Andrew J Ewald

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc The MAPK(ERK-1,2) pathway integrates distinct and antagonistic signals from TGFalpha and FGF7 in morphogenesis of mouse mammary epithelium
    Jimmie E Fata
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Dev Biol 306:193-207. 2007
  2. pmc GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model
    Hosein Kouros-Mehr
    Department of Anatomy, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0452, USA
    Cancer Cell 13:141-52. 2008
  3. pmc Collective epithelial migration and cell rearrangements drive mammary branching morphogenesis
    Andrew J Ewald
    Department of Anatomy and Program in Cell Biology, University of California, San Francisco, San Francisco, CA 94143, USA
    Dev Cell 14:570-81. 2008
  4. pmc Mammary collective cell migration involves transient loss of epithelial features and individual cell migration within the epithelium
    Andrew J Ewald
    Department of Anatomy, University of California San Francisco, San Francisco, CA 94143, USA
    J Cell Sci 125:2638-54. 2012
  5. pmc Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy
    Mikala Egeblad
    Department of Anatomy, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Dis Model Mech 1:155-67; discussion 165. 2008
  6. pmc Genetic mosaic analysis reveals FGF receptor 2 function in terminal end buds during mammary gland branching morphogenesis
    Pengfei Lu
    Department of Anatomy and Program in Developmental Biology, University of California at San Francisco, San Francisco, CA 94143 0452, USA
    Dev Biol 321:77-87. 2008
  7. ncbi request reprint A model of intussusceptive angiogenesis
    Max Levin
    Department of Anatomy, University of California, San Francisco, CA 94143, USA
    Novartis Found Symp 283:37-42; discussion 42-5, 238-41. 2007
  8. pmc PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival
    Steven Song
    Department of Neurological Surgery, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Nat Cell Biol 7:870-9. 2005
  9. pmc Cell-polarity dynamics controls the mechanism of lumen formation in epithelial morphogenesis
    Fernando Martin-Belmonte
    Centro de Biologia Molecular Severo Ochoa, CSIC, Universidad Autonoma de Madrid, Madrid 28049, Spain
    Curr Biol 18:507-13. 2008
  10. pmc Matrix metalloproteinases and the regulation of tissue remodelling
    Andrea Page-McCaw
    Department of Biology and Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180, USA
    Nat Rev Mol Cell Biol 8:221-33. 2007

Collaborators

Detail Information

Publications12

  1. pmc The MAPK(ERK-1,2) pathway integrates distinct and antagonistic signals from TGFalpha and FGF7 in morphogenesis of mouse mammary epithelium
    Jimmie E Fata
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Dev Biol 306:193-207. 2007
    ..Our findings indicate that expression of morphogenetic effectors, proliferation, and cell-type decisions during mammary organoid morphogenesis are intimately dependent on the duration of activation of MAPK(ERK1,2) activation...
  2. pmc GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model
    Hosein Kouros-Mehr
    Department of Anatomy, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0452, USA
    Cancer Cell 13:141-52. 2008
    ..Rather, malignant progression occurred with an expanding GATA-3-negative tumor cell population. These data indicate that GATA-3 regulates tumor differentiation and suppresses tumor dissemination in breast cancer...
  3. pmc Collective epithelial migration and cell rearrangements drive mammary branching morphogenesis
    Andrew J Ewald
    Department of Anatomy and Program in Cell Biology, University of California, San Francisco, San Francisco, CA 94143, USA
    Dev Cell 14:570-81. 2008
    ..Significantly, we observed that normal epithelium and neoplastic hyperplasias are organized similarly, suggesting common mechanisms of epithelial growth...
  4. pmc Mammary collective cell migration involves transient loss of epithelial features and individual cell migration within the epithelium
    Andrew J Ewald
    Department of Anatomy, University of California San Francisco, San Francisco, CA 94143, USA
    J Cell Sci 125:2638-54. 2012
    ..Our data suggest that reductions in polarity and adhesion during breast cancer progression might reflect partial recapitulation of a normal developmental program...
  5. pmc Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy
    Mikala Egeblad
    Department of Anatomy, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Dis Model Mech 1:155-67; discussion 165. 2008
    ..The techniques are not limited to investigations in cancer, but could give new insights into cell behavior more broadly in development and disease...
  6. pmc Genetic mosaic analysis reveals FGF receptor 2 function in terminal end buds during mammary gland branching morphogenesis
    Pengfei Lu
    Department of Anatomy and Program in Developmental Biology, University of California at San Francisco, San Francisco, CA 94143 0452, USA
    Dev Biol 321:77-87. 2008
    ..Together, our data demonstrate that Fgfr2 functions in the proliferating and invading TEBs, but it is not required in the mature ducts of the pubertal mammary gland...
  7. ncbi request reprint A model of intussusceptive angiogenesis
    Max Levin
    Department of Anatomy, University of California, San Francisco, CA 94143, USA
    Novartis Found Symp 283:37-42; discussion 42-5, 238-41. 2007
    ..We have established a cell culture model of vascular pillar formation in an endothelial cell-smooth muscle cell co-culture system. Vascular pillar formation was inhibited by broad spectrum matrix metalloproteinase inhibitors...
  8. pmc PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival
    Steven Song
    Department of Neurological Surgery, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Nat Cell Biol 7:870-9. 2005
    ....
  9. pmc Cell-polarity dynamics controls the mechanism of lumen formation in epithelial morphogenesis
    Fernando Martin-Belmonte
    Centro de Biologia Molecular Severo Ochoa, CSIC, Universidad Autonoma de Madrid, Madrid 28049, Spain
    Curr Biol 18:507-13. 2008
    ..The mechanism of lumen formation in the 3D-MDCK model can shift between hollowing and cavitation, depending on cell polarization...
  10. pmc Matrix metalloproteinases and the regulation of tissue remodelling
    Andrea Page-McCaw
    Department of Biology and Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180, USA
    Nat Rev Mol Cell Biol 8:221-33. 2007
    ..Recent studies in mice and flies point to essential roles of MMPs as mediators of change and physical adaptation in tissues, whether developmentally regulated, environmentally induced or disease associated...
  11. ncbi request reprint Regional requirements for Dishevelled signaling during Xenopus gastrulation: separable effects on blastopore closure, mesendoderm internalization and archenteron formation
    Andrew J Ewald
    Department of Biology and Biological Imaging Center, California Institute of Technology, Pasadena, CA 91125, USA
    Development 131:6195-209. 2004
    ....
  12. pmc Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development
    Hsiuchen Chen
    Division of Biology, Beckman Institute, California Institute of Technology, Pasadena, CA 91125, USA
    J Cell Biol 160:189-200. 2003
    ..Therefore, mitochondrial fusion is essential for embryonic development, and by enabling cooperation between mitochondria, has protective effects on the mitochondrial population...