Muller Fabbri

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint MicroRNAs and cancer: towards a personalized medicine
    M Fabbri
    Department of Pediatrics and Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Children s Hospital Los Angeles, 4650 Sunset Blvd, Mailstop 57, Los Angeles, CA 90027, USA
    Curr Mol Med 13:751-6. 2013
  2. pmc A new role for microRNAs, as ligands of Toll-like receptors
    Muller Fabbri
    Department of Pediatrics and Molecular Microbiology and Immunology, Keck School of Medicine, Norris Comprehensive Cancer Center, Children s Center for Cancer and Blood Diseases, Children s Hospital Los Angeles, University of Southern California, Los Angeles, CA, USA
    RNA Biol 10:169-74. 2013
  3. doi request reprint TLRs as miRNA receptors
    Muller Fabbri
    Department of Pediatrics and Molecular Microbiology and Immunology, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California and Children s Center for Cancer and Blood Diseases, Children s Hospital Los Angeles, Los Angeles, California, USA
    Cancer Res 72:6333-7. 2012
  4. pmc MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response
    Muller Fabbri
    Department of Molecular Virology, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 109:E2110-6. 2012
  5. doi request reprint Epigenetic regulation of miRNAs in cancer
    Muller Fabbri
    Department of Pediatrics, Division of Hematology Oncology, Keck School of Medicine, University of Southern California, Children s Hospital Los Angeles, 4650 Sunset Blvd, Mailstop 57, Los Angeles, CA 90027, USA
    Adv Exp Med Biol 754:137-48. 2013
  6. pmc MiR-15a and miR-16-1 cluster functions in human leukemia
    George A Calin
    Human Cancer Genetics Program and Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 105:5166-71. 2008
  7. ncbi request reprint Inhibition of breast cancer cell growth in vitro and in vivo: effect of restoration of Wwox expression
    Dimitrios Iliopoulos
    Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
    Clin Cancer Res 13:268-74. 2007
  8. pmc MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1
    Ramiro Garzon
    Department of Medicine, Ohio State University, Columbus, 43210, USA
    Blood 113:6411-8. 2009
  9. pmc MicroRNA 29b functions in acute myeloid leukemia
    Ramiro Garzon
    Division of Hematology and Oncology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
    Blood 114:5331-41. 2009
  10. pmc Modulation of mismatch repair and genomic stability by miR-155
    Nicola Valeri
    Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Medical Center, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 107:6982-7. 2010

Collaborators

Detail Information

Publications39

  1. ncbi request reprint MicroRNAs and cancer: towards a personalized medicine
    M Fabbri
    Department of Pediatrics and Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Children s Hospital Los Angeles, 4650 Sunset Blvd, Mailstop 57, Los Angeles, CA 90027, USA
    Curr Mol Med 13:751-6. 2013
    ..This review will focus on those findings that have provided the rationale for the use of miRNAs as patient "tailored" anti-cancer agents...
  2. pmc A new role for microRNAs, as ligands of Toll-like receptors
    Muller Fabbri
    Department of Pediatrics and Molecular Microbiology and Immunology, Keck School of Medicine, Norris Comprehensive Cancer Center, Children s Center for Cancer and Blood Diseases, Children s Hospital Los Angeles, University of Southern California, Los Angeles, CA, USA
    RNA Biol 10:169-74. 2013
    ..This discovery provides the rationale for the development of new drugs that might be used in the treatment of cancer as well as other inflammation-related diseases...
  3. doi request reprint TLRs as miRNA receptors
    Muller Fabbri
    Department of Pediatrics and Molecular Microbiology and Immunology, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California and Children s Center for Cancer and Blood Diseases, Children s Hospital Los Angeles, Los Angeles, California, USA
    Cancer Res 72:6333-7. 2012
    ..This review discusses the meaning of this discovery and comments on the exciting future implications of these findings in the context of tumor microenvironment biology as well as of other human diseases...
  4. pmc MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response
    Muller Fabbri
    Department of Molecular Virology, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 109:E2110-6. 2012
    ..This mechanism of action of miRNAs is implicated in tumor-immune system communication and is important in tumor growth and spread, thus representing a possible target for cancer treatment...
  5. doi request reprint Epigenetic regulation of miRNAs in cancer
    Muller Fabbri
    Department of Pediatrics, Division of Hematology Oncology, Keck School of Medicine, University of Southern California, Children s Hospital Los Angeles, 4650 Sunset Blvd, Mailstop 57, Los Angeles, CA 90027, USA
    Adv Exp Med Biol 754:137-48. 2013
    ....
  6. pmc MiR-15a and miR-16-1 cluster functions in human leukemia
    George A Calin
    Human Cancer Genetics Program and Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 105:5166-71. 2008
    ..By examining the Gene Ontology (GO) database, a significant enrichment in cancer genes (such as MCL1, BCL2, ETS1, or JUN) that directly or indirectly affect apoptosis and cell cycle was found...
  7. ncbi request reprint Inhibition of breast cancer cell growth in vitro and in vivo: effect of restoration of Wwox expression
    Dimitrios Iliopoulos
    Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
    Clin Cancer Res 13:268-74. 2007
    ..The WWOX gene is down-regulated in breast cancer and loss of Wwox expression correlates with important clinical features of breast cancer. Thus, we have examined the effect of restoration of Wwox expression in breast cancer-derived cells...
  8. pmc MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1
    Ramiro Garzon
    Department of Medicine, Ohio State University, Columbus, 43210, USA
    Blood 113:6411-8. 2009
    ....
  9. pmc MicroRNA 29b functions in acute myeloid leukemia
    Ramiro Garzon
    Division of Hematology and Oncology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
    Blood 114:5331-41. 2009
    ..Together, the data support a tumor suppressor role for miR-29 and provide a rationale for the use of synthetic miR-29b oligonucleotides as a novel strategy to improve treatment response in AML...
  10. pmc Modulation of mismatch repair and genomic stability by miR-155
    Nicola Valeri
    Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Medical Center, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 107:6982-7. 2010
    ..Finally, a number of MSI tumors with unknown cause of MMR inactivation displayed miR-155 overexpression. These data provide support for miR-155 modulation of MMR as a mechanism of cancer pathogenesis...
  11. pmc Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells
    Francesco Trapasso
    Ohio State University, Comprehensive Cancer Center, Columbus, Ohio 43210, USA
    J Biol Chem 283:13736-44. 2008
    ..Characterization of Fhit interacting proteins has identified direct effectors of the Fhit-mediated apoptotic pathway that is lost in most cancers through loss of Fhit...
  12. doi request reprint Comprehensive miRNA profiling of surgically staged endometrial cancer
    David E Cohn
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus, OH, USA
    Am J Obstet Gynecol 202:656.e1-8. 2010
    ..We sought to determine a microRNA (miRNA) profile of surgically staged endometrial cancers...
  13. doi request reprint MicroRNAs in cancer: personalizing diagnosis and therapy
    S Patrick Nana-Sinkam
    Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Ann N Y Acad Sci 1210:25-33. 2010
    ....
  14. ncbi request reprint Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas
    George A Calin
    Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
    Cancer Cell 12:215-29. 2007
    ..Our findings argue that ncRNAs and interaction between noncoding genes are involved in tumorigenesis to a greater extent than previously thought...
  15. pmc MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia
    Ramiro Garzon
    Division of Hematology and Oncology, Department of Internal Medicine, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
    Blood 111:3183-9. 2008
    ..03; and miR-199a, P = .001, Cox regression). In conclusion, miRNA expression in AML is closely associated with cytogenetics and FLT3-ITD mutations. A small subset of miRNAs is correlated with survival...
  16. pmc MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2)
    Nicola Valeri
    Departments of Molecular Virology, Ohio State University Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 107:21098-103. 2010
    ..These studies suggest that the down-regulation of the MMR mutator gene associated with miR-21 overexpression may be an important clinical indicator of therapeutic efficacy in colorectal cancer...
  17. ncbi request reprint A role for the WWOX gene in prostate cancer
    Haiyan R Qin
    Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Cancer Res 66:6477-81. 2006
    ..The data are consistent with a role for WWOX as a prostate cancer tumor suppressor and suggest that WWOX signal pathways should be further investigated in normal and cancerous prostate cells and tissues...
  18. pmc MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B
    Muller Fabbri
    Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, and College of Pharmacy, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 104:15805-10. 2007
    ..These findings support a role of miR-29s in epigenetic normalization of NSCLC, providing a rationale for the development of miRNA-based strategies for the treatment of lung cancer...
  19. pmc Heat shock protein 70 regulates Tcl1 expression in leukemia and lymphomas
    Eugenio Gaudio
    Department of Molecular Immunology, Virology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
    Blood 121:351-9. 2013
    ..These findings suggest that inhibition of Hsp70 may represent an alternative effective therapy for chronic lymphocytic leukemia and lymphomas via its ability to inhibit the oncogenic functions of Tcl1...
  20. doi request reprint Epigenetics, miRNAs, and human cancer: a new chapter in human gene regulation
    Nicola Valeri
    Department of Molecular Virology, Immunology, and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
    Mamm Genome 20:573-80. 2009
    ..This review focuses on how epigenetics affects the miRNome and how the recently identified epi-miRNAs regulate the epigenome in human cancers, ultimately contributing to human carcinogenesis...
  21. pmc Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia
    Muller Fabbri
    Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
    JAMA 305:59-67. 2011
    ....
  22. ncbi request reprint Regulatory mechanisms of microRNAs involvement in cancer
    Muller Fabbri
    Ohio State University, Comprehensive Cancer Center, Columbus, OH 43210, USA
    Expert Opin Biol Ther 7:1009-19. 2007
    ..In this review, the authors analyse the regulatory mechanisms of the main miRNA genes involved in human tumourigenesis...
  23. ncbi request reprint MicroRNA expression and function in cancer
    Ramiro Garzon
    Department of Virology, Immunology and Human Genetics, and Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Trends Mol Med 12:580-7. 2006
    ..Here, we summarize miRNA-profiling studies in human malignancies and examine the role of miRNAs in the pathogenesis of cancer. We also discuss the implications of these findings for the diagnosis and treatment of cancer...
  24. doi request reprint MicroRNAs
    Muller Fabbri
    Human Cancer Genetics, Molecular Virology, Immunology and Medical Genetics, Ohio State University, Columbus, OH, USA
    Cancer J 14:1-6. 2008
    ..miRNA expression levels have diagnostic and prognostic implications, and their roles as anticancer therapeutic agents is promising and currently under investigation...
  25. doi request reprint Epigenetics and miRNAs in human cancer
    Muller Fabbri
    Department of Molecular Virology, Ohio State University, Columbus, OH, USA
    Adv Genet 70:87-99. 2010
    ..The result of this epigenetic-miRNA interaction is a new layer of complexity in gene regulation, whose comprehension opens new avenues to understand human cancerogenesis and to achieve new cancer treatments...
  26. ncbi request reprint A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia
    George Adrian Calin
    Department of Molecular Virology, Immunology, and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
    N Engl J Med 353:1793-801. 2005
    ..We investigated whether microRNA profiles are associated with known prognostic factors in CLL...
  27. ncbi request reprint Beyond genomics: interpreting the 93% of the human genome that does not encode proteins
    Muller Fabbri
    Ohio State University, Department of Molecular Virology, Immunology, and Medical Genetics and Comprehensive Cancer Center, 1060 Biomedical Research Tower, 460 West 12th Avenue, Columbus, OH 43210, USA
    Curr Opin Drug Discov Devel 13:350-8. 2010
    ..This review focuses on the role of ncRNAs in human carcinogenesis and describes why deciphering the function of these RNAs might lead to the development of new anticancer drugs...
  28. doi request reprint High-throughput profiling in the hematopoietic system
    Muller Fabbri
    Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University, Columbus, OH, USA
    Methods Mol Biol 667:79-91. 2010
    ..These techniques provide the basis for further investigations focused on the miRNAs, which are most frequently and widely differentially expressed under the different investigated conditions...
  29. doi request reprint MicroRNAs in the ontogeny of leukemias and lymphomas
    Muller Fabbri
    Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
    Leuk Lymphoma 50:160-70. 2009
    ....
  30. ncbi request reprint Pathogenetic and clinical relevance of microRNAs in colorectal cancer
    Nicola Valeri
    Department of Molecular Virology, Immunology, and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
    Cancer Genomics Proteomics 6:195-204. 2009
    ....
  31. doi request reprint MicroRNAs and genomic variations: from Proteus tricks to Prometheus gift
    Muller Fabbri
    Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, 43210, USA
    Carcinogenesis 30:912-7. 2009
    ..Furthermore, we propose that sequence variations in miRNAs or interactor sites located in mRNAs can be involved in cancer predisposition...
  32. ncbi request reprint Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock
    Esmerina Tili
    Ohio State University, Department of Molecular Virology, Immunology and Medical Genetics and Comprehensive Cancer Center, Columbus, OH 43210, USA
    J Immunol 179:5082-9. 2007
    ..Altogether, our data suggest that the LPS/TNF-alpha-dependent regulation of miR-155 and miR-125b may be implicated in the response to endotoxin shock, thus offering new targets for drug design...
  33. ncbi request reprint MicroRNAs and cancer epigenetics
    Muller Fabbri
    Ohio State University, Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, 410 W 12th Avenue, Columbus, OH 43210, USA
    Curr Opin Investig Drugs 9:583-90. 2008
    ..A deeper understanding of this correlation could lead to new therapeutic avenues...
  34. doi request reprint miRNAs as molecular biomarkers of cancer
    Muller Fabbri
    Department of Molecular Virology, Immunology and Medical Genetics The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA
    Expert Rev Mol Diagn 10:435-44. 2010
    ..Finally, miRNAs are differentially expressed in the blood of cancer patients versus healthy donors, providing a rationale for the detection of miRNAs and diagnostic and prognostic circulating biomarkers...
  35. pmc Role of microRNAs in lymphoid biology and disease
    Muller Fabbri
    Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio 43210, USA
    Curr Opin Hematol 18:266-72. 2011
    ..This review provides a state-of-the-art knowledge on the implications of microRNA (miRNA) dysregulation in lymphoid malignancies...
  36. ncbi request reprint MicroRNA gene expression deregulation in human breast cancer
    Marilena V Iorio
    Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 65:7065-70. 2005
    ..We could identify miRNAs whose expression was correlated with specific breast cancer biopathologic features, such as estrogen and progesterone receptor expression, tumor stage, vascular invasion, or proliferation index...
  37. pmc WWOX gene restoration prevents lung cancer growth in vitro and in vivo
    Muller Fabbri
    Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, Ohio State University, 410 West 12th Avenue, Columbus, OH 43201, USA
    Proc Natl Acad Sci U S A 102:15611-6. 2005
    ..This study confirms that WWOX is a tumor suppressor gene and is highly effective in preventing growth of lung cancer xenografts, whether introduced through viral infection or by induction of a silent WWOX transgene...
  38. pmc miR-15 and miR-16 induce apoptosis by targeting BCL2
    Amelia Cimmino
    Department of Molecular Virology, Immunology, and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus OH 43210, USA
    Proc Natl Acad Sci U S A 102:13944-9. 2005
    ..BCL2 repression by these microRNAs induces apoptopsis in a leukemic cell line model. Therefore, miR-15 and miR-16 are natural antisense Bcl2 interactors that could be used for therapy of Bcl2-overexpressing tumors...
  39. pmc MicroRNAs as New Characters in the Plot between Epigenetics and Prostate Cancer
    Alessio Paone
    Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Comprehensive Cancer Center Columbus, OH, USA
    Front Genet 2:62. 2011
    ..This review will focus on the role of epigenetically regulated and epigenetically regulating miRNAs in PCA and on the fine regulation of AR expression, as mediated by this miRNA-epigenetics interaction...