Research Topics
| D Mark EstesSummaryAffiliation: University of Texas Medical Branch Country: USA Publications
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Regulation of IgA responses in cattle, humans and miceD Mark Estes
University of Texas Medical Branch, Department of Pathology and Microbiology and Immunology, Sealy Center for Vaccine Development and Center for Biodefense and Emerging Infectious Diseases, 6 200T Galveston National Laboratory, 301 University Boulevard, Galveston, TX 77555 0610, USA
Vet Immunol Immunopathol 138:312-7. 2010..The factor is regulated differently in various species but is consistently produced by dendritic cells...
Present and future therapeutic strategies for melioidosis and glandersD Mark Estes
Department of Microbiology and Immunology, Department of Pathology and The Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX 77555 1070, USA
Expert Rev Anti Infect Ther 8:325-38. 2010..This review provides a compilation of literature covering studies in antimelioidosis and antiglanders antimicrobial drug discovery, with a particular focus on potential novel therapeutic approaches to combat these diseases...- Prophylactic application of CpG oligonucleotides augments the early host response and confers protection in acute melioidosisBarbara M Judy
Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America
PLoS ONE 7:e34176. 2012..In contrast, a delay in recruitment of inflammatory cell populations, despite a robust production of pro-inflammatory cytokines, was associated with poorly controlled bacterial growth, severe lung pathology, and death of control animals... - Comparison of the in vitro and in vivo susceptibilities of Burkholderia mallei to Ceftazidime and LevofloxacinBarbara M Judy
Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas, USA
BMC Microbiol 9:88. 2009..The effect of two antibiotics with different modes of action on Burkholderia mallei strain ATCC23344 was investigated by using in vitro and in vivo studies... - Host immunity in the protective response to vaccination with heat-killed Burkholderia malleiGregory C Whitlock
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA
BMC Immunol 9:55. 2008..We performed initial cell, cytokine and complement depletion studies to investigate the possible role of these effectors in response to vaccination with heat-killed Burkholderia mallei in a susceptible BALB/c mouse model of infection... - The calf model of immunity for development of a vaccine against tuberculosisJanice J Endsley
University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, United States
Vet Immunol Immunopathol 128:199-204. 2009..The findings indicated more numerous and severe lesions in the lung in addition to higher levels of IFN-gamma producing cells. BCG vaccinates demonstrated higher levels of FoxP3 transcripts and lower levels of IL-4 mRNA... - Construction of a reporter system to study Burkholderia mallei type III secretion and identification of the BopA effector protein function in intracellular survivalGregory C Whitlock
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA
Trans R Soc Trop Med Hyg 102:S127-33. 2008..mallei invasion and intracellular survival. Overall, our study elucidates how BopA can aid in the optimization of TTS and defines the function of TTS effectors in bacterial intracellular survival and invasion... - Burkholderia mallei cellular interactions in a respiratory cell modelGregory C Whitlock
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555 1070, USA
J Med Microbiol 58:554-62. 2009..Overall, these data suggest that B. mallei induces apoptotic cell death, whilst the BopA effector protein participates in intracellular survival... - Production of IL-8, IL-17, IFN-gamma and IP-10 in human astrocytes correlates with alphavirus attenuationBi Hung Peng
Department of Pathology Institute for Human Infections and Immunity, Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
Vet Microbiol 163:223-34. 2013..This growth factor and cytokine profile modeled by astrocytes in vitro may contribute to both neuroprotection and repair and may play a role in leukocyte recruitment in vivo... - Human IgA-inducing protein from dendritic cells induces IgA production by naive IgD+ B cellsMark A Endsley
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA
J Immunol 182:1854-9. 2009..Finally, we demonstrate that IGIP stimulation drives the production of mu-alpha switch circles from IgM(+)IgD(+) naive human B cells, indicating its role as an IgA switch factor... - Natural killer cell mediated pathogenesis determines outcome of central nervous system infection with Venezuelan equine encephalitis virus in C3H/HeN miceKatherine Taylor
Sealy Center for Vaccine Development, Galveston National Lab, Department of Pathology, University of Texas Medical Branch, Galveston, TX 77550, USA
Vaccine 30:4095-105. 2012..Our analysis indicated the potential importance of natural killer cells in the encephalitic disease development. This paper describes for the first time a pathogenic role for natural killer cells in VEEV encephalitis... - Sero-characterization of lipopolysaccharide from Burkholderia thailandensisOmar Qazi
Department of Pediatrics and the Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX 77555, USA
Trans R Soc Trop Med Hyg 102:S58-60. 2008..thailandensis LPS shares similar structural features with LPS molecules from highly pathogenic Burkholderia species. This information may prove useful in ongoing efforts to develop novel vaccines and/or diagnostic reagents... - Protective antigens against glanders identified by expression library immunizationGregory C Whitlock
Department of Microbiology and Immunology, University of Texas Medical Branch Galveston, TX, USA
Front Microbiol 2:227. 2011..We suggest that these pathogen components, discovered using genetic immunization and confirmed in a conventional protein format, will be useful toward the development of a safe and effective glanders vaccine... - Alpha-beta T cells provide protection against lethal encephalitis in the murine model of VEEV infectionSlobodan Paessler
Center for Biodefense and Emerging Infectious Diseases, Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
Virology 367:307-23. 2007..Prolonged replication of encephalitic VEEV in the brain of pre-immunized mice is not lethal and adoptive transfer experiments indicate that CD3(+) T cells are required for protection... 
Estrogenic regulation of host immunity against an estrogen receptor-negative human breast cancerEdward M Curran
Department of Pediatrics, Sealy Center for Vaccine Development, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA
Clin Cancer Res 12:5641-7. 2006..In part, this is due to a lack of suitable models for studying this relationship...- Estrogen receptor-alpha deficiency promotes increased TNF-alpha secretion and bacterial killing by murine macrophages in response to microbial stimuli in vitroK Chad Lambert
Department of Pediatrics, 2 212 Children s Hospital, Galveston, TX 77554, USA
J Leukoc Biol 75:1166-72. 2004..In contrast, ERbeta-deficient PM possessed no significant difference in TNF-alpha secretion or in bacterial load when compared with WT littermates. These studies suggest that ERalpha, but not ERbeta, modulates murine PM function... - Bovine natural killer cells acquire cytotoxic/effector activity following activation with IL-12/15 and reduce Mycobacterium bovis BCG in infected macrophagesJanice J Endsley
Department of Pediatrics, Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX 77555, USA
J Leukoc Biol 79:71-9. 2006..These NK cell receptors bearing T lymphocytes may represent memory subsets characterized in humans. The results of these studies demonstrate that bovine NK cells may play an important role in the innate immune responses of cattle... - In vivo Bioluminescence Imaging of Burkholderia mallei Respiratory Infection and Treatment in the Mouse ModelShane Massey
Department of Microbiology and Immunology, University of Texas Medical Branch Galveston, TX, USA
Front Microbiol 2:174. 2011..Finally, we report an alternative method to mini-Tn5::luxKm2 transposon using mini-Tn7-lux elements that insert site-specifically at known genomic attachment sites and that can also be used to tag bacteria... - Comparative antimicrobial activity of granulysin against bacterial biothreat agentsJanice J Endsley
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555 0436, USA
Open Microbiol J 3:92-6. 2009..Investigations of the microbial surface molecules that determine susceptibility to granulysin may identify important mechanisms that contribute to pathogenesis... - Glanders: off to the races with Burkholderia malleiGregory C Whitlock
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555 1070, USA
FEMS Microbiol Lett 277:115-22. 2007..Therefore, this minireview will focus on current efforts to elucidate B. mallei virulence, the associated host immune responses elicited during infection and discuss the feasibility of vaccine development... - Environmental estrogens induce mast cell degranulation and enhance IgE-mediated release of allergic mediatorsShin ichiro Narita
Department of Pediatrics, Child Health Research Center, University of Texas Medical Branch, Galveston, Texas 77555 0366, USA
Environ Health Perspect 115:48-52. 2007..These pollutants tend to degrade slowly in the environment and to bioaccumulate and bioconcentrate in the food chain; they also have long biological half-lives... - Early production of type I interferon during West Nile virus infection: role for lymphoid tissues in IRF3-independent interferon productionNigel Bourne
Department of Pediatrics, University of Texas Medical Branch, Galveston, TX 77555 0436, USA
J Virol 81:9100-8. 2007.... - Mycobacterium bovis BCG vaccination induces memory CD4+ T cells characterized by effector biomarker expression and anti-mycobacterial activityJanice J Endsley
Department of Pediatrics and Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX 77555, United States
Vaccine 25:8384-94. 2007.... - CD4+ T cells provide protection against acute lethal encephalitis caused by Venezuelan equine encephalitis virusNadezhda E Yun
Department of Pathology, Galveston National Laboratory and Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555 0609, United States
Vaccine 27:4064-73. 2009..On the contrary, the adoptive transfer of primed CD4(+) T cells was necessary to prevent lethal encephalitis in mice lacking alphabeta T cell receptor... - Genetic deficiency of estrogen receptor alpha fails to influence experimental autoimmune myasthenia gravis pathogenesisHuibin Qi
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA
J Neuroimmunol 234:165-7. 2011..ERα KO mice were equally susceptible to EAMG as WT mice and exhibited comparable antibody and immunopathological responses to AChR, suggesting a lack of involvement of ERα in EAMG pathogenesis... - Characterization of bovine homologues of granulysin and NK-lysinJanice J Endsley
Department of Pediatrics and Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX 77555, USA
J Immunol 173:2607-14. 2004..The identification of a biologically active bovine homologue to granulysin demonstrates the potential of the bovine model in characterizing the role of granulysin in the immune response to a variety of infectious agents... - Estradiol activates mast cells via a non-genomic estrogen receptor-alpha and calcium influxMasafumi Zaitsu
Department of Pediatrics, Child Health Research Center, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 0366, USA
Mol Immunol 44:1977-85. 2007..A relationship between female hormones and asthma prevalence and severity has been suggested, but the cellular and molecular mechanisms are not understood... - Potential of ancestral sylvatic dengue-2 viruses to re-emergeNikos Vasilakis
Center for Biodefense and Emerging Infectious Diseases and Department of Pathology, University of Texas Medical Branch, Keiller Bldg, Rm 3 135, 301 University Boulevard, Galveston, TX 77555 0609, USA
Virology 358:402-12. 2007..The shared replication profiles of the American endemic and sylvatic strains suggest that American strains have maintained or regained the ancestral phenotype... - Estrogen increases menopausal host susceptibility to experimental ascending urinary-tract infectionEdward M Curran
Department of Pediatrics, University of Texas Medical Branch, Galveston, TX, USA
J Infect Dis 195:680-3. 2007..001) in the estrogen-treated group. Surprisingly, despite the hypothesis that estrogen would protect mice from infection, estrogen treatment significantly increased the susceptibility of the mice to ascending UTI... - Analysis of immune responses directed toward a recombinant early secretory antigenic target six-kilodalton protein-culture filtrate protein 10 fusion protein in Mycobacterium bovis-infected cattleAlexander C Maue
Department of Molecular Microbiology and Immunology, University of Missouri, Columbia, 65211, USA
Infect Immun 73:6659-67. 2005..Collectively, data indicate that recall immune responses directed toward the rESAT-6-CFP10 fusion protein or purified protein derivative are comparable and that recall to mycobacterial antigens correlates with a CD45RO(+) phenotype... - CD80 and CD86, but not CD154, augment DNA vaccine-induced protection in experimental bovine tuberculosisAlexander C Maue
Department of Molecular Microbiology and Immunology, University of Missouri, Columbia, MO 65211, USA
Vaccine 23:769-79. 2004.... - Failure of a Mycobacterium tuberculosis DeltaRD1 DeltapanCD double deletion mutant in a neonatal calf aerosol M. bovis challenge model: comparisons to responses elicited by M. bovis bacille Calmette GuerinW Ray Waters
National Animal Disease Center, Agricultural Research Service, US Department of Agriculture, 2300 Dayton Avenue, Ames, IA 50010, USA
Vaccine 25:7832-40. 2007..The calf sensitization and challenge model provides an informative screen for candidate tuberculosis vaccines before their evaluation in costly non-human, primates... - Peripheral blood-derived bovine dendritic cells promote IgG1-restricted B cell responses in vitroAnna A Bajer
Department of Veterinary Pathobiology, Program for Prevention of Animal Infectious Diseases, University of Missouri, Columbia, MO 65211, USA
J Leukoc Biol 73:100-6. 2003..Collectively, these results suggest that direct B cell-DC interactions may promote an immunoglobulin-isotype expression pattern consistent with type 2 responses, independent of direct T cell involvement... - An ESAT-6:CFP10 DNA vaccine administered in conjunction with Mycobacterium bovis BCG confers protection to cattle challenged with virulent M. bovisAlexander C Maue
Department of Molecular Microbiology and Immunology, University of Missouri, Columbia, MO 65211, USA
Vaccine 25:4735-46. 2007..These data suggest that a combined vaccine regimen of M. bovis BCG and a candidate ESAT-6:CFP10 DNA vaccine may offer greater protection against tuberculosis in cattle than vaccination with BCG alone... - Estrogen receptor alpha (ERalpha) deficiency in macrophages results in increased stimulation of CD4+ T cells while 17beta-estradiol acts through ERalpha to increase IL-4 and GATA-3 expression in CD4+ T cells independent of antigen presentationK Chad Lambert
Department of Molecular Microbiology and Immunology, University of Missouri, Columbia, MO 65211, USA
J Immunol 175:5716-23. 2005..However, the addition of E2 significantly increased IL-4 secretion, as well as increased GATA-3 mRNA levels from ERalpha-replete CD4+ T cells, while this effect was abrogated in ERalpha-deficient CD4+ T cells... - Evaluation of shedding of bovine herpesvirus 1, bovine viral diarrhea virus 1, and bovine viral diarrhea virus 2 after vaccination of calves with a multivalent modified-live virus vaccineSteven B Kleiboeker
Department of Veterinary Pathobiology and the Veterinary Medical Diagnostic Laboratory, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USA
J Am Vet Med Assoc 222:1399-403. 2003..CONCLUSIONS AND CLINICAL RELEVANCE: Shedding of BHV1, BVDV1, and BVDV2 after vaccination was either nonexistent or undetected and did not result in transmission of BHV1, BVDV1, or BVDV2 vaccine viruses to pregnant contact control cows... - Identification and characterization of a novel regulatory factor: IgA-inducing proteinAmy S Austin
Departments of Molecular Microbiology and Immunology, University of Missouri, Columbia, MO 65211, USA
J Immunol 171:1336-42. 2003..Our data suggest that IgA-inducing protein regulates IgA by acting as a switch or differentiation factor and is expressed in a variety of lymphoid and nonlymphoid tissues... - Effects of supplemental lactoferrin on serum lactoferrin and IgG concentrations and neutrophil oxidative metabolism in Holstein calvesMaisie E Dawes
Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA
J Vet Intern Med 18:104-8. 2004..Oral LF is absorbed in calves but does not alter PMN superoxide production and does not alter IgG absorption... - Vesicular stomatitis New Jersey virus (VSNJV) infects keratinocytes and is restricted to lesion sites and local lymph nodes in the bovine, a natural hostCharles F C Scherer
Plum Island Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, PO Box 848, Greenport, NY 11944, USA
Vet Res 38:375-90. 2007..The pathogenesis model shown herein could be useful for in-vivo tracking of virus infection and local immune responses... - Comparison of the response of primary human blood monocytes and the U937 human monocytic cell line to two different sizes of alumina ceramic particlesEfrat Yagil-Kelmer
Department of Veterinary Pathobiology, University of Missouri, 1600 East Rollins Road, Columbia, MO 65211, USA
J Orthop Res 22:832-8. 2004..Implant materials of this type may induce relatively lower levels of production of inflammatory cytokines resulting in a reduced incidence of failure due to aseptic loosening... - Type 1 and type 2 responses in regulation of Ig isotype expression in cattleD Mark Estes
Program for the Prevention of Animal Infectious Diseases, Department of Veterinary Pathobiology, University of Missouri, Columbia, MO 65211, USA
Vet Immunol Immunopathol 90:1-10. 2002..Based on studies to date, several "holes" in the cytokine repertoire exist and these roles may be assumed by unique factors or activities of other known cytokines...
Research Grants
- IgA inducing peptideD Estes; Fiscal Year: 2005..In addition, the proposed studies will begin to examine determine the potential relationship between IGIP and clinical abnormality in IgA production. ..