Sylvia M Evans

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis
    Lizhu Lin
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 104:9313-8. 2007
  2. pmc Foxa2 mediates critical functions of prechordal plate in patterning and morphogenesis and is cell autonomously required for early ventral endoderm morphogenesis
    Zachary Harrelson
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive MC0613C, La Jolla, CA 92093, USA
    Biol Open 1:173-81. 2012
  3. pmc MicroRNAs in a cardiac loop: progenitor or myocyte?
    Sylvia M Evans
    Department of Medicine, University of California San Diego, La Jolla, 92093, USA
    Dev Cell 19:787-8. 2010
  4. pmc Myocardial lineage development
    Sylvia M Evans
    Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of Medicine, University of California San Diego, 9500 Gilman Dr, La Jolla CA 92093, USA
    Circ Res 107:1428-44. 2010
  5. ncbi request reprint Progenitor cells for cardiac repair
    Sylvia M Evans
    Skaggs School of Pharmacy and Pharmaceutical Sciences and Department of Medicine, University of California, San Diego, CA 92014, USA
    Semin Cell Dev Biol 18:153-60. 2007
  6. doi request reprint A myocardial lineage derives from Tbx18 epicardial cells
    Chen Leng Cai
    Skaggs School of Pharmacy, University of California, San Diego, La Jolla, California 92093, USA
    Nature 454:104-8. 2008
  7. ncbi request reprint Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2
    Wenlai Zhou
    Howard Hughes Medical Institute and Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Nat Genet 39:1225-34. 2007
  8. pmc Thymosin beta 4 is dispensable for murine cardiac development and function
    Indroneal Banerjee
    Department of Medicine, University of California San Diego, La Jolla, 92093, USA
    Circ Res 110:456-64. 2012
  9. pmc HCN4 dynamically marks the first heart field and conduction system precursors
    Xingqun Liang
    Skaggs School of Pharmacy and Department of Medicine, University of California, San Diego, CA 92093, USA
    Circ Res 113:399-407. 2013
  10. pmc Tbx20 regulates a genetic program essential to adult mouse cardiomyocyte function
    Tao Shen
    Skaggs School of Pharmacy, UCSD, La Jolla, California 92093, USA
    J Clin Invest 121:4640-54. 2011

Research Grants

Detail Information

Publications31

  1. pmc Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis
    Lizhu Lin
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 104:9313-8. 2007
    ..Our findings demonstrate that beta-catenin signaling regulates proliferation and survival of cardiac progenitors...
  2. pmc Foxa2 mediates critical functions of prechordal plate in patterning and morphogenesis and is cell autonomously required for early ventral endoderm morphogenesis
    Zachary Harrelson
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive MC0613C, La Jolla, CA 92093, USA
    Biol Open 1:173-81. 2012
    ..Loss of Foxa2 in ventral endoderm resulted in reduced expression of Sox17, Gata4, and ZO proteins, accounting at least in part for observed lack of foregut fusion, cardia bifida, and increased apoptosis of ventral endoderm...
  3. pmc MicroRNAs in a cardiac loop: progenitor or myocyte?
    Sylvia M Evans
    Department of Medicine, University of California San Diego, La Jolla, 92093, USA
    Dev Cell 19:787-8. 2010
    ..In this issue, Wang et al. (2010) identify a critical microRNA pathway under the control of Bmp signaling that promotes outflow tract myocardial differentiation from cardiac progenitors in vivo...
  4. pmc Myocardial lineage development
    Sylvia M Evans
    Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of Medicine, University of California San Diego, 9500 Gilman Dr, La Jolla CA 92093, USA
    Circ Res 107:1428-44. 2010
    ....
  5. ncbi request reprint Progenitor cells for cardiac repair
    Sylvia M Evans
    Skaggs School of Pharmacy and Pharmaceutical Sciences and Department of Medicine, University of California, San Diego, CA 92014, USA
    Semin Cell Dev Biol 18:153-60. 2007
    ..In this review, we discuss several issues to be considered in cell-based cardiac repair, some progress which has been made toward this goal, and future directions...
  6. doi request reprint A myocardial lineage derives from Tbx18 epicardial cells
    Chen Leng Cai
    Skaggs School of Pharmacy, University of California, San Diego, La Jolla, California 92093, USA
    Nature 454:104-8. 2008
    ..The pluripotency of Tbx18 proepicardial cells provides a theoretical framework for applying these progenitors to effect cardiac repair and regeneration...
  7. ncbi request reprint Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2
    Wenlai Zhou
    Howard Hughes Medical Institute and Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Nat Genet 39:1225-34. 2007
    ..Thus, we propose that transcriptional readout mediated at least in part by a Wnt11 --> ATF/CREB --> TGFbeta2 pathway is critical in regulating morphogenesis in response to noncanonical Wnt signaling...
  8. pmc Thymosin beta 4 is dispensable for murine cardiac development and function
    Indroneal Banerjee
    Department of Medicine, University of California San Diego, La Jolla, 92093, USA
    Circ Res 110:456-64. 2012
    ..To completely ablate Tβ4 and to rule out the possibility of off-target effects associated with shRNA gene silencing, further studies of global or cardiac-specific knockouts are critical...
  9. pmc HCN4 dynamically marks the first heart field and conduction system precursors
    Xingqun Liang
    Skaggs School of Pharmacy and Department of Medicine, University of California, San Diego, CA 92093, USA
    Circ Res 113:399-407. 2013
    ..Understanding origins and identifying markers of CCS lineages are essential steps toward modeling diseases of the CCS and for development of biological pacemakers...
  10. pmc Tbx20 regulates a genetic program essential to adult mouse cardiomyocyte function
    Tao Shen
    Skaggs School of Pharmacy, UCSD, La Jolla, California 92093, USA
    J Clin Invest 121:4640-54. 2011
    ..Our data provide insight into the mechanisms by which mutations in TBX20 cause adult heart disease in humans...
  11. pmc Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor
    Tien Peng
    Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 500:589-92. 2013
    ..Together, these studies identify a novel population of multipotent cardiopulmonary progenitors that coordinates heart and lung co-development that is required for adaptation to terrestrial existence. ..
  12. pmc Selective deletion of long but not short Cypher isoforms leads to late-onset dilated cardiomyopathy
    Hongqiang Cheng
    Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Hum Mol Genet 20:1751-62. 2011
    ....
  13. pmc A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs
    Yunfu Sun
    Department of Medicine, University of California San Diego, La Jolla, California 93093, USA
    Nat Neurosci 11:1283-93. 2008
    ..Together these results establish a central role for Islet1 in the transition from sensory neurogenesis to subtype specification...
  14. pmc Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells
    Yunfu Sun
    Skaggs School of Pharmacy, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Dev Biol 304:286-96. 2007
    ..Our studies suggest a role for Isl1 in these distinct domains of expression within the heart...
  15. pmc Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality
    Xingqun Liang
    Department of Medicine, University of California at San Diego, La Jolla, CA 92093 0613, USA
    Circulation 120:568-76. 2009
    ..A potential role for PINCH proteins in myocardium remains unknown...
  16. pmc Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium
    Ben Van Handel
    Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell 150:590-605. 2012
    ..These results reveal unexpected plasticity in embryonic endothelium such that loss of a single master regulator can induce ectopic cardiomyogenesis from endothelial cells...
  17. pmc Loss of enigma homolog protein results in dilated cardiomyopathy
    Hongqiang Cheng
    Department of Medicine, University of California San Diego, La Jolla, 92093, USA
    Circ Res 107:348-56. 2010
    ..Among the Enigma subfamily, Cypher has been demonstrated to play a pivotal role in the structure and function of striated muscle, whereas the role of Enigma homolog protein (ENH) in muscle remains largely unknown...
  18. pmc Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart
    Byung Kwan Lim
    Department of Medicine, University of California San Diego, Division of Cardiology, La Jolla, California 92093 0613, USA
    J Clin Invest 118:2758-70. 2008
    ..Furthermore, localization of connexin 45 at the AV-node cell-cell junction and of beta-catenin and ZO-1 at the ventricular intercalated disc are dependent on CAR...
  19. pmc Thymosin β4 is not required for embryonic viability or vascular development
    Indroneal Banerjee
    Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Circ Res 112:e25-8. 2013
    ..These data are in direct contrast to our published global and cardiac-specific Tβ4-knockout lines. Thus, the role of Tβ4 needs to be clarified to understand its importance in cardiovascular development...
  20. pmc Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response
    Indroneal Banerjee
    Department of Medicine, University of California San Diego, La Jolla, California, United States of America
    PLoS Genet 10:e1004114. 2014
    ....
  21. ncbi request reprint T-Box transcription factor Tbx20 regulates a genetic program for cranial motor neuron cell body migration
    Mi Ryoung Song
    Gene Expression Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Development 133:4945-55. 2006
    ..Our study suggests that Tbx20 programs a variety of hindbrain motor neurons for migration, independent of directionality, and in facial neurons is a positive regulator of the non-canonical Wnt signaling pathway...
  22. pmc Islet1-mediated activation of the β-catenin pathway is necessary for hindlimb initiation in mice
    Yasuhiko Kawakami
    Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
    Development 138:4465-73. 2011
    ..Our study identifies Islet1 as a hindlimb-specific transcriptional regulator of initiation, and clarifies the controversy regarding the requirement of β-catenin for limb initiation...
  23. ncbi request reprint Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block
    Mohammad Pashmforoush
    UCSD Institute of Molecular Medicine, University of California San Diego School of Medicine, La Jolla, CA 92093, USA
    Cell 117:373-86. 2004
    ..Accordingly, loss of ventricular muscle cell lineage specification into trabecular and conduction system myocytes is a new mechanistic pathway for progressive cardiomyopathy and conduction defects in congenital heart disease...
  24. pmc Antagonism between retinoic acid and fibroblast growth factor signaling during limb development
    Thomas J Cunningham
    Development and Aging Program, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Cell Rep 3:1503-11. 2013
    ..These findings reconcile disparate ideas regarding RA-FGF antagonism and provide insight into how endogenous RA programs the early embryo...
  25. pmc Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis
    Tatiana Kisseleva
    Department of Medicine, School of Pharmacy, University of California, San Diego, CA 92093, USA
    Proc Natl Acad Sci U S A 109:9448-53. 2012
    ..Inactivation of HSCs was associated with up-regulation of the anti-apoptotic genes Hspa1a/b, which participate in the survival of HSCs in culture and in vivo...
  26. pmc Early postmyocardial infarction survival in Murphy Roths Large mice is mediated by attenuated apoptosis and inflammation but depends on genetic background
    Darlene L Hunt
    Department of Bioengineering, University of California at San Diego, La Jolla, CA, USA
    Exp Physiol 97:102-14. 2012
    ..The intermediate survival, apoptosis and inflammation profile of LG/J mice suggests that this high tolerance for MI in the MRL mouse could be derived from its shared genetic background with the LG/J mouse...
  27. ncbi request reprint Expression of the hyperpolarization-activated cyclic nucleotide-gated cation channel HCN4 during mouse heart development
    Cristina Garcia-Frigola
    Institute of Molecular Medicine and Department of Medicine, University of California at San Diego, La Jolla, CA 92093 0613, USA
    Gene Expr Patterns 3:777-83. 2003
    ..The site of HCN4 expression in late embryonic heart coincided with the location of the SA node in postnatal and adult heart [Cardiovasc. Res. 52 (2001) 51]. Our results suggest that HCN4 may be a unique marker of the developing SA node...
  28. ncbi request reprint Development of the cardiac conduction system as delineated by minK-lacZ
    Richard P Kondo
    Institute of Molecular Medicine, University of California, San Diego, California, La Jolla 92093, USA
    J Cardiovasc Electrophysiol 14:383-91. 2003
    ..More recently, the spatial expression of minK-lacZ in the adult mouse heart has been shown, for the larger part, to be coincident with the conduction tissues...
  29. ncbi request reprint Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification
    Alessandra Moretti
    Massachusetts General Hospital Cardiovascular Research Center, Charles River Plaza CPZN 3208, 185 Cambridge Street, Boston, MA 02114, USA
    Cell 127:1151-65. 2006
    ....
  30. doi request reprint The contribution of Islet1-expressing splanchnic mesoderm cells to distinct branchiomeric muscles reveals significant heterogeneity in head muscle development
    Elisha Nathan
    Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel
    Development 135:647-57. 2008
    ..Our findings demonstrate, for the first time, the contribution of Isl1(+) SpM cells to a subset of branchiomeric skeletal muscles...
  31. doi request reprint The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway
    Yibing Qyang
    Cardiovascular Research Center, Massachusetts General Hospital, Charles River Plaza CPZN 3208, 185 Cambridge Street, Boston, MA 02114 2790, USA
    Cell Stem Cell 1:165-79. 2007
    ..Agents that manipulate Wnt signals can markedly expand isl1(+) progenitors from human neonatal hearts, a key advance toward the cloning of human isl1(+) heart progenitors...

Research Grants27

  1. Approaches to Cardiac Regeneration
    Sylvia Evans; Fiscal Year: 2009
    ..We will gain insights into senescence behavior of cardiac fibroblasts, to activate these pathways in an injury setting. If successful, results of these studies will define new therapeuti ..
  2. Mechanisms of Islet1 Action in Heart Development
    Sylvia M Evans; Fiscal Year: 2010
    ..The proposed studies will provide mechanistic insight as to where, when, and how Isl1 is required to effect cell behaviors during cardiogenesis. ..
  3. Mechanisms of Islet1 Action in Heart Development
    Sylvia Evans; Fiscal Year: 2009
    ..The proposed studies will provide mechanistic insight as to where, when, and how Isl1 is required to effect cell behaviors during cardiogenesis. ..
  4. The Role of Tbox20 in Cardiac Development & Adult Heart
    Sylvia Evans; Fiscal Year: 2009
    ....
  5. Role of Tbox20 in Cardiac Development and Adult Heart
    Sylvia Evans; Fiscal Year: 2005
    ..3) To investigate the role of tbx20 in cardiogenesis and in the adult heart, by generation or floxed allele of tbx20 in mice. ..
  6. Development of the Secondary Heart Field
    Sylvia Evans; Fiscal Year: 2004
    ..abstract_text> ..
  7. Temporal and Spatial BMP Signalling and Cardiogenesis
    Sylvia Evans; Fiscal Year: 2004
    ..Development of this technology should have far-reaching impact for future studies of cell and organ fate decisions in frogs, and will make possible experiments which are currently not possible in other systems. ..
  8. Role of Tbox20 in Cardiac Development and Adult Heart
    Sylvia Evans; Fiscal Year: 2004
    ..3) To investigate the role of tbx20 in cardiogenesis and in the adult heart, by generation or floxed allele of tbx20 in mice. ..
  9. TINMAN HOMOLOGUES AND CARDIAC DEVELOPMENT
    Sylvia Evans; Fiscal Year: 2001
    ....
  10. Temporal and Spatial BMP Signalling and Cardiogenesis
    Sylvia Evans; Fiscal Year: 2003
    ..Development of this technology should have far-reaching impact for future studies of cell and organ fate decisions in frogs, and will make possible experiments which are currently not possible in other systems. ..
  11. Role of Tbox20 in Cardiac Development and Adult Heart
    Sylvia Evans; Fiscal Year: 2003
    ..3) To investigate the role of tbx20 in cardiogenesis and in the adult heart, by generation or floxed allele of tbx20 in mice. ..
  12. TINMAN HOMOLOGUES AND CARDIAC DEVELOPMENT
    Sylvia Evans; Fiscal Year: 1999
    ....
  13. TINMAN HOMOLOGUES AND CARDIAC DEVELOPMENT
    Sylvia Evans; Fiscal Year: 2000
    ....
  14. Development of the Secondary Heart Field
    Sylvia Evans; Fiscal Year: 2006
    ..abstract_text> ..
  15. Role of Tbox20 in Cardiac Development and Adult Heart
    Sylvia Evans; Fiscal Year: 2002
    ..3) To investigate the role of tbx20 in cardiogenesis and in the adult heart, by generation or floxed allele of tbx20 in mice. ..
  16. Temporal and Spatial BMP Signalling and Cardiogenesis
    Sylvia Evans; Fiscal Year: 2002
    ..Development of this technology should have far-reaching impact for future studies of cell and organ fate decisions in frogs, and will make possible experiments which are currently not possible in other systems. ..
  17. The Role of Tbox20 in Cardiac Development & Adult Heart
    Sylvia M Evans; Fiscal Year: 2010
    ....
  18. Temporal and Spatial BMP Signalling and Cardiogenesis
    Sylvia Evans; Fiscal Year: 2001
    ..Development of this technology should have far-reaching impact for future studies of cell and organ fate decisions in frogs, and will make possible experiments which are currently not possible in other systems. ..
  19. Development of the Secondary Heart Field
    Sylvia Evans; Fiscal Year: 2005
    ..abstract_text> ..
  20. The Role of Tbox20 in Cardiac Development & Adult Heart
    Sylvia Evans; Fiscal Year: 2007
    ..Tbx20, Tbx2 and Nmyc1 play essential roles in heart development, and Tbx2 and Nmyc1 play critical roles in tumor cells, suggesting that results of our studies will be of significance for congenital heart disease, and potentially cancer. ..
  21. The Role of Tbox20 in Cardiac Development & Adult Heart
    Sylvia Evans; Fiscal Year: 2006
    ..Tbx20, Tbx2 and Nmyc1 play essential roles in heart development, and Tbx2 and Nmyc1 play critical roles in tumor cells, suggesting that results of our studies will be of significance for congenital heart disease, and potentially cancer. ..
  22. Development of the Secondary Heart Field
    Sylvia Evans; Fiscal Year: 2004
    ..abstract_text> ..
  23. Development of the Secondary Heart Field
    Sylvia Evans; Fiscal Year: 2003
    ..abstract_text> ..