Research Topics
| William EvansSummaryAffiliation: University of Arkansas for Medical Sciences Country: USA Publications
Research Grants
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Detail Information
Publications
Anthropometric assessment of 10-y changes in body composition in the elderlyVirginia A Hughes
Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
Am J Clin Nutr 80:475-82. 2004..Waist and thigh girths, rather than skinfold thicknesses, should be considered for use in longitudinal studies in the elderly because the changes in these girths capture increased abdominal adiposity and sarcopenia, respectively...
Functional outcomes for clinical trials in frail older persons: time to be movingShalender Bhasin
J Gerontol A Biol Sci Med Sci 63:160-4. 2008- Protein nutrition, exercise and agingWilliam J Evans
Nutrition, Metabolism, and Exercise Laboratory, Donald W Reynolds Center on Aging, Slot 806, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
J Am Coll Nutr 23:601S-609S. 2004..It has also been demonstrated that in very old men and women the use of a protein-calorie supplement was associated with greater strength and muscle mass gains than did the use of placebo... 
Cachexia: a new definitionWilliam J Evans
Donald W Reynolds Institute on Aging, University of Arkansas for Medical Sciences, 4301 W Markham, Slot 806, Little Rock, AR 72205, USA
Clin Nutr 27:793-9. 2008..While this definition has not been tested in epidemiological or intervention studies, a consensus operational definition provides an opportunity for increased research...- Effects of an ad libitum, high carbohydrate diet and aerobic exercise training on insulin action and muscle metabolism in older men and womenNicholas P Hays
Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
J Gerontol A Biol Sci Med Sci 61:299-304. 2006..Furthermore, exercise combined with this diet appears to limit additional increases in insulin sensitivity due to muscle glycogen supercompensation with a concomitant adaptive response of glycogen synthase... - Effects of an ad libitum low-fat, high-carbohydrate diet on body weight, body composition, and fat distribution in older men and women: a randomized controlled trialNicholas P Hays
Nutrition, Metabolism, and Exercise Laboratory, Donald W Reynolds Department of Geriatrics, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock 72205, USA
Arch Intern Med 164:210-7. 2004..CONCLUSION: A high-carbohydrate diet consumed ad libitum, with no attempt at energy restriction or change in energy intake, results in losses of body weight and body fat in older men and women... - Effects of testosterone replacement and/or resistance exercise on the composition of megestrol acetate stimulated weight gain in elderly men: a randomized controlled trialCharles P Lambert
Nutrition, Metabolism, and Exercise Laboratory, Donald W. Reynolds Center on Aging, The University of Arkansas for Medical Sciences and the Geriatric Research, Little Rock, Arkansas 72205, USA
J Clin Endocrinol Metab 87:2100-6. 2002..Resistance exercise attenuated this reduction in muscle mass and when combined with T had an anabolic effect on muscle mass... - Fat distribution and glucose metabolism in older, obese men and womenSophie E Yeo
Nutrition, Metabolism, and Exercise Laboratory, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
J Gerontol A Biol Sci Med Sci 62:1393-401. 2007..In addition, lower muscle attenuation and decreased adiponectin have also been associated with insulin resistance... - Longitudinal changes in body composition in older men and women: role of body weight change and physical activityVirginia A Hughes
Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Am J Clin Nutr 76:473-81. 2002..Estimates of body-composition change in older adults are mostly derived from cross-sectional data... - Effect of recombinant human growth hormone on exercise capacity in patients with HIV-associated wasting on HAARTWilliam J Evans
Donald W. Reynolds Institute on Aging, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
AIDS Read 15:301-3, 306-8, 310, 314. 2005..85 kJ (P < .0001). These improvements suggest that rhGH treatment may enable patients with wasting to perform activities of daily living that would be exhausting without rhGH treatment... - Effects of megestrol acetate on circulating interleukin-15 and interleukin-18 concentrations in healthy elderly menCharles P Lambert
Nutrition, Metabolism, and Exercise Laboratory, Donald W Reynolds Center on Aging, University of Arkansas for Medical Sciences, Central Arkansas Veterans Health System, Little Rock, AR 72205, USA
J Gerontol A Biol Sci Med Sci 59:855-8. 2004..Therefore, the purpose of this investigation was to evaluate the effects of megestrol acetate ingestion on circulating IL-15 and IL-18 concentrations in healthy elderly men... - Macronutrient considerations for the sport of bodybuildingCharles P Lambert
Nutrition, Metabolism, and Exercise Laboratory, Donald W Reynolds Center on Aging, Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Sports Med 34:317-27. 2004..During the off-season the diet should be slightly hyperenergetic (approximately 15% increase in energy intake) and during the pre-contest phase the diet should be hypoenergetic (approximately 15% decrease in energy intake)... - Adaptations to aerobic and resistance exercise in the elderlyCharles P Lambert
Nutrition, Metabolism, and Exercise Laboratory, Dept. of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Rev Endocr Metab Disord 6:137-43. 2005 - Effects of megestrol acetate on pituitary function and end-organ hormone secretion: a post hoc analysis of serum samples from a 12-week study in healthy older menDonald L Bodenner
Department of Geriatrics, Donald W Reynolds Center on Aging, University of Arkansas for Medical Sciences, Little Rock 72205, USA
Am J Geriatr Pharmacother 3:160-7. 2005..A randomized, placebo-controlled study of the effects of testosterone (T) and resistance training (RT) on body composition after MA administration in older men has been reported previously... - Effects of muscle strength training and testosterone in frail elderly malesDennis H Sullivan
Geriatric Research Education and Clinical Center, Central Arkansas Veterans Healthcare System, Little Rock, AR 72205, USA
Med Sci Sports Exerc 37:1664-72. 2005..Determine the independent and combined effects of progressive resistance muscle strength training (PRMST) and testosterone on strength, muscle mass, and function in hypogonadal elderly male recuperative care patients... - Comparison of insulin sensitivity assessment indices with euglycemic-hyperinsulinemic clamp data after a dietary and exercise intervention in older adultsNicholas P Hays
Nutrition, Metabolism, and Exercise Laboratory, and Reynolds Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Metabolism 55:525-32. 2006..Further research is necessary to examine agreement between indices and clamp data in larger, more heterogeneous populations and in response to other interventions where the magnitude of change in insulin sensitivity may be larger... - Functional impact of 10 days of bed rest in healthy older adultsPatrick Kortebein
University of Arkansas for Medical Sciences, Little Rock, AR, USA
J Gerontol A Biol Sci Med Sci 63:1076-81. 2008..This study reports on the effect of 10 days of bed rest on multiple functional parameters in healthy older adults... - Visceral fat and adiponectin: associations with insulin resistance are tissue-specific in womenRobert H Coker
Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Metab Syndr Relat Disord 7:61-7. 2009.... - Influence of exercise intensity on abdominal fat and adiponectin in elderly adultsRobert H Coker
Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Metab Syndr Relat Disord 7:363-8. 2009..In summary, our direct comparison of exercise intensity without weight loss promotes the efficacy of HI in the reduction in visceral fat, even without changes in adiponectin... - Effects of whey and fortified collagen hydrolysate protein supplements on nitrogen balance and body composition in older womenNicholas P Hays
Nutrition, Metabolism, and Exercise Laboratory, D W Reynolds Institute on Aging, University of Arkansas for Medical Sciences, 4301 W Markham St, Slot 806, Little Rock, AR 72205, USA
J Am Diet Assoc 109:1082-7. 2009..047). Therefore, a concentrated, fortified, hydrolyzed collagen protein supplement maintained nitrogen balance and preserved lean body mass during 15 days of consumption of a relatively low-protein diet... - Influence of creatine monohydrate ingestion on muscle metabolites and intense exercise capacity in individuals with multiple sclerosisCharles P Lambert
Nutrition, Metabolism, and Exercise Laboratory, Donald W Reynolds Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA
Arch Phys Med Rehabil 84:1206-10. 2003..To evaluate the effectiveness of ingesting creatine monohydrate in elevating intramuscular creatine stores and improving exercise capacity in individuals with multiple sclerosis (MS)... - Titin and nebulin content in human skeletal muscle following eccentric resistance exerciseTodd A Trappe
Nutrition, Metabolism, and Exercise Laboratory, Donald W Reynolds Center on Aging, Department of Geriatrics, University of Arkansas for Medical Sciences, 4301 W Markham, Slot 806, Little Rock, Arkansas 72205, USA
Muscle Nerve 25:289-92. 2002..Loss of these proteins may have important implications for the mechanisms regulating the adaptive response of skeletal muscle to resistance exercise... - The impact of exercise training compared to caloric restriction on hepatic and peripheral insulin resistance in obesityRobert H Coker
Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
J Clin Endocrinol Metab 94:4258-66. 2009..It has been difficult to distinguish the independent effects of caloric restriction versus exercise training on insulin resistance... - Body composition in ambulatory women with multiple sclerosisCharles P Lambert
Nutrition, Metabolism, and Exercise Laboratory, Donald W Reynolds Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Arch Phys Med Rehabil 83:1559-61. 2002..To compare whole-body fat mass and fat-free mass (FFM) in ambulatory patients with multiple sclerosis (MS) and control subjects without MS... - Effects of testosterone replacement and/or resistance training on interleukin-6, tumor necrosis factor alpha, and leptin in elderly men ingesting megestrol acetate: a randomized controlled trialCharles P Lambert
Nutrition, Metabolism, and Exercise Laboratory, Donald W Reynolds Center on Aging, Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock 72205, USA
J Gerontol A Biol Sci Med Sci 58:165-70. 2003..We attempted to increase gains in fat-free mass with MA using resistance training and/or testosterone replacement and examined the effects on circulating IL-6, TNF alpha, and leptin in elderly men... - Megestrol acetate-induced weight gain does not negatively affect blood lipids in elderly men: effects of resistance training and testosterone replacementCharles P Lambert
Nutrition, Metabolism, and Exercise Laboratory, Donald W Reynolds Center on Aging, Department of Geriatrics, University of Arkansas for Medical Sciences, and Central Arkansas Veterans Healthcare System, Little Rock, 72205, USA
J Gerontol A Biol Sci Med Sci 58:644-7. 2003..Thus, in this study we examined the effects of MA--alone and in combination with resistance training and/or testosterone replacement--on blood lipids... - Aging alters macrophage properties in human skeletal muscle both at rest and in response to acute resistance exerciseBeata Przybyla
Department of Geriatrics, University of Arkansas for Medical Sciences, 4301 West Markham #807, Little Rock, AR 72205, USA
Exp Gerontol 41:320-7. 2006..These findings suggest that aging results in a defective regulation of muscle macrophage function, both at baseline and in response to resistance exercise, that may limit muscle hypertrophy in older adults... - EAA supplementation to increase nitrogen intake improves muscle function during bed rest in the elderlyArny A Ferrando
University of Arkansas for Medical Sciences, USA
Clin Nutr 29:18-23. 2010..In the present study, we examined the effects of increasing protein intake by essential amino acid (EAA) supplementation in older individuals subjected to 10 d bed rest on LBM and muscle function... - Physiological basis of fatigueWilliam J Evans
Nutrition, Metabolism, and Exercise Laboratory, University of Arkansas for Medical Sciences, Central Arkansas Veterans Healthcare System, Little Rock, Arkansas 72205, USA
Am J Phys Med Rehabil 86:S29-46. 2007..Antifatigue therapy should be the standard of care for most chronic conditions associated with fatigue... - Albuterol improves response to levodopa and increases skeletal muscle mass in patients with fluctuating Parkinson diseaseErgun Y Uc
Department of Neurology, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, AR, USA
Clin Neuropharmacol 26:207-12. 2003..A double-blind, placebo-controlled study is needed to confirm the effects and safety profile of beta(2)-agonists in PD... - Exercise-induced changes in insulin action and glycogen metabolism in elderly adultsRobert H Coker
Nutrition, Metabolism, and Exercise Laboratory, University of Arkansas for Medical Sciences, Little Rock, AR, USA
Med Sci Sports Exerc 38:433-8. 2006..CONCLUSION: In weight-stable subjects, MI resulted in no change in ISGD, and the improvement in ISGD with HI was completely reliant on improvements in nonoxidative glucose disposal... - Physical function in men and women with cancer. Effects of anemia and conditioningWilliam J Evans
Donald W. Reynolds Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock 72205, USA
Oncology (Williston Park) 16:109-15. 2002..In this way, the physiological causes of fatigue may be addressed and quality of life improved... - Interleukin-1 polymorphisms are associated with the inflammatory response in human muscle to acute resistance exerciseRichard A Dennis
Department of Geriatrics, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, AR 72205, USA
J Physiol 560:617-26. 2004..This is the first report that IL-1 genotype is associated with the inflammation of skeletal muscle following acute resistance exercise that may potentially affect the adaptations to chronic resistance exercise... - The Yale Physical Activity Survey for older adults: predictions in the energy expenditure due to physical activityLaura J Kruskall
Department of Nutrition Sciences, University of Nevada, Las Vegas, 89154 3026, USA
J Am Diet Assoc 104:1251-7. 2004..To evaluate the accuracy of the Yale Physical Activity Survey (YPAS) for older adults... - Effects of different doses of caffeine on exercise responses in young childrenKenneth R Turley
Human Performance Laboratory, Department of Kinesiology, Harding University, Searcy, AR 72149, USA
Med Sci Sports Exerc 40:871-8. 2008..This study investigated the effects of three different doses of caffeine on physiological responses to exercise in young children... - Higher dietary variety is associated with better nutritional status in frail elderly peopleMelissa A Bernstein
Gerald J and Dorothy R. Friedman School of Nutrition Science and Policy, Tufts University, USA
J Am Diet Assoc 102:1096-104. 2002..Preventive measures to improve dietary variety, as measured by the dietary variety score, should be evaluated and introduced before nutrition and health complications arise... - Lower body versus whole body resistive exercise training and energy requirements of older men and womenWayne W Campbell
Noll Physiological Research Center, The Pennsylvania State University, University Park, PA, USA
Metabolism 51:989-97. 2002..Also, these data show that the energy requirement of older men is greater than that of older women... - Dietary protein adequacy and lower body versus whole body resistive training in older humansWayne W Campbell
Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907, USA
J Physiol 542:631-42. 2002.... - Resistive training and chromium picolinate: effects on inositols and liver and kidney functions in older adultsWayne W Campbell
Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907, USA
Int J Sport Nutr Exerc Metab 14:430-42. 2004..These results suggest that RT did not influence the urinary excretions of inositols. High dose Cr-pic did not influence the urinary excretion of inositols and the selected indices of kidney and liver functions in conjunction with RT... - Effect of 10 days of bed rest on skeletal muscle in healthy older adultsPatrick Kortebein
JAMA 297:1772-4. 2007 - Effects of resistive training and chromium picolinate on body composition and skeletal muscle size in older womenWayne W Campbell
Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907, USA
Int J Sport Nutr Exerc Metab 12:125-35. 2002..Further, these data show that, under these experimental conditions, whole body composition and skeletal muscle size were not significantly changed due to resistive training and were not influenced by supplemental chromium picolinate... - Ibuprofen and acetaminophen: effect on muscle inflammation after eccentric exerciseJennifer M Peterson
The University of Toledo, Department of Kinesiology, OH 43606, USA
Med Sci Sports Exerc 35:892-6. 2003..CONCLUSIONS: Maximal over-the-counter doses of ibuprofen or acetaminophen, when administered therapeutically, do not affect muscle concentrations of neutrophils or macrophages 24 h after a novel bout of eccentric contractions... - Impaired substrate oxidation in healthy elderly men after eccentric exerciseRaj K Krishnan
Noll Physiological Research Center and the General Clinical Research Center, The Pennsylvania State University, University Park 16802, USA
J Appl Physiol 94:716-23. 2003..02 and r = -0.60, P < 0.02, respectively). Despite normal glucose tolerance and the absence of obesity per se, older men experience a reduction in carbohydrate oxidation in response to hyperglycemia after eccentric exercise... - Predictors of weight loss in Parkinson's diseaseErgun Y Uc
Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
Mov Disord 21:930-6. 2006..We demonstrated significant weight loss in PD patients compared to controls over approximately 1 decade. Neurodegeneration involving both motor and nonmotor systems may be associated with weight loss in PD... - The Atwater energy equivalents overestimate metabolizable energy intake in older humans: results from a 96-day strictly controlled feeding studyLaura J Kruskall
Department of Nutrition Sciences, The University of Nevada Las Vegas, Las Vegas, NV 89154, USA
J Nutr 133:2581-4. 2003..Resting energy expenditure was measured using indirect calorimetry. At wk 14, MEI(AT) overestimated MEI(MEAS) by 26%. These results suggest that the Atwater energy equivalent values may overestimate the actual MEI of older people... - Efficacy and feasibility of a novel tri-modal robust exercise prescription in a retirement community: a randomized, controlled trialMichael K Baker
School of Exercise and Sport Science, University of Sydney, Lidcombe, NSW, Australia
J Am Geriatr Soc 55:1-10. 2007..To test the feasibility and efficacy of current guidelines for multimodal exercise programs in older adults... - Exercise as the standard of care for elderly peopleWilliam J Evans
J Gerontol A Biol Sci Med Sci 57:M260-1. 2002 - All calories are not equalWilliam J Evans
Arch Intern Med 165:1069. 2005 - Glucose clearance is delayed after hyperglycemia in healthy elderly menRaj K Krishnan
Noll Physiological Research Center, Penn State University, University Park, PA 16802, USA
J Nutr 133:2363-6. 2003.... - Editorial: Megestrol acetate use for weight gain should be carefully consideredWilliam J Evans
J Clin Endocrinol Metab 92:420-1. 2007
Research Grants
- Nutritional needs of elderly people in long-term careWilliam Evans; Fiscal Year: 2005..We have reserved the National Press Club in Washington DC to hold this meeting on May 3-5, 2005. ..
- EXERCISE AND A HIGH CARBOHYDRATE DIETWilliam Evans; Fiscal Year: 2003..The proposed studies will have important implications for the treatment of obesity and its vast array of complications that are often seen in older men and women. ..
- Physical Activity on Insulin Resistance in the ElderlyWilliam Evans; Fiscal Year: 2003..This New Investigator application will provide data to base future aerobic exercise recommendations in elderly adults. ..
- Bedrest and AgingWilliam Evans; Fiscal Year: 2007..abstract_text> ..