-SR) instrumentsAntonella Armani
Department of Psychiatry, University of Pisa, Via Roma 67, 56100 Pisa, Italy
Compr Psychiatry 43:69-73. 2002..Agreement between the self-report and the interview formats was substantial. Intraclass correlation coefficients (ICC) ranged from 0.88 to 0.97. Our findings provide support for the reliability of the MOODS-SR questionnaire...
Impact of concurrent naturalistic pharmacotherapy on psychotherapy of complicated griefNaomi M Simon
Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital and Harvard Medical School, Boston MA 02114, USA
Psychiatry Res 159:31-6. 2008..77%). Our naturalistic data underscore the need for prospective, randomized controlled studies of CG pharmacotherapy and psychotherapy alone and in combination...
Sexual disorders in subjects treated for mood and anxiety diseasesLetizia Bossini
J Clin Psychopharmacol 27:310-2. 2007
Schizoaffective disorder: diagnostic issues and future recommendationsGin S Malhi
Northern Clinical School, University of Sydney, Sydney, Australia
Bipolar Disord 10:215-30. 2008..This paper addresses the controversy regarding the diagnostic validity of schizoaffective disorder (SAD), a diagnosis that is used in both DSM-IV and ICD-10 and one that encroaches on both schizophrenia (SCZ) and bipolar disorder (BD)...
Effects of an educational intervention on weight gain in patients treated with antipsychoticsMauro Mauri
Department of Psychiatry, University of Pisa School of Medicine, Via Roma, Pisa, Italy
J Clin Psychopharmacol 26:462-6. 2006..CONCLUSIONS: Educational intervention can be an important tool for the management of weight increase in patients treated with APs. A larger prospective and controlled study is now needed to confirm our findings...
Aripiprazole in the treatment of schizophrenia: a consensus report produced by schizophrenia experts in ItalyGiovan B Cassano
Universita di Pisa, Casa di Cura S Rossore Viale delle Cascine, Pisa, Italy
Clin Drug Investig 27:1-13. 2007..Switching to aripiprazole from maintenance therapy with another antipsychotic also works well, provided the change is made gradually, involving tapering of the original medication...
Integrating medical and psychiatric care in patients with bipolar disorderAndrea Fagiolini
J Clin Psychopharmacol 28:257-8. 2008
Quality of life and subthreshold affective symptomsArianna Goracci
Department of Neuroscience, Division of Psychiatry, University of Siena, Viale Bracci 1, Siena 53100, Italy
Qual Life Res 14:905-9. 2005..Our data suggests that subjects who report subthreshold affective symptomatology also report a low degree of enjoyment and satisfaction from life. The depressive aspects of the mood spectrum seem to have the greatest negative influence...
Using computerized adaptive testing to reduce the burden of mental health assessmentRobert D Gibbons
Center for Health Statistics, University of Illinois at Chicago, Psychiatric Institute 457, M C 912, Chicago, IL 60680 6998, USA
Psychiatr Serv 59:361-8. 2008..This study investigated the combination of item response theory and computerized adaptive testing (CAT) for psychiatric measurement as a means of reducing the burden of research and clinical assessments...
Prospective predictors of suicide and suicide attempts in 1,556 patients with bipolar disorders followed for up to 2 yearsLauren B Marangell
Mood Disorders Center, Menninger Department of Psychiatry, Baylor College of Medicine and the Department of Veterans Affairs, VISN 16 MIRECC, Houston, TX 77030, USA
Bipolar Disord 8:566-75. 2006....
The mood spectrum in unipolar and bipolar disorder: arguments for a unitary approachGiovanni B Cassano
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Via Roma no 67, 56100 Pisa, Italy
Am J Psychiatry 161:1264-9. 2004....
Mood stabilizers and atypical antipsychotics: bimodal treatments for bipolar disorderTerence A Ketter
Stanford University School of Medicine, Stanford, CA 94305, USA
Psychopharmacol Bull 39:120-46. 2006..Further investigation of combinations of agents such as mood stabilizers and atypical antipsychotics may yield valuable insights into the potential of combination therapies to enhance clinical outcomes in patients with bipolar disorder...
Gender differences in bipolar disorder type 1: a 48-week prospective follow-up of 72 patients treated in an Italian tertiary care centerAlessandra Benedetti
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa, Italy
J Nerv Ment Dis 195:93-6. 2007..Although differences may exist between bipolar I male and female subjects, prospective course does not seem to reveal differences in a 48-week period, at least when similar treatment strategies are adopted...
The use of antidepressants in bipolar disorderVirginio Salvi
Department of Neuroscience, University of Turin, Italy
J Clin Psychiatry 69:1307-18. 2008..Nevertheless, many clinicians continue to employ antidepressants, especially in the management of severe depression that is unresponsive to mood stabilizers alone...
The rabbit syndrome: state of the artMario Catena
Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Via Roma 67, 56100, Pisa, Italy
Curr Clin Pharmacol 2:212-6. 2007..Treatment strategy: The available data suggest that RS responds favourably to anticholinergic drugs and to the change of the antipsychotic...
Metabolic syndrome in patients with bipolar disorderAndrea Fagiolini
J Clin Psychiatry 69:678-9. 2008
