David M Euhus

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. doi Genetic predisposition syndromes and their management
    David M Euhus
    Department of Surgery, UT Southwestern Medical Center at Dallas, Dallas, TX, USA
    Surg Clin North Am 93:341-62. 2013
  2. doi Managing the breast in patients who test positive for hereditary breast cancer
    David Euhus
    Department of Surgery and Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Ann Surg Oncol 19:1738-44. 2012
  3. pmc Axillary lymph node dissection for breast cancer utilizing Harmonic Focus®
    Katherine T Ostapoff
    Department of Surgery, Division of Surgical Oncology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9155, USA
    World J Surg Oncol 9:90. 2011
  4. pmc Identification of 5 novel genes methylated in breast and other epithelial cancers
    Victoria K Hill
    Department of Medical and Molecular Genetics, University of Birmingham, UK
    Mol Cancer 9:51. 2010
  5. pmc Tamoxifen downregulates ets oncogene family members ETV4 and ETV5 in benign breast tissue: implications for durable risk reduction
    David Euhus
    Department of Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Cancer Prev Res (Phila) 4:1852-62. 2011
  6. doi New insights into the prevention and treatment of familial breast cancer
    David M Euhus
    UT Southwestern Medical Center at Dallas, Texas 75390 9155, USA
    J Surg Oncol 103:294-8. 2011
  7. doi DNA methylation in benign breast epithelium in relation to age and breast cancer risk
    David M Euhus
    Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Cancer Epidemiol Biomarkers Prev 17:1051-9. 2008
  8. ncbi Atypia and DNA methylation in nipple duct lavage in relation to predicted breast cancer risk
    David M Euhus
    E6 222, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9155, USA
    Cancer Epidemiol Biomarkers Prev 16:1812-21. 2007
  9. ncbi Limitations of the Gail model in the specialized breast cancer risk assessment clinic
    David M Euhus
    The University of Texas Southwestern Center for Breast Care, Dallas, Texas 75390 9155, USA
    Breast J 8:23-7. 2002
  10. ncbi Cytokeratin staining and other sentinel node controversies
    David M Euhus
    Division of Surgical Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Clin Breast Cancer 4:S49-54. 2003

Detail Information

Publications37

  1. doi Genetic predisposition syndromes and their management
    David M Euhus
    Department of Surgery, UT Southwestern Medical Center at Dallas, Dallas, TX, USA
    Surg Clin North Am 93:341-62. 2013
    ....
  2. doi Managing the breast in patients who test positive for hereditary breast cancer
    David Euhus
    Department of Surgery and Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Ann Surg Oncol 19:1738-44. 2012
    ..Finally, we discuss management decisions for women who test positive and who are diagnosed with a primary breast cancer, compared to women who have no obvious primary tumor but test positive...
  3. pmc Axillary lymph node dissection for breast cancer utilizing Harmonic Focus®
    Katherine T Ostapoff
    Department of Surgery, Division of Surgical Oncology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9155, USA
    World J Surg Oncol 9:90. 2011
    ..We hypothesize that ALND performed with the Harmonic Focus® will decrease operative time and reduce post-operative complications...
  4. pmc Identification of 5 novel genes methylated in breast and other epithelial cancers
    Victoria K Hill
    Department of Medical and Molecular Genetics, University of Birmingham, UK
    Mol Cancer 9:51. 2010
    ..We utilized one such recently developed approach, MIRA (methylated-CpG island recovery assay) combined with CpG island arrays to identify novel genes that are epigenetically inactivated in breast cancer...
  5. pmc Tamoxifen downregulates ets oncogene family members ETV4 and ETV5 in benign breast tissue: implications for durable risk reduction
    David Euhus
    Department of Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Cancer Prev Res (Phila) 4:1852-62. 2011
    ..The human equivalent of murine multipotential progenitor cap cells of terminal end buds may be the primary target...
  6. doi New insights into the prevention and treatment of familial breast cancer
    David M Euhus
    UT Southwestern Medical Center at Dallas, Texas 75390 9155, USA
    J Surg Oncol 103:294-8. 2011
    ..DNA damaging agents, like cisplatin, and the new class of drugs called PARP inhibitors exploit the underlying defect in DNA damage repair to great effect...
  7. doi DNA methylation in benign breast epithelium in relation to age and breast cancer risk
    David M Euhus
    Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Cancer Epidemiol Biomarkers Prev 17:1051-9. 2008
    ..In proliferative epithelium, such as breast, this may provide an individualized cell-based measure of cancer risk...
  8. ncbi Atypia and DNA methylation in nipple duct lavage in relation to predicted breast cancer risk
    David M Euhus
    E6 222, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9155, USA
    Cancer Epidemiol Biomarkers Prev 16:1812-21. 2007
    ..It is not known whether TSG methylation or atypia in nipple duct lavage (NDL) samples is related to predicted breast cancer risk...
  9. ncbi Limitations of the Gail model in the specialized breast cancer risk assessment clinic
    David M Euhus
    The University of Texas Southwestern Center for Breast Care, Dallas, Texas 75390 9155, USA
    Breast J 8:23-7. 2002
    ....
  10. ncbi Cytokeratin staining and other sentinel node controversies
    David M Euhus
    Division of Surgical Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Clin Breast Cancer 4:S49-54. 2003
    ..Internal mammary SLN biopsy may have value in patients with tumors < 1 cm, but requires additional evaluation in clinical trials...
  11. ncbi ETV6-NTRK3--Trk-ing the primary event in human secretory breast cancer
    David M Euhus
    Department of Surgery, University of Texas, Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cancer Cell 2:347-8. 2002
    ..Their data highlight the role of Trk signaling in breast cancer and also suggest a target for drug development...
  12. ncbi Loss of heterozygosity in benign breast epithelium in relation to breast cancer risk
    David M Euhus
    Department of Pathology, University of Texas Southwestern Medical Center at Dallas, 75390 9155, USA
    J Natl Cancer Inst 94:858-60. 2002
    ..Accurate individualized breast cancer risk assessment may be possible based on molecular analysis of breast epithelial cells obtained by random FNA...
  13. ncbi Pretest prediction of BRCA1 or BRCA2 mutation by risk counselors and the computer model BRCAPRO
    David M Euhus
    The University of Texas Southwestern Medical Center at Dallas, 75390 9155, USA
    J Natl Cancer Inst 94:844-51. 2002
    ..We measured the performance of eight cancer risk counselors and of a computer model, BRCAPRO, at identifying families likely to carry a BRCA gene mutation...
  14. ncbi Validating the performance of the mammary sentinel lymph node team
    David M Euhus
    Division of Surgical Oncology, U T Southwestern Medical Center, Dallas, Texas 75390 9155, USA
    J Surg Oncol 79:209-15. 2002
    ..Standardized performance measures need to be established in order to optimize the transition to SLN biopsy only...
  15. ncbi Aberrant methylation of the cyclin D2 promoter in primary small cell, nonsmall cell lung and breast cancers
    Arvind Virmani
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 8593, USA
    Int J Cancer 107:341-5. 2003
    ..Our results confirm earlier reports in breast cancer and indicate that aberrant methylation of cyclin D2 may contribute to the pathogenesis of the 2 major types of lung cancers...
  16. ncbi Promoter hypermethylation in benign breast epithelium in relation to predicted breast cancer risk
    Cheryl M Lewis
    Hamon Center for Therapeutic Oncology Research, Department of Surgery, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9155, USA
    Clin Cancer Res 11:166-72. 2005
    ..However, it is unclear whether promoter methylation of tumor suppressor genes in benign breast tissue is associated with an increased risk for breast cancer...
  17. pmc A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies
    David S Shames
    Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
    PLoS Med 3:e486. 2006
    ....
  18. pmc RASSF1A polymorphism A133S is associated with early onset breast cancer in BRCA1/2 mutation carriers
    Boning Gao
    Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, TX 75390 8593, USA
    Cancer Res 68:22-5. 2008
    ..Our results warrant a large-scale study to examine the effect of the A133S polymorphism in the development of breast and other types of cancers...
  19. ncbi Role of physical activity in modulating breast cancer risk as defined by APC and RASSF1A promoter hypermethylation in nonmalignant breast tissue
    Yvonne M Coyle
    Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9103, USA
    Cancer Epidemiol Biomarkers Prev 16:192-6. 2007
    ..34-0.94; P = 0.03). The study provides indirect evidence supporting the hypothesis that physical activity is inversely associated with promoter hypermethylation of tumor suppressor genes, such as APC, in nonmalignant breast tissue...
  20. ncbi Clinical relevance of reverse transcriptase-polymerase chain reaction for the detection of axillary lymph node metastases in breast cancer
    Masahiro Sakaguchi
    Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Ann Surg Oncol 10:117-25. 2003
    ....
  21. ncbi Reproducibility of cytologic atypia in repeat nipple duct lavage
    April Johnson-Maddux
    Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Cancer 103:1129-36. 2005
    ....
  22. ncbi An intronic polymorphism associated with increased XRCC1 expression, reduced apoptosis and familial breast cancer
    Dawei Bu
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 9155, USA
    Breast Cancer Res Treat 99:257-65. 2006
    ..XRCC1 IVS10+141G>A is an intronic polymorphism that is associated with XRCC1 expression, apoptosis and familial breast cancer. It may occur within an intronic regulatory sequence...
  23. ncbi Telomerase immortalization of human mammary epithelial cells derived from a BRCA2 mutation carrier
    Cheryl M Lewis
    Hamon Center for Therapeutic Oncology Research and Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390 9039, USA
    Breast Cancer Res Treat 99:103-15. 2006
    ....
  24. doi The clinical consequences of hemizygosity across 2 MB of 10q23 are restricted to Cowden syndrome
    Cheryl M Lewis
    Department of Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8548, USA
    Breast Cancer Res Treat 136:911-8. 2012
    ..However, because all significant clinical features of the proband and her father are common to patients with genetic alterations in PTEN, the other 22 hemizygous protein-coding genes appear to be haplosufficient...
  25. ncbi A variant of DNA polymerase beta is not cancer specific
    Dawei Bu
    Department of Surgery, UT Southwestern Medical Center, Dallas, Texas 75390 9155, USA
    J Invest Surg 17:327-31. 2004
    ..We conclude that expression of the DNA polymerase beta variant (pol betadelta208-236) is ubiquitous and not breast cancer specific...
  26. doi The American Cancer Society guidelines for breast screening with magnetic resonance imaging: an argument for genetic testing
    Colleen D Murphy
    Department of Surgery, Division of Surgical Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Cancer 113:3116-20. 2008
    ....
  27. ncbi An ecological study of the association of environmental chemicals on breast cancer incidence in Texas
    Yvonne M Coyle
    Department of Internal Medicine, Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9103, USA
    Breast Cancer Res Treat 92:107-14. 2005
    ..To investigate the role of environment in breast cancer development, we conducted an ecological study to examine the association of releases for selected industrial chemicals with breast cancer incidence in Texas...
  28. doi Evaluation of a hydrogel based breast biopsy marker (HydroMARK®) as an alternative to wire and radioactive seed localization for non-palpable breast lesions
    Rebecca L Klein
    Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA
    J Surg Oncol 105:591-4. 2012
    ..Objective was to determine if the marker could be utilized independently for lesion localization using intra-operative ultrasound alone...
  29. ncbi Primary breast tumor characteristics predicting aggressive nodal involvement
    Aye Moe Thu Ma
    Department of Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9155, USA
    Am J Surg 194:474-6. 2007
    ..pN3 breast cancer is historically associated with a poor prognosis, but the biology of aggressive nodal involvement or lymphatotropism is not well understood...
  30. ncbi Aberrant methylation of TMS1 in small cell, non small cell lung cancer and breast cancer
    Arvind Virmani
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Int J Cancer 106:198-204. 2003
    ..Our results suggest that methylation of TMS1 may play a role in the pathogenesis of small cell and non small lung and breast cancers...
  31. ncbi Ductal lavage and the clinical management of women at high risk for breast carcinoma: a commentary
    Joyce A O'Shaughnessy
    Baylor Sammons Cancer Center, Dallas, Texas 75246, USA
    Cancer 94:292-8. 2002
  32. ncbi Adenoviral-mediated gene transfer of interleukin-2 in a human breast cancer cell line and a fresh primary breast cancer culture
    Neal W Wilkinson
    Department of Surgery, Tripler Army Medical Center, Honolulu, Hawaii, USA
    J Invest Surg 16:203-8. 2003
    ..Adenoviral-mediated gene transfer was accomplished in breast cancer cells with high efficiency across a wide range of conditions. The optimal IL-2 dose required to maximally stimulate the immune system remains unknown...
  33. ncbi Outcome of HIV-infected patients with invasive squamous-cell carcinoma of the anal canal in the era of highly active antiretroviral therapy
    Ronney F Stadler
    Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9156, USA
    Dis Colon Rectum 47:1305-9. 2004
    ..This study was designed to determine the outcome in a similar group of patients in the era of highly active antiretroviral therapy...
  34. pmc Paracrine and endocrine effects of adipose tissue on cancer development and progression
    Jiyoung Park
    Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA
    Endocr Rev 32:550-70. 2011
    ..Here, we discuss the role of adipocyte dysfunction associated with obesity and its potential impact on cancer biology...
  35. pmc Characterization of BRCA1 and BRCA2 mutations in a large United States sample
    Sining Chen
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Clin Oncol 24:863-71. 2006
    ..Existing studies have focused on Ashkenazi Jews (AJ) or on families from outside the United States. In this article, we consider the US population using the largest US-based cohort to date of both AJ and non-AJ families...
  36. pmc Validity of models for predicting BRCA1 and BRCA2 mutations
    Giovanni Parmigiani
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland 21205 2011, USA
    Ann Intern Med 147:441-50. 2007
    ..At least 7 models for estimating the probabilities of having a mutation are used widely in clinical and scientific activities; however, the merits and limitations of these models are not fully understood...
  37. ncbi Breast cancer prevention in the 21st century: defining the challenge
    David M Euhus
    Breast J 12:97-8. 2006