M G Ewend

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc A compact VEGF signature associated with distant metastases and poor outcomes
    Zhiyuan Hu
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    BMC Med 7:9. 2009
  2. pmc The molecular portraits of breast tumors are conserved across microarray platforms
    Zhiyuan Hu
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    BMC Genomics 7:96. 2006
  3. ncbi request reprint Guidelines for the initial management of metastatic brain tumors: role of surgery, radiosurgery, and radiation therapy
    Matthew G Ewend
    Division of Neurosurgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    J Natl Compr Canc Netw 6:505-13; quiz 514. 2008
  4. ncbi request reprint Treatment of single brain metastasis with resection, intracavity carmustine polymer wafers, and radiation therapy is safe and provides excellent local control
    Matthew G Ewend
    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Clin Cancer Res 13:3637-41. 2007
  5. ncbi request reprint Brain metastases
    M G Ewend
    Division of Neurosurgery, University of North Carolina at Chapel Hill, 148 Burnett Womack Building, Campus Box 7060, Chapel Hill, NC 27599 7060, USA
    Curr Treat Options Oncol 2:537-47. 2001
  6. ncbi request reprint Current treatment paradigms for the management of patients with brain metastases
    Matthew G Ewend
    Division of Neurological Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7060, USA
    Neurosurgery 57:S66-77; discusssion S1-4. 2005
  7. pmc Vessel tortuosity and brain tumor malignancy: a blinded study
    Elizabeth Bullitt
    Department of Surgery, University of North Carolina, Chapel Hill, CASILab, 349 Wing C, CB 7062, Chapel Hill, NC 27599, USA
    Acad Radiol 12:1232-40. 2005
  8. doi request reprint Concurrent temozolomide and radiation, a reasonable option for elderly patients with glioblastoma multiforme?
    Randall J Kimple
    Departments of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Am J Clin Oncol 33:265-70. 2010
  9. ncbi request reprint Clinical applications of proton MR spectroscopy in oncology
    Lester Kwock
    Department of Radiology, Lineberger Comprehensive Cancer Center, University of North Carolina, School of Medicine, Chapel Hill NC 27599 7515, USA
    Technol Cancer Res Treat 1:17-28. 2002
  10. pmc Blood vessel morphologic changes depicted with MR angiography during treatment of brain metastases: a feasibility study
    Elizabeth Bullitt
    Computer Assisted Surgery and Imaging Laboratory, University of North Carolina, 247 Wing E, CB 7062, Chapel Hill, NC 27599, USA
    Radiology 245:824-30. 2007

Detail Information

Publications18

  1. pmc A compact VEGF signature associated with distant metastases and poor outcomes
    Zhiyuan Hu
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    BMC Med 7:9. 2009
    ..Tumor metastases pose the greatest threat to a patient's survival, and thus, understanding the biology of disseminated cancer cells is critical for developing effective therapies...
  2. pmc The molecular portraits of breast tumors are conserved across microarray platforms
    Zhiyuan Hu
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    BMC Genomics 7:96. 2006
    ..To overcome this problem we used publicly available breast cancer gene expression data sets and a novel approach to data fusion, in order to validate a new breast tumor intrinsic list...
  3. ncbi request reprint Guidelines for the initial management of metastatic brain tumors: role of surgery, radiosurgery, and radiation therapy
    Matthew G Ewend
    Division of Neurosurgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    J Natl Compr Canc Netw 6:505-13; quiz 514. 2008
    ....
  4. ncbi request reprint Treatment of single brain metastasis with resection, intracavity carmustine polymer wafers, and radiation therapy is safe and provides excellent local control
    Matthew G Ewend
    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Clin Cancer Res 13:3637-41. 2007
    ..To define the safety and efficacy of carmustine polymer wafers when added to a regimen of surgery and external beam radiotherapy for treatment of a single brain metastasis...
  5. ncbi request reprint Brain metastases
    M G Ewend
    Division of Neurosurgery, University of North Carolina at Chapel Hill, 148 Burnett Womack Building, Campus Box 7060, Chapel Hill, NC 27599 7060, USA
    Curr Treat Options Oncol 2:537-47. 2001
    ..Also, we must recognize differences in each tumor's sensitivity to chemotherapy and radiotherapy and differences in their biology...
  6. ncbi request reprint Current treatment paradigms for the management of patients with brain metastases
    Matthew G Ewend
    Division of Neurological Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7060, USA
    Neurosurgery 57:S66-77; discusssion S1-4. 2005
    ..With advances in systemic therapy for cancer, the treatment of brain metastases is becoming an increasingly important determinant of the length of survival and quality of life for cancer patients...
  7. pmc Vessel tortuosity and brain tumor malignancy: a blinded study
    Elizabeth Bullitt
    Department of Surgery, University of North Carolina, Chapel Hill, CASILab, 349 Wing C, CB 7062, Chapel Hill, NC 27599, USA
    Acad Radiol 12:1232-40. 2005
    ..This report evaluates a computerized, statistical method of analyzing the shapes of vessels extracted from MRA in diagnosing cancer...
  8. doi request reprint Concurrent temozolomide and radiation, a reasonable option for elderly patients with glioblastoma multiforme?
    Randall J Kimple
    Departments of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Am J Clin Oncol 33:265-70. 2010
    ..We began this study to describe our results and toxicities in the over 70 population treated with concurrent temozolomide and radiation for GBM, and to describe our outcomes treating elderly patients with GBM regardless of therapy...
  9. ncbi request reprint Clinical applications of proton MR spectroscopy in oncology
    Lester Kwock
    Department of Radiology, Lineberger Comprehensive Cancer Center, University of North Carolina, School of Medicine, Chapel Hill NC 27599 7515, USA
    Technol Cancer Res Treat 1:17-28. 2002
    ....
  10. pmc Blood vessel morphologic changes depicted with MR angiography during treatment of brain metastases: a feasibility study
    Elizabeth Bullitt
    Computer Assisted Surgery and Imaging Laboratory, University of North Carolina, 247 Wing E, CB 7062, Chapel Hill, NC 27599, USA
    Radiology 245:824-30. 2007
    ....
  11. pmc Abnormal vessel tortuosity as a marker of treatment response of malignant gliomas: preliminary report
    Elizabeth Bullitt
    Department of Surgery, University of North Carolina, 349 Wing C, CB 7062, Chapel Hill, NC 27599, USA
    Technol Cancer Res Treat 3:577-84. 2004
    ..The abnormalities resolve during effective treatment and recur with tumor recurrence. We conclude that vessel shape analysis could provide an important means of assessing tumor activity...
  12. pmc Tumor therapeutic response and vessel tortuosity: preliminary report in metastatic breast cancer
    Elizabeth Bullitt
    CASILab, CB 7062, University of North Carolina, Chapel Hill, NC 27599, USA
    Med Image Comput Comput Assist Interv 9:561-8. 2006
    ..In this preliminary study of 16 patients undergoing treatment for metastatic breast cancer we conclude that vessel shape may predict tumor response several months in advance of traditional methods...
  13. ncbi request reprint Clinical role of proton magnetic resonance spectroscopy in oncology: brain, breast, and prostate cancer
    Lester Kwock
    Department of Radiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Lancet Oncol 7:859-68. 2006
    ....
  14. ncbi request reprint Central nervous system metastases in women after multimodality therapy for high risk breast cancer
    Lisa A Carey
    Division of Hematology Oncology, Department of Medicine, University of North Carolina, 3009 Old Clinic Building, Chapel Hill, NC, 27599 7305, USA
    Breast Cancer Res Treat 88:273-80. 2004
    ..This increase may reflect altered failure patterns from adjuvant therapy, more effective systemic therapy with improved control in non-CNS sites, or a resistant breast cancer subtype...
  15. doi request reprint The prognostic contribution of clinical breast cancer subtype, age, and race among patients with breast cancer brain metastases
    Carey K Anders
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7305, USA
    Cancer 117:1602-11. 2011
    ..In a single-institution cohort study, the authors attempted to determine whether the inferior outcome noted with TNBC brain metastases is more reflective of a higher risk population or the subtype itself...
  16. ncbi request reprint Potentiation of chemotherapeutic agents following antagonism of nuclear factor kappa B in human gliomas
    Kyle D Weaver
    Division of Neurosurgery, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, NC 27599 7060, USA
    J Neurooncol 61:187-96. 2003
    ..Insertion of a mutant inhibitor of NF-kappaB strips cells of this antiapoptotic defense and renders them more susceptible to killing by chemotherapy via increased apoptosis...
  17. pmc Correlation of MR perfusion imaging and vessel tortuosity parameters in assessment of intracranial neoplasms
    Anup H Parikh
    School of Medicine, University of North Carolina, School of Medicine, 3327 Old Infirmary CB 7510, Chapel Hill, NC 27599 7510, USA
    Technol Cancer Res Treat 3:585-90. 2004
    ..However, for subgroups of a particular tumor type such as GBM, there may be significant correlations. It appears that perfusion and tortuosity data may provide independently useful data in the assessment of cerebral neoplasms...
  18. ncbi request reprint Molecular portraits and 70-gene prognosis signature are preserved throughout the metastatic process of breast cancer
    Britta Weigelt
    Divisions of Experimental Therapy and Diagnostic Oncology, The Netherlands Cancer Institute, The Netherlands
    Cancer Res 65:9155-8. 2005
    ..Furthermore, our data imply that poor prognosis breast carcinomas classified either by the intrinsic gene set or the 70 prognosis genes represent distinct disease entities that seem sustained throughout the metastatic process...