James M Ervasti

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Costameres: the Achilles' heel of Herculean muscle
    James M Ervasti
    Department of Physiology, University of Wisconsin Medical School, Madison 53706, USA
    J Biol Chem 278:13591-4. 2003
  2. ncbi request reprint Dystrophin and utrophin bind actin through distinct modes of contact
    Inna N Rybakova
    Department of Physiology, University of Wisconsin Medical School, 127 Service Memorial Institute, 1300 University Avenue, Madison, WI 53706, USA
    J Biol Chem 281:9996-10001. 2006
  3. pmc Cytoplasmic gamma-actin contributes to a compensatory remodeling response in dystrophin-deficient muscle
    Laurin M Hanft
    Department of Physiology, University of Wisconsin, 1300 University Avenue, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 103:5385-90. 2006
  4. ncbi request reprint Identification of spectrin-like repeats required for high affinity utrophin-actin interaction
    Inna N Rybakova
    Department of Physiology, University of Wisconsin Medical School, Madison, 53706, USA
    J Biol Chem 280:23018-23. 2005
  5. ncbi request reprint Brain alpha-dystroglycan displays unique glycoepitopes and preferential binding to laminin-10/11
    Erin L McDearmon
    Department of Physiology, University of Wisconsin, Madison, 53706, USA
    FEBS Lett 580:3381-5. 2006
  6. ncbi request reprint Dystrophin, its interactions with other proteins, and implications for muscular dystrophy
    James M Ervasti
    Department of Physiology, 127 Service Memorial Institute, University of Wisconsin Medical School, 1300 University Avenue, Madison, WI 53706, USA
    Biochim Biophys Acta 1772:108-17. 2007
  7. pmc Enhanced laminin binding by alpha-dystroglycan after enzymatic deglycosylation
    Ariana C Combs
    Department of Physiology, Madison Medical School, University of Wisconsin, 127 Service Memorial Institute, 1300 University Avenue, Madison, WI 53706, USA
    Biochem J 390:303-9. 2005
  8. pmc Utrophin binds laterally along actin filaments and can couple costameric actin with sarcolemma when overexpressed in dystrophin-deficient muscle
    Inna N Rybakova
    Department of Physiology, University of Wisconsin Medical School, Madison 53706, USA
    Mol Biol Cell 13:1512-21. 2002
  9. pmc Destabilization of the dystrophin-glycoprotein complex without functional deficits in alpha-dystrobrevin null muscle
    Tina M Bunnell
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS ONE 3:e2604. 2008
  10. ncbi request reprint Expression of Dp260 in muscle tethers the actin cytoskeleton to the dystrophin-glycoprotein complex and partially prevents dystrophy
    Laura E Warner
    Department of Neurology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Hum Mol Genet 11:1095-105. 2002

Collaborators

  • Yoshinao Wada
  • Inna N Rybakova
  • Jitandrakumar R Patel
  • Kay E Davies
  • Martin F Schneider
  • DAWN LOWE
  • Jeffrey Chamberlain
  • Ulrike Mayer
  • Ariana C Combs
  • Erin L McDearmon
  • Laurin M Hanft
  • Kurt W Prins
  • Tina M Bunnell
  • Daniel P Fitzsimons
  • Kevin J Sonnemann
  • Kiyotoshi Sekiguchi
  • Hiroyuki Ido
  • Sergei P Smirnov
  • Laura E Warner
  • Vitold E Galkin
  • Michele A Jaeger
  • Stephen J Kaufman
  • Joe N Kornegay
  • Daniel J Bogan
  • Jill A Rafael-Fortney
  • Richard L Moss
  • Yewei Liu
  • Hironobu Fujiwara
  • Kenji Harada
  • Sugiko Futaki
  • Yoshitaka Hayashi
  • Shaoliang Li
  • Yuko Natsuka
  • Ryoko Nishiuchi
  • Edward H Egelman
  • Margaret S VanLoock
  • Robert W Crawford
  • Shaohua Li
  • Christiana DelloRusso
  • Karl Tryggvason
  • Peter D Yurchenco
  • Albina Orlova

Detail Information

Publications19

  1. ncbi request reprint Costameres: the Achilles' heel of Herculean muscle
    James M Ervasti
    Department of Physiology, University of Wisconsin Medical School, Madison 53706, USA
    J Biol Chem 278:13591-4. 2003
  2. ncbi request reprint Dystrophin and utrophin bind actin through distinct modes of contact
    Inna N Rybakova
    Department of Physiology, University of Wisconsin Medical School, 127 Service Memorial Institute, 1300 University Avenue, Madison, WI 53706, USA
    J Biol Chem 281:9996-10001. 2006
    ..Finally, we reassessed the abundance of dystrophin in striated muscle using full-length protein as the standard and measured greater than 10-fold higher values than previously reported...
  3. pmc Cytoplasmic gamma-actin contributes to a compensatory remodeling response in dystrophin-deficient muscle
    Laurin M Hanft
    Department of Physiology, University of Wisconsin, 1300 University Avenue, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 103:5385-90. 2006
    ..However, the presence of excessive myoplasmic gamma-actin may also contribute to altered cell signaling or gene expression in dystrophin-deficient muscle...
  4. ncbi request reprint Identification of spectrin-like repeats required for high affinity utrophin-actin interaction
    Inna N Rybakova
    Department of Physiology, University of Wisconsin Medical School, Madison, 53706, USA
    J Biol Chem 280:23018-23. 2005
    ..These findings support the model for lateral association of utrophin along the actin filament and provide the molecular basis for designing the most effective utrophin "mini-genes" for treatment of dystrophinopathies...
  5. ncbi request reprint Brain alpha-dystroglycan displays unique glycoepitopes and preferential binding to laminin-10/11
    Erin L McDearmon
    Department of Physiology, University of Wisconsin, Madison, 53706, USA
    FEBS Lett 580:3381-5. 2006
    ..Our results suggest that tissue-specific glycosylation modifies the laminin binding specificity of alpha-dystroglycan...
  6. ncbi request reprint Dystrophin, its interactions with other proteins, and implications for muscular dystrophy
    James M Ervasti
    Department of Physiology, 127 Service Memorial Institute, University of Wisconsin Medical School, 1300 University Avenue, Madison, WI 53706, USA
    Biochim Biophys Acta 1772:108-17. 2007
    ..The dystrophin homologue utrophin can compensate at the cell/tissue level for dystrophin deficiency, but functions through distinct molecular mechanisms of protein-protein interaction...
  7. pmc Enhanced laminin binding by alpha-dystroglycan after enzymatic deglycosylation
    Ariana C Combs
    Department of Physiology, Madison Medical School, University of Wisconsin, 127 Service Memorial Institute, 1300 University Avenue, Madison, WI 53706, USA
    Biochem J 390:303-9. 2005
    ....
  8. pmc Utrophin binds laterally along actin filaments and can couple costameric actin with sarcolemma when overexpressed in dystrophin-deficient muscle
    Inna N Rybakova
    Department of Physiology, University of Wisconsin Medical School, Madison 53706, USA
    Mol Biol Cell 13:1512-21. 2002
    ..More generally, our results raise the possibility that spectrin-like repeats may enable some members of the plakin family of cytolinkers to laterally bind and stabilize actin filaments...
  9. pmc Destabilization of the dystrophin-glycoprotein complex without functional deficits in alpha-dystrobrevin null muscle
    Tina M Bunnell
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS ONE 3:e2604. 2008
    ..Our results demonstrate that myofiber degeneration alone does not cause functional deficits and suggests that more complex pathological factors contribute to the development of muscle weakness in muscular dystrophy...
  10. ncbi request reprint Expression of Dp260 in muscle tethers the actin cytoskeleton to the dystrophin-glycoprotein complex and partially prevents dystrophy
    Laura E Warner
    Department of Neurology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Hum Mol Genet 11:1095-105. 2002
    ..We suggest that a non-mechanical defect, attributed to the loss of the N terminus of dystrophin, is likely responsible for the residual dystrophy observed...
  11. ncbi request reprint Cytoplasmic gamma-actin is not required for skeletal muscle development but its absence leads to a progressive myopathy
    Kevin J Sonnemann
    Program in Cellular and Molecular Biology, University of Wisconsin Madison, 53706, USA
    Dev Cell 11:387-97. 2006
    ....
  12. pmc Skeletal muscle-specific ablation of gamma(cyto)-actin does not exacerbate the mdx phenotype
    Kurt W Prins
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS ONE 3:e2419. 2008
    ....
  13. doi request reprint Biology of the striated muscle dystrophin-glycoprotein complex
    James M Ervasti
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Int Rev Cytol 265:191-225. 2008
    ..Studies in model organisms confirm the importance of the dystrophin-glycoprotein complex for muscle cell viability and have provided new leads toward a full understanding of its secondary roles in muscle biology...
  14. pmc Cytoplasmic gamma-actin expression in diverse animal models of muscular dystrophy
    Laurin M Hanft
    Department of Physiology, University of Wisconsin, Madison, WI, United States
    Neuromuscul Disord 17:569-74. 2007
    ..These data suggest that elevated gamma(cyto)-actin is part of a compensatory cytoskeletal remodeling program that may partially stabilize dystrophic muscle in some cases where the dystrophin-glycoprotein complex is compromised...
  15. ncbi request reprint Contributions of the LG modules and furin processing to laminin-2 functions
    Sergei P Smirnov
    Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Biol Chem 277:18928-37. 2002
    ....
  16. pmc The utrophin actin-binding domain binds F-actin in two different modes: implications for the spectrin superfamily of proteins
    Vitold E Galkin
    Department of Biochemistry and Molecular Genetics, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    J Cell Biol 157:243-51. 2002
    ..The cell may use the modular CH domains found in the spectrin superfamily of actin-binding proteins to bind actin in manifold ways, allowing for complexity to arise from the interactions of a relatively few simple modules with actin...
  17. ncbi request reprint Core 1 glycans on alpha-dystroglycan mediate laminin-induced acetylcholine receptor clustering but not laminin binding
    Erin L McDearmon
    Graduate Program in Molecular and Cellular Pharmacology, University of Wisconsin Madison Medical School, 53706, USA
    J Biol Chem 278:44868-73. 2003
    ....
  18. ncbi request reprint Molecular dissection of the alpha-dystroglycan- and integrin-binding sites within the globular domain of human laminin-10
    Hiroyuki Ido
    Division of Protein Chemistry, Institute for Protein Research, Osaka University, Suita, Osaka 565 0871, Japan
    J Biol Chem 279:10946-54. 2004
    ....