Simon J Evans

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Dietary intake and plasma metabolomic analysis of polyunsaturated fatty acids in bipolar subjects reveal dysregulation of linoleic acid metabolism
    Simon J Evans
    Department of Psychiatry, University of Michigan, United States Electronic address
    J Psychiatr Res 57:58-64. 2014
  2. pmc Association of plasma ω-3 and ω-6 lipids with burden of disease measures in bipolar subjects
    Simon J Evans
    Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA
    J Psychiatr Res 46:1435-41. 2012
  3. pmc Fats and factors: lipid profiles associate with personality factors and suicidal history in bipolar subjects
    Simon J Evans
    Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 7:e29297. 2012
  4. pmc Dietary n-3:n-6 fatty acid ratios differentially influence hormonal signature in a rodent model of metabolic syndrome relative to healthy controls
    Paul R Burghardt
    Molecular and Behavioral Neuroscience Institute, The University of Michigan, MBNI 2028, 205 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Nutr Metab (Lond) 7:53. 2010
  5. pmc Dysregulation of the fibroblast growth factor system in major depression
    S J Evans
    Department of Psychiatry and Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 101:15506-11. 2004
  6. pmc DNA microarray analysis of functionally discrete human brain regions reveals divergent transcriptional profiles
    S J Evans
    Pritzker Consortium for Severe Psychiatric Disorders, San Francisco, CA, USA
    Neurobiol Dis 14:240-50. 2003
  7. pmc Gene expression profiling of neurochemically defined regions of the human brain by in situ hybridization-guided laser capture microdissection
    Rene Bernard
    Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA
    J Neurosci Methods 178:46-54. 2009
  8. pmc Metabolic syndrome in bipolar disorder and schizophrenia: dietary and lifestyle factors compared to the general population
    Michael J Bly
    Department of Clinical Social and Administrative Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA
    Bipolar Disord 16:277-88. 2014
  9. pmc Circadian patterns of gene expression in the human brain and disruption in major depressive disorder
    Jun Z Li
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 110:9950-5. 2013
  10. pmc Sample matching by inferred agonal stress in gene expression analyses of the brain
    Jun Z Li
    Stanford Human Genome Center, Stanford University, Palo Alto, CA, USA
    BMC Genomics 8:336. 2007

Research Grants

Detail Information

Publications21

  1. pmc Dietary intake and plasma metabolomic analysis of polyunsaturated fatty acids in bipolar subjects reveal dysregulation of linoleic acid metabolism
    Simon J Evans
    Department of Psychiatry, University of Michigan, United States Electronic address
    J Psychiatr Res 57:58-64. 2014
    ..These findings suggest that specific dietary interventions aimed towards correcting these metabolic disparities may impact health outcomes for individuals with bipolar disorder. ..
  2. pmc Association of plasma ω-3 and ω-6 lipids with burden of disease measures in bipolar subjects
    Simon J Evans
    Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA
    J Psychiatr Res 46:1435-41. 2012
    ....
  3. pmc Fats and factors: lipid profiles associate with personality factors and suicidal history in bipolar subjects
    Simon J Evans
    Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 7:e29297. 2012
    ....
  4. pmc Dietary n-3:n-6 fatty acid ratios differentially influence hormonal signature in a rodent model of metabolic syndrome relative to healthy controls
    Paul R Burghardt
    Molecular and Behavioral Neuroscience Institute, The University of Michigan, MBNI 2028, 205 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Nutr Metab (Lond) 7:53. 2010
    ..Further research is necessary to establish these responses in human populations...
  5. pmc Dysregulation of the fibroblast growth factor system in major depression
    S J Evans
    Department of Psychiatry and Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 101:15506-11. 2004
    ..We also make available the gene-expression profile of all of the other growth factors and growth factor receptors detected in these postmortem samples...
  6. pmc DNA microarray analysis of functionally discrete human brain regions reveals divergent transcriptional profiles
    S J Evans
    Pritzker Consortium for Severe Psychiatric Disorders, San Francisco, CA, USA
    Neurobiol Dis 14:240-50. 2003
    ....
  7. pmc Gene expression profiling of neurochemically defined regions of the human brain by in situ hybridization-guided laser capture microdissection
    Rene Bernard
    Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA
    J Neurosci Methods 178:46-54. 2009
    ..Future studies will utilize this approach for gene expression profiling of neurochemically defined regions of postmortem brains collected from mood disorder patients...
  8. pmc Metabolic syndrome in bipolar disorder and schizophrenia: dietary and lifestyle factors compared to the general population
    Michael J Bly
    Department of Clinical Social and Administrative Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA
    Bipolar Disord 16:277-88. 2014
    ....
  9. pmc Circadian patterns of gene expression in the human brain and disruption in major depressive disorder
    Jun Z Li
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 110:9950-5. 2013
    ..The description of its breakdown in MDD suggests potentially important molecular targets for treatment of mood disorders...
  10. pmc Sample matching by inferred agonal stress in gene expression analyses of the brain
    Jun Z Li
    Stanford Human Genome Center, Stanford University, Palo Alto, CA, USA
    BMC Genomics 8:336. 2007
    ..This problem is analogous to the one encountered in genetic association studies, where self-reported race and ethnicity are often imprecise proxies for an individual's actual genetic ancestry...
  11. ncbi request reprint Combining laser capture microdissection with quantitative real-time PCR: effects of tissue manipulation on RNA quality and gene expression
    Ilan A Kerman
    Molecular and Behavioral Neuroscience Institute, Department of Psychiatry, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    J Neurosci Methods 153:71-85. 2006
    ..These results demonstrate feasibility of performing accurate semi-quantitative gene expression analyses in LCM samples...
  12. pmc A pilot study investigating tumor necrosis factor-α as a potential intervening variable of atypical antipsychotic-associated metabolic syndrome in bipolar disorder
    Alan R Prossin
    Department of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Ther Drug Monit 35:194-202. 2013
    ..Here, we investigate the potential intervening role of TNF-α in the indirect relationship between AAP treatment and MetS in BD...
  13. ncbi request reprint Overexpressing the glucocorticoid receptor in forebrain causes an aging-like neuroendocrine phenotype and mild cognitive dysfunction
    Qiang Wei
    Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 27:8836-44. 2007
    ..Thus, even in the absence of chronic stress, elevation of GR gene expression can lead to an increased allostatic load and result in an "aging-like" phenotype in young animals...
  14. ncbi request reprint The fibroblast growth factor system and mood disorders
    Cortney A Turner
    Department of Psychiatry, Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
    Biol Psychiatry 59:1128-35. 2006
    ..In summary, a reduced tone in the FGF system might alter brain development or remodeling and result in a predisposition or vulnerability to mood disorders, including major depression...
  15. ncbi request reprint Microarray technology: a review of new strategies to discover candidate vulnerability genes in psychiatric disorders
    William E Bunney
    Department of Psychiatry, University of California, Irvine 92697, USA
    Am J Psychiatry 160:657-66. 2003
    ..Instead of studying one gene at a time, microarrays provide the opportunity to analyze thousands of genes at once...
  16. pmc Dietary, lifestyle and pharmacogenetic factors associated with arteriole endothelial-dependent vasodilatation in schizophrenia patients treated with atypical antipsychotics (AAPs)
    Vicki L Ellingrod
    University of Michigan, College of Pharmacy, Department of Clinical Social and Administrative Sciences, 428 Church Street, Ann Arbor, Michigan 48109, USA
    Schizophr Res 130:20-6. 2011
    ..This study examined the status of endothelial function within the schizophrenia population and determined pharmacogenetic, medication, dietary, and lifestyle factors associated with this functioning...
  17. ncbi request reprint Evaluation of Affymetrix Gene Chip sensitivity in rat hippocampal tissue using SAGE analysis. Serial Analysis of Gene Expression
    Simon J Evans
    Mental Health Research Institute, 205 Zina Pitcher Place, University of Michigan, Ann Arbor, MI 48109 0720, USA
    Eur J Neurosci 16:409-13. 2002
    ..This report provides the first broad evaluation of Affymetrix Gene Chip sensitivity relevant to studying the brain...
  18. ncbi request reprint The fibroblast growth factor family and mood disorders
    H Akil
    University of Michigan, Mental Health Research Institute, Ann Arbor 48109, USA
    Novartis Found Symp 289:94-6; discussion 97-100, 193-5. 2008
    ..This paper is focused on a group of growth factors, the fibroblast growth factor (FGF) family and their potential role in mood disorders...
  19. pmc Effect of agonal and postmortem factors on gene expression profile: quality control in microarray analyses of postmortem human brain
    Hiroaki Tomita
    Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA 92697 1675, USA
    Biol Psychiatry 55:346-52. 2004
    ..Reducing the variance due to agonal factors is critical in investigating small but validated gene expression differences in messenger RNA levels between psychiatric patients and control subjects...
  20. ncbi request reprint Application of microarray technology in primate behavioral neuroscience research
    Adriaan M Karssen
    Department of Psychiatry and Behavioral Sciences, Stanford University, USA
    Methods 38:227-34. 2006
    ....
  21. ncbi request reprint Systematic changes in gene expression in postmortem human brains associated with tissue pH and terminal medical conditions
    Jun Z Li
    Department of Genetics, Stanford University School of Medicine, California 94305, USA
    Hum Mol Genet 13:609-16. 2004
    ..These findings shed light on critical molecular mechanisms that are engaged during different forms of terminal stress, and may suggest clinical targets of protection or restoration...

Research Grants1