M L Escolar

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Transplantation of umbilical-cord blood in babies with infantile Krabbe's disease
    Maria L Escolar
    Program for Neurodevelopmental Function in Rare Disorders, Clinical Center for the Study of Development and Learning, University of North Carolina at Chapel Hill, Chapel Hill 27599 7255, USA
    N Engl J Med 352:2069-81. 2005
  2. pmc Diffusion tensor imaging detects abnormalities in the corticospinal tracts of neonates with infantile Krabbe disease
    M L Escolar
    Program for Neurodevelopmental Function in Rare Disorders at the Center for the Study of Development and Learning, University of North Carolina at Chapel Hill, Chapel Hill, NC 27517, USA
    AJNR Am J Neuroradiol 30:1017-21. 2009
  3. ncbi request reprint A staging system for infantile Krabbe disease to predict outcome after unrelated umbilical cord blood transplantation
    Maria L Escolar
    Program for Neurodevelopmental Function in Rare Disorders, Clinical Center for the Study of Development and Learning, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7255, USA
    Pediatrics 118:e879-89. 2006
  4. doi request reprint Multidisciplinary management of Hunter syndrome
    Joseph Muenzer
    Department of Pediatrics, University of North Carolina, Chapel Hill, North Carolina 27599 7487, USA
    Pediatrics 124:e1228-39. 2009
  5. ncbi request reprint Gross motor development of children with hurler syndrome after umbilical cord blood transplantation
    Stacey C Dusing
    Department of Physical Therapy, School of Allied Health Professions, Virginia Commonwealth University, 1200 E Broad St, PO Box 980224, Richmond, VA 23298 0224, USA
    Phys Ther 87:1433-40. 2007
  6. ncbi request reprint Cord-blood transplants from unrelated donors in patients with Hurler's syndrome
    Susan L Staba
    Pediatric Stem Cell Transplant Program, Duke University Medical Center, Durham, NC 27710, USA
    N Engl J Med 350:1960-9. 2004
  7. ncbi request reprint Outcomes of unrelated umbilical cord blood transplantation for X-linked adrenoleukodystrophy
    Donald Beam
    Department of Pediatrics, Division of Pediatric Blood and Marrow Transplantation, Duke University Medical Center, Durham, NC, USA
    Biol Blood Marrow Transplant 13:665-74. 2007
  8. pmc Unrelated donor umbilical cord blood transplantation for inherited metabolic disorders in 159 pediatric patients from a single center: influence of cellular composition of the graft on transplantation outcomes
    Vinod K Prasad
    Pediatric Blood and Marrow Transplant Program, Duke University Medical Center, Durham, NC, USA
    Blood 112:2979-89. 2008
  9. ncbi request reprint Neurophysiologic assessment of mucopolysaccharidosis III
    Aatif M Husain
    Department of Medicine Neurology, 202 Bell Building, Box 3678, Duke University Medical Center, Durham, NC 27710, USA
    Clin Neurophysiol 117:2059-63. 2006
  10. ncbi request reprint Temporal and spatial gait characteristics of children with Hurler syndrome after umbilical cord blood transplantation
    Stacey C Dusing
    Department of Physical Therapy, School of Allied Health Professions, Virginia Commonwealth University, 1200 E Broad St, PO Box 980224, Richmond, VA 23298 0224, USA
    Phys Ther 87:978-85. 2007

Detail Information

Publications10

  1. ncbi request reprint Transplantation of umbilical-cord blood in babies with infantile Krabbe's disease
    Maria L Escolar
    Program for Neurodevelopmental Function in Rare Disorders, Clinical Center for the Study of Development and Learning, University of North Carolina at Chapel Hill, Chapel Hill 27599 7255, USA
    N Engl J Med 352:2069-81. 2005
    ..We compared the outcomes among these newborns with the outcomes among infants who underwent transplantation after the development of symptoms and with the outcomes in an untreated cohort of affected children...
  2. pmc Diffusion tensor imaging detects abnormalities in the corticospinal tracts of neonates with infantile Krabbe disease
    M L Escolar
    Program for Neurodevelopmental Function in Rare Disorders at the Center for the Study of Development and Learning, University of North Carolina at Chapel Hill, Chapel Hill, NC 27517, USA
    AJNR Am J Neuroradiol 30:1017-21. 2009
    ..The purpose of this study was to evaluate the use of diffusion tensor imaging (DTI) with fiber tracking in identifying early changes in major motor tracts of asymptomatic neonates with infantile Krabbe disease...
  3. ncbi request reprint A staging system for infantile Krabbe disease to predict outcome after unrelated umbilical cord blood transplantation
    Maria L Escolar
    Program for Neurodevelopmental Function in Rare Disorders, Clinical Center for the Study of Development and Learning, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7255, USA
    Pediatrics 118:e879-89. 2006
    ..We hypothesized that a staging system based on clinical indicators and neurophysiological and neuroimaging measures can predict posttreatment variation in patients diagnosed with infantile Krabbe disease...
  4. doi request reprint Multidisciplinary management of Hunter syndrome
    Joseph Muenzer
    Department of Pediatrics, University of North Carolina, Chapel Hill, North Carolina 27599 7487, USA
    Pediatrics 124:e1228-39. 2009
    ..The important management topics are discussed in this review, and the use of enzyme-replacement therapy with recombinant human iduronate-2-sulfatase as a specific treatment for Hunter syndrome is presented...
  5. ncbi request reprint Gross motor development of children with hurler syndrome after umbilical cord blood transplantation
    Stacey C Dusing
    Department of Physical Therapy, School of Allied Health Professions, Virginia Commonwealth University, 1200 E Broad St, PO Box 980224, Richmond, VA 23298 0224, USA
    Phys Ther 87:1433-40. 2007
    ..The purpose of this study was to provide a description of gross motor development in children with Hurler syndrome after UCBT...
  6. ncbi request reprint Cord-blood transplants from unrelated donors in patients with Hurler's syndrome
    Susan L Staba
    Pediatric Stem Cell Transplant Program, Duke University Medical Center, Durham, NC 27710, USA
    N Engl J Med 350:1960-9. 2004
    ..We investigated the feasibility of using cord-blood transplants from unrelated donors and a myeloablative preparative regimen that did not involve total-body irradiation in young children with Hurler's syndrome...
  7. ncbi request reprint Outcomes of unrelated umbilical cord blood transplantation for X-linked adrenoleukodystrophy
    Donald Beam
    Department of Pediatrics, Division of Pediatric Blood and Marrow Transplantation, Duke University Medical Center, Durham, NC, USA
    Biol Blood Marrow Transplant 13:665-74. 2007
    ..Superior outcomes were seen in neurologically asymptomatic boys less than 3.5 years of age at the time of transplantation. Baseline Loes scores were a strong predictor of cognitive and motor outcome...
  8. pmc Unrelated donor umbilical cord blood transplantation for inherited metabolic disorders in 159 pediatric patients from a single center: influence of cellular composition of the graft on transplantation outcomes
    Vinod K Prasad
    Pediatric Blood and Marrow Transplant Program, Duke University Medical Center, Durham, NC, USA
    Blood 112:2979-89. 2008
    ..1%-85.3%) in patients with high (80-100) performance score. In multivariate analysis, favorable factors for OS were high pretransplantation performance status, matched donor/recipient ethnicity, and higher infused colony forming units...
  9. ncbi request reprint Neurophysiologic assessment of mucopolysaccharidosis III
    Aatif M Husain
    Department of Medicine Neurology, 202 Bell Building, Box 3678, Duke University Medical Center, Durham, NC 27710, USA
    Clin Neurophysiol 117:2059-63. 2006
    ..To describe finding of various neurophysiologic tests in patients with mucopolysaccharidosis III (MPS III) early in the disease course...
  10. ncbi request reprint Temporal and spatial gait characteristics of children with Hurler syndrome after umbilical cord blood transplantation
    Stacey C Dusing
    Department of Physical Therapy, School of Allied Health Professions, Virginia Commonwealth University, 1200 E Broad St, PO Box 980224, Richmond, VA 23298 0224, USA
    Phys Ther 87:978-85. 2007
    ....

Research Grants3

  1. DTI as a tool to identify infants with Krabbe Disease in need of urgent treatment
    Maria L Escolar; Fiscal Year: 2010
    ..This study will examine the potential for Diffusion Tensor Imaging to be used prognostically for treatment decisions, and as a marker of disease progression associated with motor disability after UCBT. ..