Research Topics
| Adrien A EshraghiSummaryAffiliation: University of Miami Country: USA Publications
| Collaborators
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Detail Information
Publications
Dexamethasone base conserves hearing from electrode trauma-induced hearing lossRichard J Vivero
Cochlear Implant Research Program, University of Miami Ear Institute, Department of Otolaryngology, University of Miami, Miller School of Medicine, Miami, Florida 33136 1015, USA
Laryngoscope 118:2028-35. 2008..Local treatment of the cochlea after electrode insertion trauma with dexamethasone base conserves hearing against trauma-induced loss...- The cochlear implant: historical aspects and future prospectsAdrien A Eshraghi
Department of Otolaryngology, University of Miami Ear Institute, University of Miami Miller School of Medicine, Miami, Florida
Anat Rec (Hoboken) 295:1967-80. 2012..Anat Rec, 2012. © 2012 Wiley Periodicals, Inc... - Biomedical engineering principles of modern cochlear implants and recent surgical innovationsAdrien A Eshraghi
Department of Otolaryngology, University of Miami Miller School of Medicine, University of Miami Ear Institute, Miami, Florida
Anat Rec (Hoboken) 295:1957-66. 2012..Anat Rec, 2012. © 2012 Wiley Periodicals, Inc... - Cochlear implant surgery in patients more than seventy-nine years oldAdrien A Eshraghi
Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
Laryngoscope 119:1180-3. 2009..To evaluate the surgical complications, auditory performance, and hearing handicap following cochlear implantation in patients greater than 79 years of age... 
Prevention of cochlear implant electrode damageAdrien A Eshraghi
University of Miami Ear Institute, Department of Otolaryngology, University of Miami, Miller School of Medicine, Miami, Florida 33136, USA
Curr Opin Otolaryngol Head Neck Surg 14:323-8. 2006..This article summarizes current research endeavors to prevent electrode insertion trauma and resulting hearing loss...- [Hearing loss in adults]Adrien A Eshraghi
University of Miami Miller School of Medicine, Miami, FL, USA
Rev Prat 59:645-52. 2009..Antioxidant molecules, molecules against apoptosis are at this time the most promising molecules than need further investigations... - Changes in programming over time in postmeningitis cochlear implant usersAdrien A Eshraghi
University of Miami School of Medicine, Department of Otolaryngology, University of Miami Eear Institute, Florida, USA
Otolaryngol Head Neck Surg 131:885-9. 2004..This study evaluated changes in programming for patients deafened by bacterial meningitis and stability of auditory performance over time... - Mechanisms of hearing loss from trauma and inflammation: otoprotective therapies from the laboratory to the clinicThomas R Van De Water
Cochlear Implant Research Program, University of Miami Ear Institute, Department of Otolaryngology, University of Miami, Miller School of Medicine, Miami, FL 33136 1015, USA
Acta Otolaryngol 130:308-11. 2010..Locally delivered dexamethasone is a promising therapeutic approach for the conservation of hearing during the process of cochlear implantation... - D-JNKI-1 treatment prevents the progression of hearing loss in a model of cochlear implantation traumaAdrien A Eshraghi
Department of Otolaryngology, University of Miami Ear Institute, Miami, Florida 33136-1015, USA
Otol Neurotol 27:504-11. 2006..CONCLUSION: Hearing loss caused by cochlear implant electrode insertion trauma in guinea pigs has both acute and delayed components. The delayed component can be prevented by treating the cochlea with D-JNKI-1... - Pattern of hearing loss in a rat model of cochlear implantation traumaAdrien A Eshraghi
Department of Otolaryngology, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, USA
Otol Neurotol 26:442-7; discussion 447. 2005..CONCLUSION: These results document a progressive loss of hearing acuity postimplantation and strongly suggest that electrode insertion trauma generated oxidative stress within injured cochlear tissues... - Conservation of hearing and protection of auditory hair cells against trauma-induced losses by local dexamethasone therapy: molecular and genetic mechanismsThomas R Van De Water
Cochlear Implant Research Program, University of Miami Ear Institute, Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL 33136 1015, USA
Cochlear Implants Int 11:42-55. 2010..Dexamethasone (DXM) protects hearing against trauma-induced loss... - Conservation of residual acoustic hearing after cochlear implantationThomas J Balkany
Department of Otolaryngology, University of Miami Ear Institute, Miller School of Medicine, Miami, Florida 33101, USA
Otol Neurotol 27:1083-8. 2006..Surgical strategies for hearing conservation during cochlear implantation are described... - Local dexamethasone therapy conserves hearing in an animal model of electrode insertion trauma-induced hearing lossAdrien A Eshraghi
Cochlear Implant Research Program, University of Miami Ear Institute, Department of Otolaryngology, Miller School of Medicine, University of Miami, Miami, FL, USA
Otol Neurotol 28:842-9. 2007..The progressive loss of hearing that develops after electrode insertion trauma (EIT) can be attenuated by local dexamethasone (DXM) therapy... - Biopolymer-released dexamethasone prevents tumor necrosis factor alpha-induced loss of auditory hair cells in vitro: implications toward the development of a drug-eluting cochlear implant electrode arrayChristine Dinh
Cochlear Implant Research Program, University of Miami Ear Institute, Department of Otolaryngology, University of Miami, Miller School of Medicine, Miami, Florida, USA
Otol Neurotol 29:1012-9. 2008..Polymer-eluted dexamethasone (DXM) will retain its ability to protect against tumor necrosis factor alpha (TNFalpha)-induced hair cell (HC) loss... - Dexamethasone treatment of naïve organ of Corti explants alters the expression pattern of apoptosis-related genesKimberly N Hoang
University of Miami Ear Institute, Department of Otolaryngology, University of Miami, FL 33136 1015, USA
Brain Res 1301:1-8. 2009..It is not known if naïve organ of Corti explants will respond in a similar manner to treatment with a corticosteroid. This study examines the response of naïve organ of Corti explants to treatment with dexamethasone... - Blocking c-Jun-N-terminal kinase signaling can prevent hearing loss induced by both electrode insertion trauma and neomycin ototoxicityAdrien A Eshraghi
Cochlear Implant Research Program, University of Miami Ear Institute, Department of Otolaryngology, University of Miami Miller School of Medicine, 1600 NW 10th Avenue, RMSB 3160, Miami, FL 33136 1015, USA
Hear Res 226:168-77. 2007..This unique therapeutic approach may have clinical application for preventing: (1) hearing loss caused by neomycin ototoxicity; and (2) the progressive component of electrode insertion trauma-induced hearing loss... - The temporalis pocket technique for cochlear implantation: an anatomic and clinical studyThomas J Balkany
University of Miami Ear Institute Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, USA
Otol Neurotol 30:903-7. 2009..Newer R/S designs feature a low profile and larger, rigid flat bottoms in which drilling a seat may be less appropriate. We report a technique for securing the R/S without drilling bone... - Cochlear temperature correlates with both temporalis muscle and rectal temperatures. Application for testing the otoprotective effect of hypothermiaAdrien A Eshraghi
Department of Otolaryngology, University of Miami, Miami, Florida 33136, USA
Acta Otolaryngol 125:922-8. 2005..RESULTS: The strongest correlations with the internal temperature of the cochlea during the induction of mild-to-moderate hypothermia were obtained for the temperatures of the ipsilateral temporalis muscle and rectum... - Mild hypothermia protects auditory function during cochlear implant surgeryThomas J Balkany
Department of Otolaryngology, University Ear Institute, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA
Laryngoscope 115:1543-7. 2005..However, the hypothermia group had significantly less functional loss in the immediate stage and no significant loss in the progressive stage. CONCLUSION: Mild hypothermia protects auditory function during CI electrode insertion... - Triamcinolone acetonide protects auditory hair cells from 4-hydroxy-2,3-nonenal (HNE) ototoxicity in vitroJose Guzman
University of Miami Ear Institute, Department of Otolaryngology, Miller School of Medicine University of Miami, Miami, FL 33136, USA
Acta Otolaryngol 126:685-90. 2006.... - Electrode migration after cochlear implantationSarah S Connell
Department of Otolaryngology, University of Miami Ear Institute, Miami, Florida, USA
Otol Neurotol 29:156-9. 2008..To review the occurrence of electrode migration after cochlear implantation... - Dexamethasone and methylprednisolone do not inhibit neuritic outgrowth while inhibiting outgrowth of fibroblasts from spiral ganglion explantsAlexis Furze
Department of Otolaryngology, University of Miami Ear Institute, Miller School of Medicine, Miami, FL, USA
Acta Otolaryngol 128:122-7. 2008..Dexamethasone and methylprednisolone do not inhibit neuritic outgrowth while inhibiting fibroblastic outgrowth from spiral ganglion micro-explants... - Cochlear implantation in organ transplantationD Michael Patterson
Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL 33101, USA
Laryngoscope 118:116-9. 2008..This study was designed to retrospectively review the outcomes of cochlear implantation among organ transplant patients... - Glutathione ester protects against hydroxynonenal-induced loss of auditory hair cellsJose W Ruiz
University of Miami Ear Institute, Department of Otolaryngology, University of Miami, Leonard M. Miller School of Medicine, Miami, Florida, USA
Otolaryngol Head Neck Surg 135:792-7. 2006..SIGNIFICANCE: Treatment with GSH(e) may be an effective therapy to protect the cochlea against the adverse effects of traumas (eg, electrode insertion) that generate oxidative stress... - Partial medial canal fibrosisAdrien A Eshraghi
University of Miami Ear Institute, Department of Otolaryngology, University of Miami, Miller School of Medicine, USA
Ear Nose Throat J 85:75. 2006 - Evaluation of hearing and auditory nerve function by combining ABR, DPOAE and eABR tests into a single recording sessionMarek Polak
Department of Otolaryngology, Cochlear Implant Research Program, University of Miami Ear Institute, 1600 NW 10th Avenue, RMSB 3160, Miami, FL 33136, USA
J Neurosci Methods 134:141-9. 2004..All measurements were obtained from anesthetized laboratory rats during single recording sessions using hardware and software stimulation and analysis programs developed by Intelligent Hearing Systems, Miami, FL... - Induction of localized cochlear hypothermiaLee P Smith
Department of Otolaryngology, Leonard M Miller School of Medicine, University of Miami, Miami, FL 33136, USA
Acta Otolaryngol 127:228-33. 2007..Localized cochlear hypothermia was induced in a rat model, demonstrating the feasibility of modulating cochlear temperature without affecting core body temperature... - The perceived angle of the round window affects electrode insertion trauma in round window insertion - an anatomical studyYisgav Shapira
University of Miami Ear Institute, Department of Otolaryngology, University of Miami Miller School of Medicine, FL, USA
Acta Otolaryngol 131:284-9. 2011..6% of cases. Therefore RW insertion is a valid option to be considered in selected cochlear implant patients, especially when hearing preservation is a goal. In most cases drilling of the overhangs is required... - Comparative study of cochlear damage with three perimodiolar electrode designsAdrien A Eshraghi
Department of Otolaryngology, Medical School, University of Miami Ear Institute, Miami, FL 33131, USA
Laryngoscope 113:415-9. 2003..To describe intracochlear insertion trauma caused by three perimodiolar cochlear implant electrodes... - Modiolar proximity of three perimodiolar cochlear implant electrodesThomas J Balkany
University of Miami Ear Institute, Florida 33136, USA
Acta Otolaryngol 122:363-9. 2002..All three devices were successful in terms of locating electrode contacts very close to the modiolar wall... - Cochlear implantation trauma and noise-induced hearing loss: Apoptosis and therapeutic strategiesAdrien A Eshraghi
University of Miami Ear Institute, Department of Otolaryngology, University of Miami, Miller School of Medicine, Miami, Florida 33136, USA
Anat Rec A Discov Mol Cell Evol Biol 288:473-81. 2006..g., electrode array insertional trauma. These forward-looking strategies have the potential of improving hearing outcomes after cochlear implantation and providing novel means of otoprotection from noise-induced trauma... - Dexamethasone protects auditory hair cells against TNFalpha-initiated apoptosis via activation of PI3K/Akt and NFkappaB signalingScott M Haake
Cochlear Implant Research Program, University of Miami Ear Institute, Department of Otolaryngology, University of Miami, Miller School of Medicine, RMSB 3160, Miami, FL 33136 1015, USA
Hear Res 255:22-32. 2009..Local treatment of cochleae of trauma-exposed animals with a glucocorticoid is effective in reducing the level of hearing loss that occurs post-trauma (e.g., electrode insertion trauma-induced hearing loss/dexamethasone treatment)... - Cochlear implants in children--a reviewThomas J Balkany
Department of Otolaryngology, University of Miami Ear Institute, Florida 33101, USA
Acta Otolaryngol 122:356-62. 2002..Hearing, language and social development outcomes have been positive. We review current issues in cochlear implantation, candidacy, evaluation, surgery, habilitation, ethics and outcomes... - Complete medial canal fibrosisS Arif Ulubil
University of Miami Ear Institute, Department of Otolaryngology, University of Miami Miller School of Medicine, USA
Ear Nose Throat J 85:10. 2006 - Arrest of apoptosis in auditory neurons: implications for sensorineural preservation in cochlear implantationUlysses Scarpidis
Department of Otolaryngology, Albert Einstein College of Medicine, Bronx, New York, USA
Otol Neurotol 24:409-17. 2003..CONCLUSION: Blocking the JNK/c-Jun cell death pathway is a feasible approach to treating oxidative stress-induced apoptosis within the cochlea and may have application as an otoprotective strategy during cochlear implantation... - Tympanomeatal flapsThomas J Balkany
Department of Otolaryngology, University of Miami Ear Institute, Box 016960 (D-48, Miami, FL 33101, USA
Laryngoscope 113:1266-8. 2003 
Otoplasty for the protruded earRonen Nazarian
Department of Otolaryngology, Head and Neck Surgery, University of Miami Miller School of Medicine, Miami, Florida
Semin Plast Surg 25:288-94. 2011..They also describe in more detail some of the more common methods for correcting the protruded ear, as well as postoperative management and common complications faced after surgery...- Sensory auricular branch of the facial nerveAdrien A Eshraghi
Department of Otolaryngology, University of Miami School of Medicine, Miami, Florida, USA
Otol Neurotol 23:393-6. 2002.... - Caloric function after endolymphatic sac surgeryS Arif Ulubil
Department of Otolaryngology, Kocaeli University Faculty of Medicine, Kocaeli, Turkey
Laryngoscope 118:295-9. 2008..To evaluate the effect of endolymphatic sac surgery on vestibular functions using caloric testing on electronystagmography (ENG)... - Vibrant soundbridge surgery: evaluation of transcanal surgical approachesEric Truy
Département d ORL, de Chirurgie Maxillo Cervico Faciale et d Audiophonologie, Hopital Edouard Herriot, Lyon, France
Otol Neurotol 27:887-95. 2006..e., facial palsy and/or taste disturbance. The purpose of this study is to develop and compare transcanal surgical approaches for leading the VSB into the middle ear...