M Extermann

Summary

Affiliation: University of South Florida
Country: USA

Publications

  1. ncbi Comorbidity and functional status are independent in older cancer patients
    M Extermann
    Senior Adult Oncology Program, H Lee Moffitt Cancer and Research Institute, University of South Florida, Tampa 33612, USA
    J Clin Oncol 16:1582-7. 1998
  2. ncbi Use of comprehensive geriatric assessment in older cancer patients: recommendations from the task force on CGA of the International Society of Geriatric Oncology (SIOG)
    Martine Extermann
    H Lee Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Crit Rev Oncol Hematol 55:241-52. 2005
  3. ncbi Comprehensive geriatric assessment basics for the cancer professional
    Martine Extermann
    Moffitt Cancer Center, Tampa, FL 33612, USA
    J Oncol Manag 12:13-7. 2003
  4. ncbi Are older French patients as willing as older American patients to undertake chemotherapy?
    Martine Extermann
    H Lee Moffitt Cancer Center, Tampa, FL, USA
    J Clin Oncol 21:3214-9. 2003
  5. ncbi Treating advanced breast cancer in the older woman
    Martine Extermann
    Moffitt Cancer Center, Tampa, Florida 33612, USA
    Oncology (Williston Park) 20:1355-60; discussion 1360, 1362, 1367-8. 2006
  6. ncbi Studies of comprehensive geriatric assessment in patients with cancer
    Martine Extermann
    Senior Adult Oncology Program, H Lee Moffitt Cancer Center Research Institute, Tampa, FL 33612, USA
    Cancer Control 10:463-8. 2003
  7. ncbi A comprehensive geriatric intervention detects multiple problems in older breast cancer patients
    Martine Extermann
    Senior Adult Oncology, H Lee Moffitt Cancer Center, University of South Florida, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Crit Rev Oncol Hematol 49:69-75. 2004
  8. ncbi Management issues for elderly patients with breast cancer
    Martine Extermann
    Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Curr Treat Options Oncol 5:161-9. 2004
  9. ncbi MAX2--a convenient index to estimate the average per patient risk for chemotherapy toxicity; validation in ECOG trials
    M Extermann
    H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL, USA
    Eur J Cancer 40:1193-8. 2004
  10. ncbi Comprehensive geriatric assessment for older patients with cancer
    Martine Extermann
    H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
    J Clin Oncol 25:1824-31. 2007

Detail Information

Publications44

  1. ncbi Comorbidity and functional status are independent in older cancer patients
    M Extermann
    Senior Adult Oncology Program, H Lee Moffitt Cancer and Research Institute, University of South Florida, Tampa 33612, USA
    J Clin Oncol 16:1582-7. 1998
    ..However, to date, there is no standard measure of the comorbidity burden available for these patients. We tested the performance of two comorbidity scales and their relationship with functional status...
  2. ncbi Use of comprehensive geriatric assessment in older cancer patients: recommendations from the task force on CGA of the International Society of Geriatric Oncology (SIOG)
    Martine Extermann
    H Lee Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Crit Rev Oncol Hematol 55:241-52. 2005
    ..As more and more cancers occur in elderly people, oncologists are increasingly confronted with the necessity of integrating geriatric parameters in the treatment of their patients...
  3. ncbi Comprehensive geriatric assessment basics for the cancer professional
    Martine Extermann
    Moffitt Cancer Center, Tampa, FL 33612, USA
    J Oncol Manag 12:13-7. 2003
    ..It is, for example, part of the National Comprehensive Cancer Network (NCCN) guidelines for the elderly'. This article offers a primer on CGA for the reader unfamiliar with the approach in an oncologic setting...
  4. ncbi Are older French patients as willing as older American patients to undertake chemotherapy?
    Martine Extermann
    H Lee Moffitt Cancer Center, Tampa, FL, USA
    J Clin Oncol 21:3214-9. 2003
    ..A view often held in Europe is that older Europeans are less willing than older Americans to undertake chemotherapy. This study assesses whether this view is valid...
  5. ncbi Treating advanced breast cancer in the older woman
    Martine Extermann
    Moffitt Cancer Center, Tampa, Florida 33612, USA
    Oncology (Williston Park) 20:1355-60; discussion 1360, 1362, 1367-8. 2006
    ..For most patients in this setting, sequential single-agent chemotherapy appears at this time to be the preferred course of treatment...
  6. ncbi Studies of comprehensive geriatric assessment in patients with cancer
    Martine Extermann
    Senior Adult Oncology Program, H Lee Moffitt Cancer Center Research Institute, Tampa, FL 33612, USA
    Cancer Control 10:463-8. 2003
    ..The comprehensive geriatric assessment (CGA) has been developed to individually assess the health status of older patients...
  7. ncbi A comprehensive geriatric intervention detects multiple problems in older breast cancer patients
    Martine Extermann
    Senior Adult Oncology, H Lee Moffitt Cancer Center, University of South Florida, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Crit Rev Oncol Hematol 49:69-75. 2004
    ..Success rate in addressing problems was 87%. Mean Functional Assessment of Cancer Treatment-Breast (FACT-B) scores improved from 110.5 (S.D. 16.7) to 116.3 (S.D. 16.5) (t=0.025). Function and independence were maintained...
  8. ncbi Management issues for elderly patients with breast cancer
    Martine Extermann
    Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Curr Treat Options Oncol 5:161-9. 2004
    ..The cumulative result of the introduction of these new agents, at a population level, is a 7.5-month increase in the median survival time of patients with metastatic breast cancer over the past decade...
  9. ncbi MAX2--a convenient index to estimate the average per patient risk for chemotherapy toxicity; validation in ECOG trials
    M Extermann
    H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL, USA
    Eur J Cancer 40:1193-8. 2004
    ..The MAX2 index is a convenient and reproducible way of comparing the average per patient risk for toxicity from chemotherapy across several regimens...
  10. ncbi Comprehensive geriatric assessment for older patients with cancer
    Martine Extermann
    H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
    J Clin Oncol 25:1824-31. 2007
    ..This article discusses recent advances on the use of a CGA in older patients with cancer...
  11. ncbi Predictors of tolerance to chemotherapy in older cancer patients: a prospective pilot study
    M Extermann
    H Lee Moffitt Cancer Center, University of South Florida, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Eur J Cancer 38:1466-73. 2002
    ..Designing a composite predictive score to use in assessing the toxicity of multiple chemotherapy regimens therefore appears to be a valid undertaking...
  12. ncbi Older patients, cognitive impairment, and cancer: an increasingly frequent triad
    Martine Extermann
    Departments of Oncology and Medicine, University of South Florida, H Lee Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, USA
    J Natl Compr Canc Netw 3:593-6. 2005
    ..Cancer patients with cognitive impairment are at high risk of concomitant depression...
  13. ncbi Assessment of the older cancer patient
    M Extermann
    Department of Internal Medicine, University of South Florida College of Medicine, USA
    Hematol Oncol Clin North Am 14:63-77, viii-ix. 2000
    ..This article reviews the various aspects of a comprehensive assessment applicable to the cancer patient in settings such as academic oncology programs, cooperative group studies, and private oncology practice...
  14. ncbi What threshold for adjuvant therapy in older breast cancer patients?
    M Extermann
    Senior Adult Oncology Program and Epidemiology and Biostatistics Program, H Lee Moffitt Cancer Center at the University of South Florida, Tampa, FL, USA
    J Clin Oncol 18:1709-17. 2000
    ..Knowledge of the threshold relapse risks above which adjuvant treatment is worth prescribing would enhance decision making...
  15. ncbi Measurement and impact of comorbidity in older cancer patients
    M Extermann
    H Lee Moffitt Cancer Center at the University of South Florida, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Crit Rev Oncol Hematol 35:181-200. 2000
    ..A largely open challenge remains to correlate comorbidity with treatment tolerance, and functional and quality of life outcomes, as well as to integrate it in clinical decision-making...
  16. ncbi Pilot testing of the computerized cognitive test Microcog in chemotherapy-treated older cancer patients
    Martine Extermann
    Senior Adult Oncology, H Lee Moffitt Cancer Center, University of South Florida, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Crit Rev Oncol Hematol 54:137-43. 2005
    ..Computerized cognitive tests are available and could simplify cooperative group studies on the matter, but have not been applied to older cancer patients...
  17. ncbi Geriatric assessment with focus on instrument selectivity for outcomes
    Martine Extermann
    H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
    Cancer J 11:474-80. 2005
    ..Some evidence is beginning to appear as to the impact a comprehensive geriatric assessment could have on the oncologic management of older patients with cancer...
  18. ncbi Management of breast cancer in the older woman
    L Balducci
    Senior Adult Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Cancer Control 8:431-41. 2001
    ....
  19. ncbi Management of cancer in the older person: a practical approach
    L Balducci
    Senior Adult Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    Oncologist 5:224-37. 2000
    ....
  20. ncbi Validity and reliability of the FACT-G scale for use in the older person with cancer
    J Overcash
    Senior Adult Oncology Program at the H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612-9497, USA
    Am J Clin Oncol 24:591-6. 2001
    ..9 +/- 14.4 SD. Subjects with a PS of 3 had a mean score of 59.0 +/- 23.2 SD. The FACT-G is a valid and reliable instrument for use in the older patient with cancer. The FACT-G is not an age-biased instrument...
  21. ncbi Measuring comorbidity in older cancer patients
    M Extermann
    Senior Adult Oncology Program, H Lee Moffitt Cancer Center at the University of South Florida, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Eur J Cancer 36:453-71. 2000
    ..Since little is still known about the importance of individual comorbidities for various outcomes and the way comorbidity cumulates in influencing cancer treatment, a wide integration of comorbidity in prospective studies is essential...
  22. ncbi Methotrexate-induced status epilepticus
    Aung Naing
    H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, 33612, USA
    Am J Hematol 80:35-7. 2005
  23. ncbi The abbreviated comprehensive geriatric assessment (aCGA) for use in the older cancer patient as a prescreen: scoring and interpretation
    Janine A Overcash
    College of Nursing, University of South Florida, Tampa, FL 33612 4766, USA
    Crit Rev Oncol Hematol 59:205-10. 2006
    ..The abbreviated CGA (aCGA) can be used as a prescreening assessment to identify patients who would most benefit from the complete CGA...
  24. ncbi Impact of breast cancer survivorship on quality of life in older women
    Claire Robb
    Department of Health Administration, Biostatistics and Epidemiology, College of Public Health, University of Georgia, Athens, GA 30602 7396, USA
    Crit Rev Oncol Hematol 62:84-91. 2007
    ..Results suggest a need for greater attention to promoting functioning and psychological well-being among older cancer survivors, even when they may not have obvious cancer-related medical complications...
  25. pmc Individual differences in well-being in older breast cancer survivors
    Elizabeth A Perkins
    School of Aging Studies, University of South Florida, 4202 East Fowler Avenue, MHC 1308, Tampa, FL 33612, USA
    Crit Rev Oncol Hematol 62:74-83. 2007
    ....
  26. ncbi Management of breast cancer in elderly individuals: recommendations of the International Society of Geriatric Oncology
    Hans Wildiers
    Department of General Medical Oncology, University Hospital Gasthuisberg, Leuven, Belgium
    Lancet Oncol 8:1101-15. 2007
    ..The available evidence was reviewed and synthesised to provide consensus recommendations regarding the care of breast cancer in older adults...
  27. doi Phase 2 trial of docetaxel and gefitinib in the first-line treatment of patients with advanced nonsmall-cell lung cancer (NSCLC) who are 70 years of age or older
    George R Simon
    Thoracic Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Cancer 112:2021-9. 2008
    ..The primary endpoint was response rate (RR). Secondary endpoints were overall survival (OS) and progression-free survival (PFS)...
  28. pmc Toward optimal screening strategies for older women. Costs, benefits, and harms of breast cancer screening by age, biology, and health status
    Jeanne S Mandelblatt
    Department of Oncology, Georgetown University Medical Center, Lombardi Comprehensive Cancer Center, Washington, DC, USA
    J Gen Intern Med 20:487-96. 2005
    ..Optimal ages of breast cancer screening cessation remain uncertain...
  29. ncbi Never too old? Age should not be a barrier to enrollment in cancer clinical trials
    Matti S Aapro
    Institut Multidisciplinaire d Oncologie, CH 1272 Genolier, Switzerland
    Oncologist 10:198-204. 2005
    ..Possible reasons for the disparity, and the resulting clinical consequences, are also considered...
  30. ncbi The abbreviated comprehensive geriatric assessment (aCGA): a retrospective analysis
    Janine A Overcash
    College of Nursing, University of South Florida, 12901 Bruce B Downs Blvd, MDC 22, Tampa, FL 33612 4766, USA
    Crit Rev Oncol Hematol 54:129-36. 2005
    ..A comprehensive geriatric assessment (CGA) is a multidimensional assessment that is designed to detect health problems. A barrier to conducting the CGA is the length of time required to complete the entire assessment...
  31. ncbi Decision analysis for cancer prevention and cancer treatment in the elderly
    Martine Extermann
    Senior Adult Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
    Cancer Treat Res 124:223-32. 2005
  32. ncbi Biological basis of the association of cancer and aging comorbidity
    Martine Extermann
    Senior Adult Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
    Cancer Treat Res 124:173-86. 2005
  33. doi Fatigue and functional dependence in older cancer patients
    Andrea Luciani
    Division of Medical Oncology, S Paolo Hospital, University of Milan, Milan, Italy
    Am J Clin Oncol 31:424-30. 2008
    ..In addition, we studied the prevalence of fatigue and its correlation with anemia, depression, and nutritional status...
  34. ncbi Can older cancer patients tolerate chemotherapy? A prospective pilot study
    Hongbin Chen
    Senior Adult Oncology Program, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612, USA
    Cancer 97:1107-14. 2003
    ..This prospective pilot study evaluated the changes in functional, mental, nutritional, and comorbid status, as well as the quality of life (QOL), in geriatric oncology patients receiving chemotherapy...
  35. ncbi Comorbidity and geriatric assessment in the elderly patient over the age of 70
    Martine Extermann
    Senior Adult Oncology, H Lee Moffit Cancer Center, Tampa, FL, USA
    Tumori 88:S9. 2002
  36. ncbi Optimizing cancer care in the elderly: progress in geriatric oncology
    Martine Extermann
    Cancer Control 10:440-1. 2003
  37. ncbi Phase I trial of a B7-1 (CD80) gene modified autologous tumor cell vaccine in combination with systemic interleukin-2 in patients with metastatic renal cell carcinoma
    Scott J Antonia
    Interdisciplinary Oncology Program and Genitourinary Program, H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
    J Urol 167:1995-2000. 2002
    ..We conducted a phase I clinical trial testing this approach in patients with metastatic renal cell carcinoma...
  38. ncbi Cancer in the older person
    Ignazio Carreca
    University of Palermo School of Medicine, Italy
    Cancer Treat Rev 31:380-402. 2005
    ..Important interventions include prevention of neutropaenic infections with filgrastim and peg-filgrastim, prevention of anaemia with epoietin or darbepoietin, and prevention and early management of mucositis...
  39. ncbi Indoleamine 2,3-dioxygenase contributes to tumor cell evasion of T cell-mediated rejection
    Maria Friberg
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center, Tampa, FL 33612, USA
    Int J Cancer 101:151-5. 2002
    ..Our study provides evidence for a novel mechanism whereby tumors evade rejection by the immune system, and suggests the possibility that inhibiting IDO may be developed as an anti-cancer immunotherapeutic strategy...
  40. ncbi More thoughts on the reporting of adverse events in cancer clinical trials
    Martine Extermann
    J Clin Oncol 25:918; author reply 918-9. 2007
  41. ncbi Biological screening and impact in elderly cancer patients
    Anne Chantal Braud
    H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
    Cancer Treat Res 124:165-71. 2005
  42. ncbi Paclitaxel pharmacokinetics, threshold models, and dosing strategies
    Martine Extermann
    J Clin Oncol 21:2804-5; author reply 2805-6. 2003
  43. ncbi Performance status and comorbidity predict transplant-related mortality after allogeneic hematopoietic cell transplantation
    Andrew S Artz
    Section of Hematology Oncology, University of Chicago, Chicago, Illinois 60637, USA
    Biol Blood Marrow Transplant 12:954-64. 2006
    ..001) and enhanced prognostic power over the CCI alone (P = .018). Prospective studies evaluating more comprehensive functional and comorbidity measurements are warranted...
  44. ncbi Interaction between comorbidity and cancer
    Martine Extermann
    Senior Adult Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Cancer Control 14:13-22. 2007
    ..There is mounting evidence that comorbidity interacts with risk, survival, disease progression, and treatment of elderly patients with cancer. The strength of many of these interactions increases with age...