Lisa T Eyler

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint A preliminary study of interactive questioning methods to assess and improve understanding of informed consent among patients with schizophrenia
    Lisa T Eyler
    Mental Illness Research, Education and Clinical Center, Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    Schizophr Res 75:193-8. 2005
  2. ncbi request reprint Genetics of brain structure: contributions from the Vietnam Era Twin Study of Aging
    William S Kremen
    Department of Psychiatry, University of California, San Diego, La Jolla, California Twin Research Laboratory, Center for Behavioral Genomics, University of California, San Diego, La Jolla, California Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, La Jolla, California
    Am J Med Genet B Neuropsychiatr Genet 162:751-61. 2013
  3. pmc Presence of ApoE ε4 allele associated with thinner frontal cortex in middle age
    Christine Fennema-Notestine
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0738, USA
    J Alzheimers Dis 26:49-60. 2011
  4. pmc Assessment of medication management ability in middle-aged and older adults with bipolar disorder
    Colin A Depp
    Department of Psychiatry, University of California, San Diego, CA, USA
    J Clin Psychopharmacol 28:225-9. 2008
  5. pmc Genetic and environmental influences of white and gray matter signal contrast: a new phenotype for imaging genetics?
    Matthew S Panizzon
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Neuroimage 60:1686-95. 2012
  6. pmc Genetic and environmental contributions to regional cortical surface area in humans: a magnetic resonance imaging twin study
    Lisa T Eyler
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Cereb Cortex 21:2313-21. 2011
  7. pmc Heritability of brain ventricle volume: converging evidence from inconsistent results
    William S Kremen
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Neurobiol Aging 33:1-8. 2012
  8. pmc Genetic influences on hippocampal volume differ as a function of testosterone level in middle-aged men
    Matthew S Panizzon
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Neuroimage 59:1123-31. 2012
  9. ncbi request reprint Identification of Alzheimer disease risk by functional magnetic resonance imaging
    Adam S Fleisher
    Department of Neurosciences, University of California, San Diego, La Jolla 92037, USA
    Arch Neurol 62:1881-8. 2005
  10. doi request reprint Performance-based and subjective measures of functioning in middle-aged and older adults with bipolar disorder
    Colin A Depp
    Department of Psychiatry, University of California, San Diego VA San Diego Healthcare System, 3350 La Jolla Village Drive 116A 1, San Diego, CA 92161, USA
    J Nerv Ment Dis 197:471-5. 2009

Detail Information

Publications44

  1. ncbi request reprint A preliminary study of interactive questioning methods to assess and improve understanding of informed consent among patients with schizophrenia
    Lisa T Eyler
    Mental Illness Research, Education and Clinical Center, Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    Schizophr Res 75:193-8. 2005
    ..Other considerations, however, may favor use of such methods in the consenting process...
  2. ncbi request reprint Genetics of brain structure: contributions from the Vietnam Era Twin Study of Aging
    William S Kremen
    Department of Psychiatry, University of California, San Diego, La Jolla, California Twin Research Laboratory, Center for Behavioral Genomics, University of California, San Diego, La Jolla, California Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, La Jolla, California
    Am J Med Genet B Neuropsychiatr Genet 162:751-61. 2013
    ..Examples supporting the validity of these conclusions are provided...
  3. pmc Presence of ApoE ε4 allele associated with thinner frontal cortex in middle age
    Christine Fennema-Notestine
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0738, USA
    J Alzheimers Dis 26:49-60. 2011
    ..Ongoing follow-up of the VETSA sample may shed light on the potential for age- and disease-related mediation of the influence of ApoE allele status...
  4. pmc Assessment of medication management ability in middle-aged and older adults with bipolar disorder
    Colin A Depp
    Department of Psychiatry, University of California, San Diego, CA, USA
    J Clin Psychopharmacol 28:225-9. 2008
    ..This small cross-sectional study suggests that deficits in medication management ability may be present in later-life BD. Neurocognitive deficits may be important in understanding problems with unintentional nonadherence...
  5. pmc Genetic and environmental influences of white and gray matter signal contrast: a new phenotype for imaging genetics?
    Matthew S Panizzon
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Neuroimage 60:1686-95. 2012
    ..The lack of significant genetic correlations with cortical thickness suggests that this measure potentially represents a unique source of genetic variance, one that has yet to be explored by the field of imaging genetics...
  6. pmc Genetic and environmental contributions to regional cortical surface area in humans: a magnetic resonance imaging twin study
    Lisa T Eyler
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Cereb Cortex 21:2313-21. 2011
    ....
  7. pmc Heritability of brain ventricle volume: converging evidence from inconsistent results
    William S Kremen
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Neurobiol Aging 33:1-8. 2012
    ..These conclusions have implications for the basic understanding of the genetic and environmental underpinnings of normative and pathological brain aging...
  8. pmc Genetic influences on hippocampal volume differ as a function of testosterone level in middle-aged men
    Matthew S Panizzon
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Neuroimage 59:1123-31. 2012
    ..To the best of our knowledge, this is the first study to demonstrate that the heritability of a brain structure in adults may be modified by an endogenous biological factor...
  9. ncbi request reprint Identification of Alzheimer disease risk by functional magnetic resonance imaging
    Adam S Fleisher
    Department of Neurosciences, University of California, San Diego, La Jolla 92037, USA
    Arch Neurol 62:1881-8. 2005
    ..Functional magnetic resonance imaging plays a promising role in the preclinical characterization of Alzheimer disease (AD) for use in early diagnosis and in preventive drug trials...
  10. doi request reprint Performance-based and subjective measures of functioning in middle-aged and older adults with bipolar disorder
    Colin A Depp
    Department of Psychiatry, University of California, San Diego VA San Diego Healthcare System, 3350 La Jolla Village Drive 116A 1, San Diego, CA 92161, USA
    J Nerv Ment Dis 197:471-5. 2009
    ..Given its relative independence from symptoms, the UPSA may be useful in gauging the effectiveness of rehabilitation for bipolar disorder...
  11. pmc Genetic patterns of correlation among subcortical volumes in humans: results from a magnetic resonance imaging twin study
    Lisa T Eyler
    Department of Psychiatry, University of California, San Diego, La Jolla, California, USA
    Hum Brain Mapp 32:641-53. 2011
    ....
  12. pmc Hierarchical genetic organization of human cortical surface area
    Chi Hua Chen
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Science 335:1634-6. 2012
    ..We also found that the results were consistent with human-specific regions being subdivisions of previously described, genetically based lobar regionalization patterns...
  13. pmc Multimedia consent for research in people with schizophrenia and normal subjects: a randomized controlled trial
    Dilip V Jeste
    University of California, San Diego, USA
    Schizophr Bull 35:719-29. 2009
    ....
  14. pmc Distinct genetic influences on cortical surface area and cortical thickness
    Matthew S Panizzon
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Cereb Cortex 19:2728-35. 2009
    ..We conclude that using volume in a genetically informative study, or as an endophenotype for a disorder, may confound the underlying genetic architecture of brain structure...
  15. pmc Brain response abnormalities during verbal learning among patients with schizophrenia
    Lisa T Eyler
    Department of Psychiatry, University of California San Diego, San Diego, CA 92161, USA
    Psychiatry Res 162:11-25. 2008
    ..Thus, verbal learning deficits found among patients with schizophrenia appear to be related to hypofunction of distributed brain networks...
  16. ncbi request reprint Performance of schizophrenia and bipolar patients on verbal and figural working memory tasks
    Gregory G Brown
    Psychology Service, Veterans Affairs San Diego Healthcare System, University of California, San Diego, CA, USA
    J Abnorm Psychol 116:741-53. 2007
    ....
  17. pmc Salivary cortisol and prefrontal cortical thickness in middle-aged men: A twin study
    William S Kremen
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Neuroimage 53:1093-102. 2010
    ..Longitudinal assessments are underway to elucidate the direction of the associations and the genetic underpinnings of longitudinal phenotypes for changes in cortisol and brain morphology...
  18. pmc Genetic and environmental influences on the size of specific brain regions in midlife: the VETSA MRI study
    William S Kremen
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive MC 0738, La Jolla, CA 92093, USA
    Neuroimage 49:1213-23. 2010
    ..Longitudinal analysis will be needed to determine whether the degree of genetic and environmental influences changes for different ROIs from midlife to later life...
  19. pmc Cognitive reserve moderates the association between hippocampal volume and episodic memory in middle age
    Eero Vuoksimaa
    Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
    Neuropsychologia 51:1124-31. 2013
    ..e., lower levels of cognitive reserve. Our results provide support for the hypothesis that cognitive reserve moderates the relationship between brain structure and cognition in middle age, well before the onset of dementia...
  20. ncbi request reprint Brain response correlates of decisional capacity in schizophrenia: a preliminary FMRI study
    Lisa T Eyler
    Department of Psychiatry, University of California, San Diego, Mail Code 151B, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    J Neuropsychiatry Clin Neurosci 19:137-44. 2007
    ..Reasoning scores were not significantly related to brain activation. Understanding deficits during informed consent relates to particular brain abnormalities among schizophrenia patients...
  21. pmc A review of the brain structure correlates of successful cognitive aging
    Allison R Kaup
    Department of Psychiatry, University of California San Diego, San Diego, CA 92161, USA
    J Neuropsychiatry Clin Neurosci 23:6-15. 2011
    ..Additional longitudinal study is needed to further evaluate structure-cognition relationships in older adulthood and across the adult lifespan...
  22. doi request reprint Disability and self-management practices of people with bipolar disorder: a web-based survey
    Colin A Depp
    Department of Psychiatry, Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, La Jolla, CA 92093 0664, USA
    Community Ment Health J 45:179-87. 2009
    ..001 level. Given limitations of web-based surveys, our study underscores the substantial negative impact of bipolar disorder, along with the potential of the Internet to enhance the use of self-management strategies...
  23. pmc Overlapping prefrontal systems involved in cognitive and emotional processing in euthymic bipolar disorder and following sleep deprivation: a review of functional neuroimaging studies
    Benjamin S McKenna
    Mental Illness Research, Education, and Clinical Center, Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA
    Clin Psychol Rev 32:650-63. 2012
    ..Further research into the role of sleep and circadian rhythms in cognition and emotional processing in bipolar disorder is warranted...
  24. pmc A review of functional brain imaging correlates of successful cognitive aging
    Lisa T Eyler
    Sam and Rose Stein Institute for Research on Aging, University of California San Diego, San Diego, California, USA
    Biol Psychiatry 70:115-22. 2011
    ..However, a simple model of bigger structure → greater brain response → better cognitive performance might not be accurate. Suggestions for future research are discussed...
  25. pmc Verbal paired-associate learning by APOE genotype in non-demented older adults: fMRI evidence of a right hemispheric compensatory response
    S Duke Han
    University of California San Diego, Department of Psychiatry, La Jolla, CA 92093 0603, United States
    Neurobiol Aging 28:238-47. 2007
    ....
  26. ncbi request reprint A functional magnetic resonance imaging study of cortical asymmetry in bipolar disorder
    Michael P Caligiuri
    Department of Psychiatry, University of California at San Diego, and VISN 22 Mental Illness Research, Education, and Clinical Center, VA San Diego Healthcare System, USA
    Bipolar Disord 6:183-96. 2004
    ..A secondary goal of the study was to examine effects of psychotropic medications on blood volume changes in the motor cortices...
  27. pmc Neurocognitive impairment in middle-aged and older adults with bipolar disorder: comparison to schizophrenia and normal comparison subjects
    Colin A Depp
    Department of Psychiatry, University of California, San Diego, United States
    J Affect Disord 101:201-9. 2007
    ..We examined neurocognitive abilities in middle-aged and older adults with bipolar disorder to groups with schizophrenia or normal subjects, as well as the relation of neurocognition to clinical characteristics...
  28. doi request reprint Bridging the bench to bedside gap: validation of a reverse-translated rodent continuous performance test using functional magnetic resonance imaging
    Benjamin S McKenna
    Mental Illness Research, Education, and Clinical Center, Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA
    Psychiatry Res 212:183-91. 2013
    ..This task can be used for powerful parallel human and animal investigations of the biological basis of vigilance deficits in populations with severe mental illness...
  29. pmc A failure of left temporal cortex to specialize for language is an early emerging and fundamental property of autism
    Lisa T Eyler
    UCSD Autism Center of Excellence, University of California, San Diego, La Jolla, CA 92037, USA
    Brain 135:949-60. 2012
    ....
  30. pmc Schizophrenia patients lack normal positive correlation between age and brain response during verbal learning
    Lisa T Eyler
    Mental Illness Research, Education and Clinical Center, Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    Am J Geriatr Psychiatry 17:43-55. 2009
    ..The authors hypothesized that the correlation with age would be more strongly negative among schizophrenia patients, particularly in the frontal cortex...
  31. ncbi request reprint Decisional capacity to consent to research among patients with bipolar disorder: comparison with schizophrenia patients and healthy subjects
    Barton W Palmer
    Department of Psychiatry, University of California, San Diego, Veterans Affairs San Diego Healthcare System, Calif 92161, USA
    J Clin Psychiatry 68:689-96. 2007
    ....
  32. ncbi request reprint Methodological and conceptual issues in functional magnetic resonance imaging: applications to schizophrenia research
    Gregory G Brown
    Psychology Service, Veterans Administration San Diego Healthcare System, and Psychiatry Department, University of California, San Diego, California 92161, USA
    Annu Rev Clin Psychol 2:51-81. 2006
    ..The limitations of cognitive subtraction designs for functional MRI are also discussed. Functional MRI studies of schizophrenia patients are used to illustrate these points...
  33. ncbi request reprint Enhancing the informed consent process: a conceptual overview
    Lisa T Eyler
    Department of Psychiatry, University of California, San Diego, CA 92161, USA
    Behav Sci Law 24:553-68. 2006
    ....
  34. pmc Associations between circadian activity rhythms and functional brain abnormalities among euthymic bipolar patients: a preliminary study
    Benjamin S McKenna
    VA San Diego Healthcare System, VISN 22 Mental Illness Research, Education, and Clinical Center, San Diego, CA 92161, USA University of California, San Diego, Department of Psychiatry, La Jolla, CA 92161, USA Electronic address
    J Affect Disord 164:101-6. 2014
    ..This preliminary study examined associations between sleep/circadian rhythm abnormalities and functional magnetic resonance imaging (fMRI) brain response on a working memory task among BD patients...
  35. pmc Decreased perfusion in young alcohol-dependent women as compared with age-matched controls
    Camellia P Clark
    VA San Diego Healthcare System, Department of Psychiatry, University of California at San Diego, San Diego, California, USA
    Am J Drug Alcohol Abuse 33:13-9. 2007
    ..To use the superior spatial resolution of magnetic resonance imaging (MRI) to examine differences in cerebral perfusion between young alcohol dependent and normal women...
  36. pmc Cortical thickness is influenced by regionally specific genetic factors
    Lars M Rimol
    Department of Radiology, University of California, San Diego, La Jolla, California 92093 0738, USA
    Biol Psychiatry 67:493-9. 2010
    ..Yet, little is known about the patterning of those genetic influences, i.e., whether the same genes influence structure throughout the brain or whether there are regionally specific sets of genes...
  37. pmc Abnormalities of brain response during encoding into verbal working memory among euthymic patients with bipolar disorder
    Benjamin S McKenna
    Mental Illness Research, Education, and Clinical Center, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA Department of Psychiatry, University of California at San Diego, San Diego, CA, USA
    Bipolar Disord 16:289-99. 2014
    ..The present study examined if patients with BD demonstrate differential neural changes in encoding and maintenance WM processes that underlie cognitive impairment...
  38. pmc fMRI evidence of compensatory mechanisms in older adults at genetic risk for Alzheimer disease
    Mark W Bondi
    University of California San Diego and VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    Neurology 64:501-8. 2005
    ..The relationship between APOE genotype and blood oxygenation level dependent (BOLD) brain response was examined during a picture-encoding task in nondemented older adults...
  39. ncbi request reprint Abnormal brain response of chronic schizophrenia patients despite normal performance during a visual vigilance task
    Lisa T Eyler
    Mental Illness Research, Education and Clinical Center, Veterans Affairs San Diego Healthcare System, and Department of Psychiatry, University of California at San Diego, La Jolla, USA
    Psychiatry Res 130:245-57. 2004
    ....
  40. ncbi request reprint The neural correlates of habituation of response to startling tactile stimuli presented in a functional magnetic resonance imaging environment
    Jennifer E McDowell
    Department of Psychology, University of Georgia, Athens, GA 30602, USA
    Psychiatry Res 148:1-10. 2006
    ..Thus, startling tactile stimuli initially induce widespread cortical and thalamic activity, perhaps mediated by the reticular activating system. The activity then habituates in a graded fashion with repeated presentations of the stimuli...
  41. ncbi request reprint Review of longitudinal functional neuroimaging studies of drug treatments in patients with schizophrenia
    C Ervin Davis
    Department of Psychiatry, University of California San Diego, USA
    Schizophr Res 78:45-60. 2005
    ..Suggestions are made for improving future longitudinal neuroimaging studies of treatment effects in schizophrenia...
  42. ncbi request reprint Structural neuroimaging in geriatric psychiatry
    Gwenn S Smith
    Am J Geriatr Psychiatry 14:809-11. 2006
  43. ncbi request reprint Amygdala reactivity and mood-congruent memory in individuals at risk for depressive relapse
    Wiveka Ramel
    Department of Psychology, Stanford University, Stanford, CA 94305 2130, USA
    Biol Psychiatry 61:231-9. 2007
    ..This study examined whether amygdala modulates memory for negatively valenced words before and after a sad mood induction in healthy individuals with and without a history of recurrent major depression...
  44. pmc Review of twin and family studies on neuroanatomic phenotypes and typical neurodevelopment
    J Eric Schmitt
    Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA
    Twin Res Hum Genet 10:683-94. 2007
    ....