BERNARD MARK EVERS

Summary

Affiliation: University of Texas Medical Branch
Country: USA

Publications

  1. ncbi request reprint Neurotensin and growth of normal and neoplastic tissues
    B Mark Evers
    Department of Surgery, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA
    Peptides 27:2424-33. 2006
  2. pmc Molecular mechanisms contributing to glutamine-mediated intestinal cell survival
    Shawn D Larson
    Dept of Surgery, Univ of Texas Medical Branch, 301 University Blvd, Galveston, Texas 77555 0536, USA
    Am J Physiol Gastrointest Liver Physiol 293:G1262-71. 2007
  3. ncbi request reprint Enhancement of drug delivery in tumors by using interaction of nanoparticles with ultrasound radiation
    Irina V Larina
    Center for Biomedical Engineering, University of Texas, Medical Branch at Galveston, 301 University Blvd, Galveston, TX 77555 0456, USA
    Technol Cancer Res Treat 4:217-26. 2005
  4. ncbi request reprint Effect of 5-fluorouracil, Optison and ultrasound on MCF-7 cell viability
    Olga V Chumakova
    Center for Biomedical Engineering, The University of Texas Medical Branch, Galveston, TX 77555 0456, USA
    Ultrasound Med Biol 32:751-8. 2006
  5. ncbi request reprint Effects of aging on mortality, hypothermia, and cytokine induction in mice with endotoxemia or sepsis
    Hiroshi Saito
    Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA
    Mech Ageing Dev 124:1047-58. 2003
  6. pmc Curcumin inhibits neurotensin-mediated interleukin-8 production and migration of HCT116 human colon cancer cells
    Xiaofu Wang
    Department of Surgery and the Sealy Center for Cancer Cell Biology, The University of Texas Medical Branch, Galveston, Texas 77555 0536, USA
    Clin Cancer Res 12:5346-55. 2006
  7. ncbi request reprint Analysis of differential gene expression patterns in colon cancer and cancer stroma using microdissected tissues
    Yuko Sugiyama
    Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA
    Gastroenterology 128:480-6. 2005
  8. ncbi request reprint Inflammation and the development of pancreatic cancer
    Buckminster Farrow
    Department of Surgery, The University of Texas Medical Branch, 301 University Boulevard, Galveston 77555, USA
    Surg Oncol 10:153-69. 2002
  9. ncbi request reprint COX-2 inhibition results in alterations in nuclear factor (NF)-kappaB activation but not cytokine production in acute pancreatitis
    Michele I Slogoff
    Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Gastrointest Surg 8:511-9. 2004
  10. ncbi request reprint Induction of cIAP-2 in human colon cancer cells through PKC delta/NF-kappa B
    Qingding Wang
    Department of Surgery and the Sealy Center for Cancer Cell Biology, The University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Biol Chem 278:51091-9. 2003

Research Grants

Collaborators

Detail Information

Publications62

  1. ncbi request reprint Neurotensin and growth of normal and neoplastic tissues
    B Mark Evers
    Department of Surgery, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA
    Peptides 27:2424-33. 2006
    ....
  2. pmc Molecular mechanisms contributing to glutamine-mediated intestinal cell survival
    Shawn D Larson
    Dept of Surgery, Univ of Texas Medical Branch, 301 University Blvd, Galveston, Texas 77555 0536, USA
    Am J Physiol Gastrointest Liver Physiol 293:G1262-71. 2007
    ..Importantly, our findings provide novel mechanistic insights into the antiapoptotic effects of glutamine in the intestine...
  3. ncbi request reprint Enhancement of drug delivery in tumors by using interaction of nanoparticles with ultrasound radiation
    Irina V Larina
    Center for Biomedical Engineering, University of Texas, Medical Branch at Galveston, 301 University Blvd, Galveston, TX 77555 0456, USA
    Technol Cancer Res Treat 4:217-26. 2005
    ..These data suggest that ultrasound-induced drug delivery may improve efficacy of current cancer treatment regimens...
  4. ncbi request reprint Effect of 5-fluorouracil, Optison and ultrasound on MCF-7 cell viability
    Olga V Chumakova
    Center for Biomedical Engineering, The University of Texas Medical Branch, Galveston, TX 77555 0456, USA
    Ultrasound Med Biol 32:751-8. 2006
    ..Furthermore, we show that treatment with 5-FU and ultrasound increased the levels of the Bax and p27kip1 proteins, but the addition of Optison appears to suppress apoptotic protein expression...
  5. ncbi request reprint Effects of aging on mortality, hypothermia, and cytokine induction in mice with endotoxemia or sepsis
    Hiroshi Saito
    Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA
    Mech Ageing Dev 124:1047-58. 2003
    ..These results clearly demonstrate an age-associated increase in mortality, hypothermia, and induction of IL-6 during endotoxemia and sepsis...
  6. pmc Curcumin inhibits neurotensin-mediated interleukin-8 production and migration of HCT116 human colon cancer cells
    Xiaofu Wang
    Department of Surgery and the Sealy Center for Cancer Cell Biology, The University of Texas Medical Branch, Galveston, Texas 77555 0536, USA
    Clin Cancer Res 12:5346-55. 2006
    ....
  7. ncbi request reprint Analysis of differential gene expression patterns in colon cancer and cancer stroma using microdissected tissues
    Yuko Sugiyama
    Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA
    Gastroenterology 128:480-6. 2005
    ..Here, we analyzed patterns of gene expression in colon cancer cells, surrounding stroma, and normal mucosa and normal stroma using laser capture microdissection...
  8. ncbi request reprint Inflammation and the development of pancreatic cancer
    Buckminster Farrow
    Department of Surgery, The University of Texas Medical Branch, 301 University Boulevard, Galveston 77555, USA
    Surg Oncol 10:153-69. 2002
    ....
  9. ncbi request reprint COX-2 inhibition results in alterations in nuclear factor (NF)-kappaB activation but not cytokine production in acute pancreatitis
    Michele I Slogoff
    Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Gastrointest Surg 8:511-9. 2004
    ..The attenuation of inflammation, despite unaltered cytokine levels, suggests that cytokines may not be critical for the inflammatory phase of pancreatitis...
  10. ncbi request reprint Induction of cIAP-2 in human colon cancer cells through PKC delta/NF-kappa B
    Qingding Wang
    Department of Surgery and the Sealy Center for Cancer Cell Biology, The University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Biol Chem 278:51091-9. 2003
    ..These data suggest a novel mechanism for the anti-apoptotic function mediated by the PKC delta/NF-kappa B/cIAP-2 pathway in certain cancers...
  11. ncbi request reprint Inhibition of mitochondrial gene transcription suppresses neurotensin secretion in the human carcinoid cell line BON
    Nan Li
    Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77555 0536, USA
    Am J Physiol Gastrointest Liver Physiol 288:G213-20. 2005
    ..These findings are the first to demonstrate that mitochondrial function is important for agonist-mediated NT secretion...
  12. ncbi request reprint The PPARgamma ligand, 15d-PGJ2, attenuates the severity of cerulein-induced acute pancreatitis
    Koji Hashimoto
    Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77555 0536, USA
    Pancreas 27:58-66. 2003
    ..Ligands specific for PPARgamma may represent novel and effective means of clinical therapy for AP...
  13. ncbi request reprint Effect of aging on the adaptive and proliferative capacity of the small bowel
    Robert P Thomas
    Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77555 0536, USA
    J Gastrointest Surg 7:88-95. 2003
    ....
  14. pmc Age-dependent vulnerability to endotoxemia is associated with reduction of anticoagulant factors activated protein C and thrombomodulin
    Marlene E Starr
    Department of Surgery, University of Texas Medical Branch, Galveston, USA
    Blood 115:4886-93. 2010
    ..These results demonstrate that PC pathway activation is suppressed with aging and is partly responsible for age-associated thrombosis and high mortality during endotoxemia...
  15. pmc Targeted molecular therapy of the PI3K pathway: therapeutic significance of PI3K subunit targeting in colorectal carcinoma
    Piotr G Rychahou
    Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA
    Ann Surg 243:833-42; discussion 843-4. 2006
    ..In addition, inhibition of in vitro proliferation and in vivo liver metastasis by p85alpha or p110alpha siRNA treatment was analyzed...
  16. pmc PTHrP increases xenograft growth and promotes integrin alpha6beta4 expression and Akt activation in colon cancer
    Xiaoli Shen
    Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Cancer Lett 258:241-52. 2007
    ..Elevated PTHrP expression in colon cancer may thus upregulate integrin alpha6beta4 expression, with consequent PI3-K activation. Targeting PTHrP might result in effective inhibition of tumor growth, migration, and invasion...
  17. pmc Age-associated increase in cytokine production during systemic inflammation: adipose tissue as a major source of IL-6
    Marlene E Starr
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, 77555 0828, USA
    J Gerontol A Biol Sci Med Sci 64:723-30. 2009
    ..These results demonstrate that increased vulnerability to systemic inflammation with age is due in part, to augmented IL-6 production by the adipose tissue...
  18. pmc Neurotensin phosphorylates GSK-3alpha/beta through the activation of PKC in human colon cancer cells
    Qingding Wang
    Department of Surgery, The University of Texas Medical Branch, Galveston, TX, USA
    Neoplasia 8:781-7. 2006
    ..Our results indicate that NT uses PKC-dependent pathways to modulate GSK-3, which may play a role in the NT regulation of intestinal cell growth...
  19. pmc Gastrin-releasing peptide receptor silencing suppresses the tumorigenesis and metastatic potential of neuroblastoma
    Jingbo Qiao
    Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555 0353, USA
    Proc Natl Acad Sci U S A 105:12891-6. 2008
    ..Our findings demonstrate that GRP and GRP-R have important oncogenic properties beyond their established mitogenic functions. Therefore, GRP-R may be an ideal therapeutic target for the treatment of aggressive neuroblastomas...
  20. pmc Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion
    Yadi Wu
    Department of Pharmacology and Toxicology, The University of Texas Medical Branch, Galveston, TX 77555, USA
    Cancer Cell 15:416-28. 2009
    ..Our study provides a plausible mechanism for inflammation-induced metastasis...
  21. pmc Decreased pulmonary extracellular superoxide dismutase during systemic inflammation
    Junji Ueda
    Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA
    Free Radic Biol Med 45:897-904. 2008
    ..These results demonstrate that the inflammation-mediated EC-SOD down-regulation has a major pathophysiological impact during the systemic inflammatory response syndrome...
  22. pmc Activation of phosphatidylinositol-3 kinase regulates pancreatic duodenal homeobox-1 in duct cells during pancreatic regeneration
    Hiroaki Watanabe
    Department of Surgery, The University of Texas Medical Branch, Galveston, TX 77555 0526, USA
    Pancreas 36:153-9. 2008
    ....
  23. pmc Increased cell survival, migration, invasion, and Akt expression in PTHrP-overexpressing LoVo colon cancer cell lines
    Xiaoli Shen
    Department of Pharmacology and Toxicology, University of Texas Medical Branch, 10th and Market Streets, Galveston, TX 77555, United States
    Regul Pept 141:61-72. 2007
    ....
  24. pmc Bombesin induces angiogenesis and neuroblastoma growth
    Junghee Kang
    Department of Surgery, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA
    Cancer Lett 253:273-81. 2007
    ..Importantly, these findings suggest that novel therapeutic agents, targeting BBS-mediated angiogenesis, may be useful adjuncts in patients with advanced-stage neuroblastomas...
  25. pmc Regulation of PTEN expression in intestinal epithelial cells by c-Jun NH2-terminal kinase activation and nuclear factor-kappaB inhibition
    Qingding Wang
    Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77555 0536, USA
    Cancer Res 67:7773-81. 2007
    ..Finally, we show a role for PTEN in NaBT-mediated cell death and differentiation. Our findings suggest that the JNK/PTEN and NF-kappaB/PTEN pathways play a critical role in normal intestinal homeostasis and colon carcinogenesis...
  26. doi request reprint Composition of PLGA and PEI/DNA nanoparticles improves ultrasound-mediated gene delivery in solid tumors in vivo
    Olga V Chumakova
    Center for Biomedical Engineering, University of Texas Medical Branch, Galveston, TX 77555, USA
    Cancer Lett 261:215-25. 2008
    ..At least an 8-fold increase of the cell transfection efficacy was obtained in irradiated tumors compared to non-irradiated controls, while little to no cell death was produced by ultrasonication...
  27. pmc Novel cross talk of Kruppel-like factor 4 and beta-catenin regulates normal intestinal homeostasis and tumor repression
    Wen Zhang
    Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, Galveston, TX 77555 1048, USA
    Mol Cell Biol 26:2055-64. 2006
    ..Our findings suggest that the cross talk of KLF4 and beta-catenin plays a critical role in homeostasis of the normal intestine as well as in tumorigenesis of colorectal cancers...
  28. ncbi request reprint Regulation of phorbol ester-mediated TRAF1 induction in human colon cancer cells through a PKC/RAF/ERK/NF-kappaB-dependent pathway
    Xiaofu Wang
    Department of Surgery and Sealy Center for Cancer Cell Biology, The University of Texas Medical Branch, Galveston, TX 77555, USA
    Oncogene 23:1885-95. 2004
    ..In conclusion, our results demonstrate selective induction of TRAF1 in human colon cancer cells through a Ca(2+)-dependent PKC/Raf-1/ERK/NF-kappaB-dependent pathway...
  29. ncbi request reprint Roles of phosphatidylinositol 3'-kinase and mammalian target of rapamycin/p70 ribosomal protein S6 kinase in K-Ras-mediated transformation of intestinal epithelial cells
    Jinyi Shao
    Department of Surgery and Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Cancer Res 64:229-35. 2004
    ..Inhibition of PI3K/mTOR activity leads to G(1) growth arrest of transformed IECs. On the other hand, inhibition of PI3K or mTOR may induce the epithelial to mesenchymal transdifferentiation of IECs under certain circumstances...
  30. ncbi request reprint Effect of ileocolonic transposition on gut morphology, gene expression, and function
    Robert P Thomas
    Department of Surgery, University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Surg Res 109:31-6. 2003
    ..In this location, the ileum functions normally without changes in the villus morphology or gene expression pattern despite the change in position and composition of the luminal content...
  31. doi request reprint Regulation of proliferation, apoptosis and cell cycle in gastrointestinal disorders
    Lindsey N Jackson
    Department of Surgery, The University of Texas Medical Branch, Galveston, TX, USA
    Curr Opin Pharmacol 9:708-14. 2009
    ....
  32. ncbi request reprint Novel and quantitative DNA dot-blotting method for assessment of in vivo proliferation
    Junji Ueda
    Dept of Surgery, Univ of Texas Medical Branch, 301 Univ Boulevard, Galveston, Texas 77555 0536, USA
    Am J Physiol Gastrointest Liver Physiol 288:G842-7. 2005
    ....
  33. ncbi request reprint Myristoylated alanine-rich C kinase substrate-mediated neurotensin release via protein kinase C-delta downstream of the Rho/ROK pathway
    Jing Li
    Department of Surgery and Sealy Center for Cancer Cell Biology, The University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Biol Chem 280:8351-7. 2005
    ..Collectively, these findings provide evidence for novel signaling pathways, including the sequential regulation of MARCKS activity by Rho/ROK and PKC-delta proteins, in stimulated gut peptide secretion...
  34. pmc Alternative medicine products as a novel treatment strategy for inflammatory bowel disease
    Lindsey N Jackson
    Department of Surgery, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA
    Am J Chin Med 36:953-65. 2008
    ..This herbal remedy may prove to be a novel and safe therapeutic alternative in the treatment of IBD...
  35. ncbi request reprint Aging is associated with decreased pancreatic acinar cell regeneration and phosphatidylinositol 3-kinase/Akt activation
    Hiroaki Watanabe
    Department of Surgery, The University of Texas Medical Branch, Galveston 77555 0536, USA
    Gastroenterology 128:1391-404. 2005
    ..The purpose of this study was to (1) delineate the effects of aging on pancreatic regeneration after partial pancreatectomy (Px) and (2) define the involvement of the PI3K/Akt pathway in pancreatic regeneration...
  36. ncbi request reprint Selective targeting of the nuclear factor-kappaB pathway enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated pancreatic cancer cell death
    Robert P Thomas
    Department of Surgery, The University of Texas Medical Branch, Galveston 77555, USA
    Surgery 132:127-34. 2002
    ..The purpose of our study was to determine whether inhibition of NF-kappaB can enhance TRAIL-mediated pancreatic cancer cell death and decrease FLIP levels...
  37. pmc Targeted inhibition of mammalian target of rapamycin signaling inhibits tumorigenesis of colorectal cancer
    Pat Gulhati
    Department of Surgery, University of Kentucky, Lexington, Kentucky 40536 0093, USA
    Clin Cancer Res 15:7207-16. 2009
    ..Because approximately 60% of sporadic colorectal cancers (CRC) exhibit high levels of activated Akt, we determined whether downstream mTOR signaling pathway components are overexpressed and activated in CRCs...
  38. pmc Novel expression patterns of PI3K/Akt/mTOR signaling pathway components in colorectal cancer
    Sara M Johnson
    Department of Surgery, The University of Texas Medical Branch, Galveston, TX, USA
    J Am Coll Surg 210:767-76, 776-8. 2010
    ....
  39. pmc PTP-PEST controls motility, adherens junction assembly, and Rho GTPase activity in colon cancer cells
    Rosario Espejo
    Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555 1074, USA
    Am J Physiol Cell Physiol 299:C454-63. 2010
    ..Taken together, these results suggest that PTP-PEST functions as a suppressor of epithelial cell motility by controlling Rho GTPase activity and the assembly of adherens junctions...
  40. pmc Curcumin inhibits proliferation of colorectal carcinoma by modulating Akt/mTOR signaling
    Sara M Johnson
    Department of Surgery, The University of Texas Medical Branch, Galveston, TX 77550, USA
    Anticancer Res 29:3185-90. 2009
    ..Curcumin, a natural polyphenol product of the plant Curcuma longa, has been shown to inhibit the growth and progression of colorectal cancer; however, the anticancer mechanism of curcumin remains to be elucidated...
  41. pmc Diacylglycerol kinase regulation of protein kinase D during oxidative stress-induced intestinal cell injury
    Jun Song
    Department of Surgery, The University of Texas Medical Branch, 301 University Blvd, Children s Hospital Room 3 200 E, Galveston, TX 77555 0353, USA
    Biochem Biophys Res Commun 375:200-4. 2008
    ..PKD activation is induced by DGKzeta, suggesting DGK is an upstream regulator of oxidative stress-induced activation of the PKD signaling pathway in intestinal epithelial cells...
  42. pmc Small C-terminal domain phosphatase enhances snail activity through dephosphorylation
    Yadi Wu
    Department of Pharmacology and Toxicology, The University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Biol Chem 284:640-8. 2009
    ..Thus, our findings indicate that SCP functions as a Snail phosphatase to control its phosphorylation and stabilization, and our study provides novel insights for the regulation of Snail during EMT and cancer metastasis...
  43. pmc PPAR-gamma agonist protects against intestinal injury during necrotizing enterocolitis
    Naira Baregamian
    Department of Surgery, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0353, USA
    Biochem Biophys Res Commun 379:423-7. 2009
    ..Pretreatment with PPAR-gamma agonist, 15d-PGJ(2), attenuated intestinal NF-kappaB response and I/R-induced gut injury. Activation of PPAR-gamma demonstrated a protective effect on small bowel during I/R-induced gut injury...
  44. pmc PKD3 is the predominant protein kinase D isoform in mouse exocrine pancreas and promotes hormone-induced amylase secretion
    L Andy Chen
    Department of Surgery and Sealy Center for Cancer Cell Biology, The University of Texas Medical Branch, Galveston, Texas 77555 0536, USA
    J Biol Chem 284:2459-71. 2009
    ..These findings reveal a novel distinction between the exocrine and endocrine cells of the pancreas and further identify PKD3 as a signaling molecule that promotes hormone-stimulated amylase secretion...
  45. pmc Suppression of neurotensin receptor type 1 expression and function by histone deacetylase inhibitors in human colorectal cancers
    Xiaofu Wang
    Department of Surgery, The University of Texas Medical Branch, Galveston, Texas, USA
    Mol Cancer Ther 9:2389-98. 2010
    ..The downregulation of NTR1 in colorectal cancers may represent an important mechanism for the anticancer effects of HDACi...
  46. ncbi request reprint RNA interference: mechanisms of action and therapeutic consideration
    Piotr G Rychahou
    Department of Surgery, The University of Texas Medical Branch, Galveston, TX 77555 0536, USA
    Surgery 140:719-25. 2006
  47. ncbi request reprint PTEN and TNF-alpha regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB/Akt, and NF-kappaB-dependent pathway
    Sunghoon Kim
    Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77555, USA
    Gastroenterology 123:1163-78. 2002
    ..However, the regulation of the Cdx-2 gene has not been entirely elucidated. Here, we hypothesize that Cdx-2 may be a target of PTEN signaling in the intestine...
  48. ncbi request reprint Selective inhibition of NF-kappaB attenuates the severity of cerulein-induced acute pancreatitis
    Richard T Ethridge
    Departments of Surgery, The University of Texas Medical Branch, Galveston 77555 0533, USA
    J Am Coll Surg 195:497-505. 2002
    ..The purpose of this study was to determine whether the inhibition of NF-kappaB binding activity with a novel peptide that binds to the NF-kappaB essential modifier binding domain (NBD) could attenuate the severity of AP...
  49. ncbi request reprint Role of cyclooxygenase 2 in protein kinase C beta II-mediated colon carcinogenesis
    Wangsheng Yu
    Sealy Center for Cancer Cell Biology and the Department of Pharmacology and Toxicology, The University of Texas Medical Branch, Galveston, Texas 77555 1048, USA
    J Biol Chem 278:11167-74. 2003
    ....
  50. ncbi request reprint Stem cells in clinical practice
    B Mark Evers
    University of Texas Medical Branch, Department of Surgery, Galveston, TX, USA
    J Am Coll Surg 197:458-78. 2003
  51. ncbi request reprint Down-regulation of the tumor suppressor PTEN by the tumor necrosis factor-alpha/nuclear factor-kappaB (NF-kappaB)-inducing kinase/NF-kappaB pathway is linked to a default IkappaB-alpha autoregulatory loop
    Sunghoon Kim
    Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77555 0536, USA
    J Biol Chem 279:4285-91. 2004
    ..In such a tumor system, these findings suggest a positive feedback loop whereby Akt activation of NF-kappaB further stimulates Akt via down-regulation of the PI3K inhibitor PTEN...
  52. ncbi request reprint The role of protein kinase D in neurotensin secretion mediated by protein kinase C-alpha/-delta and Rho/Rho kinase
    Jing Li
    Department of Surgery and Sealy Center for Cancer Cell Biology, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0536, USA
    J Biol Chem 279:28466-74. 2004
    ..Importantly, our results identify novel signaling pathways, which culminate in gut peptide release...
  53. ncbi request reprint Ets transcriptional regulation of gastrin-releasing peptide receptor in neuroblastomas
    Jingbo Qiao
    Department of Surgery and the Sealy Center for Cancer Cell Biology, The University of Texas Medical Branch, Galveston, TX 77555 0353, USA
    Surgery 136:489-94. 2004
    ..Therefore, the purpose of our study was to determine whether Ets regulates transcriptional activity of GRP-R in NBs...
  54. ncbi request reprint Proteomic analysis of colonic myofibroblasts and effect on colon cancer cell proliferation
    Andy L Chen
    Department of Surgery, The University of Texas Medical Branch, Galveston 77555, USA
    Surgery 138:382-90. 2005
    ..The purpose of this study was to determine (1) the influence of myofibroblasts on colon cancer cell proliferation and PI3K activity, and (2) the protein alterations associated with myofibroblasts derived from polyp versus normal margins...
  55. ncbi request reprint Targeted RNA interference of PI3K pathway components sensitizes colon cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)
    Piotr G Rychahou
    Department of Surgery, The University of Texas Medical Branch, Galveston 77555 0536, USA
    Surgery 138:391-7. 2005
    ....
  56. pmc Signal transduction pathways involved in oxidative stress-induced intestinal epithelial cell apoptosis
    Yuning Zhou
    Department of Surgery, The University of Texas Medical Branch, Galveston 77555 0353, USA
    Pediatr Res 58:1192-7. 2005
    ..In contrast to ERK, JNK, and PKC, PI3-K/Akt may play an important role as a protective cellular signaling pathway during this process...
  57. pmc Inhibition of transforming growth factor-beta/Smad signaling by phosphatidylinositol 3-kinase pathway
    Jingbo Qiao
    Department of Surgery, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0353, USA
    Cancer Lett 242:207-14. 2006
    ..GRP-induced activation of PI3-K, resulting in neuroblastoma cell growth promotion, is potentiated by down-regulation of TGF-beta/Smad signaling...
  58. pmc PKCdelta-mediated regulation of FLIP expression in human colon cancer cells
    Qingding Wang
    Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA
    Int J Cancer 118:326-34. 2006
    ..Moreover, PMA-induced NF-kappaB transactivation was blocked by GF109203x. In conclusion, our results demonstrate a critical role for PKCdelta/NF-kappaB in the regulation of FLIP in human colon cancer cells...
  59. pmc Overexpression of wild-type PKD2 leads to increased proliferation and invasion of BON endocrine cells
    Lindsey N Jackson
    Department of Surgery, The University of Texas Medical Branch, Galveston, TX, USA
    Biochem Biophys Res Commun 348:945-9. 2006
    ..These data support an important role for PKD2 in carcinoid tumor progression. Targeted inhibition of the PKD family may prove to be a novel treatment option for patients with carcinoid tumors...
  60. pmc IGF-1 protects intestinal epithelial cells from oxidative stress-induced apoptosis
    Naira Baregamian
    Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77555 0353, USA
    J Surg Res 136:31-7. 2006
    ..The purpose of this study was to determine whether IGF-1 protects intestinal cells from ROS-induced apoptosis...
  61. ncbi request reprint Cyclic adenosine 5'-monophosphate-stimulated neurotensin secretion is mediated through Rap1 downstream of both Epac and protein kinase A signaling pathways
    Jing Li
    Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77555 0536, USA
    Mol Endocrinol 21:159-71. 2007
    ..Moreover, PGE2, a potent mediator of inflammation and associated with colorectal carcinogenesis, stimulates NT release suggesting a possible link between PGE2 and NT on intestinal inflammatory disorders and colorectal cancers...
  62. ncbi request reprint Augmentation of sodium butyrate-induced apoptosis by phosphatidylinositol 3'-kinase inhibition in the KM20 human colon cancer cell line
    Qingding Wang
    Department of Surgery, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA
    Clin Cancer Res 8:1940-7. 2002
    ..The purpose of this study was to determine whether PI3k inhibition can enhance the inhibitory effect of NaBT on an aggressive human colon cancer cell line, KM20...

Research Grants4

  1. Research Training in Gastrointestinal Endocrinology
    BERNARD EVERS; Fiscal Year: 2007
    ..abstract_text> ..