Michael Ewers

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Prediction of conversion from mild cognitive impairment to Alzheimer's disease dementia based upon biomarkers and neuropsychological test performance
    Michael Ewers
    Department of Radiology, University of California, San Francisco, San Francisco, CA, USA
    Neurobiol Aging 33:1203-14. 2012
  2. pmc CSF biomarker and PIB-PET-derived beta-amyloid signature predicts metabolic, gray matter, and cognitive changes in nondemented subjects
    Michael Ewers
    Department of Radiology, University of California, San Francisco, 94143, USA
    Cereb Cortex 22:1993-2004. 2012
  3. pmc Staging Alzheimer's disease progression with multimodality neuroimaging
    Michael Ewers
    Department of Radiology, University of California at San Francisco, San Francisco, USA
    Prog Neurobiol 95:535-46. 2011
  4. doi request reprint Increased CSF-BACE1 activity associated with decreased hippocampus volume in Alzheimer's disease
    Michael Ewers
    Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Laboratory of Neuroimaging and Biomarker Research, Trinity College, University of Dublin, The Adelaide and Meath Hospital incorporating the National Children s Hospital, Tallaght, Ireland
    J Alzheimers Dis 25:373-81. 2011
  5. pmc Neuroimaging markers for the prediction and early diagnosis of Alzheimer's disease dementia
    Michael Ewers
    Department of Radiology, University of California San Francisco, San Francisco, CA, USA
    Trends Neurosci 34:430-42. 2011
  6. pmc Body mass index is associated with biological CSF markers of core brain pathology of Alzheimer's disease
    Michael Ewers
    University of California, VA Medical Center, Center for Neuroimaging of Neurodegenerative Diseases, San Francisco, San Francisco, CA 94121, USA
    Neurobiol Aging 33:1599-608. 2012
  7. doi request reprint Alzheimer disease: functional abnormalities in the dorsal visual pathway
    Arun L W Bokde
    Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Laboratory of Neuroimaging and Biomarker Research, Trinity College Dublin, Adelaide and Meath Hospital incorporating National Children s Hospital, Dublin, Ireland
    Radiology 254:219-26. 2010
  8. doi request reprint Assessing neuronal networks: understanding Alzheimer's disease
    Arun L W Bokde
    Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience TCIN, Laboratory of Neuroimaging and Biomarker Research, Trinity College Dublin, The Adelaide and Meath Hospital Incorporating The National Children s Hospital AMiNCH, Dublin 24, Ireland
    Prog Neurobiol 89:125-33. 2009
  9. ncbi request reprint Lithium trial in Alzheimer's disease: a randomized, single-blind, placebo-controlled, multicenter 10-week study
    Harald Hampel
    Trinity Center for Health Sciences, The Adelaide and Meath Hospital Incorporating The National Children s Hospital AMiNCH, Tallaght, Dublin 24, Ireland
    J Clin Psychiatry 70:922-31. 2009
  10. pmc Blood-based biomarkers of microvascular pathology in Alzheimer's disease
    Michael Ewers
    Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Laboratory of Neuroimaging and Biomarker Research, Trinity College, University of Dublin, The Adelaide and Meath Hospital incorporating the National Children s Hospital, Tallaght, Dublin, Ireland
    Exp Gerontol 45:75-9. 2010

Detail Information

Publications11

  1. pmc Prediction of conversion from mild cognitive impairment to Alzheimer's disease dementia based upon biomarkers and neuropsychological test performance
    Michael Ewers
    Department of Radiology, University of California, San Francisco, San Francisco, CA, USA
    Neurobiol Aging 33:1203-14. 2012
    ..5, 77.4))) and TMT-B test (prediction accuracy 64.6% (95% CI (55.5, 73.4%))). In conclusion, short-term conversion to AD is predicted by single marker models to a comparable degree as by multimarker models in amnestic MCI subjects...
  2. pmc CSF biomarker and PIB-PET-derived beta-amyloid signature predicts metabolic, gray matter, and cognitive changes in nondemented subjects
    Michael Ewers
    Department of Radiology, University of California, San Francisco, 94143, USA
    Cereb Cortex 22:1993-2004. 2012
    ....
  3. pmc Staging Alzheimer's disease progression with multimodality neuroimaging
    Michael Ewers
    Department of Radiology, University of California at San Francisco, San Francisco, USA
    Prog Neurobiol 95:535-46. 2011
    ..This will be important in designing effective treatments that target specific underlying disease AD mechanisms...
  4. doi request reprint Increased CSF-BACE1 activity associated with decreased hippocampus volume in Alzheimer's disease
    Michael Ewers
    Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Laboratory of Neuroimaging and Biomarker Research, Trinity College, University of Dublin, The Adelaide and Meath Hospital incorporating the National Children s Hospital, Tallaght, Ireland
    J Alzheimers Dis 25:373-81. 2011
    ..Thus, the CSF biomarker candidate of BACE1 activity was associated with hippocampus atrophy in AD in a robust manner and may reflect neurotoxic amyloid-β-related processes...
  5. pmc Neuroimaging markers for the prediction and early diagnosis of Alzheimer's disease dementia
    Michael Ewers
    Department of Radiology, University of California San Francisco, San Francisco, CA, USA
    Trends Neurosci 34:430-42. 2011
    ..A dynamic sequence model of changes that occur in neuroimaging markers during the different disease stages is presented and the predictive value of multimodal neuroimaging for AD dementia is considered...
  6. pmc Body mass index is associated with biological CSF markers of core brain pathology of Alzheimer's disease
    Michael Ewers
    University of California, VA Medical Center, Center for Neuroimaging of Neurodegenerative Diseases, San Francisco, San Francisco, CA 94121, USA
    Neurobiol Aging 33:1599-608. 2012
    ..There was no interaction between CSF signature and diagnosis or apolipoprotein E (ApoE) genotype. In conclusion, lower BMI is indicative of AD pathology as assessed with CSF-based biomarkers in demented and nondemented elderly subjects...
  7. doi request reprint Alzheimer disease: functional abnormalities in the dorsal visual pathway
    Arun L W Bokde
    Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Laboratory of Neuroimaging and Biomarker Research, Trinity College Dublin, Adelaide and Meath Hospital incorporating National Children s Hospital, Dublin, Ireland
    Radiology 254:219-26. 2010
    ..To evaluate whether patients with Alzheimer disease (AD) have altered activation compared with age-matched healthy control (HC) subjects during a task that typically recruits the dorsal visual pathway...
  8. doi request reprint Assessing neuronal networks: understanding Alzheimer's disease
    Arun L W Bokde
    Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience TCIN, Laboratory of Neuroimaging and Biomarker Research, Trinity College Dublin, The Adelaide and Meath Hospital Incorporating The National Children s Hospital AMiNCH, Dublin 24, Ireland
    Prog Neurobiol 89:125-33. 2009
    ....
  9. ncbi request reprint Lithium trial in Alzheimer's disease: a randomized, single-blind, placebo-controlled, multicenter 10-week study
    Harald Hampel
    Trinity Center for Health Sciences, The Adelaide and Meath Hospital Incorporating The National Children s Hospital AMiNCH, Tallaght, Dublin 24, Ireland
    J Clin Psychiatry 70:922-31. 2009
    ..In the current study, we tested the effect of short-term lithium treatment in patients with Alzheimer's disease...
  10. pmc Blood-based biomarkers of microvascular pathology in Alzheimer's disease
    Michael Ewers
    Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Laboratory of Neuroimaging and Biomarker Research, Trinity College, University of Dublin, The Adelaide and Meath Hospital incorporating the National Children s Hospital, Tallaght, Dublin, Ireland
    Exp Gerontol 45:75-9. 2010
    ....
  11. pmc Cognitive reserve associated with FDG-PET in preclinical Alzheimer disease
    Michael Ewers
    Department of Radiology, University of California, San Francisco, CA, USA
    Neurology 80:1194-201. 2013
    ..To examine the effect of education (a surrogate measure of cognitive reserve) on FDG-PET brain metabolism in elderly cognitively healthy (HC) subjects with preclinical Alzheimer disease (AD)...