C R Esther

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. doi request reprint Airway drug pharmacokinetics via analysis of exhaled breath condensate
    Charles R Esther
    Pediatric Pulmonology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA Electronic address
    Pulm Pharmacol Ther 27:76-82. 2014
  2. pmc Exhaled breath condensate adenosine tracks lung function changes in cystic fibrosis
    Charles R Esther
    Pediatric Pulmonology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Am J Physiol Lung Cell Mol Physiol 304:L504-9. 2013
  3. pmc Airway purinergic responses in healthy, atopic nonasthmatic, and atopic asthmatic subjects exposed to ozone
    Charles R Esther
    Pediatric Pulmonology, University of North Carolina at Chapel Hill, 27517, USA
    Inhal Toxicol 23:324-30. 2011
  4. doi request reprint Regulation of airway nucleotides in chronic lung diseases
    Charles R Esther
    Pediatric Pulmonology, University of North Carolina, Chapel Hill, NC, 27599, USA
    Subcell Biochem 55:75-93. 2011
  5. pmc Elevated airway purines in COPD
    Charles R Esther
    Department of Pediatric Pulmonology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Chest 140:954-60. 2011
  6. pmc Chronic Mycobacterium abscessus infection and lung function decline in cystic fibrosis
    Charles R Esther
    Statistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cyst Fibros 9:117-23. 2010
  7. ncbi request reprint Pulmonary lymphangiectasia: diagnosis and clinical course
    Charles R Esther
    Division of Pediatric Pulmonology, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Pediatr Pulmonol 38:308-13. 2004
  8. pmc Mass spectrometric analysis of biomarkers and dilution markers in exhaled breath condensate reveals elevated purines in asthma and cystic fibrosis
    Charles R Esther
    Division of Pediatric Pulmonology, Chapel Hill, North Carolina, USA
    Am J Physiol Lung Cell Mol Physiol 296:L987-93. 2009
  9. pmc A mass spectrometric method to simultaneously measure a biomarker and dilution marker in exhaled breath condensate
    Charles R Esther
    Division of Pediatric Pulmonology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27517, USA
    Rapid Commun Mass Spectrom 22:701-5. 2008
  10. ncbi request reprint Nontuberculous mycobacterial infection in young children with cystic fibrosis
    Charles R Esther
    Division of Pediatric Pulmonology, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7220, USA
    Pediatr Pulmonol 40:39-44. 2005

Detail Information

Publications19

  1. doi request reprint Airway drug pharmacokinetics via analysis of exhaled breath condensate
    Charles R Esther
    Pediatric Pulmonology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA Electronic address
    Pulm Pharmacol Ther 27:76-82. 2014
    ..Application of this methodology could provide an important tool in development and testing of drugs for airways diseases. ..
  2. pmc Exhaled breath condensate adenosine tracks lung function changes in cystic fibrosis
    Charles R Esther
    Pediatric Pulmonology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Am J Physiol Lung Cell Mol Physiol 304:L504-9. 2013
    ..EBC was readily collected in a clinic setting from a wide range of subjects. EBC Ado tracked longitudinal changes in lung function in CF, with results similar to or better than established measures...
  3. pmc Airway purinergic responses in healthy, atopic nonasthmatic, and atopic asthmatic subjects exposed to ozone
    Charles R Esther
    Pediatric Pulmonology, University of North Carolina at Chapel Hill, 27517, USA
    Inhal Toxicol 23:324-30. 2011
    ..Ozone exposure triggers airway inflammatory responses that may be influenced by biologically active purine metabolites...
  4. doi request reprint Regulation of airway nucleotides in chronic lung diseases
    Charles R Esther
    Pediatric Pulmonology, University of North Carolina, Chapel Hill, NC, 27599, USA
    Subcell Biochem 55:75-93. 2011
    ..This chapter exposes the extensive rearrangement of the enzymatic network taking place in diseased airways, and identifies signaling pathways likely involved in the aberrant regulation of the airway purines...
  5. pmc Elevated airway purines in COPD
    Charles R Esther
    Department of Pediatric Pulmonology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Chest 140:954-60. 2011
    ..However, accurate airway surface purine measurements can be confounded by stimulation of purine release during collection of typical respiratory samples...
  6. pmc Chronic Mycobacterium abscessus infection and lung function decline in cystic fibrosis
    Charles R Esther
    Statistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cyst Fibros 9:117-23. 2010
    ..Although nontuberculous mycobacteria (NTM) are recognized pathogens in cystic fibrosis (CF), associations with clinical outcomes remain unclear...
  7. ncbi request reprint Pulmonary lymphangiectasia: diagnosis and clinical course
    Charles R Esther
    Division of Pediatric Pulmonology, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Pediatr Pulmonol 38:308-13. 2004
    ..In this report, we describe the etiology, clinical presentation, diagnosis, management, and outcome of PL. A revised classification of PL is proposed, based on the current state of knowledge of its etiology and presentation...
  8. pmc Mass spectrometric analysis of biomarkers and dilution markers in exhaled breath condensate reveals elevated purines in asthma and cystic fibrosis
    Charles R Esther
    Division of Pediatric Pulmonology, Chapel Hill, North Carolina, USA
    Am J Physiol Lung Cell Mol Physiol 296:L987-93. 2009
    ..These results show that mass spectrometric analyses can be applied to measurement of purines in EBC and demonstrate that EBC adenosine-to-urea and AMP-to-urea ratios are potential noninvasive biomarkers of airways disease...
  9. pmc A mass spectrometric method to simultaneously measure a biomarker and dilution marker in exhaled breath condensate
    Charles R Esther
    Division of Pediatric Pulmonology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27517, USA
    Rapid Commun Mass Spectrom 22:701-5. 2008
    ..These results demonstrate that mass spectrometry can be used successfully in EBC analysis to simultaneously detect a biomarker for airway inflammation and control for variable dilution...
  10. ncbi request reprint Nontuberculous mycobacterial infection in young children with cystic fibrosis
    Charles R Esther
    Division of Pediatric Pulmonology, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7220, USA
    Pediatr Pulmonol 40:39-44. 2005
    ..These data suggest that NTM represent a clinically significant pathogen, even in young patients with cystic fibrosis...
  11. pmc Similarities between UDP-glucose and adenine nucleotide release in yeast: involvement of the secretory pathway
    Charles R Esther
    Division of Pediatric Pulmonology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Biochemistry 47:9269-78. 2008
    ..These studies demonstrate the involvement of the secretory pathway in nucleotide and nucleotide sugar efflux in yeast and offer a powerful model system for further investigation...
  12. pmc Extracellular purines are biomarkers of neutrophilic airway inflammation
    C R Esther
    Pediatric Pulmonology, 5 Floor Bioinformatics, CB 7220, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7220, USA
    Eur Respir J 31:949-56. 2008
    ..Measurement of purines in sputum or exhaled breath condensate may provide a relatively simple and noninvasive method to track this inflammation...
  13. doi request reprint Nucleotide release by airway epithelia
    Eduardo R Lazarowski
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, 7011 Thurston Bowles Building, Chapel Hill, NC, 27599, USA
    Subcell Biochem 55:1-15. 2011
    ..Together, these pathways provide fine tuning of epithelial responses regulated by purinergic signaling events...
  14. pmc Neutrophilic inflammation is associated with altered airway hydration in stable asthmatics
    Ceila E Loughlin
    Department of Pediatrics, Division of Pediatric Pulmonology, The School of Medicine, University of North Carolina, 130 Mason Farm Road, 5th floor Bioinformatics Bldg, CB 7217, Chapel Hill, NC 27599 7217, USA
    Respir Med 104:29-33. 2010
    ..Using sputum percent solids, as an indicator of airway hydration, we sought relationships between airway hydration and other known markers of neutrophilic (TH1) and allergic (TH2) inflammation in stable asthma...
  15. pmc Detection of rapidly growing mycobacteria in routine cultures of samples from patients with cystic fibrosis
    Charles R Esther
    Pediatric Pulmonology, CB 7217, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Clin Microbiol 49:1421-5. 2011
    ..However, this method should be used cautiously in patients with certain coinfections...
  16. ncbi request reprint Primary pulmonary lymphangiectasia in infancy and childhood
    P M Barker
    Division of Paediatric Pulmonology, Dept of Paediatrics, 200 Mason Farm Road, CB 7220, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA
    Eur Respir J 24:413-9. 2004
    ..In conclusion, these results suggest that primary pulmonary lymphangiectasia does not have as dismal a prognosis as previously described and symptoms and clinical findings improve after the first year of life...
  17. pmc Endoplasmic reticulum/golgi nucleotide sugar transporters contribute to the cellular release of UDP-sugar signaling molecules
    Juliana I Sesma
    Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7248, USA
    J Biol Chem 284:12572-83. 2009
    ..Our results illustrate that ER/Golgi lumen constitutes a significant source of extracellular UDP-sugars and therefore plays a critical role in nucleotide sugar-promoted cell signaling...
  18. pmc Atopic asthmatic subjects but not atopic subjects without asthma have enhanced inflammatory response to ozone
    Michelle L Hernandez
    Center for Environmental Medicine Asthma and Lung Biology, University of North Carolina School of Medicine, University of North Carolina at Chapel Hill, NC 27599 7310, USA
    J Allergy Clin Immunol 126:537-44.e1. 2010
    ..Ozone causes an immediate decrease in lung function and increased airway inflammation. The role of atopy and asthma in modulation of ozone-induced inflammation has not been determined...
  19. pmc Metabolomic analysis of bronchoalveolar lavage fluid from cystic fibrosis patients
    Justyna E Wolak
    Departments of Biomedical Engineering, University of North Carolina, Chapel Hill, NC, USA
    Biomarkers 14:55-60. 2009
    ....