S M Evans

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Tamoxifen induces hypoxia in MCF-7 xenografts
    S M Evans
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Cancer Res 57:5155-61. 1997
  2. ncbi request reprint Detection of hypoxia in human squamous cell carcinoma by EF5 binding
    S M Evans
    School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Cancer Res 60:2018-24. 2000
  3. ncbi request reprint Hypoxia in human intraperitoneal and extremity sarcomas
    S M Evans
    From the Schools of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Int J Radiat Oncol Biol Phys 49:587-96. 2001
  4. ncbi request reprint Low pO2 and beta-estradiol induce VEGF in MCF-7 and MCF-7-5C cells: relationship to in vivo hypoxia
    A Maity
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Breast Cancer Res Treat 67:51-60. 2001
  5. ncbi request reprint Co-localization of hypoxia and apoptosis in irradiated and untreated HCT116 human colon carcinoma xenografts
    C J Koch
    University of Pennsylvania, Philadelphia 19104 6072, USA
    Adv Exp Med Biol 454:611-8. 1998
  6. ncbi request reprint Hypoxic heterogeneity in human tumors: EF5 binding, vasculature, necrosis, and proliferation
    S M Evans
    University of Pennsylvania, School of Medicine, Department of Radiation Oncology, Philadelphia, Pennsylvania 19104, USA
    Am J Clin Oncol 24:467-72. 2001
  7. pmc Identification of hypoxia in cells and tissues of epigastric 9L rat glioma using EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide]
    S M Evans
    School of Veterinary Medicine Clinical Studies, University of Pennsylvania, Philadelphia 19104, USA
    Br J Cancer 72:875-82. 1995
  8. pmc Hypoxia and VEGF mRNA expression in human tumors
    L S Ziemer
    School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neoplasia 3:500-8. 2001
  9. pmc Oxygen dependence of cellular uptake of EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)a cet amide] : analysis of drug adducts by fluorescent antibodies vs bound radioactivity
    C J Koch
    University of Pennsylvania, Philadelphia 19104 6072, USA
    Br J Cancer 72:869-74. 1995
  10. ncbi request reprint The farnesyltransferase inhibitor L744,832 reduces hypoxia in tumors expressing activated H-ras
    E Cohen-Jonathan
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Cancer Res 61:2289-93. 2001

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Tamoxifen induces hypoxia in MCF-7 xenografts
    S M Evans
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Cancer Res 57:5155-61. 1997
    ....
  2. ncbi request reprint Detection of hypoxia in human squamous cell carcinoma by EF5 binding
    S M Evans
    School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Cancer Res 60:2018-24. 2000
    ..6% of reference binding. In tumors with minimal binding, there was little intratumoral heterogeneity. These studies demonstrate substantial heterogeneity of in situ binding between and within individual squamous cell tumors...
  3. ncbi request reprint Hypoxia in human intraperitoneal and extremity sarcomas
    S M Evans
    From the Schools of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Int J Radiat Oncol Biol Phys 49:587-96. 2001
    ..Using fluorescent immunohistochemical techniques, we provide data on the presence and distribution of EF5 binding, as a surrogate for hypoxia, in human spindle cell tumors...
  4. ncbi request reprint Low pO2 and beta-estradiol induce VEGF in MCF-7 and MCF-7-5C cells: relationship to in vivo hypoxia
    A Maity
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Breast Cancer Res Treat 67:51-60. 2001
    ..Therefore, although these two cell lines grown as tumors have substantial differences in the presence and patterns of hypoxia, this could not be explained by a difference in VEGF induction...
  5. ncbi request reprint Co-localization of hypoxia and apoptosis in irradiated and untreated HCT116 human colon carcinoma xenografts
    C J Koch
    University of Pennsylvania, Philadelphia 19104 6072, USA
    Adv Exp Med Biol 454:611-8. 1998
    ..Apoptosis was assessed using a commercial kit which stains damaged DNA. Although the apoptosis stain was unlikely to exclude other forms of cell death (necrosis, pyknosis) all staining was found to associate with regions of near anoxia...
  6. ncbi request reprint Hypoxic heterogeneity in human tumors: EF5 binding, vasculature, necrosis, and proliferation
    S M Evans
    University of Pennsylvania, School of Medicine, Department of Radiation Oncology, Philadelphia, Pennsylvania 19104, USA
    Am J Clin Oncol 24:467-72. 2001
    ..Necrosis, proliferation, and blood vessel distribution cannot predict the level or presence of hypoxia in an individual patient's tumor...
  7. pmc Identification of hypoxia in cells and tissues of epigastric 9L rat glioma using EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide]
    S M Evans
    School of Veterinary Medicine Clinical Studies, University of Pennsylvania, Philadelphia 19104, USA
    Br J Cancer 72:875-82. 1995
    ..Based upon the results presented herein, the radiation-resistant phenotype of 9L epigastric tumours grown in our laboratories can be associated with the presence of hypoxic cells...
  8. pmc Hypoxia and VEGF mRNA expression in human tumors
    L S Ziemer
    School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neoplasia 3:500-8. 2001
    ..A better understanding of the biology behind VEGF expression, including its modulation by hypoxia, is important for optimizing its use as a prognostic indicator and/or modulating its presence with biologic therapies...
  9. pmc Oxygen dependence of cellular uptake of EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)a cet amide] : analysis of drug adducts by fluorescent antibodies vs bound radioactivity
    C J Koch
    University of Pennsylvania, Philadelphia 19104 6072, USA
    Br J Cancer 72:869-74. 1995
    ....
  10. ncbi request reprint The farnesyltransferase inhibitor L744,832 reduces hypoxia in tumors expressing activated H-ras
    E Cohen-Jonathan
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Cancer Res 61:2289-93. 2001
    ..These results indicate that treatment with farnesyltransferase inhibitors can alter the oxygenation of certain tumors and suggest that such treatment might be useful in the radiosensitization of these tumors...
  11. ncbi request reprint Treatment with soybean-derived Bowman Birk inhibitor increases serum prostate-specific antigen concentration while suppressing growth of human prostate cancer xenografts in nude mice
    X S Wan
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6072, USA
    Prostate 41:243-52. 1999
    ..Bowman Birk inhibitor (BBI) is an anticarcinogenic serine protease inhibitor that may inhibit the protease activity of prostate-specific antigen (PSA) and the growth of human prostate cancer xenografts in nude mice...
  12. pmc Use of power Doppler ultrasound-guided biopsies to locate regions of tumour hypoxia
    S M Evans
    The School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Br J Cancer 76:1308-14. 1997
    ..These methods have clinical implications for the expanded use of power Doppler ultrasound as a means to direct tissue sampling when it is important to identify the presence of hypoxia...
  13. ncbi request reprint Effects of hyperglycemia on oxygenation, radiosensitivity and bioenergetic status of subcutaneous RIF-1 tumors
    L Nadal-Desbarats
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Int J Oncol 21:103-10. 2002
    ....
  14. ncbi request reprint Noninvasive imaging of tumor hypoxia in rats using the 2-nitroimidazole 18F-EF5
    L S Ziemer
    University of Pennsylvania School of Veterinary Medicine, Section of Radiology, 3850 Spruce Street, Philadelphia, PA 19104, USA
    Eur J Nucl Med Mol Imaging 30:259-66. 2003
    ..Plans are underway to initiate a research project to determine the safety and preliminary evidence for the efficacy of this preparation in patients with brain tumors...
  15. ncbi request reprint Doppler ultrasound imaging detects changes in tumor perfusion during antivascular therapy associated with vascular anatomic alterations
    M S Gee
    Biomedical Graduate Program, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Cancer Res 61:2974-82. 2001
    ....
  16. pmc Noninvasive imaging of the distribution in oxygen in tissue in vivo using near-infrared phosphors
    S A Vinogradov
    Department of Biochemistry and Biophysics, Medical School, University of Pennsylvania, Philadelphia 19104, USA
    Biophys J 70:1609-17. 1996
    ..In addition, tissue oxygen pressures can be monitored in real time, even through centimeter thicknesses of tissue...
  17. ncbi request reprint Human esophageal cancer is distinguished from adjacent esophageal tissue by tissue cysteine concentrations
    S M Evans
    University of Pennsylvania, School of Medicine, Department of Radiation Oncology, Philadelphia, Pennsylvania 19104, USA
    Dig Dis Sci 47:2743-50. 2002
    ..2 mM vs 2.1 mM, respectively), tumor tissue had significantly higher levels of cysteine than adjacent tissue (0.21 mM vs 0.13 mM, respectively). In conclusion, cysteine content distinguishes tumor from adjacent more normal tissue...
  18. ncbi request reprint MR-based statistical atlas of the Göttingen minipig brain
    H Watanabe
    PET Center, Arhus Kommunehospital, , Arhus, 8000, Denmark
    Neuroimage 14:1089-96. 2001
    ..This probabilistic threshold gave nearly quantitative recovery of the mean volumes in native space. The probabilistic volumes in stereotaxic space are now being used to extract time-radioactivity curves from dynamic PET recordings...