Research Topics
Species | Lisa T EylerSummaryAffiliation: University of California Country: USA Publications
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Publications
A preliminary study of interactive questioning methods to assess and improve understanding of informed consent among patients with schizophreniaLisa T Eyler
Mental Illness Research, Education and Clinical Center, Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
Schizophr Res 75:193-8. 2005..Other considerations, however, may favor use of such methods in the consenting process...
Presence of ApoE ε4 allele associated with thinner frontal cortex in middle ageChristine Fennema-Notestine
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0738, USA
J Alzheimers Dis 26:49-60. 2011..Ongoing follow-up of the VETSA sample may shed light on the potential for age- and disease-related mediation of the influence of ApoE allele status...- Assessment of medication management ability in middle-aged and older adults with bipolar disorderColin A Depp
Department of Psychiatry, University of California, San Diego, CA, USA
J Clin Psychopharmacol 28:225-9. 2008..This small cross-sectional study suggests that deficits in medication management ability may be present in later-life BD. Neurocognitive deficits may be important in understanding problems with unintentional nonadherence... - Genetic and environmental influences of white and gray matter signal contrast: a new phenotype for imaging genetics?Matthew S Panizzon
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
Neuroimage 60:1686-95. 2012..The lack of significant genetic correlations with cortical thickness suggests that this measure potentially represents a unique source of genetic variance, one that has yet to be explored by the field of imaging genetics... - Heritability of brain ventricle volume: converging evidence from inconsistent resultsWilliam S Kremen
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
Neurobiol Aging 33:1-8. 2012..These conclusions have implications for the basic understanding of the genetic and environmental underpinnings of normative and pathological brain aging... - Genetic and environmental contributions to regional cortical surface area in humans: a magnetic resonance imaging twin studyLisa T Eyler
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
Cereb Cortex 21:2313-21. 2011.... - Genetic influences on hippocampal volume differ as a function of testosterone level in middle-aged menMatthew S Panizzon
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
Neuroimage 59:1123-31. 2012..To the best of our knowledge, this is the first study to demonstrate that the heritability of a brain structure in adults may be modified by an endogenous biological factor... - Identification of Alzheimer disease risk by functional magnetic resonance imagingAdam S Fleisher
Department of Neurosciences, University of California, San Diego, La Jolla 92037, USA
Arch Neurol 62:1881-8. 2005..Functional magnetic resonance imaging plays a promising role in the preclinical characterization of Alzheimer disease (AD) for use in early diagnosis and in preventive drug trials... 
Performance-based and subjective measures of functioning in middle-aged and older adults with bipolar disorderColin A Depp
Department of Psychiatry, University of California, San Diego VA San Diego Healthcare System, 3350 La Jolla Village Drive 116A 1, San Diego, CA 92161, USA
J Nerv Ment Dis 197:471-5. 2009..Given its relative independence from symptoms, the UPSA may be useful in gauging the effectiveness of rehabilitation for bipolar disorder...- Genetic patterns of correlation among subcortical volumes in humans: results from a magnetic resonance imaging twin studyLisa T Eyler
Department of Psychiatry, University of California, San Diego, La Jolla, California, USA
Hum Brain Mapp 32:641-53. 2011.... - Hierarchical genetic organization of human cortical surface areaChi Hua Chen
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
Science 335:1634-6. 2012..We also found that the results were consistent with human-specific regions being subdivisions of previously described, genetically based lobar regionalization patterns... - Multimedia consent for research in people with schizophrenia and normal subjects: a randomized controlled trialDilip V Jeste
University of California, San Diego, USA
Schizophr Bull 35:719-29. 2009.... - Genetic and environmental influences on the size of specific brain regions in midlife: the VETSA MRI studyWilliam S Kremen
Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive MC 0738, La Jolla, CA 92093, USA
Neuroimage 49:1213-23. 2010..Longitudinal analysis will be needed to determine whether the degree of genetic and environmental influences changes for different ROIs from midlife to later life... - Distinct genetic influences on cortical surface area and cortical thicknessMatthew S Panizzon
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
Cereb Cortex 19:2728-35. 2009..We conclude that using volume in a genetically informative study, or as an endophenotype for a disorder, may confound the underlying genetic architecture of brain structure... - Salivary cortisol and prefrontal cortical thickness in middle-aged men: A twin studyWilliam S Kremen
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
Neuroimage 53:1093-102. 2010..Longitudinal assessments are underway to elucidate the direction of the associations and the genetic underpinnings of longitudinal phenotypes for changes in cortisol and brain morphology... - Brain response abnormalities during verbal learning among patients with schizophreniaLisa T Eyler
Department of Psychiatry, University of California San Diego, San Diego, CA 92161, USA
Psychiatry Res 162:11-25. 2008..Thus, verbal learning deficits found among patients with schizophrenia appear to be related to hypofunction of distributed brain networks... - Performance of schizophrenia and bipolar patients on verbal and figural working memory tasksGregory G Brown
Psychology Service, Veterans Affairs San Diego Healthcare System, University of California, San Diego, CA, USA
J Abnorm Psychol 116:741-53. 2007.... - Brain response correlates of decisional capacity in schizophrenia: a preliminary FMRI studyLisa T Eyler
Department of Psychiatry, University of California, San Diego, Mail Code 151B, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
J Neuropsychiatry Clin Neurosci 19:137-44. 2007..Reasoning scores were not significantly related to brain activation. Understanding deficits during informed consent relates to particular brain abnormalities among schizophrenia patients... - A review of the brain structure correlates of successful cognitive agingAllison R Kaup
Department of Psychiatry, University of California San Diego, San Diego, CA 92161, USA
J Neuropsychiatry Clin Neurosci 23:6-15. 2011..Additional longitudinal study is needed to further evaluate structure-cognition relationships in older adulthood and across the adult lifespan... - Disability and self-management practices of people with bipolar disorder: a web-based surveyColin A Depp
Department of Psychiatry, Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, La Jolla, CA 92093 0664, USA
Community Ment Health J 45:179-87. 2009..001 level. Given limitations of web-based surveys, our study underscores the substantial negative impact of bipolar disorder, along with the potential of the Internet to enhance the use of self-management strategies... - A review of functional brain imaging correlates of successful cognitive agingLisa T Eyler
Sam and Rose Stein Institute for Research on Aging, University of California San Diego, San Diego, California, USA
Biol Psychiatry 70:115-22. 2011..However, a simple model of bigger structure → greater brain response → better cognitive performance might not be accurate. Suggestions for future research are discussed... - Verbal paired-associate learning by APOE genotype in non-demented older adults: fMRI evidence of a right hemispheric compensatory responseS Duke Han
University of California San Diego, Department of Psychiatry, La Jolla, CA 92093 0603, United States
Neurobiol Aging 28:238-47. 2007.... - A functional magnetic resonance imaging study of cortical asymmetry in bipolar disorderMichael P Caligiuri
Department of Psychiatry, University of California at San Diego, and VISN 22 Mental Illness Research, Education, and Clinical Center, VA San Diego Healthcare System, USA
Bipolar Disord 6:183-96. 2004..A secondary goal of the study was to examine effects of psychotropic medications on blood volume changes in the motor cortices... - Neurocognitive impairment in middle-aged and older adults with bipolar disorder: comparison to schizophrenia and normal comparison subjectsColin A Depp
Department of Psychiatry, University of California, San Diego, United States
J Affect Disord 101:201-9. 2007..We examined neurocognitive abilities in middle-aged and older adults with bipolar disorder to groups with schizophrenia or normal subjects, as well as the relation of neurocognition to clinical characteristics... - A failure of left temporal cortex to specialize for language is an early emerging and fundamental property of autismLisa T Eyler
UCSD Autism Center of Excellence, University of California, San Diego, La Jolla, CA 92037, USA
Brain 135:949-60. 2012.... - Schizophrenia patients lack normal positive correlation between age and brain response during verbal learningLisa T Eyler
Mental Illness Research, Education and Clinical Center, Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
Am J Geriatr Psychiatry 17:43-55. 2009..The authors hypothesized that the correlation with age would be more strongly negative among schizophrenia patients, particularly in the frontal cortex... - Decisional capacity to consent to research among patients with bipolar disorder: comparison with schizophrenia patients and healthy subjectsBarton W Palmer
Department of Psychiatry, University of California, San Diego, Veterans Affairs San Diego Healthcare System, Calif 92161, USA
J Clin Psychiatry 68:689-96. 2007.... - Methodological and conceptual issues in functional magnetic resonance imaging: applications to schizophrenia researchGregory G Brown
Psychology Service, Veterans Administration San Diego Healthcare System, and Psychiatry Department, University of California, San Diego, California 92161, USA
Annu Rev Clin Psychol 2:51-81. 2006..The limitations of cognitive subtraction designs for functional MRI are also discussed. Functional MRI studies of schizophrenia patients are used to illustrate these points... - Enhancing the informed consent process: a conceptual overviewLisa T Eyler
Department of Psychiatry, University of California, San Diego, CA 92161, USA
Behav Sci Law 24:553-68. 2006.... - Decreased perfusion in young alcohol-dependent women as compared with age-matched controlsCamellia P Clark
VA San Diego Healthcare System, Department of Psychiatry, University of California at San Diego, San Diego, California, USA
Am J Drug Alcohol Abuse 33:13-9. 2007..To use the superior spatial resolution of magnetic resonance imaging (MRI) to examine differences in cerebral perfusion between young alcohol dependent and normal women... - Cortical thickness is influenced by regionally specific genetic factorsLars M Rimol
Department of Radiology, University of California, San Diego, La Jolla, California 92093 0738, USA
Biol Psychiatry 67:493-9. 2010..Yet, little is known about the patterning of those genetic influences, i.e., whether the same genes influence structure throughout the brain or whether there are regionally specific sets of genes... - fMRI evidence of compensatory mechanisms in older adults at genetic risk for Alzheimer diseaseMark W Bondi
University of California San Diego and VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
Neurology 64:501-8. 2005..The relationship between APOE genotype and blood oxygenation level dependent (BOLD) brain response was examined during a picture-encoding task in nondemented older adults... - Abnormal brain response of chronic schizophrenia patients despite normal performance during a visual vigilance taskLisa T Eyler
Mental Illness Research, Education and Clinical Center, Veterans Affairs San Diego Healthcare System, and Department of Psychiatry, University of California at San Diego, La Jolla, USA
Psychiatry Res 130:245-57. 2004.... - Amygdala reactivity and mood-congruent memory in individuals at risk for depressive relapseWiveka Ramel
Department of Psychology, Stanford University, Stanford, CA 94305 2130, USA
Biol Psychiatry 61:231-9. 2007..This study examined whether amygdala modulates memory for negatively valenced words before and after a sad mood induction in healthy individuals with and without a history of recurrent major depression... - Structural neuroimaging in geriatric psychiatryGwenn S Smith
Am J Geriatr Psychiatry 14:809-11. 2006 - Review of longitudinal functional neuroimaging studies of drug treatments in patients with schizophreniaC Ervin Davis
Department of Psychiatry, University of California San Diego, USA
Schizophr Res 78:45-60. 2005..Suggestions are made for improving future longitudinal neuroimaging studies of treatment effects in schizophrenia... - The neural correlates of habituation of response to startling tactile stimuli presented in a functional magnetic resonance imaging environmentJennifer E McDowell
Department of Psychology, University of Georgia, Athens, GA 30602, USA
Psychiatry Res 148:1-10. 2006..Thus, startling tactile stimuli initially induce widespread cortical and thalamic activity, perhaps mediated by the reticular activating system. The activity then habituates in a graded fashion with repeated presentations of the stimuli... - Review of twin and family studies on neuroanatomic phenotypes and typical neurodevelopmentJ Eric Schmitt
Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA
Twin Res Hum Genet 10:683-94. 2007....