Research Topics
Genomes and Genes | David M EuhusSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
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Publications
Managing the breast in patients who test positive for hereditary breast cancerDavid Euhus
Department of Surgery and Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
Ann Surg Oncol 19:1738-44. 2012..Finally, we discuss management decisions for women who test positive and who are diagnosed with a primary breast cancer, compared to women who have no obvious primary tumor but test positive...
Axillary lymph node dissection for breast cancer utilizing Harmonic Focus®Katherine T Ostapoff
Department of Surgery, Division of Surgical Oncology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9155, USA
World J Surg Oncol 9:90. 2011..We hypothesize that ALND performed with the Harmonic Focus® will decrease operative time and reduce post-operative complications...- Identification of 5 novel genes methylated in breast and other epithelial cancersVictoria K Hill
Department of Medical and Molecular Genetics, University of Birmingham, UK
Mol Cancer 9:51. 2010..We utilized one such recently developed approach, MIRA (methylated-CpG island recovery assay) combined with CpG island arrays to identify novel genes that are epigenetically inactivated in breast cancer... - New insights into the prevention and treatment of familial breast cancerDavid M Euhus
UT Southwestern Medical Center at Dallas, Texas 75390 9155, USA
J Surg Oncol 103:294-8. 2011..DNA damaging agents, like cisplatin, and the new class of drugs called PARP inhibitors exploit the underlying defect in DNA damage repair to great effect... - DNA methylation in benign breast epithelium in relation to age and breast cancer riskDavid M Euhus
Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Cancer Epidemiol Biomarkers Prev 17:1051-9. 2008..In proliferative epithelium, such as breast, this may provide an individualized cell-based measure of cancer risk... - Tamoxifen downregulates ets oncogene family members ETV4 and ETV5 in benign breast tissue: implications for durable risk reductionDavid Euhus
Department of Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
Cancer Prev Res (Phila) 4:1852-62. 2011..The human equivalent of murine multipotential progenitor cap cells of terminal end buds may be the primary target... 
Cytokeratin staining and other sentinel node controversiesDavid M Euhus
Division of Surgical Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
Clin Breast Cancer 4:S49-54. 2003..Internal mammary SLN biopsy may have value in patients with tumors < 1 cm, but requires additional evaluation in clinical trials...- Atypia and DNA methylation in nipple duct lavage in relation to predicted breast cancer riskDavid M Euhus
E6 222, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9155, USA
Cancer Epidemiol Biomarkers Prev 16:1812-21. 2007..It is not known whether TSG methylation or atypia in nipple duct lavage (NDL) samples is related to predicted breast cancer risk... - ETV6-NTRK3--Trk-ing the primary event in human secretory breast cancerDavid M Euhus
Department of Surgery, University of Texas, Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Cancer Cell 2:347-8. 2002..Their data highlight the role of Trk signaling in breast cancer and also suggest a target for drug development... - Loss of heterozygosity in benign breast epithelium in relation to breast cancer riskDavid M Euhus
Department of Pathology, University of Texas Southwestern Medical Center at Dallas, 75390 9155, USA
J Natl Cancer Inst 94:858-60. 2002..Accurate individualized breast cancer risk assessment may be possible based on molecular analysis of breast epithelial cells obtained by random FNA... - Pretest prediction of BRCA1 or BRCA2 mutation by risk counselors and the computer model BRCAPRODavid M Euhus
The University of Texas Southwestern Medical Center at Dallas, 75390 9155, USA
J Natl Cancer Inst 94:844-51. 2002..We measured the performance of eight cancer risk counselors and of a computer model, BRCAPRO, at identifying families likely to carry a BRCA gene mutation... - Validating the performance of the mammary sentinel lymph node teamDavid M Euhus
Division of Surgical Oncology, U T Southwestern Medical Center, Dallas, Texas 75390 9155, USA
J Surg Oncol 79:209-15. 2002..Standardized performance measures need to be established in order to optimize the transition to SLN biopsy only... - Limitations of the Gail model in the specialized breast cancer risk assessment clinicDavid M Euhus
The University of Texas Southwestern Center for Breast Care, Dallas, Texas 75390 9155, USA
Breast J 8:23-7. 2002.... 
A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignanciesDavid S Shames
Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
PLoS Med 3:e486. 2006....- Aberrant methylation of the cyclin D2 promoter in primary small cell, nonsmall cell lung and breast cancersArvind Virmani
Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390-8593, USA
Int J Cancer 107:341-5. 2003..Our results confirm earlier reports in breast cancer and indicate that aberrant methylation of cyclin D2 may contribute to the pathogenesis of the 2 major types of lung cancers... - Promoter hypermethylation in benign breast epithelium in relation to predicted breast cancer riskCheryl M Lewis
Hamon Center for Therapeutic Oncology Research, Department of Surgery, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9155, USA
Clin Cancer Res 11:166-72. 2005..Promoter methylation of APC, RARbeta2, and RASSF1A in benign breast epithelium is associated with epidemiologic markers of increased breast cancer risk... - Role of physical activity in modulating breast cancer risk as defined by APC and RASSF1A promoter hypermethylation in nonmalignant breast tissueYvonne M Coyle
Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9103, USA
Cancer Epidemiol Biomarkers Prev 16:192-6. 2007..34-0.94; P = 0.03). The study provides indirect evidence supporting the hypothesis that physical activity is inversely associated with promoter hypermethylation of tumor suppressor genes, such as APC, in nonmalignant breast tissue... - Clinical relevance of reverse transcriptase-polymerase chain reaction for the detection of axillary lymph node metastases in breast cancerMasahiro Sakaguchi
Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Ann Surg Oncol 10:117-25. 2003..03) and 93% for those with no metastases detected by either method (P =.04). CONCLUSIONS: Analysis of sentinel lymph nodes by RT-PCR for epithelial glycoprotein 2 and cytokeratin 19 is unlikely to provide clinically useful information... - Reproducibility of cytologic atypia in repeat nipple duct lavageApril Johnson-Maddux
Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Cancer 103:1129-36. 2005..Lavage atypia may be physiologic or artifactual rather than pathologic in many instances. Marked atypia occasionally may represent mammographically occult ductal carcinoma in situ... - An intronic polymorphism associated with increased XRCC1 expression, reduced apoptosis and familial breast cancerDawei Bu
Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 9155, USA
Breast Cancer Res Treat 99:257-65. 2006..XRCC1 IVS10+141G>A is an intronic polymorphism that is associated with XRCC1 expression, apoptosis and familial breast cancer. It may occur within an intronic regulatory sequence... - RASSF1A polymorphism A133S is associated with early onset breast cancer in BRCA1/2 mutation carriersBoning Gao
Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, TX 75390 8593, USA
Cancer Res 68:22-5. 2008..Our results warrant a large-scale study to examine the effect of the A133S polymorphism in the development of breast and other types of cancers... - Telomerase immortalization of human mammary epithelial cells derived from a BRCA2 mutation carrierCheryl M Lewis
Hamon Center for Therapeutic Oncology Research and Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390-9039, USA
Breast Cancer Res Treat 99:103-15. 2006.... - A variant of DNA polymerase beta is not cancer specificDawei Bu
Department of Surgery, UT Southwestern Medical Center, Dallas, Texas 75390 9155, USA
J Invest Surg 17:327-31. 2004..We conclude that expression of the DNA polymerase beta variant (pol betadelta208-236) is ubiquitous and not breast cancer specific... - An ecological study of the association of environmental chemicals on breast cancer incidence in TexasYvonne M Coyle
Department of Internal Medicine, Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9103, USA
Breast Cancer Res Treat 92:107-14. 2005..To investigate the role of environment in breast cancer development, we conducted an ecological study to examine the association of releases for selected industrial chemicals with breast cancer incidence in Texas... - The American Cancer Society guidelines for breast screening with magnetic resonance imaging: an argument for genetic testingColleen D Murphy
Department of Surgery, Division of Surgical Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA
Cancer 113:3116-20. 2008.... - The clinical consequences of hemizygosity across 2 MB of 10q23 are restricted to Cowden syndromeCheryl M Lewis
Department of Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8548, USA
Breast Cancer Res Treat 136:911-8. 2012..However, because all significant clinical features of the proband and her father are common to patients with genetic alterations in PTEN, the other 22 hemizygous protein-coding genes appear to be haplosufficient... - Evaluation of a hydrogel based breast biopsy marker (HydroMARK®) as an alternative to wire and radioactive seed localization for non-palpable breast lesionsRebecca L Klein
Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA
J Surg Oncol 105:591-4. 2012..Objective was to determine if the marker could be utilized independently for lesion localization using intra-operative ultrasound alone... - Primary breast tumor characteristics predicting aggressive nodal involvementAye Moe Thu Ma
Department of Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9155, USA
Am J Surg 194:474-6. 2007..pN3 breast cancer is historically associated with a poor prognosis, but the biology of aggressive nodal involvement or lymphatotropism is not well understood... - Aberrant methylation of TMS1 in small cell, non small cell lung cancer and breast cancerArvind Virmani
Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX, USA
Int J Cancer 106:198-204. 2003..Our results suggest that methylation of TMS1 may play a role in the pathogenesis of small cell and non small lung and breast cancers... - Ductal lavage and the clinical management of women at high risk for breast carcinoma: a commentaryBritt Marie Ljung
Baylor-Sammons Cancer Center, Dallas, Texas 75246, USA
Cancer 94:292-8. 2002 - Adenoviral-mediated gene transfer of interleukin-2 in a human breast cancer cell line and a fresh primary breast cancer cultureNeal W Wilkinson
Department of Surgery, Tripler Army Medical Center, Honolulu, Hawaii, USA
J Invest Surg 16:203-8. 2003..Adenoviral-mediated gene transfer was accomplished in breast cancer cells with high efficiency across a wide range of conditions. The optimal IL-2 dose required to maximally stimulate the immune system remains unknown... - Paracrine and endocrine effects of adipose tissue on cancer development and progressionJiyoung Park
Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA
Endocr Rev 32:550-70. 2011..Here, we discuss the role of adipocyte dysfunction associated with obesity and its potential impact on cancer biology... - Outcome of HIV-infected patients with invasive squamous-cell carcinoma of the anal canal in the era of highly active antiretroviral therapyRonney F Stadler
Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9156, USA
Dis Colon Rectum 47:1305-9. 2004..If not, highly active antiretroviral therapy should be initiated, and standard multimodality therapies for invasive squamous-cell carcinoma of the anal canal are recommended... - Characterization of BRCA1 and BRCA2 mutations in a large United States sampleSining Chen
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
J Clin Oncol 24:863-71. 2006..Existing studies have focused on Ashkenazi Jews (AJ) or on families from outside the United States. In this article, we consider the US population using the largest US-based cohort to date of both AJ and non-AJ families... - Validity of models for predicting BRCA1 and BRCA2 mutationsGiovanni Parmigiani
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland 21205 2011, USA
Ann Intern Med 147:441-50. 2007..At least 7 models for estimating the probabilities of having a mutation are used widely in clinical and scientific activities; however, the merits and limitations of these models are not fully understood... - Breast cancer prevention in the 21st century: defining the challengeDavid M Euhus
Breast J 12:97-8. 2006