Douglas W Ethell

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Metalloproteinase shedding of Fas ligand regulates beta-amyloid neurotoxicity
    Douglas W Ethell
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Curr Biol 12:1595-600. 2002
  2. ncbi Abeta-specific T-cells reverse cognitive decline and synaptic loss in Alzheimer's mice
    Douglas W Ethell
    Biomedical Sciences, University of California Riverside, 92521 0121, USA
    Neurobiol Dis 23:351-61. 2006
  3. pmc Open-label add-on treatment trial of minocycline in fragile X syndrome
    Carlo Paribello
    Surrey Place Centre, Toronto, Ontario, Canada
    BMC Neurol 10:91. 2010
  4. pmc Differential biologic effects of CPD and 6-4PP UV-induced DNA damage on the induction of apoptosis and cell-cycle arrest
    Hsin Lung Lo
    Division of Biomedical Sciences, University of California Riverside, Riverside, CA 92521, USA
    BMC Cancer 5:135. 2005
  5. ncbi Fas ligand-mediated apoptosis in degenerative disorders of the brain
    Douglas W Ethell
    Division of Biomedical Sciences, University of California Riverside, 900 University Avenue, Riverside, California 92521 0121, USA
    J Clin Immunol 23:363-70. 2003
  6. ncbi Fas ligand-mediated apoptosis in degenerative disorders of the brain
    Douglas W Ethell
    Division of Biomedical Sciences, University of California Riverside, Riverside, California, USA
    J Clin Immunol 23:439-46. 2003
  7. pmc Ephrin-B2-induced cleavage of EphB2 receptor is mediated by matrix metalloproteinases to trigger cell repulsion
    Kai Ti Lin
    Division of Biomedical Sciences, University of California, Riverside, California 92521 0121, USA
    J Biol Chem 283:28969-79. 2008
  8. pmc Matrix metalloproteinase-7 facilitates immune access to the CNS in experimental autoimmune encephalomyelitis
    Lillian A Buhler
    Division of Biomedical Sciences, University of California Riverside, 900 University Avenue, Riverside, CA 92521 0121, USA
    BMC Neurosci 10:17. 2009
  9. ncbi Matrix metalloproteinases in brain development and remodeling: synaptic functions and targets
    Iryna M Ethell
    Division of Biomedical Sciences, University of California Riverside, Riverside, California 92521 0121, USA
    J Neurosci Res 85:2813-23. 2007
  10. doi Maneb potentiates paraquat neurotoxicity by inducing key Bcl-2 family members
    Qingyan Fei
    Division of Biomedical Sciences, University of California Riverside, Riverside, California 92521 0121, USA
    J Neurochem 105:2091-7. 2008

Collaborators

Detail Information

Publications14

  1. ncbi Metalloproteinase shedding of Fas ligand regulates beta-amyloid neurotoxicity
    Douglas W Ethell
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Curr Biol 12:1595-600. 2002
    ..These findings suggest that factors that affect metalloproteinase-mediated shedding of FasL may play a role in the etiology of Alzheimer's disease and may provide an avenue for therapeutic intervention...
  2. ncbi Abeta-specific T-cells reverse cognitive decline and synaptic loss in Alzheimer's mice
    Douglas W Ethell
    Biomedical Sciences, University of California Riverside, 92521 0121, USA
    Neurobiol Dis 23:351-61. 2006
    ....
  3. pmc Open-label add-on treatment trial of minocycline in fragile X syndrome
    Carlo Paribello
    Surrey Place Centre, Toronto, Ontario, Canada
    BMC Neurol 10:91. 2010
    ..This open-label add-on pilot trial was conducted to evaluate safety and efficacy of minocycline in treating behavioural abnormalities that occur in humans with FXS...
  4. pmc Differential biologic effects of CPD and 6-4PP UV-induced DNA damage on the induction of apoptosis and cell-cycle arrest
    Hsin Lung Lo
    Division of Biomedical Sciences, University of California Riverside, Riverside, CA 92521, USA
    BMC Cancer 5:135. 2005
    ..In addition, pTpT, a molecular mimic of CPD was tested in vitro and in vivo for the ability to induce cell death and cell cycle alterations...
  5. ncbi Fas ligand-mediated apoptosis in degenerative disorders of the brain
    Douglas W Ethell
    Division of Biomedical Sciences, University of California Riverside, 900 University Avenue, Riverside, California 92521 0121, USA
    J Clin Immunol 23:363-70. 2003
    ..Here, we discuss how FasL-mediated apoptosis may balance immune cell access to the brain with Alzheimer's disease and MS representing extremes of too little and too much immune access, respectively...
  6. ncbi Fas ligand-mediated apoptosis in degenerative disorders of the brain
    Douglas W Ethell
    Division of Biomedical Sciences, University of California Riverside, Riverside, California, USA
    J Clin Immunol 23:439-46. 2003
    ..Here we discuss how FasL-mediated apoptosis may balance immune cell access to the brain with Alzheimer's disease and MS representing extremes of too little and too much immune access, respectively...
  7. pmc Ephrin-B2-induced cleavage of EphB2 receptor is mediated by matrix metalloproteinases to trigger cell repulsion
    Kai Ti Lin
    Division of Biomedical Sciences, University of California, Riverside, California 92521 0121, USA
    J Biol Chem 283:28969-79. 2008
    ..This study provides the first evidence that MMP-mediated cleavage of EphB2 is induced by receptor-ligand interactions at the cell surface and that this event triggers cell-repulsive responses...
  8. pmc Matrix metalloproteinase-7 facilitates immune access to the CNS in experimental autoimmune encephalomyelitis
    Lillian A Buhler
    Division of Biomedical Sciences, University of California Riverside, 900 University Avenue, Riverside, CA 92521 0121, USA
    BMC Neurosci 10:17. 2009
    ....
  9. ncbi Matrix metalloproteinases in brain development and remodeling: synaptic functions and targets
    Iryna M Ethell
    Division of Biomedical Sciences, University of California Riverside, Riverside, California 92521 0121, USA
    J Neurosci Res 85:2813-23. 2007
    ..Finally, we discuss how the development of therapeutics to attenuate MMP activity in neurodegenerative disorders may become powerful tools for future studies of synaptic formation and function within the developing and mature brain...
  10. doi Maneb potentiates paraquat neurotoxicity by inducing key Bcl-2 family members
    Qingyan Fei
    Division of Biomedical Sciences, University of California Riverside, Riverside, California 92521 0121, USA
    J Neurochem 105:2091-7. 2008
    ..Those responses favor Bax-dependent MOMP and apoptosis. SiRNA knockdown of Bax and Bak confirmed that individually PQ and maneb induce Bak-dependent cell death, but together they block the Bak pathway and activate apoptosis through Bax...
  11. pmc Matrix metalloproteinase-7 disrupts dendritic spines in hippocampal neurons through NMDA receptor activation
    Tina V Bilousova
    Division of Biomedical Sciences, University of California Riverside, California 92521 0121, USA
    J Neurochem 97:44-56. 2006
    ..These findings are the first direct evidence that MMPs can influence the morphology of mature dendritic spines, and hence synaptic stability...
  12. doi An amyloid-notch hypothesis for Alzheimer's disease
    Douglas W Ethell
    Division of Biomedical Sciences Neuroscience, University of California Riverside, Riverside, CA, USA
    Neuroscientist 16:614-7. 2010
    ..This revised amyloid-Notch hypothesis may also explain the disappointing results of recent clinical trials with γ-secretase inhibitors...
  13. doi Parkinson-linked genes and toxins that affect neuronal cell death through the Bcl-2 family
    Douglas W Ethell
    Division of Biomedical Sciences, University of California Riverside, Riverside, California 92521 0121, USA
    Antioxid Redox Signal 11:529-40. 2009
    ..Here we describe how related cell death mechanisms are involved in the pathophysiology of Parkinson's disease...
  14. doi Developing postmitotic mammalian neurons in vivo lacking Apaf-1 undergo programmed cell death by a caspase-independent, nonapoptotic pathway involving autophagy
    Ronald W Oppenheim
    Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Neurosci 28:1490-7. 2008
    ..e., caspases and Apaf-1) are perturbed in vivo, developing postmitotic neurons nonetheless undergo quantitatively normal PCD by a caspase-independent pathway involving autophagy and not requiring AIF...