Lisa T Eyler

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc A comparison of heritability maps of cortical surface area and thickness and the influence of adjustment for whole brain measures: a magnetic resonance imaging twin study
    Lisa T Eyler
    Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
    Twin Res Hum Genet 15:304-14. 2012
  2. pmc A failure of left temporal cortex to specialize for language is an early emerging and fundamental property of autism
    Lisa T Eyler
    UCSD Autism Center of Excellence, University of California, San Diego, La Jolla, CA 92037, USA
    Brain 135:949-60. 2012
  3. pmc Brain response abnormalities during verbal learning among patients with schizophrenia
    Lisa T Eyler
    Department of Psychiatry, University of California San Diego, San Diego, CA 92161, USA
    Psychiatry Res 162:11-25. 2008
  4. pmc Schizophrenia patients lack normal positive correlation between age and brain response during verbal learning
    Lisa T Eyler
    Mental Illness Research, Education and Clinical Center, Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    Am J Geriatr Psychiatry 17:43-55. 2009
  5. ncbi request reprint Brain response correlates of decisional capacity in schizophrenia: a preliminary FMRI study
    Lisa T Eyler
    Department of Psychiatry, University of California, San Diego, Mail Code 151B, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    J Neuropsychiatry Clin Neurosci 19:137-44. 2007
  6. pmc A review of functional brain imaging correlates of successful cognitive aging
    Lisa T Eyler
    Sam and Rose Stein Institute for Research on Aging, University of California San Diego, San Diego, California, USA
    Biol Psychiatry 70:115-22. 2011
  7. pmc Genetic and environmental contributions to regional cortical surface area in humans: a magnetic resonance imaging twin study
    Lisa T Eyler
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Cereb Cortex 21:2313-21. 2011
  8. ncbi request reprint Enhancing the informed consent process: a conceptual overview
    Lisa T Eyler
    Department of Psychiatry, University of California, San Diego, CA 92161, USA
    Behav Sci Law 24:553-68. 2006
  9. pmc Genetic patterns of correlation among subcortical volumes in humans: results from a magnetic resonance imaging twin study
    Lisa T Eyler
    Department of Psychiatry, University of California, San Diego, La Jolla, California, USA
    Hum Brain Mapp 32:641-53. 2011
  10. pmc Assessment of medication management ability in middle-aged and older adults with bipolar disorder
    Colin A Depp
    Department of Psychiatry, University of California, San Diego, CA, USA
    J Clin Psychopharmacol 28:225-9. 2008

Research Grants

Detail Information

Publications49

  1. pmc A comparison of heritability maps of cortical surface area and thickness and the influence of adjustment for whole brain measures: a magnetic resonance imaging twin study
    Lisa T Eyler
    Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
    Twin Res Hum Genet 15:304-14. 2012
    ..Implications regarding brain phenotypes for future genetic association studies are discussed...
  2. pmc A failure of left temporal cortex to specialize for language is an early emerging and fundamental property of autism
    Lisa T Eyler
    UCSD Autism Center of Excellence, University of California, San Diego, La Jolla, CA 92037, USA
    Brain 135:949-60. 2012
    ....
  3. pmc Brain response abnormalities during verbal learning among patients with schizophrenia
    Lisa T Eyler
    Department of Psychiatry, University of California San Diego, San Diego, CA 92161, USA
    Psychiatry Res 162:11-25. 2008
    ..Thus, verbal learning deficits found among patients with schizophrenia appear to be related to hypofunction of distributed brain networks...
  4. pmc Schizophrenia patients lack normal positive correlation between age and brain response during verbal learning
    Lisa T Eyler
    Mental Illness Research, Education and Clinical Center, Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    Am J Geriatr Psychiatry 17:43-55. 2009
    ..The authors hypothesized that the correlation with age would be more strongly negative among schizophrenia patients, particularly in the frontal cortex...
  5. ncbi request reprint Brain response correlates of decisional capacity in schizophrenia: a preliminary FMRI study
    Lisa T Eyler
    Department of Psychiatry, University of California, San Diego, Mail Code 151B, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    J Neuropsychiatry Clin Neurosci 19:137-44. 2007
    ..Reasoning scores were not significantly related to brain activation. Understanding deficits during informed consent relates to particular brain abnormalities among schizophrenia patients...
  6. pmc A review of functional brain imaging correlates of successful cognitive aging
    Lisa T Eyler
    Sam and Rose Stein Institute for Research on Aging, University of California San Diego, San Diego, California, USA
    Biol Psychiatry 70:115-22. 2011
    ..However, a simple model of bigger structure → greater brain response → better cognitive performance might not be accurate. Suggestions for future research are discussed...
  7. pmc Genetic and environmental contributions to regional cortical surface area in humans: a magnetic resonance imaging twin study
    Lisa T Eyler
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Cereb Cortex 21:2313-21. 2011
    ....
  8. ncbi request reprint Enhancing the informed consent process: a conceptual overview
    Lisa T Eyler
    Department of Psychiatry, University of California, San Diego, CA 92161, USA
    Behav Sci Law 24:553-68. 2006
    ....
  9. pmc Genetic patterns of correlation among subcortical volumes in humans: results from a magnetic resonance imaging twin study
    Lisa T Eyler
    Department of Psychiatry, University of California, San Diego, La Jolla, California, USA
    Hum Brain Mapp 32:641-53. 2011
    ....
  10. pmc Assessment of medication management ability in middle-aged and older adults with bipolar disorder
    Colin A Depp
    Department of Psychiatry, University of California, San Diego, CA, USA
    J Clin Psychopharmacol 28:225-9. 2008
    ..This small cross-sectional study suggests that deficits in medication management ability may be present in later-life BD. Neurocognitive deficits may be important in understanding problems with unintentional nonadherence...
  11. pmc Presence of ApoE ε4 allele associated with thinner frontal cortex in middle age
    Christine Fennema-Notestine
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0738, USA
    J Alzheimers Dis 26:49-60. 2011
    ..Ongoing follow-up of the VETSA sample may shed light on the potential for age- and disease-related mediation of the influence of ApoE allele status...
  12. pmc Genetic and environmental influences of white and gray matter signal contrast: a new phenotype for imaging genetics?
    Matthew S Panizzon
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Neuroimage 60:1686-95. 2012
    ..The lack of significant genetic correlations with cortical thickness suggests that this measure potentially represents a unique source of genetic variance, one that has yet to be explored by the field of imaging genetics...
  13. doi request reprint Performance-based and subjective measures of functioning in middle-aged and older adults with bipolar disorder
    Colin A Depp
    Department of Psychiatry, University of California, San Diego VA San Diego Healthcare System, 3350 La Jolla Village Drive 116A 1, San Diego, CA 92161, USA
    J Nerv Ment Dis 197:471-5. 2009
    ..Given its relative independence from symptoms, the UPSA may be useful in gauging the effectiveness of rehabilitation for bipolar disorder...
  14. pmc Cognitive reserve moderates the association between hippocampal volume and episodic memory in middle age
    Eero Vuoksimaa
    Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
    Neuropsychologia 51:1124-31. 2013
    ..e., lower levels of cognitive reserve. Our results provide support for the hypothesis that cognitive reserve moderates the relationship between brain structure and cognition in middle age, well before the onset of dementia...
  15. ncbi request reprint Identification of Alzheimer disease risk by functional magnetic resonance imaging
    Adam S Fleisher
    Department of Neurosciences, University of California, San Diego, La Jolla 92037, USA
    Arch Neurol 62:1881-8. 2005
    ..Functional magnetic resonance imaging plays a promising role in the preclinical characterization of Alzheimer disease (AD) for use in early diagnosis and in preventive drug trials...
  16. pmc Genetic and environmental influences on the size of specific brain regions in midlife: the VETSA MRI study
    William S Kremen
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive MC 0738, La Jolla, CA 92093, USA
    Neuroimage 49:1213-23. 2010
    ..Longitudinal analysis will be needed to determine whether the degree of genetic and environmental influences changes for different ROIs from midlife to later life...
  17. pmc Genetic influences on hippocampal volume differ as a function of testosterone level in middle-aged men
    Matthew S Panizzon
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Neuroimage 59:1123-31. 2012
    ..To the best of our knowledge, this is the first study to demonstrate that the heritability of a brain structure in adults may be modified by an endogenous biological factor...
  18. pmc Hierarchical genetic organization of human cortical surface area
    Chi Hua Chen
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Science 335:1634-6. 2012
    ..We also found that the results were consistent with human-specific regions being subdivisions of previously described, genetically based lobar regionalization patterns...
  19. pmc Heritability of brain ventricle volume: converging evidence from inconsistent results
    William S Kremen
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Neurobiol Aging 33:1-8. 2012
    ..These conclusions have implications for the basic understanding of the genetic and environmental underpinnings of normative and pathological brain aging...
  20. pmc Genetic influences on cortical regionalization in the human brain
    Chi Hua Chen
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA
    Neuron 72:537-44. 2011
    ..Broad similarities in genetic patterning between rodents and humans might suggest a conservation of cortical patterning mechanisms, whereas dissimilarities might reflect the functionalities most essential to each species...
  21. pmc Verbal paired-associate learning by APOE genotype in non-demented older adults: fMRI evidence of a right hemispheric compensatory response
    S Duke Han
    University of California San Diego, Department of Psychiatry, La Jolla, CA 92093 0603, United States
    Neurobiol Aging 28:238-47. 2007
    ....
  22. pmc Initial validation of a computerized version of the UCSD Performance-Based Skills Assessment (C-UPSA) for assessing functioning in schizophrenia
    Raeanne C Moore
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Schizophr Res 144:87-92. 2013
    ..This study aimed to validate the Computerized UCSD Performance-Based Skills Assessment (C-UPSA), a newly developed scale for assessing functional capacity in patients with schizophrenia...
  23. pmc Cortical thickness is influenced by regionally specific genetic factors
    Lars M Rimol
    Department of Radiology, University of California, San Diego, La Jolla, California 92093 0738, USA
    Biol Psychiatry 67:493-9. 2010
    ..Yet, little is known about the patterning of those genetic influences, i.e., whether the same genes influence structure throughout the brain or whether there are regionally specific sets of genes...
  24. pmc Neural correlates of verbal learning in adolescent alcohol and marijuana users
    Alecia Dager Schweinsburg
    Yale University, Department of Psychiatry, New Haven, CT, USA
    Addiction 106:564-73. 2011
    ..In this study, we characterize brain response during verbal learning among adolescent users of alcohol and marijuana...
  25. pmc Multimedia consent for research in people with schizophrenia and normal subjects: a randomized controlled trial
    Dilip V Jeste
    University of California, San Diego, USA
    Schizophr Bull 35:719-29. 2009
    ....
  26. pmc Distinct genetic influences on cortical surface area and cortical thickness
    Matthew S Panizzon
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Cereb Cortex 19:2728-35. 2009
    ..We conclude that using volume in a genetically informative study, or as an endophenotype for a disorder, may confound the underlying genetic architecture of brain structure...
  27. doi request reprint Salivary cortisol and prefrontal cortical thickness in middle-aged men: A twin study
    William S Kremen
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Neuroimage 53:1093-102. 2010
    ..Longitudinal assessments are underway to elucidate the direction of the associations and the genetic underpinnings of longitudinal phenotypes for changes in cortisol and brain morphology...
  28. doi request reprint Genetics of brain structure: contributions from the Vietnam Era Twin Study of Aging
    William S Kremen
    Department of Psychiatry, University of California, San Diego, La Jolla, California Twin Research Laboratory, Center for Behavioral Genomics, University of California, San Diego, La Jolla, California Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, La Jolla, California
    Am J Med Genet B Neuropsychiatr Genet 162:751-61. 2013
    ..Examples supporting the validity of these conclusions are provided...
  29. pmc Genetic topography of brain morphology
    Chi Hua Chen
    Departments of Psychiatry, Cognitive Science, Radiology, and Neurosciences, Center for Behavioral Genomics, and Institute of Genomic Medicine, University of California, San Diego, La Jolla, CA 92093
    Proc Natl Acad Sci U S A 110:17089-94. 2013
    ..Our findings highlight the complexity of genetic influences on cortical morphology and provide a glimpse into emerging principles of genetic organization of the cortex. ..
  30. pmc Compensatory brain activity during encoding among older adults with better recognition memory for face-name pairs: an integrative functional, structural, and perfusion imaging study
    Katherine J Bangen
    Department of Psychiatry, University of California San Diego, La Jolla, California, USA
    J Int Neuropsychol Soc 18:402-13. 2012
    ....
  31. ncbi request reprint Performance of schizophrenia and bipolar patients on verbal and figural working memory tasks
    Gregory G Brown
    Psychology Service, Veterans Affairs San Diego Healthcare System, University of California, San Diego, CA, USA
    J Abnorm Psychol 116:741-53. 2007
    ....
  32. pmc A preliminary study of functional magnetic resonance imaging response during verbal encoding among adolescent binge drinkers
    Alecia D Schweinsburg
    Department of Psychiatry, Yale University, New Haven, CT, USA
    Alcohol 44:111-7. 2010
    ..Longitudinal studies will be needed to ascertain the degree to which emergence of binge drinking is linked temporally to these brain response patterns...
  33. ncbi request reprint Decisional capacity to consent to research among patients with bipolar disorder: comparison with schizophrenia patients and healthy subjects
    Barton W Palmer
    Department of Psychiatry, University of California, San Diego, Veterans Affairs San Diego Healthcare System, Calif 92161, USA
    J Clin Psychiatry 68:689-96. 2007
    ....
  34. pmc Neurocognitive impairment in middle-aged and older adults with bipolar disorder: comparison to schizophrenia and normal comparison subjects
    Colin A Depp
    Department of Psychiatry, University of California, San Diego, United States
    J Affect Disord 101:201-9. 2007
    ..We examined neurocognitive abilities in middle-aged and older adults with bipolar disorder to groups with schizophrenia or normal subjects, as well as the relation of neurocognition to clinical characteristics...
  35. pmc A review of the brain structure correlates of successful cognitive aging
    Allison R Kaup
    Department of Psychiatry, University of California San Diego, San Diego, CA 92161, USA
    J Neuropsychiatry Clin Neurosci 23:6-15. 2011
    ..Additional longitudinal study is needed to further evaluate structure-cognition relationships in older adulthood and across the adult lifespan...
  36. ncbi request reprint A preliminary study of interactive questioning methods to assess and improve understanding of informed consent among patients with schizophrenia
    Lisa T Eyler
    Mental Illness Research, Education and Clinical Center, Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    Schizophr Res 75:193-8. 2005
    ..Other considerations, however, may favor use of such methods in the consenting process...
  37. doi request reprint Bridging the bench to bedside gap: validation of a reverse-translated rodent continuous performance test using functional magnetic resonance imaging
    Benjamin S McKenna
    Mental Illness Research, Education, and Clinical Center, Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA
    Psychiatry Res 212:183-91. 2013
    ..This task can be used for powerful parallel human and animal investigations of the biological basis of vigilance deficits in populations with severe mental illness...
  38. pmc fMRI evidence of compensatory mechanisms in older adults at genetic risk for Alzheimer disease
    Mark W Bondi
    University of California San Diego and VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    Neurology 64:501-8. 2005
    ..The relationship between APOE genotype and blood oxygenation level dependent (BOLD) brain response was examined during a picture-encoding task in nondemented older adults...
  39. doi request reprint Disability and self-management practices of people with bipolar disorder: a web-based survey
    Colin A Depp
    Department of Psychiatry, Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, La Jolla, CA 92093 0664, USA
    Community Ment Health J 45:179-87. 2009
    ..001 level. Given limitations of web-based surveys, our study underscores the substantial negative impact of bipolar disorder, along with the potential of the Internet to enhance the use of self-management strategies...
  40. doi request reprint Overlapping prefrontal systems involved in cognitive and emotional processing in euthymic bipolar disorder and following sleep deprivation: a review of functional neuroimaging studies
    Benjamin S McKenna
    Mental Illness Research, Education, and Clinical Center, Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA
    Clin Psychol Rev 32:650-63. 2012
    ..Further research into the role of sleep and circadian rhythms in cognition and emotional processing in bipolar disorder is warranted...
  41. ncbi request reprint Review of longitudinal functional neuroimaging studies of drug treatments in patients with schizophrenia
    C Ervin Davis
    Department of Psychiatry, University of California San Diego, USA
    Schizophr Res 78:45-60. 2005
    ..Suggestions are made for improving future longitudinal neuroimaging studies of treatment effects in schizophrenia...
  42. ncbi request reprint Methodological and conceptual issues in functional magnetic resonance imaging: applications to schizophrenia research
    Gregory G Brown
    Psychology Service, Veterans Administration San Diego Healthcare System, and Psychiatry Department, University of California, San Diego, California 92161, USA
    Annu Rev Clin Psychol 2:51-81. 2006
    ..The limitations of cognitive subtraction designs for functional MRI are also discussed. Functional MRI studies of schizophrenia patients are used to illustrate these points...
  43. ncbi request reprint Abnormal brain response of chronic schizophrenia patients despite normal performance during a visual vigilance task
    Lisa T Eyler
    Mental Illness Research, Education and Clinical Center, Veterans Affairs San Diego Healthcare System, and Department of Psychiatry, University of California at San Diego, La Jolla, USA
    Psychiatry Res 130:245-57. 2004
    ....
  44. pmc Decreased perfusion in young alcohol-dependent women as compared with age-matched controls
    Camellia P Clark
    VA San Diego Healthcare System, Department of Psychiatry, University of California at San Diego, San Diego, California, USA
    Am J Drug Alcohol Abuse 33:13-9. 2007
    ..To use the superior spatial resolution of magnetic resonance imaging (MRI) to examine differences in cerebral perfusion between young alcohol dependent and normal women...
  45. ncbi request reprint A functional magnetic resonance imaging study of cortical asymmetry in bipolar disorder
    Michael P Caligiuri
    Department of Psychiatry, University of California at San Diego, and VISN 22 Mental Illness Research, Education, and Clinical Center, VA San Diego Healthcare System, USA
    Bipolar Disord 6:183-96. 2004
    ..A secondary goal of the study was to examine effects of psychotropic medications on blood volume changes in the motor cortices...
  46. ncbi request reprint Amygdala reactivity and mood-congruent memory in individuals at risk for depressive relapse
    Wiveka Ramel
    Department of Psychology, Stanford University, Stanford, CA 94305 2130, USA
    Biol Psychiatry 61:231-9. 2007
    ..This study examined whether amygdala modulates memory for negatively valenced words before and after a sad mood induction in healthy individuals with and without a history of recurrent major depression...
  47. ncbi request reprint The neural correlates of habituation of response to startling tactile stimuli presented in a functional magnetic resonance imaging environment
    Jennifer E McDowell
    Department of Psychology, University of Georgia, Athens, GA 30602, USA
    Psychiatry Res 148:1-10. 2006
    ..Thus, startling tactile stimuli initially induce widespread cortical and thalamic activity, perhaps mediated by the reticular activating system. The activity then habituates in a graded fashion with repeated presentations of the stimuli...
  48. ncbi request reprint Structural neuroimaging in geriatric psychiatry
    Gwenn S Smith
    Am J Geriatr Psychiatry 14:809-11. 2006
  49. ncbi request reprint Review of twin and family studies on neuroanatomic phenotypes and typical neurodevelopment
    J Eric Schmitt
    Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA
    Twin Res Hum Genet 10:683-94. 2007
    ....

Research Grants2

  1. Structural and Functional Brain Aging in Bipolar Disorder
    Lisa T Eyler; Fiscal Year: 2010
    ..The results of this study will improve our knowledge about how aging influences brain abnormalities in bipolar disorder and may suggest new treatments designed to prevent negative effects and capitalize on any positive changes. ..
  2. Structural and Functional Brain Aging in Bipolar Disorder
    Lisa T Eyler; Fiscal Year: 2011
    ..The results of this study will improve our knowledge about how aging influences brain abnormalities in bipolar disorder and may suggest new treatments designed to prevent negative effects and capitalize on any positive changes. ..