A D Everett

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi Hepatoma derived growth factor is a nuclear targeted mitogen
    Allen D Everett
    Department of Pediatrics and the Cardiovascular Research Center, University of Virginia Health System, Charlottesville, Virginia 22908 1356, USA
    Curr Drug Targets 4:367-71. 2003
  2. ncbi Developmental expression of protein phosphatase 2A in the kidney
    A D Everett
    Department of Pediatrics, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    J Am Soc Nephrol 10:1737-45. 1999
  3. pmc Hepatoma-derived growth factor stimulates smooth muscle cell growth and is expressed in vascular development
    A D Everett
    Department of Pediatrics, Cardiovascular Research Center, and Department of Internal Medicine, Cardiovascular Division, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Clin Invest 105:567-75. 2000
  4. ncbi Nuclear targeting is required for hepatoma-derived growth factor-stimulated mitogenesis in vascular smooth muscle cells
    A D Everett
    Department of Pediatrics, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Biol Chem 276:37564-8. 2001
  5. ncbi Identification, cloning, and developmental expression of hepatoma-derived growth factor in the developing rat heart
    A D Everett
    Department of Pediatrics, Division of Pediatric Cardiology and the Cardiovascular Research Center of the University of Virginia Health System, Charlottesville, Virginia 22908 1356, USA
    Dev Dyn 222:450-8. 2001
  6. ncbi Transgenic expression of protein phosphatase 2A regulatory subunit B56gamma disrupts distal lung differentiation
    Allen D Everett
    Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Am J Physiol Lung Cell Mol Physiol 282:L1266-71. 2002
  7. ncbi Developmental expression of alpha4 protein phosphatase regulatory subunit in tissues affected by Opitz syndrome
    Allen D Everett
    Department of Pediatrics and the Cardiovascular Research Center, University of Virginia Health System, Charlottesville, Virginia 22908 1356, USA
    Dev Dyn 224:461-4. 2002
  8. pmc Renin release and gene expression in intact rat kidney microvessels and single cells
    A D Everett
    Department of Pediatrics, University of Virginia, Health Sciences Center, Charlottesville 22908
    J Clin Invest 86:169-75. 1990
  9. ncbi Angiotensin II regulates phosphorylation of translation elongation factor-2 in cardiac myocytes
    A D Everett
    Division of Pediatric Cardiology, Department of Pediatrics, University of Virginia, Charlottesville, Virginia 22908 1356, USA
    Am J Physiol Heart Circ Physiol 281:H161-7. 2001
  10. ncbi Hepatoma-derived growth factor is highly expressed in developing liver and promotes fetal hepatocyte proliferation
    Hirayuki Enomoto
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Hepatology 36:1519-27. 2002

Collaborators

Detail Information

Publications19

  1. ncbi Hepatoma derived growth factor is a nuclear targeted mitogen
    Allen D Everett
    Department of Pediatrics and the Cardiovascular Research Center, University of Virginia Health System, Charlottesville, Virginia 22908 1356, USA
    Curr Drug Targets 4:367-71. 2003
    ..Because of these roles, HDGF is a potential target for drug design. This review will describe current knowledge about the biochemical functioning of the protein and identify potential avenues for drug development...
  2. ncbi Developmental expression of protein phosphatase 2A in the kidney
    A D Everett
    Department of Pediatrics, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    J Am Soc Nephrol 10:1737-45. 1999
    ....
  3. pmc Hepatoma-derived growth factor stimulates smooth muscle cell growth and is expressed in vascular development
    A D Everett
    Department of Pediatrics, Cardiovascular Research Center, and Department of Internal Medicine, Cardiovascular Division, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Clin Invest 105:567-75. 2000
    ..Moreover, HDGF colocalizes with the proliferating cell nuclear antigen (PCNA) in SMCs in human atherosclerotic carotid arteries, suggesting that HDGF helps regulate SMC growth during development and in response to vascular injury...
  4. ncbi Nuclear targeting is required for hepatoma-derived growth factor-stimulated mitogenesis in vascular smooth muscle cells
    A D Everett
    Department of Pediatrics, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Biol Chem 276:37564-8. 2001
    ..We conclude that HDGF contains a true bipartite nuclear localization sequence with all three lysines necessary for nuclear targeting. Nuclear targeting of HDGF is required for HDGF stimulation of DNA replication in VSM...
  5. ncbi Identification, cloning, and developmental expression of hepatoma-derived growth factor in the developing rat heart
    A D Everett
    Department of Pediatrics, Division of Pediatric Cardiology and the Cardiovascular Research Center of the University of Virginia Health System, Charlottesville, Virginia 22908 1356, USA
    Dev Dyn 222:450-8. 2001
    ..The early expression of HDGF in embryonic heart and fetal gut suggests that HDGF may play a role in cardiovascular growth and differentiation...
  6. ncbi Transgenic expression of protein phosphatase 2A regulatory subunit B56gamma disrupts distal lung differentiation
    Allen D Everett
    Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Am J Physiol Lung Cell Mol Physiol 282:L1266-71. 2002
    ..We propose that B56gamma is expressed at a particular stage of lung development to modulate PP2A action on the Wnt/beta-catenin signaling pathway during lung airway morphogenesis...
  7. ncbi Developmental expression of alpha4 protein phosphatase regulatory subunit in tissues affected by Opitz syndrome
    Allen D Everett
    Department of Pediatrics and the Cardiovascular Research Center, University of Virginia Health System, Charlottesville, Virginia 22908 1356, USA
    Dev Dyn 224:461-4. 2002
    ..The alpha4 gene lies in the linkage interval for FG syndrome, characterized by skeletal muscle and brain defects that coincide closely to the expression pattern of alpha4...
  8. pmc Renin release and gene expression in intact rat kidney microvessels and single cells
    A D Everett
    Department of Pediatrics, University of Virginia, Health Sciences Center, Charlottesville 22908
    J Clin Invest 86:169-75. 1990
    ..Recruitment of hormone-secreting cells in response to stimuli may prove to be a mechanism of general biological importance shared by many endocrine cell types...
  9. ncbi Angiotensin II regulates phosphorylation of translation elongation factor-2 in cardiac myocytes
    A D Everett
    Division of Pediatric Cardiology, Department of Pediatrics, University of Virginia, Charlottesville, Virginia 22908 1356, USA
    Am J Physiol Heart Circ Physiol 281:H161-7. 2001
    ..Together these results suggest that the ANG II-dependent increase in protein synthesis includes activation of eEF-2 via dephosphorylation by PP2A by a process that involves both PI3K and MAPK...
  10. ncbi Hepatoma-derived growth factor is highly expressed in developing liver and promotes fetal hepatocyte proliferation
    Hirayuki Enomoto
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Hepatology 36:1519-27. 2002
    ..In conclusion, HDGF helps regulate the hepatocyte proliferation in liver development...
  11. ncbi Insights into developmental mechanisms and cancers in the mammalian intestine derived from serial analysis of gene expression and study of the hepatoma-derived growth factor (HDGF)
    Maina Lepourcelet
    Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Development 132:415-27. 2005
    ..Our findings also advance understanding of HDGF functions and implicate this developmentally regulated gene in RNA metabolic pathways that may influence malignant behaviors in colorectal cancer...
  12. ncbi Juxtamembrane localization of the protein phosphatase-1 inhibitor protein PHI-1 in smooth muscle cells
    Nikolaos A Tountas
    Center for Cell Signaling, University of Virginia School of Medicine, PO Box 800577, Charlottesville, VA 22908, USA
    Histochem Cell Biol 121:343-50. 2004
    ..The common tissue distribution but different cellular localization of PHI-1 and CPI-17 suggest distinctive physiological roles for these two PP1 inhibitors...
  13. ncbi Hepatoma-derived growth factor is a pulmonary endothelial cell-expressed angiogenic factor
    Allen D Everett
    Department of Pediatrics, Cardiovascular Research Center, University of Virginia Health System, Charlottesville, 22908, USA
    Am J Physiol Lung Cell Mol Physiol 286:L1194-201. 2004
    ..We conclude that HDGF is a highly expressed vascular endothelial cell protein in vivo and is a potent endothelial mitogen and regulator of endothelial cell migration by mechanisms distinct from VEGF...
  14. ncbi Hepatoma-derived growth factor induces tumorigenesis in vivo through both direct angiogenic activity and induction of vascular endothelial growth factor
    Yorihide Okuda
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871
    Cancer Sci 94:1034-41. 2003
    ..Thus, these findings suggested that HDGF-induced tumor formation in vivo involves induction of VEGF as well as direct angiogenic activity...
  15. ncbi Expression of hepatoma-derived growth factor is a strong prognostic predictor for patients with early-stage non-small-cell lung cancer
    Hening Ren
    Department of Thoracic Head and Neck Medical Oncology, Unit 432, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Clin Oncol 22:3230-7. 2004
    ..We hypothesize that HDGF plays an important role in biologic behavior of early-stage non-small-cell lung cancer (NSCLC)...
  16. ncbi Functional proteomic analysis of melanoma progression
    Karine Bernard
    Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309, USA
    Cancer Res 63:6716-25. 2003
    ..Thus, expression of this antigen likely reports a reduced dependence of protein expression on epidermal interactions...
  17. ncbi Hepatoma-derived growth factor is expressed after vascular injury in the rat and stimulates smooth muscle cell migration
    Jill V Narron
    Department of Pediatrics, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Pediatr Res 59:778-83. 2006
    ..We speculate that HDGF is involved in the SMC proliferative and migratory response to injury resulting in neointimal formation...
  18. pmc Hepatoma-derived growth factor binds DNA through the N-terminal PWWP domain
    Jun Yang
    Department of Pediatrics, Division of Pediatric Cardiology, Johns Hopkins University, Baltimore, MD 21205, USA
    BMC Mol Biol 8:101. 2007
    ..In this study, we aimed to identify if HDGF is a DNA binding protein, map the functional DNA binding domain and DNA binding element for HDGF...
  19. pmc The isolation of novel mesenchymal stromal cell chemotactic factors from the conditioned medium of tumor cells
    Siang Yo Lin
    Department of Pharmacology, The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903, USA
    Exp Cell Res 314:3107-17. 2008
    ..Two proteins, cyclophilin B and hepatoma-derived growth factor were then further characterized and shown to promote MSC chemotaxis...