M A Escamilla

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. pmc A minimalist approach to gene mapping: locating the gene for acheiropodia, by homozygosity analysis
    M A Escamilla
    Neurogenetics Laboratory, Department of Psychiatry, University of Texas Health Science Center, San Antonio, TX, USA
    Am J Hum Genet 66:1995-2000. 2000
  2. pmc Genetics of bipolar disorder
    Michael A Escamilla
    University of Texas Health Science Center at San Antonio, South Texas Medical Genetics Research Center, 1214 Schunior St, Edinburg, TX 78539, USA
    Dialogues Clin Neurosci 10:141-52. 2008
  3. doi request reprint The epsin 4 gene is associated with psychotic disorders in families of Latin American origin
    Michael Escamilla
    Psychiatric Genetics Research Center, Department of Psychiatry, University of Texas Health Science Center at San Antonio, TX 78229 3900, USA
    Schizophr Res 106:253-7. 2008
  4. doi request reprint A schizophrenia gene locus on chromosome 17q21 in a new set of families of Mexican and central american ancestry: evidence from the NIMH Genetics of schizophrenia in latino populations study
    Michael Escamilla
    Psychiatric Genetics Center, University of Texas Health Science Center at San Antonio, Suite 200, 454 Soledad St, San Antonio, TX 78205, USA
    Am J Psychiatry 166:442-9. 2009
  5. ncbi request reprint Population isolates: their special value for locating genes for bipolar disorder
    M A Escamilla
    Neurogenetics Laboratory, Department of Psychiatry, The University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Bipolar Disord 3:299-317. 2001
  6. ncbi request reprint A genome-wide scan for schizophrenia and psychosis susceptibility loci in families of Mexican and Central American ancestry
    M A Escamilla
    Department of Psychiatry, University of Texas Health Science Center at San Antonio UTHSCSA, San Antonio, Texas, 78229 3900, USA
    Am J Med Genet B Neuropsychiatr Genet 144:193-9. 2007
  7. ncbi request reprint Association analyses of the neuregulin 1 gene with schizophrenia and manic psychosis in a Hispanic population
    C Walss-Bass
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, TX, USA
    Acta Psychiatr Scand 113:314-21. 2006
  8. ncbi request reprint TGFB-induced factor (TGIF): a candidate gene for psychosis on chromosome 18p
    I Chavarria-Siles
    Psychiatric Genetics Research Center, Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Mol Psychiatry 12:1033-41. 2007
  9. ncbi request reprint Genome screening for linkage disequilibrium in a Costa Rican sample of patients with bipolar-I disorder: a follow-up study on chromosome 18
    M A Escamilla
    Neurogenetics Laboratory, University of California at San Francisco, San Francisco, California, USA
    Am J Med Genet 105:207-13. 2001
  10. ncbi request reprint Malic enzyme 2 and susceptibility to psychosis and mania
    Byung Dae Lee
    Psychiatric Genetics Research Center, Department of Psychiatry, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Psychiatry Res 150:1-11. 2007

Research Grants

  1. GENETICS OF SCHIZOPHRENIA IN LATINO POPULATIONS
    Michael Escamilla; Fiscal Year: 2000
  2. Genetics of Bipolar Disorder in Latino Populations
    Michael Escamilla; Fiscal Year: 2006
  3. POPULATION BASED MAPPING OF SCHIZOPHRENIA GENES
    Michael Escamilla; Fiscal Year: 2007
  4. Ethnicity and the Diagnosis of Affective Illness
    Michael Escamilla; Fiscal Year: 2007
  5. Genetics of Bipolar Disorder in Latino Populations
    Michael Escamilla; Fiscal Year: 2007
  6. US Psychiatric Genetics Research Training Program
    Michael Escamilla; Fiscal Year: 2007
  7. POPULATION BASED MAPPING OF SCHIZOPHRENIA GENES
    Michael Escamilla; Fiscal Year: 2009
  8. Genetics of Bipolar Disorder in Latino Populations
    Michael Escamilla; Fiscal Year: 2009
  9. Ethnicity and the Diagnosis of Affective Illness
    Michael Escamilla; Fiscal Year: 2006
  10. Genetics of Bipolar Disorder in Latino Populations
    Michael Escamilla; Fiscal Year: 2005

Detail Information

Publications27

  1. pmc A minimalist approach to gene mapping: locating the gene for acheiropodia, by homozygosity analysis
    M A Escamilla
    Neurogenetics Laboratory, Department of Psychiatry, University of Texas Health Science Center, San Antonio, TX, USA
    Am J Hum Genet 66:1995-2000. 2000
    ..6-cM region. Localization of this gene, at the screening level, by use of data from only three affected subjects, provides an example of how certain genes may be mapped by use of a minimal number of affected cases...
  2. pmc Genetics of bipolar disorder
    Michael A Escamilla
    University of Texas Health Science Center at San Antonio, South Texas Medical Genetics Research Center, 1214 Schunior St, Edinburg, TX 78539, USA
    Dialogues Clin Neurosci 10:141-52. 2008
    ..This review covers our current knowledge of the genetics of bipolar disorder, and provides a commentary on current approaches used to identify the genes involved in this complex behavioral disorder...
  3. doi request reprint The epsin 4 gene is associated with psychotic disorders in families of Latin American origin
    Michael Escamilla
    Psychiatric Genetics Research Center, Department of Psychiatry, University of Texas Health Science Center at San Antonio, TX 78229 3900, USA
    Schizophr Res 106:253-7. 2008
    ..This provides additional support for the involvement of enthoprotin in the pathogenesis of schizophrenia and other psychotic disorders...
  4. doi request reprint A schizophrenia gene locus on chromosome 17q21 in a new set of families of Mexican and central american ancestry: evidence from the NIMH Genetics of schizophrenia in latino populations study
    Michael Escamilla
    Psychiatric Genetics Center, University of Texas Health Science Center at San Antonio, Suite 200, 454 Soledad St, San Antonio, TX 78205, USA
    Am J Psychiatry 166:442-9. 2009
    ..The present study investigated a new set of families of Latin American ancestry in order to detect the location of genes predisposing to schizophrenia and related psychotic disorders...
  5. ncbi request reprint Population isolates: their special value for locating genes for bipolar disorder
    M A Escamilla
    Neurogenetics Laboratory, Department of Psychiatry, The University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Bipolar Disord 3:299-317. 2001
    ..In this review article, the rationale for performing gene mapping studies in this type of population and the results of genetic mapping studies performed to date in population isolates are presented...
  6. ncbi request reprint A genome-wide scan for schizophrenia and psychosis susceptibility loci in families of Mexican and Central American ancestry
    M A Escamilla
    Department of Psychiatry, University of Texas Health Science Center at San Antonio UTHSCSA, San Antonio, Texas, 78229 3900, USA
    Am J Med Genet B Neuropsychiatr Genet 144:193-9. 2007
    ....
  7. ncbi request reprint Association analyses of the neuregulin 1 gene with schizophrenia and manic psychosis in a Hispanic population
    C Walss-Bass
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, TX, USA
    Acta Psychiatr Scand 113:314-21. 2006
    ..This study used the population of the Central Valley of Costa Rica (CVCR) and phenotyping strategies alternative to DSMIV classifications to investigate the association of neuregulin 1 with schizophrenia...
  8. ncbi request reprint TGFB-induced factor (TGIF): a candidate gene for psychosis on chromosome 18p
    I Chavarria-Siles
    Psychiatric Genetics Research Center, Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Mol Psychiatry 12:1033-41. 2007
    ..Altogether, our results point to the possible involvement of TGIF in the pathophysiology of psychotic disorders in the CVCR population...
  9. ncbi request reprint Genome screening for linkage disequilibrium in a Costa Rican sample of patients with bipolar-I disorder: a follow-up study on chromosome 18
    M A Escamilla
    Neurogenetics Laboratory, University of California at San Francisco, San Francisco, California, USA
    Am J Med Genet 105:207-13. 2001
    ..Furthermore, the analysis continues to support a possible BP-I locus on 18pter, suggested by previous analyses in this population. Evidence for a possible BP-I locus on 18q12.2 is also described...
  10. ncbi request reprint Malic enzyme 2 and susceptibility to psychosis and mania
    Byung Dae Lee
    Psychiatric Genetics Research Center, Department of Psychiatry, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Psychiatry Res 150:1-11. 2007
    ..The present study suggests that genetic variation in or near the ME2 gene is associated with both psychotic and manic disorders, including schizophrenia and bipolar disorder...
  11. pmc Fine-scale mapping of a locus for severe bipolar mood disorder on chromosome 18p11.3 in the Costa Rican population
    L A McInnes
    Neurogenetics Laboratory, Center for Neurobiology and Psychiatry, and Department of Psychiatry, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 98:11485-90. 2001
    ..Our results suggest a candidate region containing six genes but also highlight the complexities of LD mapping of common disorders...
  12. doi request reprint Neuronal correlates of brain-derived neurotrophic factor Val66Met polymorphism and morphometric abnormalities in bipolar disorder
    Koji Matsuo
    Department of Psychiatry, The University of Texas Health Science Center, San Antonio, TX, USA
    Neuropsychopharmacology 34:1904-13. 2009
    ....
  13. ncbi request reprint Evidence of genetic overlap of schizophrenia and bipolar disorder: linkage disequilibrium analysis of chromosome 18 in the Costa Rican population
    Consuelo Walss-Bass
    Psychiatric Genetics Research Center, Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Am J Med Genet B Neuropsychiatr Genet 139:54-60. 2005
    ....
  14. ncbi request reprint Diagnosis and treatment of mood disorders that co-occur with schizophrenia
    M A Escamilla
    Department of Psychiatry at the University of Texas Health Science Center, San Antonio 78229 3900, USA
    Psychiatr Serv 52:911-9. 2001
    ..There is a great need for additional research on treatment of mood disorders that arise during the course of schizophrenia, especially with regard to newer mood stabilizers and antidepressants...
  15. pmc Methionine sulfoxide reductase: a novel schizophrenia candidate gene
    Consuelo Walss-Bass
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, USA
    Am J Med Genet B Neuropsychiatr Genet 150:219-25. 2009
    ..Further studies into the mechanisms by which MSRA is involved in schizophrenia pathophysiology may shed light into the biological underpinnings of this disorder...
  16. ncbi request reprint Adjudicating neurocognitive endophenotypes for schizophrenia
    David C Glahn
    Department of Psychiatry, University of Texas Health Science Center San Antonio, San Antonio, Texas 78229 3900, USA
    Am J Med Genet B Neuropsychiatr Genet 144:242-9. 2007
    ..We present a practical model for adjudicating endophenotypes and determining which measures are best suited for use in linkage analyses...
  17. doi request reprint Heritability of age of onset of psychosis in schizophrenia
    Elizabeth Hare
    South Texas Psychiatric Genetics Research Center, UT Health Science Center, San Antonio, San Antonio, Texas, USA
    Am J Med Genet B Neuropsychiatr Genet 153:298-302. 2010
    ..33 (SE = 0.09; P = 0.00004). These findings suggest that genetic factors significantly contribute to the age of onset of psychotic symptoms in individuals with schizophrenia and that sex influences this trait as well...
  18. ncbi request reprint The feasibility of neuropsychological endophenotypes in the search for genes associated with bipolar affective disorder
    David C Glahn
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, 78229 3900, USA
    Bipolar Disord 6:171-82. 2004
    ..We reviewed the literature to determine if neuropsychological measures could be used as effective endophenotypes to aid molecular genetic studies searching for genes predisposing to BPD...
  19. pmc Genomewide linkage disequilibrium mapping of severe bipolar disorder in a population isolate
    Roel A Ophoff
    Neurogenetics Laboratory, University of California, San Francisco, CA, USA
    Am J Hum Genet 71:565-74. 2002
    ..This region could be important for severe psychiatric disorders, rather than for a specific phenotype...
  20. ncbi request reprint Linkage disequilibrium analyses in the Costa Rican population suggests discrete gene loci for schizophrenia at 8p23.1 and 8q13.3
    Consuelo Walss-Bass
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, and Southwest Foundation for Biomedical Research, San Antonio, Texas 78229 3900, USA
    Psychiatr Genet 16:159-68. 2006
    ....
  21. doi request reprint Cannabinoid receptor 1 gene (CNR1) and susceptibility to a quantitative phenotype for hebephrenic schizophrenia
    Ivan Chavarria-Siles
    Department of Psychiatry, Psychiatric Genetics Research Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Am J Med Genet B Neuropsychiatr Genet 147:279-84. 2008
    ..The current finding points to the possibility of different genetic and pathophysiologic mechanisms underlying different types of schizophrenia...
  22. ncbi request reprint Brain-derived neurotrophic factor val66met polymorphism affects prefrontal energy metabolism in bipolar disorder
    Benicio N Frey
    Department of Psychiatry, Psychiatric Genetics Research Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Neuroreport 18:1567-70. 2007
    ..These results indicate that bipolar disorder met-carriers have abnormal energy metabolism in the left dorsolateral prefrontal cortex...
  23. ncbi request reprint Effect of catechol O-methyltransferase val(158)met polymorphism on the p50 gating endophenotype in schizophrenia
    Brett Y Lu
    Department of Psychiatry, University of New Mexico, Albuquerque, New Mexico 87108, USA
    Biol Psychiatry 62:822-5. 2007
    ..The role of prefrontal dopamine on P50 gating was investigated, using catechol-O-methyltransferase (COMT) valine (val)(158)methionine (met) polymorphism as a predictor of prefrontal dopamine activity...
  24. ncbi request reprint Genetic studies of neuropsychiatric disorders in Costa Rica: a model for the use of isolated populations
    Carol A Mathews
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0810, USA
    Psychiatr Genet 14:13-23. 2004
    ..In this paper we highlight the studies currently being conducted by our groups in the Central Valley of Costa Rica to illustrate the potential advantages of this population for genetic studies...
  25. ncbi request reprint The Lifetime Dimensions of Psychosis Scale (LDPS): description and interrater reliability
    Douglas F Levinson
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104 3309, USA
    Schizophr Bull 28:683-95. 2002
    ..Dimensional scores and multidimensional patterns might prove useful in studying the relationship of clinical phenotype to genotypes, treatment response, and other variables. They may also be useful in clinical practice...
  26. ncbi request reprint Comorbidity of bipolar disorder and substance abuse in Costa Rica: pedigree- and population-based studies
    Michael A Escamilla
    Department of Psychiatry, 7792, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Affect Disord 71:71-83. 2002
    ....
  27. pmc Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder
    Ricardo Segurado
    Neuropsychiatric Genetics Unit, Department of Genetics, Trinity College, Dublin 2, Ireland
    Am J Hum Genet 73:49-62. 2003
    ..We note that meta-analysis can sometimes provide support for linkage but cannot disprove linkage in any candidate region...

Research Grants24

  1. GENETICS OF SCHIZOPHRENIA IN LATINO POPULATIONS
    Michael Escamilla; Fiscal Year: 2000
    ....
  2. Genetics of Bipolar Disorder in Latino Populations
    Michael Escamilla; Fiscal Year: 2006
    ....
  3. POPULATION BASED MAPPING OF SCHIZOPHRENIA GENES
    Michael Escamilla; Fiscal Year: 2007
    ..This grant aims to identify the genes which contribute to causing schizophrenia. By identifying the genes which contribute to the diagnosis of schizophrenia, scientists will be able to better diagnose and treat this disabling illness. ..
  4. Ethnicity and the Diagnosis of Affective Illness
    Michael Escamilla; Fiscal Year: 2007
    ..The final objective is to determine whether Latinos are at risk for similar problems in diagnostic assessments and treatment assignment. ..
  5. Genetics of Bipolar Disorder in Latino Populations
    Michael Escamilla; Fiscal Year: 2007
    ....
  6. US Psychiatric Genetics Research Training Program
    Michael Escamilla; Fiscal Year: 2007
    ..Specific aims of the program follow. ..
  7. POPULATION BASED MAPPING OF SCHIZOPHRENIA GENES
    Michael Escamilla; Fiscal Year: 2009
    ..By identifying the genes which contribute to the diagnosis of schizophrenia, scientists will be able to better diagnose and treat this disabling illness. ..
  8. Genetics of Bipolar Disorder in Latino Populations
    Michael Escamilla; Fiscal Year: 2009
    ....
  9. Ethnicity and the Diagnosis of Affective Illness
    Michael Escamilla; Fiscal Year: 2006
    ..The final objective is to determine whether Latinos are at risk for similar problems in diagnostic assessments and treatment assignment. ..
  10. Genetics of Bipolar Disorder in Latino Populations
    Michael Escamilla; Fiscal Year: 2005
    ....
  11. POPULATION BASED MAPPING OF SCHIZOPHRENIA GENES
    Michael Escamilla; Fiscal Year: 2000
    ..Fine mapping at 1 cM density will be performed across schizophrenic candidate regions identified in this or other populations. ..
  12. GENETICS OF SCHIZOPHRENIA IN LATINO POPULATIONS
    Michael Escamilla; Fiscal Year: 2001
    ....
  13. POPULATION BASED MAPPING OF SCHIZOPHRENIA GENES
    Michael Escamilla; Fiscal Year: 2001
    ..Fine mapping at 1 cM density will be performed across schizophrenic candidate regions identified in this or other populations. ..
  14. POPULATION BASED MAPPING OF SCHIZOPHRENIA GENES
    Michael Escamilla; Fiscal Year: 2002
    ..Fine mapping at 1 cM density will be performed across schizophrenic candidate regions identified in this or other populations. ..
  15. GENETICS OF SCHIZOPHRENIA IN LATINO POPULATIONS
    Michael Escamilla; Fiscal Year: 2002
    ....
  16. POPULATION BASED MAPPING OF SCHIZOPHRENIA GENES
    Michael Escamilla; Fiscal Year: 2002
    ..Fine mapping at 1 cM density will be performed across schizophrenic candidate regions identified in this or other populations. ..
  17. GENETICS OF SCHIZOPHRENIA IN LATINO POPULATIONS
    Michael Escamilla; Fiscal Year: 2003
    ....
  18. POPULATION BASED MAPPING OF SCHIZOPHRENIA GENES
    Michael Escamilla; Fiscal Year: 2003
    ..Fine mapping at 1 cM density will be performed across schizophrenic candidate regions identified in this or other populations. ..
  19. POPULATION BASED MAPPING OF SCHIZOPHRENIA GENES
    Michael Escamilla; Fiscal Year: 2004
    ..Fine mapping at 1 cM density will be performed across schizophrenic candidate regions identified in this or other populations. ..
  20. Ethnicity and the Diagnosis of Affective Illness
    Michael Escamilla; Fiscal Year: 2005
    ..The final objective is to determine whether Latinos are at risk for similar problems in diagnostic assessments and treatment assignment. ..
  21. U.S./Costa Rica Neuropsychiatric Genetics Research Training Program
    Michael Escamilla; Fiscal Year: 2009
    ..To overcome this problem this grant extends our current Costa Rican Training Program to include the study of the genetics of neurodevelopmental disorders. ..